Compound in Profiling

Compound Information

Test on : RBC, Metz, Millipore

Compound Name
RBC, Metz, Millipore : Go 6976

Inchikey
Same : VWVYILCFSYNJHF-N
RBC, Metz, Millipore : VWVYILCFSYNJHF-UHFFFAOYSA-N

ChemSpider
RBC, Metz, Millipore : 3381

Pubchem CID
RBC, Metz, Millipore : 3501

ChEMBL
RBC, Metz, Millipore : CHEMBL302449

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
PDK1	1	1	1	1
Akt	3	3	3	3
DMPK	7	5	3	5
GRK	7	6	1	3
RSK	8	8	4	7
PKA	5	3	2	2
PKC	9	9	5	8
PKG	2	3	2	-
PKN	3	2	1	1
SGK	3	3	1	3
NDR	4	1	-	-

AGC - PDK1

Bioactivity
Kinase	RBC	Metz	Millipore
PDK1	inactive (63.23%)	active (12.59nM)	active (6%)

AGC - Akt

Bioactivity
Kinase	RBC	Metz	Millipore
AKT1	inactive (108.19%)	inactive (>7943.28nM)	inactive (106%)
AKT2	inactive (109.54%)	inactive (>7943.28nM)	inactive (100%)
AKT3	inactive (85.29%)	inactive (>10000nM)	inactive (51%)

AGC - DMPK

Bioactivity
Kinase	RBC	Metz	Millipore
DMPK1	inactive (100.61%)	-	inactive (121%)
MRCKa	inactive (89.94%)	inactive (>10000nM)	inactive (87%)
MRCKb	inactive (92.1%)	-	inactive (74%)
ROCK1	inactive (61.87%)	active (79.43nM)	inactive (98%)
ROCK2	active (48.52%)	active (316.23nM)	active (43%)

AGC - GRK

Bioactivity
Kinase	RBC	Metz	Millipore
BARK1	inactive (103.09%)	-	-
BARK2	inactive (106.22%)	-	-
GPRK4	inactive (75.15%)	-	-
GPRK5	inactive (89.07%)	-	inactive (69%)
GPRK6	active (44.44%)	-	inactive (90%)
GPRK7	active (37.86%)	-	active (16%)

AGC - RSK

Bioactivity
Kinase	RBC	Metz	Millipore
MSK1	active (23.74%)	-	active (3%)
MSK2	active (29.95%)	-	active (2%)
p70S6K	active (6.71%)	active (50.12nM)	active (1%)
p70S6Kb	active (21.58%)	-	-
RSK2	active (5.93%)	active (2.51nM)	active (1%)
RSK4	active (4.2%)	-	active (4%)
RSK1	active (9.7%)	-	active (0%)
RSK3	active (0.3%)	-	active (7%)

AGC - PKA

Bioactivity
Kinase	RBC	Metz	Millipore
PKACg	-	-	-
PRKX	inactive (60.08%)	-	active (19%)
PKACa	inactive (83.66%)	active (158.49nM)	active (28%)

AGC - PKC

Bioactivity
Kinase	RBC	Metz	Millipore
PKCa	active (7.58%)	-	active (1%)
PKCd	active (41.93%)	active (199.53nM)	inactive (59%)
PKCe	inactive (58.51%)	-	inactive (54%)
PKCh	active (35.3%)	-	inactive (72%)
PKCg	inactive (72.15%)	active (39.81nM)	active (9%)
PKCi	inactive (91.6%)	-	inactive (80%)
PKCt	inactive (76.3%)	-	active (29%)
PKCz	inactive (87.05%)	inactive (>7943.28nM)	inactive (102%)
PKCb	active (9.73%)	-	-

AGC - PKG

Bioactivity
Kinase	RBC	Metz	Millipore
PKG2	active (28.16%)	-	-
PKG1	inactive (80.22%)	-	-

