Compound in Profiling

Compound Information

Test on : DRx, RBC, Metz

Compound Name
DRx, RBC : Sunitinib
Metz : N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

Inchikey
Same : WINHZLLDWRZWRT-N
DRx, RBC : WINHZLLDWRZWRT-ATVHPVEESA-N
Metz : WINHZLLDWRZWRT-UHFFFAOYSA-N

ChemSpider
DRx, RBC : 4486264
Metz : 23346185

Pubchem CID
DRx, RBC : 5329102
Metz : 3086686

ChEMBL
DRx, RBC : CHEMBL535
Metz : CHEMBL1990885

DRx, RBC	Metz

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

Other

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
NAK	4	4	1	-
Aur	3	3	3	2
CAMKK	2	2	2	1
PEK	4	2	-	-
IRE	2	1	-	-
IKK	4	4	4	4
NEK	11	9	8	2
WEE	3	3	1	1
PLK	4	4	3	3
SgK496	1	1	1	-
NKF1	3	2	-	-
NKF4	2	1	-	-
ULK	5	4	3	-
TLK	2	2	1	-
TTK	1	1	1	-
Haspin	1	-	1	-
TOPK	1	-	1	1
WNK	4	-	2	-
CDC7	1	-	-	1

Other - NAK

Bioactivity
Kinase	DRx	RBC	Metz
AAK1	active (11nM)	-	-
BIKE	active (5.5nM)	-	-
GAK	active (20nM)	-	-
MPSK1	active (250nM)	inactive (55.75%)	-

Other - Aur

Bioactivity
Kinase	DRx	RBC	Metz
AurA	active (1700nM)	inactive (59.66%)	inactive (>630.96nM)
AurB	active (380nM)	active (48.72%)	active (630.96nM)
AurC	active (220nM)	inactive (72.82%)	-

Other - CAMKK

Bioactivity
Kinase	DRx	RBC	Metz
CaMKK1	active (420nM)	inactive (52.06%)	-
CaMKK2	active (1500nM)	inactive (65.25%)	active (630.96nM)

Other - PEK

Bioactivity
Kinase	DRx	RBC	Metz
HRI	inactive (10001nM)	-	-
PKR	active (670nM)	-	-

Other - IRE

Bioactivity
Kinase	DRx	RBC	Metz
IRE1	active (600nM)	-	-

Other - IKK

Bioactivity
Kinase	DRx	RBC	Metz
IKKa	active (520nM)	inactive (92.36%)	inactive (>3981.07nM)
IKKb	inactive (10001nM)	inactive (80.96%)	inactive (>3162.28nM)
IKKe	active (620nM)	active (45.57%)	inactive (>2511.89nM)
TBK1	active (120nM)	-	inactive (>3162.28nM)

Other - NEK

Bioactivity
Kinase	DRx	RBC	Metz
NEK1	inactive (10001nM)	inactive (72.6%)	-
NEK11	inactive (10001nM)	inactive (106.2%)	-
NEK2	active (1400nM)	inactive (105.74%)	inactive (>2511.89nM)
NEK3	inactive (10001nM)	inactive (91.57%)	-
NEK4	inactive (10001nM)	inactive (94.08%)	inactive (>6309.57nM)
NEK5	inactive (10001nM)	-	-
NEK6	inactive (10001nM)	inactive (89.04%)	-
NEK7	inactive (4100nM)	inactive (93.52%)	-
NEK9	inactive (10001nM)	inactive (100.15%)	-

Other - WEE

Bioactivity
Kinase	DRx	RBC	Metz
MYT1	inactive (10001nM)	-	-
Wee1	active (1100nM)	inactive (91.84%)	-
Wee1B	inactive (10001nM)	-	-

Other - PLK

Bioactivity
Kinase	DRx	RBC	Metz
PLK1	inactive (10001nM)	inactive (96.36%)	inactive (>7943.28nM)
PLK2	inactive (4700nM)	inactive (99.17%)	-
PLK3	inactive (10001nM)	inactive (96.5%)	inactive (>7943.28nM)
PLK4	active (190nM)	-	active (316.23nM)

Other - SgK496

Bioactivity
Kinase	DRx	RBC	Metz
SgK496	active (1300nM)	inactive (111.32%)	-

Other - NKF1

Bioactivity
Kinase	DRx	RBC	Metz
SBK	active (200nM)	-	-
SgK110	active (1900nM)	-	-

Other - NKF4

Bioactivity
Kinase	DRx	RBC	Metz
CLIK1	active (1300nM)	-	-

Other - ULK

Bioactivity
Kinase	DRx	RBC	Metz
Fused	inactive (10001nM)	-	-
ULK1	active (23nM)	active (16.28%)	-
ULK2	active (13nM)	active (40.31%)	-
ULK3	active (42nM)	inactive (57.42%)	-

