Compound in Profiling

Compound Information

Test on : RBC, Metz, Millipore

Compound Name
RBC, Metz, Millipore : SB220025

Inchikey
Same : VSPFURGQAYMVAN-N
RBC, Metz, Millipore : VSPFURGQAYMVAN-UHFFFAOYSA-N

ChemSpider
RBC, Metz, Millipore : 4980

Pubchem CID
RBC, Metz, Millipore : 5164

ChEMBL
RBC, Metz, Millipore : CHEMBL274064

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
PDK1	1	1	1	1
Akt	3	3	3	3
DMPK	7	5	3	5
GRK	7	6	1	3
RSK	8	8	4	7
PKA	5	3	2	2
PKC	9	9	5	8
PKG	2	3	2	-
PKN	3	2	1	1
SGK	3	3	1	3
NDR	4	1	-	-

AGC - PDK1

Bioactivity
Kinase	RBC	Metz	Millipore
PDK1	inactive (103.15%)	inactive (>3981.07nM)	inactive (109%)

AGC - Akt

Bioactivity
Kinase	RBC	Metz	Millipore
AKT1	inactive (99.88%)	inactive (>7943.28nM)	inactive (105%)
AKT2	inactive (94.79%)	inactive (>7943.28nM)	inactive (103%)
AKT3	inactive (92.57%)	inactive (>10000nM)	inactive (87%)

AGC - DMPK

Bioactivity
Kinase	RBC	Metz	Millipore
DMPK1	inactive (99.27%)	-	inactive (129%)
MRCKa	inactive (100.64%)	inactive (>10000nM)	inactive (113%)
MRCKb	inactive (101.23%)	-	inactive (98%)
ROCK1	inactive (102.66%)	inactive (>10000nM)	inactive (128%)
ROCK2	inactive (102.5%)	inactive (>7943.28nM)	inactive (99%)

AGC - GRK

Bioactivity
Kinase	RBC	Metz	Millipore
BARK1	inactive (99.74%)	-	-
BARK2	inactive (97.56%)	-	-
GPRK4	inactive (96.92%)	-	-
GPRK5	inactive (102.69%)	-	inactive (106%)
GPRK6	inactive (98.23%)	-	inactive (98%)
GPRK7	inactive (105.96%)	-	inactive (107%)

AGC - RSK

Bioactivity
Kinase	RBC	Metz	Millipore
MSK1	inactive (97.9%)	inactive (>1995.26nM)	inactive (106%)
MSK2	inactive (98.67%)	-	inactive (97%)
p70S6K	inactive (98.22%)	inactive (>6309.57nM)	inactive (74%)
p70S6Kb	inactive (90.87%)	-	-
RSK2	inactive (92.25%)	inactive (>7943.28nM)	inactive (54%)
RSK4	inactive (109.34%)	-	inactive (89%)
RSK1	inactive (96.75%)	-	inactive (83%)
RSK3	inactive (99.28%)	-	inactive (105%)

AGC - PKA

Bioactivity
Kinase	RBC	Metz	Millipore
PKACg	inactive (105.46%)	-	-
PRKX	inactive (96.75%)	inactive (>1584.89nM)	inactive (110%)
PKACa	inactive (82.98%)	inactive (1584.89nM)	inactive (95%)

AGC - PKC

Bioactivity
Kinase	RBC	Metz	Millipore
PKCa	inactive (89.08%)	-	inactive (105%)
PKCd	inactive (99.76%)	inactive (>7943.28nM)	inactive (105%)
PKCe	inactive (104.77%)	-	inactive (114%)
PKCh	inactive (91.94%)	-	inactive (114%)
PKCg	inactive (87.81%)	inactive (6309.57nM)	inactive (107%)
PKCi	inactive (98.47%)	-	inactive (113%)
PKCt	inactive (106.77%)	-	inactive (93%)
PKCz	inactive (105.77%)	inactive (>7943.28nM)	inactive (111%)
PKCb	inactive (79.38%)	-	-

AGC - PKG

Bioactivity
Kinase	RBC	Metz	Millipore
PKG2	inactive (97.19%)	inactive (>1584.89nM)	-
PKG1	inactive (97.69%)	inactive (>1995.26nM)	-

