Compound in Profiling

Compound Information

Test on : RBC

Compound Name : -

Inchikey : VQNCIRRXQQTXEL-UHFFFAOYSA-N

ChemSpider : 7828217

Pubchem CID : 9549301

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDK1	1	1
Akt	3	3
DMPK	7	5
GRK	7	6
RSK	8	8
PKA	5	3
PKC	9	9
PKG	2	3
PKN	3	2
SGK	3	3
NDR	4	1

AGC - PDK1

Bioactivity
Kinase	RBC
PDK1	inactive (94.92%)

AGC - Akt

Bioactivity
Kinase	RBC
AKT1	inactive (94.67%)
AKT2	inactive (92.4%)
AKT3	-

AGC - DMPK

Bioactivity
Kinase	RBC
DMPK1	inactive (99.34%)
MRCKa	inactive (89.48%)
MRCKb	inactive (105.26%)
ROCK1	inactive (100.75%)
ROCK2	inactive (92.54%)

AGC - GRK

Bioactivity
Kinase	RBC
BARK1	inactive (94.83%)
BARK2	inactive (87.88%)
GPRK4	inactive (97.34%)
GPRK5	inactive (108.29%)
GPRK6	inactive (101.21%)
GPRK7	inactive (105.67%)

AGC - RSK

Bioactivity
Kinase	RBC
MSK1	inactive (85.56%)
MSK2	inactive (95.31%)
p70S6K	inactive (94.82%)
p70S6Kb	inactive (105.96%)
RSK2	inactive (88.43%)
RSK4	inactive (84.76%)
RSK1	inactive (91.33%)
RSK3	inactive (80.79%)

AGC - PKA

Bioactivity
Kinase	RBC
PKACg	-
PRKX	inactive (96.33%)
PKACa	inactive (99.82%)

AGC - PKC

Bioactivity
Kinase	RBC
PKCa	inactive (89.87%)
PKCd	inactive (107.9%)
PKCe	inactive (90.53%)
PKCh	inactive (87.36%)
PKCg	inactive (81.08%)
PKCi	inactive (95.21%)
PKCt	inactive (97.3%)
PKCz	inactive (96.88%)
PKCb	inactive (96.72%)

AGC - PKG

Bioactivity
Kinase	RBC
PKG2	inactive (61.59%)
PKG1	inactive (92.27%)

AGC - PKN

Bioactivity
Kinase	RBC
PKN1	inactive (97.02%)
PKN2	inactive (97.46%)

AGC - SGK

Bioactivity
Kinase	RBC
SGK1	inactive (118.1%)
SGK2	inactive (101.37%)
SGK3	inactive (92.57%)

AGC - NDR

Bioactivity
Kinase	RBC
NDR1	active (0%)

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Abl	2	2
Ack	2	1
ALK	2	2
Axl	3	3
Src	11	11
Tec	5	5
PDGFR	5	5
Csk	2	2
DDR	2	1
EGFR	4	3
Eph	14	12
FAK	2	2
Fer	2	2
FGFR	4	4
VEGFR	3	3
InsR	3	3
JakA	4	4
Musk	1	1
Ret	1	1
Met	2	2
Sev	1	1
Syk	2	2
Tie	2	1
Trk	3	3

TK - Abl

Bioactivity
Kinase	RBC
ABL1	inactive (95.65%)
ABL2	inactive (96.32%)

TK - Ack

Bioactivity
Kinase	RBC
ACK	inactive (98.86%)

TK - ALK

Bioactivity
Kinase	RBC
ALK	inactive (103.18%)
LTK	inactive (87.44%)

TK - Axl

Bioactivity
Kinase	RBC
AXL	inactive (97.99%)
MER	inactive (96.06%)
TYRO3	inactive (97.76%)

TK - Src

Bioactivity
Kinase	RBC
BLK	inactive (98.84%)
BRK	inactive (87.07%)
SRC	inactive (86.67%)
FGR	inactive (92.04%)
FRK	inactive (89.58%)
FYN	inactive (101.63%)
HCK	inactive (94.66%)
LCK	inactive (88.6%)
SRM	inactive (91.49%)
YES	inactive (86.29%)
LYN	inactive (101.56%)

TK - Tec

Bioactivity
Kinase	RBC
BMX	inactive (104.2%)
BTK	inactive (100.46%)
ITK	inactive (98.63%)
TEC	inactive (105.38%)
TXK	inactive (100.78%)