Other - TLK

Bioactivity
Kinase	DRx	RBC	Metz
TLK1	active (740nM)	-	-
TLK2	active (330nM)	inactive (63.31%)	-

Other - TTK

Bioactivity
Kinase	DRx	RBC	Metz
TTK	active (63nM)	inactive (68%)	-

Other - Haspin

Bioactivity
Kinase	DRx	RBC	Metz
Haspin	-	inactive (53.17%)	-

Other - TOPK

Bioactivity
Kinase	DRx	RBC	Metz
PBK	-	inactive (106.16%)	inactive (>10000nM)

Other - WNK

Bioactivity
Kinase	DRx	RBC	Metz
Wnk2	-	inactive (100.21%)	-
Wnk3	-	inactive (94.26%)	-

Other - CDC7

Bioactivity
Kinase	DRx	RBC	Metz
CDC7	-	-	inactive (>1258.93nM)

TK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
Abl	2	2	2	1
ALK	2	2	2	2
Axl	3	3	3	2
Src	11	11	11	9
Tec	5	5	5	3
PDGFR	5	5	5	5
Csk	2	2	2	1
DDR	2	2	1	-
EGFR	4	4	3	3
Eph	14	13	12	1
FAK	2	2	2	2
Fer	2	2	2	2
FGFR	4	4	4	2
VEGFR	3	3	3	3
InsR	3	3	3	2
JakA	4	4	4	3
Met	2	2	2	2
Musk	1	1	1	-
Ret	1	1	1	1
Sev	1	1	1	1
Syk	2	2	2	1
Tie	2	2	1	-
Ack	2	2	1	1
Trk	3	3	3	3

TK - Abl

Bioactivity
Kinase	DRx	RBC	Metz
ABL1	active (270nM)	active (47.24%)	inactive (>316.23nM)
ABL2	active (1000nM)	inactive (61.78%)	-

TK - ALK

Bioactivity
Kinase	DRx	RBC	Metz
ALK	active (170nM)	active (16.62%)	inactive (>1584.89nM)
LTK	active (1800nM)	active (34.39%)	inactive (>2511.89nM)

TK - Axl

Bioactivity
Kinase	DRx	RBC	Metz
AXL	active (9nM)	active (27.41%)	active (15.85nM)
MER	active (26nM)	active (39.82%)	-
TYRO3	active (49nM)	active (28.31%)	inactive (>1000nM)

TK - Src

Bioactivity
Kinase	DRx	RBC	Metz
BLK	active (65nM)	active (28.66%)	active (63.1nM)
BRK	inactive (4600nM)	inactive (84.49%)	inactive (>2511.89nM)
FGR	active (270nM)	active (16.44%)	-
FRK	active (530nM)	inactive (84.45%)	active (125.89nM)
FYN	active (520nM)	inactive (71.31%)	active (251.19nM)
HCK	active (880nM)	active (39.95%)	active (199.53nM)
LCK	active (230nM)	active (13.24%)	active (31.62nM)
LYN	active (270nM)	active (23%)	active (79.43nM)
SRC	active (2100nM)	active (39.81%)	active (630.96nM)
SRM	inactive (10001nM)	inactive (99.6%)	inactive (>1584.89nM)
YES	active (120nM)	active (5.91%)	-

TK - Tec

Bioactivity
Kinase	DRx	RBC	Metz
BMX	inactive (10001nM)	inactive (99%)	-
BTK	active (2100nM)	inactive (50.19%)	inactive (>3981.07nM)
ITK	active (13nM)	inactive (64.35%)	active (25.12nM)
TEC	inactive (10001nM)	inactive (94.83%)	-
TXK	inactive (10001nM)	inactive (92.62%)	-

TK - PDGFR

Bioactivity
Kinase	DRx	RBC	Metz
FMS	active (2.5nM)	active (7.28%)	active (2.51nM)
FLT3	active (0.41nM)	active (2.71%)	active (1.58nM)
KIT	active (0.37nM)	active (8.74%)	inactive (>3162.28nM)
PDGFRa	active (0.79nM)	active (10.85%)	inactive (>794.33nM)
PDGFRb	active (0.08nM)	active (17.64%)	active (1nM)

TK - Csk

Bioactivity
Kinase	DRx	RBC	Metz
CSK	inactive (10001nM)	inactive (90.17%)	-
CTK	inactive (7700nM)	inactive (88.84%)	inactive (1584.89nM)

TK - DDR

Bioactivity
Kinase	DRx	RBC	Metz
DDR1	active (2000nM)	-	-
DDR2	active (2900nM)	inactive (154.16%)	-