AGC - PKN

Bioactivity
Kinase	RBC	Metz	Millipore
PKN1	inactive (96.35%)	-	-
PKN2	inactive (97.14%)	inactive (>7943.28nM)	inactive (111%)

AGC - SGK

Bioactivity
Kinase	RBC	Metz	Millipore
SGK1	inactive (97.41%)	inactive (6309.57nM)	inactive (93%)
SGK2	inactive (96.93%)	-	inactive (97%)
SGK3	inactive (97.48%)	-	inactive (108%)

AGC - NDR

Bioactivity
Kinase	RBC	Metz	Millipore
NDR1	inactive (99.83%)	-	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
Abl	2	2	1	2
Ack	2	1	1	1
ALK	2	2	2	1
Axl	3	3	2	3
Src	11	11	9	10
Tec	5	5	3	4
PDGFR	5	5	5	5
Csk	2	2	1	1
DDR	2	1	-	1
EGFR	4	3	3	2
Eph	14	12	1	11
FAK	2	2	2	2
Fer	2	2	2	2
FGFR	4	4	2	4
VEGFR	3	3	3	3
InsR	3	3	2	3
JakA	4	4	3	2
Musk	1	1	-	1
Ret	1	1	1	1
Met	2	2	2	2
Sev	1	1	1	1
Syk	2	2	1	2
Tie	2	1	-	1
Trk	3	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Metz	Millipore
ABL1	inactive (100.65%)	inactive (>630.96nM)	inactive (104%)
ABL2	inactive (95.13%)	-	inactive (108%)

TK - Ack

Bioactivity
Kinase	RBC	Metz	Millipore
ACK	inactive (97.95%)	-	inactive (76%)

TK - ALK

Bioactivity
Kinase	RBC	Metz	Millipore
ALK	inactive (102.03%)	inactive (>1258.93nM)	inactive (81%)
LTK	inactive (97.28%)	-	-

TK - Axl

Bioactivity
Kinase	RBC	Metz	Millipore
AXL	inactive (101.56%)	inactive (>1995.26nM)	inactive (94%)
MER	inactive (98.01%)	-	inactive (67%)
TYRO3	inactive (96.94%)	-	inactive (91%)

TK - Src

Bioactivity
Kinase	RBC	Metz	Millipore
BLK	inactive (102.39%)	inactive (>1584.89nM)	inactive (99%)
BRK	inactive (73.42%)	inactive (>2511.89nM)	inactive (88%)
SRC	inactive (94.25%)	inactive (>5011.87nM)	inactive (117%)
FGR	inactive (95.91%)	-	inactive (81%)
FRK	inactive (95.42%)	-	inactive (92%)
FYN	inactive (91.1%)	inactive (>794.33nM)	inactive (75%)
HCK	inactive (95.54%)	-	inactive (84%)
LCK	inactive (80.12%)	active (125.89nM)	inactive (58%)
SRM	inactive (97.49%)	-	-
YES	inactive (85.25%)	-	inactive (78%)
LYN	inactive (87.49%)	active (316.23nM)	active (50%)

TK - Tec

Bioactivity
Kinase	RBC	Metz	Millipore
BMX	inactive (92.85%)	-	inactive (67%)
BTK	inactive (100.32%)	-	inactive (97%)
ITK	inactive (90.55%)	inactive (>1584.89nM)	inactive (98%)
TEC	inactive (110.5%)	-	-
TXK	inactive (99.07%)	-	inactive (83%)

TK - PDGFR

Bioactivity
Kinase	RBC	Metz	Millipore
KIT	inactive (98.39%)	inactive (>1258.93nM)	inactive (121%)
FLT3	inactive (90.33%)	inactive (>2511.89nM)	inactive (108%)
FMS	inactive (100.08%)	inactive (>2511.89nM)	inactive (93%)
PDGFRb	inactive (98.67%)	-	inactive (114%)
PDGFRa	inactive (95.79%)	-	inactive (110%)

TK - Csk

Bioactivity
Kinase	RBC	Metz	Millipore
CSK	inactive (90.78%)	-	inactive (114%)
CTK	inactive (99.49%)	-	-

TK - DDR

Bioactivity
Kinase	RBC	Metz	Millipore
DDR2	inactive (106.6%)	-	inactive (94%)