TK - PDGFR

Bioactivity
Kinase	RBC
KIT	inactive (71%)
FLT3	inactive (74.16%)
FMS	inactive (94.58%)
PDGFRb	inactive (98.92%)
PDGFRa	inactive (91.6%)

TK - Csk

Bioactivity
Kinase	RBC
CSK	inactive (105.59%)
CTK	inactive (91.13%)

TK - DDR

Bioactivity
Kinase	RBC
DDR2	inactive (96.25%)

TK - EGFR

Bioactivity
Kinase	RBC
EGFR	inactive (95.15%)
ErbB2	inactive (101.46%)
ErbB4	inactive (101.25%)

TK - Eph

Bioactivity
Kinase	RBC
EphA1	inactive (94.96%)
EphA2	inactive (100.5%)
EphA3	inactive (86.21%)
EphA4	inactive (102.31%)
EphA5	inactive (109.68%)
EphA6	-
EphA7	inactive (97.9%)
EphA8	inactive (101.65%)
EphB1	inactive (91.29%)
EphB2	inactive (92.54%)
EphB3	inactive (92.62%)
EphB4	inactive (90.67%)

TK - FAK

Bioactivity
Kinase	RBC
FAK	inactive (103.29%)
PYK2	inactive (96.15%)

TK - Fer

Bioactivity
Kinase	RBC
FER	inactive (89.36%)
FES	inactive (97.05%)

TK - FGFR

Bioactivity
Kinase	RBC
FGFR1	inactive (84.15%)
FGFR2	inactive (97.51%)
FGFR3	inactive (97%)
FGFR4	inactive (91.51%)

TK - VEGFR

Bioactivity
Kinase	RBC
FLT1	inactive (87.18%)
FLT4	inactive (102.76%)
KDR	inactive (104.85%)

TK - InsR

Bioactivity
Kinase	RBC
IGF1R	active (24.82%)
IRR	inactive (94.18%)
INSR	inactive (99.96%)

TK - JakA

Bioactivity
Kinase	RBC
JAK1	inactive (101.28%)
JAK2	inactive (98.31%)
JAK3	inactive (102.85%)
TYK2	inactive (111.47%)

TK - Musk

Bioactivity
Kinase	RBC
MUSK	inactive (96.23%)

TK - Ret

Bioactivity
Kinase	RBC
RET	inactive (97.5%)

TK - Met

Bioactivity
Kinase	RBC
RON	inactive (97.55%)
MET	inactive (91.02%)

TK - Sev

Bioactivity
Kinase	RBC
ROS	inactive (104.81%)

TK - Syk

Bioactivity
Kinase	RBC
SYK	inactive (98.61%)
ZAP70	inactive (103%)

TK - Tie

Bioactivity
Kinase	RBC
TIE2	inactive (100.45%)

TK - Trk

Bioactivity
Kinase	RBC
TRKA	inactive (89.01%)
TRKB	inactive (100.79%)
TRKC	inactive (90.51%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STKR	12	5
RAF	5	3
IRAK	4	2
LISK	4	1
LRRK	2	1
MLK	10	5
RIPK	5	1

TKL - STKR

Bioactivity
Kinase	RBC
ALK1	inactive (102.86%)
ALK2	inactive (94.74%)
ALK4	inactive (109.15%)
TGFbR1	inactive (97.96%)
TGFbR2	inactive (74.3%)

TKL - RAF

Bioactivity
Kinase	RBC
ARAF	inactive (125.33%)
BRAF	inactive (96.18%)
RAF1	inactive (95.78%)

TKL - IRAK

Bioactivity
Kinase	RBC
IRAK1	inactive (99.17%)
IRAK4	inactive (112.33%)

TKL - LISK

Bioactivity
Kinase	RBC
LIMK1	inactive (106.68%)

TKL - LRRK

Bioactivity
Kinase	RBC
LRRK2	inactive (109.15%)

TKL - MLK

Bioactivity
Kinase	RBC
MLK1	inactive (95.72%)
MLK2	inactive (90.27%)
MLK3	inactive (100.55%)
TAK1	inactive (98.54%)
ZAK	inactive (94.41%)