TK - EGFR

Bioactivity
Kinase	DRx	RBC	Metz
EGFR	inactive (10001nM)	inactive (89.17%)	inactive (>1995.26nM)
ErbB2	inactive (10001nM)	inactive (104.84%)	inactive (>1584.89nM)
ErbB3	inactive (10001nM)	-	-
ErbB4	inactive (10001nM)	inactive (94.81%)	inactive (>3981.07nM)

TK - Eph

Bioactivity
Kinase	DRx	RBC	Metz
EphA1	inactive (10001nM)	inactive (95.12%)	-
EphA2	inactive (10001nM)	inactive (83.62%)	inactive (>3162.28nM)
EphA3	active (2100nM)	inactive (83.96%)	-
EphA4	inactive (10001nM)	inactive (84.49%)	-
EphA5	active (1200nM)	inactive (87.6%)	-
EphA6	active (960nM)	active (29.55%)	-
EphA7	active (2400nM)	inactive (50.79%)	-
EphA8	inactive (10001nM)	inactive (92.12%)	-
EphB1	active (480nM)	inactive (53.59%)	-
EphB2	inactive (10001nM)	inactive (72.06%)	-
EphB3	inactive (10001nM)	inactive (77.43%)	-
EphB4	inactive (3100nM)	inactive (65.53%)	-
EphB6	active (1000nM)	-	-

TK - FAK

Bioactivity
Kinase	DRx	RBC	Metz
FAK	active (440nM)	active (27%)	active (316.23nM)
PYK2	active (82nM)	active (38.33%)	active (125.89nM)

TK - Fer

Bioactivity
Kinase	DRx	RBC	Metz
FER	active (1100nM)	active (31.57%)	active (63.1nM)
FES	active (960nM)	active (33.67%)	active (125.89nM)

TK - FGFR

Bioactivity
Kinase	DRx	RBC	Metz
FGFR1	active (520nM)	inactive (66.14%)	inactive (>1584.89nM)
FGFR2	active (570nM)	inactive (50.48%)	-
FGFR3	active (290nM)	active (39.73%)	active (398.11nM)
FGFR4	active (2100nM)	inactive (92.51%)	-

TK - VEGFR

Bioactivity
Kinase	DRx	RBC	Metz
FLT1	active (1.8nM)	inactive (58.72%)	inactive (>1258.93nM)
FLT4	active (50nM)	active (17.36%)	active (25.12nM)
KDR	active (1.5nM)	active (28.67%)	active (12.59nM)

TK - InsR

Bioactivity
Kinase	DRx	RBC	Metz
IGF1R	active (2600nM)	inactive (62.55%)	active (630.96nM)
INSR	active (500nM)	inactive (51.17%)	active (199.53nM)
IRR	active (430nM)	active (21.69%)	-

TK - JakA

Bioactivity
Kinase	DRx	RBC	Metz
JAK1	inactive (6000nM)	inactive (71.88%)	-
JAK2	active (410nM)	inactive (88.82%)	inactive (>1995.26nM)
JAK3	active (1200nM)	inactive (80.67%)	inactive (>3981.07nM)
TYK2	active (1600nM)	inactive (52.6%)	inactive (>1258.93nM)

TK - Met

Bioactivity
Kinase	DRx	RBC	Metz
MET	inactive (7200nM)	inactive (90.96%)	inactive (>2511.89nM)
RON	inactive (10001nM)	inactive (92.01%)	active (25.12nM)

TK - Musk

Bioactivity
Kinase	DRx	RBC	Metz
MUSK	active (490nM)	inactive (51.26%)	-

TK - Ret

Bioactivity
Kinase	DRx	RBC	Metz
RET	active (13nM)	active (3.43%)	active (2.51nM)

TK - Sev

Bioactivity
Kinase	DRx	RBC	Metz
ROS	inactive (10001nM)	inactive (71.58%)	inactive (>2511.89nM)

TK - Syk

Bioactivity
Kinase	DRx	RBC	Metz
SYK	inactive (10001nM)	inactive (89.19%)	inactive (>1584.89nM)
ZAP70	inactive (10001nM)	inactive (97.22%)	-

TK - Tie

Bioactivity
Kinase	DRx	RBC	Metz
TIE1	inactive (3900nM)	-	-
TIE2	inactive (10001nM)	inactive (88.57%)	-

TK - Ack

Bioactivity
Kinase	DRx	RBC	Metz
TNK1	active (680nM)	-	-
ACK	inactive (8900nM)	inactive (64.11%)	inactive (>3162.28nM)