TK - EGFR

Bioactivity
Kinase	RBC	Metz	Millipore
EGFR	inactive (94.41%)	inactive (>1258.93nM)	inactive (105%)
ErbB2	inactive (93.69%)	inactive (>1584.89nM)	-
ErbB4	inactive (86.81%)	inactive (2511.89nM)	inactive (97%)

TK - Eph

Bioactivity
Kinase	RBC	Metz	Millipore
EphA1	inactive (98.15%)	-	inactive (119%)
EphA2	inactive (102.37%)	inactive (>7943.28nM)	inactive (92%)
EphA3	inactive (97.35%)	-	inactive (97%)
EphA4	inactive (99.81%)	-	inactive (103%)
EphA5	inactive (97.83%)	-	inactive (113%)
EphA6	inactive (78.03%)	-	-
EphA7	inactive (93.96%)	-	inactive (96%)
EphA8	inactive (101.38%)	-	inactive (90%)
EphB1	inactive (99.86%)	-	inactive (104%)
EphB2	inactive (102.56%)	-	inactive (98%)
EphB3	inactive (100.87%)	-	inactive (117%)
EphB4	inactive (91.55%)	-	inactive (77%)

TK - FAK

Bioactivity
Kinase	RBC	Metz	Millipore
FAK	inactive (94.06%)	inactive (>1584.89nM)	inactive (103%)
PYK2	inactive (94.57%)	inactive (>1584.89nM)	inactive (107%)

TK - Fer

Bioactivity
Kinase	RBC	Metz	Millipore
FER	inactive (98.27%)	-	inactive (103%)
FES	inactive (103.14%)	-	inactive (106%)

TK - FGFR

Bioactivity
Kinase	RBC	Metz	Millipore
FGFR1	inactive (91.2%)	inactive (>5011.87nM)	inactive (119%)
FGFR2	inactive (103.74%)	-	inactive (113%)
FGFR3	inactive (100.47%)	inactive (>1995.26nM)	inactive (120%)
FGFR4	inactive (85.67%)	-	inactive (116%)

TK - VEGFR

Bioactivity
Kinase	RBC	Metz	Millipore
FLT1	inactive (89.27%)	inactive (>398.11nM)	inactive (94%)
FLT4	inactive (116.34%)	inactive (6309.57nM)	inactive (69%)
KDR	inactive (102%)	inactive (5011.87nM)	inactive (104%)

TK - InsR

Bioactivity
Kinase	RBC	Metz	Millipore
IGF1R	inactive (103.63%)	inactive (>1258.93nM)	inactive (96%)
IRR	inactive (103.46%)	-	inactive (140%)
INSR	inactive (94.15%)	inactive (>5011.87nM)	inactive (112%)

TK - JakA

Bioactivity
Kinase	RBC	Metz	Millipore
JAK1	inactive (104.17%)	-	-
JAK2	inactive (99.57%)	inactive (>1584.89nM)	inactive (106%)
JAK3	inactive (96.93%)	inactive (>1584.89nM)	inactive (120%)
TYK2	inactive (99.77%)	inactive (>1995.26nM)	-

TK - Musk

Bioactivity
Kinase	RBC	Metz	Millipore
MUSK	inactive (86.87%)	-	inactive (99%)

TK - Ret

Bioactivity
Kinase	RBC	Metz	Millipore
RET	inactive (89.44%)	inactive (1258.93nM)	inactive (97%)

TK - Met

Bioactivity
Kinase	RBC	Metz	Millipore
RON	inactive (100.35%)	-	inactive (100%)
MET	inactive (103.56%)	inactive (>3162.28nM)	inactive (114%)

TK - Sev

Bioactivity
Kinase	RBC	Metz	Millipore
ROS	inactive (94.09%)	-	inactive (108%)

TK - Syk

Bioactivity
Kinase	RBC	Metz	Millipore
SYK	inactive (98%)	-	inactive (99%)
ZAP70	inactive (92.34%)	-	inactive (130%)

TK - Tie

Bioactivity
Kinase	RBC	Metz	Millipore
TIE2	inactive (101.43%)	-	inactive (113%)