AGC - PKN

Bioactivity
Kinase	RBC	Metz	Millipore
PKN1	active (10.28%)	-	-
PKN2	inactive (67.73%)	-	active (11%)

AGC - SGK

Bioactivity
Kinase	RBC	Metz	Millipore
SGK1	inactive (79.08%)	inactive (>10000nM)	inactive (82%)
SGK2	inactive (94.03%)	-	inactive (76%)
SGK3	inactive (112.31%)	-	inactive (85%)

AGC - NDR

Bioactivity
Kinase	RBC	Metz	Millipore
NDR1	active (0%)	-	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
Abl	2	2	1	2
Ack	2	1	1	1
ALK	2	2	2	1
Axl	3	3	2	3
Src	11	11	9	10
Tec	5	5	3	4
PDGFR	5	5	5	5
Csk	2	2	1	1
DDR	2	1	-	1
EGFR	4	3	3	2
Eph	14	12	1	11
FAK	2	2	2	2
Fer	2	2	2	2
FGFR	4	4	2	4
VEGFR	3	3	3	3
InsR	3	3	2	3
JakA	4	4	3	2
Musk	1	1	-	1
Ret	1	1	1	1
Met	2	2	2	2
Sev	1	1	1	1
Syk	2	2	1	2
Tie	2	1	-	1
Trk	3	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Metz	Millipore
ABL1	inactive (84.61%)	inactive (>630.96nM)	inactive (79%)
ABL2	active (42.28%)	-	inactive (85%)

TK - Ack

Bioactivity
Kinase	RBC	Metz	Millipore
ACK	active (2.78%)	-	active (3%)

TK - ALK

Bioactivity
Kinase	RBC	Metz	Millipore
ALK	active (12.2%)	-	active (0%)
LTK	active (8.79%)	-	-

TK - Axl

Bioactivity
Kinase	RBC	Metz	Millipore
AXL	inactive (101.62%)	-	inactive (53%)
MER	inactive (59.92%)	-	active (46%)
TYRO3	inactive (85.62%)	-	inactive (87%)

TK - Src

Bioactivity
Kinase	RBC	Metz	Millipore
BLK	inactive (68.07%)	active (31.62nM)	active (28%)
BRK	active (38.69%)	-	active (29%)
SRC	inactive (74.83%)	inactive (>5011.87nM)	inactive (69%)
FGR	inactive (70.72%)	-	active (41%)
FRK	inactive (84.7%)	-	active (42%)
FYN	inactive (90.64%)	inactive (>794.33nM)	active (47%)
HCK	inactive (96.78%)	-	active (31%)
LCK	inactive (84.27%)	inactive (1995.26nM)	inactive (65%)
SRM	inactive (96.63%)	-	-
YES	inactive (68.72%)	-	active (45%)
LYN	inactive (94.35%)	active (251.19nM)	active (21%)

TK - Tec

Bioactivity
Kinase	RBC	Metz	Millipore
BMX	active (13.71%)	-	active (5%)
BTK	active (22.02%)	-	active (10%)
ITK	active (4.32%)	active (25.12nM)	active (4%)
TEC	inactive (96.45%)	-	-
TXK	active (6.39%)	-	active (8%)

TK - PDGFR

Bioactivity
Kinase	RBC	Metz	Millipore
KIT	inactive (96.94%)	inactive (>1258.93nM)	inactive (113%)
FLT3	active (5.27%)	active (31.62nM)	active (0%)
FMS	inactive (84.08%)	inactive (1584.89nM)	active (14%)
PDGFRb	inactive (60.64%)	-	inactive (88%)
PDGFRa	inactive (83.51%)	-	inactive (98%)

TK - Csk

Bioactivity
Kinase	RBC	Metz	Millipore
CSK	inactive (80.97%)	-	inactive (107%)
CTK	inactive (100.38%)	-	-