TK - Trk

Bioactivity
Kinase	DRx	RBC	Metz
TRKA	active (100nM)	active (11.46%)	active (794.33nM)
TRKB	active (590nM)	active (9.78%)	active (1000nM)
TRKC	inactive (5100nM)	active (2.37%)	active (794.33nM)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
STKR	12	10	5	1
RIPK	5	4	1	-
RAF	5	2	3	1
MLK	10	8	5	2
IRAK	4	3	2	2
LISK	4	3	1	1
LRRK	2	1	1	1

TKL - STKR

Bioactivity
Kinase	DRx	RBC	Metz
ALK2	inactive (10001nM)	inactive (120.84%)	inactive (>3981.07nM)
ALK4	inactive (10001nM)	inactive (100.56%)	-
ACTR2	inactive (10001nM)	-	-
ACTR2B	inactive (10001nM)	-	-
ALK1	inactive (10001nM)	inactive (111.78%)	-
BMPR1A	inactive (10001nM)	-	-
BMPR1B	active (2400nM)	-	-
BMPR2	active (570nM)	-	-
TGFbR1	inactive (10001nM)	inactive (100.85%)	-
TGFbR2	inactive (10001nM)	inactive (92.46%)	-

TKL - RIPK

Bioactivity
Kinase	DRx	RBC	Metz
SgK288	active (310nM)	-	-
RIPK1	active (370nM)	-	-
RIPK2	inactive (10001nM)	inactive (104.04%)	-
ANKRD3	active (2100nM)	-	-

TKL - RAF

Bioactivity
Kinase	DRx	RBC	Metz
BRAF	inactive (10001nM)	inactive (106.18%)	-
RAF1	inactive (10001nM)	inactive (109.94%)	-
ARAF	-	inactive (124.44%)	-

TKL - MLK

Bioactivity
Kinase	DRx	RBC	Metz
DLK	active (100nM)	-	-
LZK	active (95nM)	-	-
MLK1	inactive (3400nM)	inactive (87.89%)	-
MLK2	inactive (10001nM)	inactive (104.25%)	inactive (>3162.28nM)
MLK3	active (1300nM)	inactive (68.4%)	-
TAK1	active (93nM)	active (18.64%)	-
HH498	inactive (10001nM)	-	-
ZAK	inactive (10001nM)	inactive (97.77%)	inactive (>7943.28nM)

TKL - IRAK

Bioactivity
Kinase	DRx	RBC	Metz
IRAK1	active (14nM)	active (31.41%)	active (125.89nM)
IRAK3	active (940nM)	-	-
IRAK4	active (66nM)	active (27.4%)	active (1000nM)

TKL - LISK

Bioactivity
Kinase	DRx	RBC	Metz
LIMK1	inactive (10001nM)	inactive (94.26%)	inactive (2511.89nM)
LIMK2	inactive (10001nM)	-	-
TESK1	inactive (10001nM)	-	-

TKL - LRRK

Bioactivity
Kinase	DRx	RBC	Metz
LRRK2	active (110nM)	active (3.34%)	inactive (>1584.89nM)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
ABC1	5	2	-	-
PIKK	6	1	-	-
RIO	3	3	-	-
Alpha	6	1	-	1
PDHK	5	-	1	-

Atypical - ABC1

Bioactivity
Kinase	DRx	RBC	Metz
ADCK3	inactive (10001nM)	-	-
ADCK4	inactive (10001nM)	-	-

Atypical - PIKK

Bioactivity
Kinase	DRx	RBC	Metz
FRAP	inactive (10001nM)	-	-

Atypical - RIO

Bioactivity
Kinase	DRx	RBC	Metz
RIOK1	active (35nM)	-	-
RIOK2	active (49nM)	-	-
RIOK3	inactive (3800nM)	-	-

Atypical - Alpha

Bioactivity
Kinase	DRx	RBC	Metz
ChaK2	inactive (10001nM)	-	-
eEF2K	-	-	inactive (>3981.07nM)

Atypical - PDHK

Bioactivity
Kinase	DRx	RBC	Metz
PDHK1	-	inactive (81.56%)	-

AGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
Akt	3	3	3	3
DMPK	7	7	5	3
GRK	7	3	6	1
NDR	4	4	1	-
MAST	5	1	-	-
PDK1	1	1	1	1
PKA	5	3	3	2
PKN	3	2	2	1
PKC	9	5	9	5
PKG	2	2	3	2
RSK	8	1	8	4
SGK	3	1	3	1
YANK	3	3	-	-

AGC - Akt

Bioactivity
Kinase	DRx	RBC	Metz
AKT1	inactive (10001nM)	inactive (104.83%)	inactive (>5011.87nM)
AKT2	active (2700nM)	inactive (87.36%)	inactive (>7943.28nM)
AKT3	inactive (10001nM)	inactive (71.68%)	inactive (>6309.57nM)