TK - Trk

Bioactivity
Kinase	RBC	Metz	Millipore
TRKA	inactive (100.39%)	inactive (>2511.89nM)	inactive (100%)
TRKB	inactive (102.88%)	inactive (>5011.87nM)	inactive (118%)
TRKC	inactive (97.14%)	-	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
STKR	12	5	1	2
RAF	5	3	1	1
IRAK	4	2	2	2
LISK	4	1	1	1
LRRK	2	1	1	-
MLK	10	5	2	2
RIPK	5	1	-	1

TKL - STKR

Bioactivity
Kinase	RBC	Metz	Millipore
ALK1	inactive (95.62%)	-	-
ALK2	inactive (86.49%)	-	-
ALK4	inactive (121.3%)	-	inactive (101%)
TGFbR1	inactive (101.8%)	-	inactive (81%)
TGFbR2	inactive (118.94%)	-	-

TKL - RAF

Bioactivity
Kinase	RBC	Metz	Millipore
ARAF	inactive (93.11%)	-	-
BRAF	inactive (102.62%)	-	-
RAF1	inactive (90.85%)	-	inactive (64%)

TKL - IRAK

Bioactivity
Kinase	RBC	Metz	Millipore
IRAK1	inactive (114.45%)	inactive (6309.57nM)	inactive (102%)
IRAK4	inactive (123.14%)	inactive (>10000nM)	inactive (92%)

TKL - LISK

Bioactivity
Kinase	RBC	Metz	Millipore
LIMK1	inactive (89.56%)	active (794.33nM)	inactive (64%)

TKL - LRRK

Bioactivity
Kinase	RBC	Metz	Millipore
LRRK2	inactive (99.91%)	-	-

TKL - MLK

Bioactivity
Kinase	RBC	Metz	Millipore
MLK1	inactive (94.51%)	-	inactive (96%)
MLK2	inactive (99.79%)	-	-
MLK3	inactive (96.26%)	-	-
TAK1	inactive (96.86%)	-	inactive (101%)
ZAK	inactive (98%)	inactive (>7943.28nM)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Metz	Millipore
RIPK2	inactive (77.17%)	-	active (43%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
CAMKL	20	13	9	12
CAMK1	5	5	2	3
CAMK2	4	4	4	3
RAD53	1	1	1	1
DAPK	5	4	2	4
DCAMKL	3	1	1	1
MAPKAPK	5	5	4	4
MLCK	5	2	-	1
PHK	2	2	1	1
PIM	3	3	3	3
PKD	3	3	2	2
TSSK	5	2	2	2
STK33	1	-	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Metz	Millipore
NuaK1	inactive (98.36%)	-	inactive (111%)
BRSK1	inactive (99.71%)	inactive (>10000nM)	inactive (94%)
BRSK2	inactive (96.63%)	-	inactive (128%)
CHK1	inactive (99.76%)	inactive (>7943.28nM)	inactive (101%)
LKB1	inactive (89.14%)	-	inactive (104%)
MARK1	inactive (97.93%)	-	inactive (89%)
MARK3	inactive (102.83%)	inactive (>6309.57nM)	-
MARK4	inactive (97.37%)	-	-
MELK	inactive (100.04%)	active (794.33nM)	inactive (71%)
PASK	inactive (98.48%)	-	inactive (129%)
QIK	inactive (64.69%)	-	-
NuaK2	inactive (121.9%)	-	-
MARK2	inactive (97.04%)	inactive (>7943.28nM)	inactive (96%)
AMPKa1	-	inactive (>6309.57nM)	inactive (102%)
AMPKa2	-	-	inactive (96%)
SIK	-	-	inactive (132%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Metz	Millipore
CaMK1a	inactive (106.88%)	inactive (>3162.28nM)	inactive (92%)
CaMK1b	inactive (94.31%)	-	-
CaMK1d	inactive (103.12%)	-	inactive (112%)
CaMK1g	inactive (99.33%)	-	-
CaMK4	inactive (103.44%)	-	inactive (107%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Metz	Millipore
CaMK2a	inactive (100.28%)	-	-
CaMK2b	inactive (97.71%)	-	inactive (91%)
CaMK2d	inactive (100.38%)	-	inactive (100%)
CaMK2g	inactive (93%)	-	inactive (108%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Metz	Millipore
CHK2	inactive (101.29%)	inactive (>5011.87nM)	inactive (92%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Metz	Millipore
DAPK1	inactive (88.24%)	-	inactive (86%)
DAPK2	inactive (94.09%)	-	inactive (103%)
DRAK1	inactive (97.75%)	-	inactive (95%)
DAPK3	inactive (96.51%)	inactive (>1258.93nM)	inactive (86%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Metz	Millipore
DCLK2	inactive (99.91%)	-	inactive (102%)
DCLK1	-	inactive (>10000nM)	-