TK - DDR

Bioactivity
Kinase	RBC	Metz	Millipore
DDR2	inactive (73.31%)	-	inactive (90%)

TK - EGFR

Bioactivity
Kinase	RBC	Metz	Millipore
EGFR	inactive (63.62%)	active (19.95nM)	inactive (68%)
ErbB2	inactive (106.91%)	active (251.19nM)	-
ErbB4	inactive (100.39%)	inactive (>3981.07nM)	inactive (91%)

TK - Eph

Bioactivity
Kinase	RBC	Metz	Millipore
EphA1	inactive (81.58%)	-	inactive (90%)
EphA2	inactive (92.48%)	inactive (>3162.28nM)	inactive (91%)
EphA3	inactive (97.87%)	-	inactive (83%)
EphA4	inactive (90.42%)	-	inactive (112%)
EphA5	inactive (88.21%)	-	inactive (88%)
EphA6	-	-	-
EphA7	inactive (62.58%)	-	active (43%)
EphA8	inactive (91.71%)	-	inactive (83%)
EphB1	inactive (94.96%)	-	inactive (63%)
EphB2	inactive (77.74%)	-	inactive (116%)
EphB3	inactive (87.16%)	-	inactive (105%)
EphB4	inactive (96.33%)	-	inactive (91%)

TK - FAK

Bioactivity
Kinase	RBC	Metz	Millipore
FAK	inactive (77.03%)	-	active (33%)
PYK2	active (26.69%)	-	active (4%)

TK - Fer

Bioactivity
Kinase	RBC	Metz	Millipore
FER	active (5.9%)	-	active (4%)
FES	inactive (78.41%)	-	active (32%)

TK - FGFR

Bioactivity
Kinase	RBC	Metz	Millipore
FGFR1	inactive (63.31%)	active (100nM)	active (7%)
FGFR2	inactive (79.84%)	-	inactive (53%)
FGFR3	inactive (76.72%)	inactive (>1995.26nM)	inactive (90%)
FGFR4	inactive (86.49%)	-	inactive (111%)

TK - VEGFR

Bioactivity
Kinase	RBC	Metz	Millipore
FLT1	inactive (63.61%)	active (158.49nM)	active (4%)
FLT4	active (38.24%)	active (125.89nM)	active (2%)
KDR	inactive (56.99%)	active (125.89nM)	active (7%)

TK - InsR

Bioactivity
Kinase	RBC	Metz	Millipore
IGF1R	inactive (98.32%)	inactive (>1000nM)	inactive (145%)
IRR	inactive (82.5%)	-	inactive (69%)
INSR	inactive (89.32%)	inactive (1584.89nM)	inactive (89%)

TK - JakA

Bioactivity
Kinase	RBC	Metz	Millipore
JAK1	active (20.16%)	-	-
JAK2	active (5.58%)	-	active (4%)
JAK3	active (2.44%)	active (0.63nM)	active (1%)
TYK2	active (2.62%)	active (3.16nM)	-

TK - Musk

Bioactivity
Kinase	RBC	Metz	Millipore
MUSK	active (34.76%)	-	active (32%)

TK - Ret

Bioactivity
Kinase	RBC	Metz	Millipore
RET	active (0.52%)	-	active (-1%)

TK - Met

Bioactivity
Kinase	RBC	Metz	Millipore
RON	inactive (110.65%)	-	inactive (89%)
MET	inactive (100.43%)	inactive (>3162.28nM)	inactive (107%)

TK - Sev

Bioactivity
Kinase	RBC	Metz	Millipore
ROS	active (1.18%)	-	active (1%)

TK - Syk

Bioactivity
Kinase	RBC	Metz	Millipore
SYK	active (14.61%)	-	active (3%)
ZAP70	inactive (77.66%)	-	inactive (81%)

TK - Tie

Bioactivity
Kinase	RBC	Metz	Millipore
TIE2	inactive (103.72%)	-	inactive (54%)