TKL - RIPK

Bioactivity
Kinase	RBC
RIPK2	inactive (89.28%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CAMKL	20	13
CAMK1	5	5
CAMK2	4	4
RAD53	1	1
DAPK	5	4
DCAMKL	3	1
MAPKAPK	5	5
MLCK	5	2
PHK	2	2
PIM	3	3
PKD	3	3
TSSK	5	2
STK33	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC
NuaK1	inactive (96.92%)
BRSK1	inactive (91.34%)
BRSK2	inactive (98.28%)
CHK1	inactive (96.19%)
LKB1	active (47.7%)
MARK1	inactive (93.32%)
MARK3	inactive (92.22%)
MARK4	inactive (99.46%)
MELK	inactive (83.97%)
PASK	inactive (95.65%)
QIK	inactive (115.93%)
NuaK2	inactive (91.69%)
MARK2	inactive (88.04%)

CAMK - CAMK1

Bioactivity
Kinase	RBC
CaMK1a	inactive (85.15%)
CaMK1b	inactive (94.32%)
CaMK1d	inactive (102.32%)
CaMK1g	inactive (99.96%)
CaMK4	inactive (101.52%)

CAMK - CAMK2

Bioactivity
Kinase	RBC
CaMK2a	inactive (106.32%)
CaMK2b	inactive (104.29%)
CaMK2d	inactive (85.75%)
CaMK2g	inactive (98.88%)

CAMK - RAD53

Bioactivity
Kinase	RBC
CHK2	inactive (98.76%)

CAMK - DAPK

Bioactivity
Kinase	RBC
DAPK1	inactive (99.47%)
DAPK2	inactive (88.32%)
DRAK1	inactive (98.27%)
DAPK3	inactive (103.54%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC
DCLK2	inactive (95.89%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC
MAPKAPK2	inactive (95.37%)
MAPKAPK3	inactive (89.22%)
MAPKAPK5	inactive (110.86%)
MNK1	inactive (109.91%)
MNK2	inactive (88.89%)

CAMK - MLCK

Bioactivity
Kinase	RBC
smMLCK	inactive (98.34%)
skMLCK	inactive (96.57%)

CAMK - PHK

Bioactivity
Kinase	RBC
PHKg1	inactive (87.03%)
PHKg2	inactive (101.56%)

CAMK - PIM

Bioactivity
Kinase	RBC
PIM1	inactive (99.02%)
PIM2	inactive (104.1%)
PIM3	inactive (104.93%)

CAMK - PKD

Bioactivity
Kinase	RBC
PKD1	inactive (102.53%)
PKD3	inactive (92.25%)
PKD2	inactive (88.41%)

CAMK - TSSK

Bioactivity
Kinase	RBC
TSSK1	inactive (103.94%)
TSSK2	inactive (104.71%)

CAMK - STK33

Bioactivity
Kinase	RBC
STK33	inactive (97.52%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STE11	8	3
STE-Unique	2	2
STE20	31	23
STE7	7	3

STE - STE11

Bioactivity
Kinase	RBC
MAP3K5	inactive (118.68%)
MAP3K2	inactive (94.75%)
MAP3K3	inactive (110.26%)

STE - STE-Unique

Bioactivity
Kinase	RBC
COT	inactive (96.38%)
NIK	inactive (97.27%)

STE - STE20

Bioactivity
Kinase	RBC
GCK	inactive (105.71%)
HGK	inactive (84.5%)
KHS1	inactive (89.91%)
LOK	inactive (96.63%)
MINK	inactive (97.06%)
MST1	inactive (96.74%)
MST2	inactive (93.54%)
MST3	active (47.87%)
MST4	active (46.82%)
OSR1	inactive (93.78%)
PAK1	inactive (89.68%)
PAK2	inactive (95.6%)
PAK3	inactive (94.82%)
PAK4	inactive (105.57%)
PAK5	inactive (76.42%)
PAK6	inactive (102.08%)
SLK	inactive (86.88%)
YSK1	inactive (68.1%)
STLK3	inactive (99.9%)
TAO1	inactive (72.13%)
TAO2	inactive (93.3%)
TAO3	inactive (91.26%)
MYO3B	active (0%)

STE - STE7

Bioactivity
Kinase	RBC
MAP2K1	inactive (99.7%)
MAP2K2	inactive (98.47%)
MAP2K6	inactive (92.7%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Aur	3	3
CAMKK	2	2
Haspin	1	1
IKK	4	4
NEK	11	8
TOPK	1	1
PLK	4	3
SgK496	1	1
NAK	4	1
TTK	1	1
ULK	5	3
WEE	3	1
WNK	4	2
TLK	2	1