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Metz	Millipore
MAPKAPK2	inactive (97.63%)	inactive (>7943.28nM)	inactive (79%)
MAPKAPK3	inactive (99.42%)	inactive (>10000nM)	inactive (123%)
MAPKAPK5	inactive (94%)	inactive (>1584.89nM)	inactive (118%)
MNK1	inactive (98.99%)	-	-
MNK2	inactive (92.14%)	inactive (>10000nM)	inactive (101%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Metz	Millipore
smMLCK	inactive (99.79%)	-	inactive (102%)
skMLCK	inactive (103.05%)	-	-

CAMK - PHK

Bioactivity
Kinase	RBC	Metz	Millipore
PHKg1	inactive (98.25%)	-	-
PHKg2	inactive (104.5%)	inactive (>5011.87nM)	inactive (125%)

CAMK - PIM

Bioactivity
Kinase	RBC	Metz	Millipore
PIM1	inactive (96.99%)	active (1000nM)	inactive (75%)
PIM2	inactive (100.22%)	inactive (>1584.89nM)	inactive (120%)
PIM3	inactive (96.03%)	-	inactive (87%)

CAMK - PKD

Bioactivity
Kinase	RBC	Metz	Millipore
PKD1	inactive (54.62%)	-	active (46%)
PKD3	active (37.89%)	active (251.19nM)	-
PKD2	inactive (50.37%)	inactive (1258.93nM)	inactive (102%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Metz	Millipore
TSSK1	inactive (106%)	inactive (>1584.89nM)	inactive (105%)
TSSK2	inactive (100.03%)	inactive (>1584.89nM)	inactive (95%)

CAMK - STK33

Bioactivity
Kinase	RBC	Metz	Millipore
STK33	inactive (98.59%)	-	inactive (107%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
STE11	8	3	-	1
STE-Unique	2	2	-	-
STE20	31	23	9	14
STE7	7	3	2	3

STE - STE11

Bioactivity
Kinase	RBC	Metz	Millipore
MAP3K5	inactive (102.44%)	-	inactive (100%)
MAP3K2	inactive (93.96%)	-	-
MAP3K3	inactive (100.82%)	-	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Metz	Millipore
COT	inactive (101.58%)	-	-
NIK	inactive (107.36%)	-	-

STE - STE20

Bioactivity
Kinase	RBC	Metz	Millipore
GCK	inactive (101.62%)	inactive (>6309.57nM)	inactive (82%)
HGK	inactive (76.26%)	active (794.33nM)	-
KHS1	inactive (68.14%)	active (501.19nM)	-
LOK	inactive (90.34%)	-	inactive (99%)
MINK	inactive (96.13%)	inactive (1258.93nM)	inactive (92%)
MST1	inactive (102.85%)	-	inactive (101%)
MST2	inactive (103.48%)	inactive (3162.28nM)	inactive (87%)
MST3	inactive (98.75%)	-	inactive (82%)
MST4	inactive (98.41%)	-	-
OSR1	inactive (101.35%)	-	-
PAK1	inactive (97.37%)	inactive (>10000nM)	-
PAK2	inactive (76.89%)	-	inactive (99%)
PAK3	inactive (104.64%)	-	inactive (87%)
PAK4	inactive (95.13%)	inactive (>5011.87nM)	inactive (102%)
PAK5	inactive (100.63%)	-	inactive (103%)
PAK6	inactive (111.42%)	-	inactive (105%)
SLK	inactive (99.94%)	inactive (>10000nM)	-
YSK1	inactive (99.77%)	-	-
STLK3	inactive (93.45%)	-	-
TAO1	inactive (92.66%)	inactive (>10000nM)	inactive (98%)
TAO2	inactive (98.05%)	-	inactive (101%)
TAO3	inactive (95.32%)	-	inactive (98%)
MYO3B	inactive (97.85%)	-	-