AGC - DMPK

Bioactivity
Kinase	DRx	RBC	Metz
CRIK	inactive (3900nM)	-	-
DMPK1	inactive (10001nM)	inactive (97.74%)	-
DMPK2	inactive (10001nM)	-	-
MRCKa	inactive (10001nM)	inactive (89.52%)	inactive (>10000nM)
MRCKb	inactive (10001nM)	inactive (100.93%)	-
ROCK1	active (460nM)	inactive (99.65%)	inactive (>2511.89nM)
ROCK2	active (140nM)	inactive (72.1%)	active (1000nM)

AGC - GRK

Bioactivity
Kinase	DRx	RBC	Metz
RHOK	active (290nM)	-	-
GPRK4	active (140nM)	inactive (75.79%)	-
GPRK7	active (180nM)	inactive (71.25%)	-
BARK1	-	inactive (94.71%)	-
BARK2	-	inactive (94.8%)	-
GPRK5	-	inactive (85.3%)	inactive (>3981.07nM)
GPRK6	-	inactive (74.68%)	-

AGC - NDR

Bioactivity
Kinase	DRx	RBC	Metz
LATS1	active (630nM)	-	-
LATS2	active (460nM)	-	-
NDR1	active (410nM)	inactive (93.85%)	-
NDR2	active (970nM)	-	-

AGC - MAST

Bioactivity
Kinase	DRx	RBC	Metz
MAST1	active (200nM)	-	-

AGC - PDK1

Bioactivity
Kinase	DRx	RBC	Metz
PDK1	inactive (3500nM)	inactive (81.56%)	active (1000nM)

AGC - PKA

Bioactivity
Kinase	DRx	RBC	Metz
PKACa	inactive (10001nM)	inactive (89.1%)	inactive (>1995.26nM)
PKACb	inactive (10001nM)	-	-
PRKX	inactive (10001nM)	inactive (104.89%)	inactive (>3162.28nM)
PKACg	-	inactive (109.09%)	-

AGC - PKN

Bioactivity
Kinase	DRx	RBC	Metz
PKN1	active (710nM)	inactive (71.42%)	-
PKN2	active (1300nM)	inactive (89.13%)	inactive (2511.89nM)

AGC - PKC

Bioactivity
Kinase	DRx	RBC	Metz
PKCd	inactive (10001nM)	inactive (95.08%)	inactive (5011.87nM)
PKCe	inactive (10001nM)	inactive (97.95%)	-
PKCh	inactive (10001nM)	inactive (111.79%)	-
PKCi	inactive (10001nM)	inactive (102.61%)	inactive (>5011.87nM)
PKCt	inactive (4300nM)	inactive (63.49%)	inactive (>2511.89nM)
PKCa	-	inactive (79.88%)	-
PKCg	-	inactive (83.81%)	inactive (>6309.57nM)
PKCz	-	inactive (91.71%)	inactive (>7943.28nM)
PKCb	-	inactive (103.78%)	-

AGC - PKG

Bioactivity
Kinase	DRx	RBC	Metz
PKG1	inactive (10001nM)	inactive (65.35%)	inactive (>1995.26nM)
PKG2	inactive (10001nM)	inactive (96.06%)	inactive (>1584.89nM)

AGC - RSK

Bioactivity
Kinase	DRx	RBC	Metz
p70S6K	active (48nM)	active (42.32%)	active (398.11nM)
MSK1	-	inactive (60.05%)	active (398.11nM)
MSK2	-	inactive (50.84%)	active (63.1nM)
p70S6Kb	-	inactive (113.44%)	-
RSK2	-	active (35.46%)	inactive (>1258.93nM)
RSK4	-	active (17.51%)	-
RSK1	-	active (28.05%)	-
RSK3	-	active (17.34%)	-

AGC - SGK

Bioactivity
Kinase	DRx	RBC	Metz
SGK3	active (220nM)	inactive (101.31%)	-
SGK1	-	inactive (62.78%)	active (316.23nM)
SGK2	-	inactive (93.15%)	-

AGC - YANK

Bioactivity
Kinase	DRx	RBC	Metz
YANK1	inactive (10001nM)	-	-
YANK2	inactive (10001nM)	-	-
YANK3	inactive (10001nM)	-	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
CAMKL	20	19	13	9
CAMK1	5	4	5	2
CAMK2	4	4	4	4
CASK	1	1	-	-
RAD53	1	1	1	1
DAPK	5	5	4	2
DCAMKL	3	3	1	1
MAPKAPK	5	4	5	4
MLCK	5	4	2	-
PHK	2	2	2	1
PIM	3	3	3	3
PKD	3	3	3	2
STK33	1	1	-	1
TSSK	5	1	2	2