TK - Trk

Bioactivity
Kinase	RBC	Metz	Millipore
TRKA	active (1.64%)	-	active (0%)
TRKB	active (0.81%)	-	active (44%)
TRKC	active (0.2%)	-	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
STKR	12	5	1	2
RAF	5	3	1	1
IRAK	4	2	2	2
LISK	4	1	1	1
LRRK	2	1	1	-
MLK	10	5	2	2
RIPK	5	1	-	1

TKL - STKR

Bioactivity
Kinase	RBC	Metz	Millipore
ALK1	inactive (73.64%)	-	-
ALK2	inactive (155.15%)	-	-
ALK4	inactive (115.42%)	-	inactive (108%)
TGFbR1	inactive (103.73%)	-	inactive (69%)
TGFbR2	inactive (116.62%)	-	-

TKL - RAF

Bioactivity
Kinase	RBC	Metz	Millipore
ARAF	inactive (102.81%)	-	-
BRAF	inactive (110.04%)	-	-
RAF1	inactive (111.11%)	-	inactive (72%)

TKL - IRAK

Bioactivity
Kinase	RBC	Metz	Millipore
IRAK1	active (6.43%)	-	active (47%)
IRAK4	inactive (63.52%)	active (12.59nM)	active (-1%)

TKL - LISK

Bioactivity
Kinase	RBC	Metz	Millipore
LIMK1	active (45.34%)	active (50.12nM)	active (48%)

TKL - LRRK

Bioactivity
Kinase	RBC	Metz	Millipore
LRRK2	active (30.52%)	-	-

TKL - MLK

Bioactivity
Kinase	RBC	Metz	Millipore
MLK1	active (1.49%)	-	active (2%)
MLK2	active (25.76%)	-	-
MLK3	active (2.19%)	-	-
TAK1	active (25.43%)	-	inactive (59%)
ZAK	inactive (86.63%)	-	-

TKL - RIPK

Bioactivity
Kinase	RBC	Metz	Millipore
RIPK2	inactive (55.06%)	-	inactive (70%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
CAMKL	20	13	9	12
CAMK1	5	5	2	3
CAMK2	4	4	4	3
RAD53	1	1	1	1
DAPK	5	4	2	4
DCAMKL	3	1	1	1
MAPKAPK	5	5	4	4
MLCK	5	2	-	1
PHK	2	2	1	1
PIM	3	3	3	3
PKD	3	3	2	2
TSSK	5	2	2	2
STK33	1	-	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Metz	Millipore
NuaK1	active (3.86%)	-	active (10%)
BRSK1	active (20.17%)	-	active (6%)
BRSK2	active (26.3%)	-	active (7%)
CHK1	active (7.95%)	-	active (2%)
LKB1	active (31.83%)	-	inactive (82%)
MARK1	active (20.77%)	-	active (4%)
MARK3	active (13.88%)	active (19.95nM)	-
MARK4	active (10.75%)	-	-
MELK	active (21.08%)	-	active (9%)
PASK	inactive (84.31%)	-	inactive (93%)
QIK	inactive (54.55%)	-	-
NuaK2	active (40.52%)	-	-
MARK2	active (11.77%)	active (25.12nM)	active (5%)
AMPKa1	-	-	active (22%)
AMPKa2	-	-	active (19%)
SIK	-	-	active (9%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Metz	Millipore
CaMK1a	inactive (94.2%)	inactive (>7943.28nM)	inactive (80%)
CaMK1b	inactive (103.11%)	-	-
CaMK1d	inactive (82.41%)	-	inactive (56%)
CaMK1g	inactive (100.61%)	-	-
CaMK4	inactive (88.1%)	-	inactive (100%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Metz	Millipore
CaMK2a	active (19.08%)	-	-
CaMK2b	inactive (51.25%)	-	active (11%)
CaMK2d	active (20.3%)	-	active (1%)
CaMK2g	active (21.88%)	-	active (2%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Metz	Millipore
CHK2	inactive (50.2%)	active (79.43nM)	active (25%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Metz	Millipore
DAPK1	inactive (101.69%)	-	inactive (101%)
DAPK2	inactive (84.36%)	-	inactive (93%)
DRAK1	inactive (85.31%)	-	active (36%)
DAPK3	inactive (93.65%)	inactive (>1258.93nM)	inactive (89%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Metz	Millipore
DCLK2	inactive (84.72%)	-	inactive (56%)
DCLK1	-	-	-