STE - STE7

Bioactivity
Kinase	RBC	Metz	Millipore
MAP2K1	inactive (98.25%)	-	inactive (109%)
MAP2K2	inactive (105.22%)	-	-
MAP2K6	inactive (105.87%)	-	inactive (80%)
MAP2K7	-	-	inactive (92%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
Aur	3	3	2	3
CAMKK	2	2	1	-
Haspin	1	1	-	1
IKK	4	4	4	3
NEK	11	8	2	5
TOPK	1	1	1	-
PLK	4	3	3	3
SgK496	1	1	-	-
NAK	4	1	-	-
TTK	1	1	-	-
ULK	5	3	-	2
WEE	3	1	1	-
WNK	4	2	-	2
TLK	2	1	-	1
CDC7	1	-	1	-

Other - Aur

Bioactivity
Kinase	RBC	Metz	Millipore
AurA	inactive (100.28%)	inactive (>1995.26nM)	inactive (124%)
AurB	inactive (103.18%)	inactive (>6309.57nM)	inactive (111%)
AurC	inactive (97.77%)	-	inactive (103%)

Other - CAMKK

Bioactivity
Kinase	RBC	Metz	Millipore
CaMKK1	inactive (102.8%)	-	-
CaMKK2	inactive (110.19%)	-	-

Other - Haspin

Bioactivity
Kinase	RBC	Metz	Millipore
Haspin	inactive (91.37%)	-	inactive (54%)

Other - IKK

Bioactivity
Kinase	RBC	Metz	Millipore
IKKa	inactive (101.5%)	inactive (>3981.07nM)	inactive (120%)
IKKb	inactive (104.32%)	inactive (>3162.28nM)	inactive (116%)
IKKe	inactive (99.51%)	-	-
TBK1	inactive (102.32%)	-	inactive (88%)

Other - NEK

Bioactivity
Kinase	RBC	Metz	Millipore
NEK1	inactive (100.29%)	-	-
NEK11	inactive (104.69%)	-	inactive (68%)
NEK2	inactive (102.69%)	inactive (>10000nM)	inactive (97%)
NEK4	inactive (99.45%)	inactive (>6309.57nM)	-
NEK6	inactive (104.39%)	-	inactive (113%)
NEK7	inactive (98.85%)	-	inactive (109%)
NEK9	inactive (100.36%)	-	-
NEK3	inactive (99%)	-	inactive (82%)

Other - TOPK

Bioactivity
Kinase	RBC	Metz	Millipore
PBK	inactive (94.94%)	inactive (>10000nM)	-

Other - PLK

Bioactivity
Kinase	RBC	Metz	Millipore
PLK1	inactive (101.22%)	inactive (>7943.28nM)	inactive (85%)
PLK2	inactive (93%)	-	inactive (108%)
PLK3	inactive (97.83%)	inactive (>7943.28nM)	inactive (104%)
PLK4	-	inactive (>3981.07nM)	-

Other - SgK496

Bioactivity
Kinase	RBC	Metz	Millipore
SgK496	inactive (102.29%)	-	-

Other - NAK

Bioactivity
Kinase	RBC	Metz	Millipore
MPSK1	inactive (107.79%)	-	-

Other - TTK

Bioactivity
Kinase	RBC	Metz	Millipore
TTK	inactive (107.22%)	-	-

Other - ULK

Bioactivity
Kinase	RBC	Metz	Millipore
ULK1	inactive (95.26%)	-	-
ULK2	inactive (113.28%)	-	inactive (114%)
ULK3	inactive (95.53%)	-	inactive (101%)

Other - WEE

Bioactivity
Kinase	RBC	Metz	Millipore
Wee1	inactive (106.32%)	-	-

Other - WNK

Bioactivity
Kinase	RBC	Metz	Millipore
Wnk2	inactive (93.06%)	-	inactive (104%)
Wnk3	inactive (95.34%)	-	inactive (95%)

Other - TLK

Bioactivity
Kinase	RBC	Metz	Millipore
TLK2	inactive (95.12%)	-	inactive (104%)