Other - Aur

Bioactivity
Kinase	RBC
AurA	inactive (107.44%)
AurB	inactive (103.72%)
AurC	inactive (87.58%)

Other - CAMKK

Bioactivity
Kinase	RBC
CaMKK1	inactive (100.1%)
CaMKK2	inactive (90.93%)

Other - Haspin

Bioactivity
Kinase	RBC
Haspin	inactive (94.28%)

Other - IKK

Bioactivity
Kinase	RBC
IKKa	inactive (98.51%)
IKKb	inactive (103.3%)
IKKe	inactive (95.63%)
TBK1	inactive (97.72%)

Other - NEK

Bioactivity
Kinase	RBC
NEK1	inactive (90.9%)
NEK11	inactive (108.64%)
NEK2	inactive (97.73%)
NEK4	inactive (96.31%)
NEK6	inactive (104.51%)
NEK7	inactive (94%)
NEK9	inactive (97.34%)
NEK3	inactive (87.32%)

Other - TOPK

Bioactivity
Kinase	RBC
PBK	inactive (100.57%)

Other - PLK

Bioactivity
Kinase	RBC
PLK1	inactive (93.86%)
PLK2	inactive (99.79%)
PLK3	inactive (99.1%)

Other - SgK496

Bioactivity
Kinase	RBC
SgK496	inactive (93.12%)

Other - NAK

Bioactivity
Kinase	RBC
MPSK1	inactive (83.85%)

Other - TTK

Bioactivity
Kinase	RBC
TTK	inactive (101.06%)

Other - ULK

Bioactivity
Kinase	RBC
ULK1	inactive (124.87%)
ULK2	inactive (86.65%)
ULK3	active (0%)

Other - WEE

Bioactivity
Kinase	RBC
Wee1	inactive (109.48%)

Other - WNK

Bioactivity
Kinase	RBC
Wnk2	inactive (95.69%)
Wnk3	inactive (96.72%)

Other - TLK

Bioactivity
Kinase	RBC
TLK2	active (0%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK1	7	6
VRK	3	1

CK1 - CK1

Bioactivity
Kinase	RBC
CK1d	inactive (97.06%)
CK1g1	inactive (101.11%)
CK1g2	inactive (95.72%)
CK1g3	inactive (95.7%)
CK1a	inactive (98.96%)
CK1e	inactive (83.64%)

CK1 - VRK

Bioactivity
Kinase	RBC
VRK1	inactive (102.73%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK2	3	2
CLK	4	4
DYRK	10	9
MAPK	14	10
GSK	2	2
SRPK	3	3

CMGC - CK2

Bioactivity
Kinase	RBC
CK2a1	inactive (88.85%)
CK2a2	inactive (92.21%)

CMGC - CLK

Bioactivity
Kinase	RBC
CLK1	inactive (94.73%)
CLK2	active (44.05%)
CLK3	inactive (91.28%)
CLK4	inactive (81.15%)

CMGC - DYRK

Bioactivity
Kinase	RBC
DYRK1A	inactive (104.6%)
DYRK1B	inactive (99.94%)
DYRK2	inactive (100.01%)
DYRK3	inactive (99.03%)
DYRK4	inactive (96.69%)
HIPK1	inactive (102.11%)
HIPK2	inactive (104.02%)
HIPK3	inactive (99.01%)
HIPK4	inactive (94.69%)

CMGC - MAPK

Bioactivity
Kinase	RBC
Erk1	inactive (101.28%)
Erk2	inactive (91.74%)
JNK3	inactive (108.61%)
NLK	inactive (97.59%)
p38a	inactive (96.75%)
p38b	inactive (81.83%)
p38d	inactive (103.63%)
p38g	inactive (103.43%)
JNK1	inactive (95.42%)
JNK2	inactive (96.55%)

CMGC - GSK

Bioactivity
Kinase	RBC
GSK3A	inactive (73.09%)
GSK3B	active (47.09%)

CMGC - SRPK

Bioactivity
Kinase	RBC
MSSK1	inactive (92.87%)
SRPK1	inactive (97.37%)
SRPK2	inactive (89.16%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDHK	5	1

Atypical - PDHK

Bioactivity
Kinase	RBC
PDHK1	inactive (94.92%)