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Metz	Millipore
MAPKAPK2	inactive (108.57%)	inactive (>7943.28nM)	inactive (95%)
MAPKAPK3	inactive (83.7%)	inactive (>10000nM)	inactive (131%)
MAPKAPK5	inactive (127.15%)	-	inactive (55%)
MNK1	inactive (75.17%)	-	-
MNK2	active (17.96%)	-	active (10%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Metz	Millipore
smMLCK	active (24.56%)	-	active (16%)
skMLCK	inactive (59.6%)	-	-

CAMK - PHK

Bioactivity
Kinase	RBC	Metz	Millipore
PHKg1	active (1.76%)	-	-
PHKg2	active (8.4%)	-	active (1%)

CAMK - PIM

Bioactivity
Kinase	RBC	Metz	Millipore
PIM1	active (36.08%)	active (100nM)	active (18%)
PIM2	inactive (100.66%)	inactive (>1584.89nM)	active (25%)
PIM3	active (17.32%)	-	inactive (58%)

CAMK - PKD

Bioactivity
Kinase	RBC	Metz	Millipore
PKD1	active (17.32%)	-	active (5%)
PKD3	active (7.3%)	-	-
PKD2	active (18.7%)	active (15.85nM)	active (29%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Metz	Millipore
TSSK1	active (10.12%)	-	active (12%)
TSSK2	inactive (74.34%)	-	inactive (64%)

CAMK - STK33

Bioactivity
Kinase	RBC	Metz	Millipore
STK33	active (26.54%)	-	active (6%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
STE11	8	3	-	1
STE-Unique	2	2	-	-
STE20	31	23	9	14
STE7	7	3	2	3

STE - STE11

Bioactivity
Kinase	RBC	Metz	Millipore
MAP3K5	active (49.79%)	-	active (17%)
MAP3K2	active (2.96%)	-	-
MAP3K3	active (5.86%)	-	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Metz	Millipore
COT	inactive (111.46%)	-	-
NIK	inactive (84.09%)	-	-

STE - STE20

Bioactivity
Kinase	RBC	Metz	Millipore
GCK	active (5.68%)	-	active (2%)
HGK	active (0.43%)	-	-
KHS1	active (4.18%)	-	-
LOK	active (20.09%)	-	active (21%)
MINK	active (2.48%)	-	active (21%)
MST1	active (3.73%)	-	active (1%)
MST2	active (3.07%)	-	active (2%)
MST3	inactive (62.8%)	-	active (47%)
MST4	inactive (89.76%)	-	-
OSR1	inactive (102.27%)	-	-
PAK1	inactive (83.28%)	inactive (>10000nM)	-
PAK2	inactive (91.66%)	-	inactive (101%)
PAK3	inactive (122.24%)	-	active (47%)
PAK4	active (43.99%)	active (63.1nM)	active (3%)
PAK5	active (37.07%)	-	active (12%)
PAK6	active (20.37%)	-	active (4%)
SLK	active (34.09%)	-	-
YSK1	inactive (83.86%)	-	-
STLK3	inactive (96.74%)	-	-
TAO1	active (43.95%)	-	active (7%)
TAO2	active (13.35%)	-	active (10%)
TAO3	-	-	active (19%)
MYO3B	active (0%)	-	-