Other - CDC7

Bioactivity
Kinase	RBC	Metz	Millipore
CDC7	-	inactive (>1258.93nM)	-

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
CK1	7	6	5	4
VRK	3	1	-	1

CK1 - CK1

Bioactivity
Kinase	RBC	Metz	Millipore
CK1d	active (1.25%)	active (12.59nM)	active (-2%)
CK1g1	inactive (83.08%)	-	inactive (72%)
CK1g2	inactive (118.98%)	inactive (3162.28nM)	inactive (89%)
CK1g3	inactive (83.87%)	-	inactive (84%)
CK1a	active (2.82%)	active (12.59nM)	-
CK1e	active (2.39%)	-	-

CK1 - VRK

Bioactivity
Kinase	RBC	Metz	Millipore
VRK1	inactive (83.43%)	-	-
VRK2	-	-	inactive (93%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
CK2	3	2	1	2
CLK	4	4	2	2
DYRK	10	9	6	4
MAPK	14	10	8	10
GSK	2	2	2	2
SRPK	3	3	1	3
CDK	20	-	7	-

CMGC - CK2

Bioactivity
Kinase	RBC	Metz	Millipore
CK2a1	inactive (94.74%)	active (794.33nM)	inactive (93%)
CK2a2	inactive (92.2%)	-	inactive (107%)

CMGC - CLK

Bioactivity
Kinase	RBC	Metz	Millipore
CLK1	inactive (98.22%)	-	-
CLK2	inactive (99.67%)	inactive (1258.93nM)	inactive (69%)
CLK3	inactive (102.49%)	-	inactive (89%)
CLK4	inactive (96.94%)	active (1000nM)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Metz	Millipore
DYRK1A	inactive (96.27%)	inactive (>6309.57nM)	-
DYRK1B	inactive (100.25%)	-	-
DYRK2	inactive (95.9%)	-	inactive (83%)
DYRK3	inactive (96.05%)	inactive (1995.26nM)	-
DYRK4	inactive (99.34%)	-	-
HIPK1	inactive (101.05%)	-	inactive (110%)
HIPK2	inactive (105.81%)	inactive (>3162.28nM)	inactive (95%)
HIPK3	inactive (97.63%)	-	inactive (111%)
HIPK4	inactive (96.57%)	inactive (>7943.28nM)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Metz	Millipore
Erk1	inactive (100.45%)	-	inactive (88%)
Erk2	inactive (96.62%)	inactive (3162.28nM)	inactive (111%)
JNK3	inactive (104.9%)	-	inactive (69%)
NLK	active (12.1%)	-	active (34%)
p38a	active (13.08%)	-	active (2%)
p38b	inactive (101.33%)	-	inactive (58%)
p38d	inactive (102%)	inactive (>7943.28nM)	inactive (105%)
p38g	inactive (102.16%)	inactive (>6309.57nM)	inactive (104%)
JNK1	inactive (94.84%)	inactive (>3162.28nM)	inactive (108%)
JNK2	inactive (105.46%)	inactive (2511.89nM)	inactive (76%)

CMGC - GSK

Bioactivity
Kinase	RBC	Metz	Millipore
GSK3A	inactive (97.54%)	inactive (2511.89nM)	inactive (92%)
GSK3B	inactive (101.23%)	inactive (>6309.57nM)	inactive (111%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Metz	Millipore
MSSK1	inactive (99.29%)	-	inactive (101%)
SRPK1	inactive (103.26%)	inactive (>7943.28nM)	inactive (108%)
SRPK2	inactive (96.39%)	-	inactive (101%)

CMGC - CDK

Bioactivity
Kinase	RBC	Metz	Millipore
CDC2	-	inactive (>7943.28nM)	-
CDK2	-	inactive (>7943.28nM)	-
CDK5	-	inactive (>10000nM)	-
CDK8	-	-	-
CDK7	-	-	-
CDK9	-	-	-
CDK11	-	-	-

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
PDHK	5	1	-	-
Alpha	6	-	1	1
PIKK	6	-	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Metz	Millipore
PDHK1	inactive (103.15%)	-	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Metz	Millipore
eEF2K	-	inactive (>3981.07nM)	inactive (117%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Metz	Millipore
FRAP	-	-	inactive (109%)