CAMK - CAMKL

Bioactivity
Kinase	DRx	RBC	Metz
AMPKa1	active (19nM)	-	active (63.1nM)
AMPKa2	active (89nM)	-	-
NuaK1	active (48nM)	active (2.75%)	-
BRSK1	inactive (3500nM)	active (45.15%)	active (158.49nM)
BRSK2	active (1100nM)	inactive (54.53%)	-
CHK1	active (300nM)	active (29.2%)	inactive (>1258.93nM)
HUNK	active (500nM)	-	-
LKB1	active (38nM)	inactive (97.2%)	-
MARK1	active (1200nM)	active (40.94%)	-
MARK2	active (310nM)	active (40.6%)	active (199.53nM)
MARK3	active (410nM)	active (30.35%)	active (199.53nM)
MARK4	inactive (3600nM)	active (24.74%)	inactive (>5011.87nM)
MELK	active (350nM)	active (10.39%)	inactive (>1258.93nM)
NIM1	active (850nM)	-	-
QSK	inactive (10001nM)	-	-
SIK	inactive (3200nM)	-	-
QIK	active (580nM)	active (27.84%)	active (316.23nM)
NuaK2	active (150nM)	inactive (65.01%)	-
SNRK	active (640nM)	-	-
PASK	-	inactive (102.25%)	-

CAMK - CAMK1

Bioactivity
Kinase	DRx	RBC	Metz
CaMK1a	active (970nM)	inactive (75.19%)	inactive (1258.93nM)
CaMK1d	active (510nM)	inactive (77.9%)	inactive (>1995.26nM)
CaMK1g	active (440nM)	inactive (67.03%)	-
CaMK4	active (890nM)	inactive (88.63%)	-
CaMK1b	-	inactive (98.47%)	-

CAMK - CAMK2

Bioactivity
Kinase	DRx	RBC	Metz
CaMK2a	active (80nM)	active (14.46%)	active (158.49nM)
CaMK2b	active (1400nM)	active (46.66%)	inactive (1258.93nM)
CaMK2d	active (420nM)	active (11.56%)	active (25.12nM)
CaMK2g	active (690nM)	active (25.07%)	active (39.81nM)

CAMK - CASK

Bioactivity
Kinase	DRx	RBC	Metz
CASK	inactive (10001nM)	-	-

CAMK - RAD53

Bioactivity
Kinase	DRx	RBC	Metz
CHK2	active (10nM)	active (7.13%)	active (31.62nM)

CAMK - DAPK

Bioactivity
Kinase	DRx	RBC	Metz
DAPK1	active (120nM)	inactive (66.85%)	-
DAPK2	active (150nM)	-	-
DAPK3	active (22nM)	inactive (74.21%)	active (199.53nM)
DRAK1	active (1nM)	active (26.74%)	active (794.33nM)
DRAK2	active (110nM)	-	-

CAMK - DCAMKL

Bioactivity
Kinase	DRx	RBC	Metz
DCLK1	active (370nM)	-	inactive (3981.07nM)
DCLK2	active (2700nM)	inactive (85.02%)	-
DCLK3	active (110nM)	-	-

CAMK - MAPKAPK

Bioactivity
Kinase	DRx	RBC	Metz
MAPKAPK2	inactive (10001nM)	inactive (93.22%)	inactive (>7943.28nM)
MAPKAPK5	inactive (10001nM)	inactive (82.74%)	inactive (>1584.89nM)
MNK1	inactive (3900nM)	inactive (99.35%)	-
MNK2	inactive (5700nM)	inactive (99.33%)	inactive (>10000nM)
MAPKAPK3	-	inactive (102.23%)	inactive (>10000nM)

CAMK - MLCK

Bioactivity
Kinase	DRx	RBC	Metz
caMLCK	active (23nM)	-	-
smMLCK	active (280nM)	active (25.61%)	-
skMLCK	active (49nM)	active (7.74%)	-
SgK085	active (15nM)	-	-

CAMK - PHK

Bioactivity
Kinase	DRx	RBC	Metz
PHKg1	active (5.5nM)	active (5.12%)	-
PHKg2	active (5.9nM)	active (20.55%)	active (15.85nM)

CAMK - PIM

Bioactivity
Kinase	DRx	RBC	Metz
PIM1	inactive (10001nM)	inactive (94.44%)	inactive (>6309.57nM)
PIM2	inactive (10001nM)	inactive (97.16%)	inactive (>1584.89nM)
PIM3	active (2400nM)	inactive (56.81%)	inactive (1584.89nM)