STE - STE7

Bioactivity
Kinase	RBC	Metz	Millipore
MAP2K1	inactive (90.15%)	-	active (36%)
MAP2K2	inactive (92.46%)	-	-
MAP2K6	active (21.07%)	-	active (0%)
MAP2K7	-	-	inactive (52%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
Aur	3	3	2	3
CAMKK	2	2	1	-
Haspin	1	1	-	1
IKK	4	4	4	3
NEK	11	8	2	5
TOPK	1	1	1	-
PLK	4	3	3	3
SgK496	1	1	-	-
NAK	4	1	-	-
TTK	1	1	-	-
ULK	5	3	-	2
WEE	3	1	1	-
WNK	4	2	-	2
TLK	2	1	-	1
CDC7	1	-	1	-

Other - Aur

Bioactivity
Kinase	RBC	Metz	Millipore
AurA	inactive (56.8%)	active (31.62nM)	active (4%)
AurB	active (33.13%)	active (12.59nM)	active (0%)
AurC	inactive (55.73%)	-	active (47%)

Other - CAMKK

Bioactivity
Kinase	RBC	Metz	Millipore
CaMKK1	active (19.25%)	-	-
CaMKK2	active (3.88%)	-	-

Other - Haspin

Bioactivity
Kinase	RBC	Metz	Millipore
Haspin	active (27.21%)	-	active (11%)

Other - IKK

Bioactivity
Kinase	RBC	Metz	Millipore
IKKa	inactive (101.99%)	inactive (>3981.07nM)	active (48%)
IKKb	inactive (90.38%)	inactive (>3162.28nM)	inactive (72%)
IKKe	inactive (69.39%)	-	-
TBK1	inactive (72.12%)	-	active (11%)

Other - NEK

Bioactivity
Kinase	RBC	Metz	Millipore
NEK1	inactive (62.89%)	-	-
NEK11	inactive (109.51%)	-	active (49%)
NEK2	inactive (89.93%)	inactive (>10000nM)	inactive (76%)
NEK4	active (49.14%)	-	-
NEK6	inactive (102.75%)	-	inactive (93%)
NEK7	inactive (97.02%)	-	inactive (95%)
NEK9	inactive (96.86%)	-	-
NEK3	inactive (133.46%)	-	inactive (100%)

Other - TOPK

Bioactivity
Kinase	RBC	Metz	Millipore
PBK	inactive (84.16%)	-	-

Other - PLK

Bioactivity
Kinase	RBC	Metz	Millipore
PLK1	inactive (102.77%)	inactive (>7943.28nM)	inactive (84%)
PLK2	inactive (104.58%)	-	inactive (95%)
PLK3	inactive (88.08%)	inactive (>7943.28nM)	inactive (92%)
PLK4	-	active (19.95nM)	-

Other - SgK496

Bioactivity
Kinase	RBC	Metz	Millipore
SgK496	active (9.91%)	-	-

Other - NAK

Bioactivity
Kinase	RBC	Metz	Millipore
MPSK1	inactive (81.08%)	-	-

Other - TTK

Bioactivity
Kinase	RBC	Metz	Millipore
TTK	inactive (69.04%)	-	-

Other - ULK

Bioactivity
Kinase	RBC	Metz	Millipore
ULK1	inactive (105.7%)	-	-
ULK2	inactive (92.89%)	-	inactive (99%)
ULK3	active (0%)	-	active (39%)

Other - WEE

Bioactivity
Kinase	RBC	Metz	Millipore
Wee1	inactive (85.44%)	-	-

Other - WNK

Bioactivity
Kinase	RBC	Metz	Millipore
Wnk2	inactive (103.29%)	-	inactive (97%)
Wnk3	inactive (93.07%)	-	inactive (105%)

Other - TLK

Bioactivity
Kinase	RBC	Metz	Millipore
TLK2	active (0%)	-	inactive (73%)

Other - CDC7

Bioactivity
Kinase	RBC	Metz	Millipore
CDC7	-	-	-

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
CK1	7	6	5	4
VRK	3	1	-	1

CK1 - CK1

Bioactivity
Kinase	RBC	Metz	Millipore
CK1d	inactive (97.55%)	inactive (>7943.28nM)	inactive (70%)
CK1g1	inactive (93.31%)	-	inactive (78%)
CK1g2	inactive (105.11%)	-	inactive (93%)
CK1g3	inactive (136.91%)	-	inactive (74%)
CK1a	inactive (75.45%)	-	-
CK1e	inactive (80.41%)	-	-

CK1 - VRK

Bioactivity
Kinase	RBC	Metz	Millipore
VRK1	inactive (83.98%)	-	-
VRK2	-	-	inactive (97%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
CK2	3	2	1	2
CLK	4	4	2	2
DYRK	10	9	6	4
MAPK	14	10	8	10
GSK	2	2	2	2
SRPK	3	3	1	3
CDK	20	-	7	-

CMGC - CK2

Bioactivity
Kinase	RBC	Metz	Millipore
CK2a1	inactive (73.13%)	inactive (>6309.57nM)	inactive (89%)
CK2a2	inactive (103.67%)	-	inactive (129%)

CMGC - CLK

Bioactivity
Kinase	RBC	Metz	Millipore
CLK1	inactive (69.89%)	-	-
CLK2	inactive (88.74%)	-	inactive (51%)
CLK3	active (23.08%)	-	inactive (80%)
CLK4	inactive (66.18%)	-	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Metz	Millipore
DYRK1A	active (46.27%)	active (100nM)	-
DYRK1B	active (25.55%)	-	-
DYRK2	active (48.94%)	-	inactive (76%)
DYRK3	inactive (83.92%)	-	-
DYRK4	inactive (95.65%)	-	-
HIPK1	inactive (81.11%)	-	inactive (85%)
HIPK2	inactive (97.75%)	-	active (20%)
HIPK3	active (29.78%)	-	active (31%)
HIPK4	inactive (102.78%)	-	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Metz	Millipore
Erk1	inactive (72.55%)	-	inactive (52%)
Erk2	inactive (104.09%)	active (100nM)	active (48%)
JNK3	inactive (94.51%)	-	active (7%)
NLK	inactive (57.28%)	-	active (50%)
p38a	inactive (93.53%)	-	inactive (84%)
p38b	inactive (99.49%)	-	inactive (97%)
p38d	inactive (104.36%)	inactive (>7943.28nM)	inactive (99%)
p38g	inactive (85.85%)	inactive (>6309.57nM)	inactive (61%)
JNK1	inactive (78.66%)	active (79.43nM)	inactive (88%)
JNK2	inactive (86.03%)	inactive (3981.07nM)	inactive (94%)

CMGC - GSK

Bioactivity
Kinase	RBC	Metz	Millipore
GSK3A	active (35.63%)	active (63.1nM)	active (20%)
GSK3B	active (38.91%)	active (15.85nM)	active (15%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Metz	Millipore
MSSK1	inactive (92.75%)	-	inactive (90%)
SRPK1	inactive (98.3%)	-	inactive (90%)
SRPK2	inactive (95%)	-	inactive (85%)

CMGC - CDK

Bioactivity
Kinase	RBC	Metz	Millipore
CDC2	-	active (15.85nM)	-
CDK2	-	active (15.85nM)	-
CDK5	-	active (15.85nM)	-
CDK8	-	-	-
CDK7	-	-	-
CDK9	-	-	-
CDK11	-	-	-

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
PDHK	5	1	-	-
Alpha	6	-	1	1
PIKK	6	-	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Metz	Millipore
PDHK1	inactive (63.23%)	-	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Metz	Millipore
eEF2K	-	-	inactive (100%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Metz	Millipore
FRAP	-	-	inactive (115%)