CAMK - PKD

Bioactivity
Kinase	DRx	RBC	Metz
PKD1	active (310nM)	active (20.02%)	-
PKD2	active (380nM)	active (21.14%)	active (398.11nM)
PKD3	active (280nM)	active (16.57%)	inactive (>1584.89nM)

CAMK - STK33

Bioactivity
Kinase	DRx	RBC	Metz
STK33	active (17nM)	active (31.82%)	-

CAMK - TSSK

Bioactivity
Kinase	DRx	RBC	Metz
TSSK1	inactive (6300nM)	active (20.67%)	active (199.53nM)
TSSK2	-	inactive (72.91%)	active (630.96nM)

STE

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
STE11	8	8	3	-
STE20	31	27	23	9
STE7	7	7	3	2
STE-Unique	2	-	2	-

STE - STE11

Bioactivity
Kinase	DRx	RBC	Metz
MAP3K5	inactive (10001nM)	inactive (100.2%)	-
MAP3K6	inactive (10001nM)	-	-
MAP3K1	inactive (10001nM)	-	-
MAP3K7	active (1300nM)	-	-
MAP3K2	active (57nM)	inactive (51.88%)	-
MAP3K3	active (220nM)	active (42%)	-
MAP3K4	inactive (4800nM)	-	-
MAP3K8	active (17nM)	-	-

STE - STE20

Bioactivity
Kinase	DRx	RBC	Metz
HPK1	active (16nM)	-	-
LOK	active (19nM)	active (31.22%)	-
GCK	active (33nM)	active (34.44%)	inactive (>1584.89nM)
KHS2	active (180nM)	-	-
HGK	active (140nM)	active (12.44%)	active (31.62nM)
KHS1	active (41nM)	active (4.06%)	active (15.85nM)
MINK	active (29nM)	active (10.46%)	active (79.43nM)
MST1	active (19nM)	active (10.7%)	-
MST2	active (56nM)	active (24.8%)	active (100nM)
MST3	active (63nM)	active (39.71%)	-
MST4	active (340nM)	inactive (110.06%)	-
MYO3A	inactive (3100nM)	-	-
MYO3B	inactive (4500nM)	inactive (54.48%)	-
OSR1	active (530nM)	inactive (105.18%)	-
PAK1	inactive (10001nM)	inactive (118.32%)	inactive (>10000nM)
PAK2	inactive (10001nM)	inactive (98.11%)	-
PAK3	active (16nM)	inactive (108.98%)	-
PAK4	active (2300nM)	inactive (80.93%)	inactive (>3162.28nM)
PAK6	active (2400nM)	inactive (107.24%)	-
PAK5	active (640nM)	inactive (81.55%)	-
SLK	active (56nM)	inactive (63.84%)	active (79.43nM)
STLK3	active (140nM)	inactive (87.36%)	-
TAO1	active (890nM)	inactive (71.46%)	inactive (>3981.07nM)
TAO2	inactive (10001nM)	inactive (90.31%)	-
TAO3	active (210nM)	inactive (82.92%)	-
TNIK	active (25nM)	-	-
YSK1	active (290nM)	inactive (76.06%)	-

STE - STE7

Bioactivity
Kinase	DRx	RBC	Metz
MAP2K1	active (130nM)	inactive (67.8%)	active (39.81nM)
MAP2K2	active (110nM)	active (25.41%)	active (50.12nM)
MAP2K3	active (1700nM)	-	-
MAP2K4	active (700nM)	-	-
MAP2K5	active (46nM)	-	-
MAP2K6	inactive (5200nM)	inactive (75.85%)	-
MAP2K7	inactive (10001nM)	-	-

STE - STE-Unique

Bioactivity
Kinase	DRx	RBC	Metz
COT	-	inactive (116.82%)	-
NIK	-	inactive (127.37%)	-

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
CDK	20	8	-	7
CDKL	5	4	-	-
CLK	4	4	4	2
CK2	3	2	2	1
DYRK	10	8	9	6
MAPK	14	14	10	8
GSK	2	2	2	2
RCK	3	2	-	-
SRPK	3	3	3	1

CMGC - CDK

Bioactivity
Kinase	DRx	RBC	Metz
PITSLRE	inactive (10001nM)	-	-
CHED	inactive (10001nM)	-	-
CDK11	inactive (10001nM)	-	inactive (>100000nM)
PCTAIRE1	active (150nM)	-	-
PCTAIRE2	active (1200nM)	-	-
PCTAIRE3	active (1700nM)	-	-
PFTAIRE2	inactive (10001nM)	-	-
PFTAIRE1	active (270nM)	-	-
CDC2	-	-	inactive (>7943.28nM)
CDK2	-	-	inactive (>7943.28nM)
CDK5	-	-	inactive (>3162.28nM)
CDK8	-	-	inactive (>3981.07nM)
CDK7	-	-	active (19.95nM)
CDK9	-	-	inactive (>1584.89nM)

CMGC - CDKL

Bioactivity
Kinase	DRx	RBC	Metz
CDKL1	inactive (10001nM)	-	-
CDKL2	active (1100nM)	-	-
CDKL3	inactive (10001nM)	-	-
CDKL5	inactive (10001nM)	-	-

CMGC - CLK

Bioactivity
Kinase	DRx	RBC	Metz
CLK1	active (22nM)	active (23.26%)	-
CLK2	active (20nM)	active (13.59%)	inactive (>2511.89nM)
CLK3	inactive (10001nM)	inactive (105.22%)	-
CLK4	active (29nM)	active (26.32%)	inactive (>1000nM)

CMGC - CK2

Bioactivity
Kinase	DRx	RBC	Metz
CK2a1	active (900nM)	inactive (120.61%)	inactive (>5011.87nM)
CK2a2	active (160nM)	inactive (92.18%)	-

CMGC - DYRK

Bioactivity
Kinase	DRx	RBC	Metz
DYRK1A	active (200nM)	inactive (56.86%)	inactive (>1995.26nM)
DYRK1B	active (2300nM)	inactive (59.97%)	inactive (>1995.26nM)
DYRK2	active (680nM)	inactive (82.57%)	-
HIPK1	active (55nM)	inactive (71.29%)	-
HIPK2	active (31nM)	active (41.32%)	active (251.19nM)
HIPK3	active (41nM)	active (47.26%)	-
HIPK4	active (160nM)	inactive (74.66%)	inactive (1584.89nM)
PRP4	active (390nM)	-	-
DYRK3	-	inactive (58.21%)	active (1000nM)
DYRK4	-	inactive (104.04%)	inactive (>7943.28nM)

CMGC - MAPK

Bioactivity
Kinase	DRx	RBC	Metz
Erk1	inactive (10001nM)	inactive (107.7%)	-
Erk2	inactive (10001nM)	inactive (98.48%)	inactive (>7943.28nM)
Erk3	inactive (10001nM)	-	-
Erk4	inactive (10001nM)	-	-
Erk5	inactive (9900nM)	-	-
Erk7	inactive (10001nM)	-	-
JNK1	inactive (10001nM)	inactive (91.84%)	inactive (>3981.07nM)
JNK2	active (2400nM)	inactive (96.74%)	inactive (>3981.07nM)
JNK3	inactive (4300nM)	inactive (99.52%)	inactive (>3162.28nM)
NLK	inactive (10001nM)	inactive (104.58%)	-
p38a	inactive (10001nM)	inactive (104.88%)	inactive (>3981.07nM)
p38b	inactive (10001nM)	inactive (99.95%)	-
p38d	inactive (10001nM)	inactive (92.39%)	inactive (>7943.28nM)
p38g	inactive (10001nM)	inactive (95.76%)	inactive (>6309.57nM)

CMGC - GSK

Bioactivity
Kinase	DRx	RBC	Metz
GSK3A	inactive (10001nM)	inactive (85.51%)	inactive (>6309.57nM)
GSK3B	inactive (10001nM)	inactive (95.78%)	inactive (>2511.89nM)

CMGC - RCK

Bioactivity
Kinase	DRx	RBC	Metz
ICK	active (470nM)	-	-
MAK	inactive (10001nM)	-	-

CMGC - SRPK

Bioactivity
Kinase	DRx	RBC	Metz
SRPK1	active (250nM)	inactive (97.04%)	inactive (>7943.28nM)
SRPK2	active (190nM)	inactive (94.98%)	-
MSSK1	active (59nM)	inactive (102.34%)	-

CK1

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
CK1	7	7	6	5
VRK	3	1	1	-

CK1 - CK1

Bioactivity
Kinase	DRx	RBC	Metz
CK1a	active (99nM)	inactive (53.97%)	inactive (>3162.28nM)
CK1a2	active (550nM)	-	-
CK1d	active (15nM)	active (31.77%)	active (100nM)
CK1e	active (13nM)	active (46.95%)	-
CK1g1	active (930nM)	inactive (55.93%)	active (1000nM)
CK1g2	active (110nM)	-	active (630.96nM)
CK1g3	active (240nM)	active (30.02%)	active (501.19nM)

CK1 - VRK

Bioactivity
Kinase	DRx	RBC	Metz
VRK2	inactive (10001nM)	-	-
VRK1	-	inactive (97.28%)	-