Compound in Profiling

Compound Information

Test on : RBC

Compound Name : STO-609 acetate

Inchikey : WNRSTFUVBWNELX-UHFFFAOYSA-N

ChemSpider : 21395794

Pubchem CID : 16760660

ChEMBL : CHEMBL265470

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDK1	1	1
Akt	3	3
DMPK	7	5
GRK	7	6
RSK	8	8
PKA	5	3
PKC	9	9
PKG	2	3
PKN	3	2
SGK	3	3
NDR	4	1

AGC - PDK1

Bioactivity
Kinase	RBC
PDK1	inactive (108.47%)

AGC - Akt

Bioactivity
Kinase	RBC
AKT1	inactive (100.76%)
AKT2	inactive (101.37%)
AKT3	inactive (103.77%)

AGC - DMPK

Bioactivity
Kinase	RBC
DMPK1	inactive (98.95%)
MRCKa	inactive (96.06%)
MRCKb	inactive (109.11%)
ROCK1	inactive (103.53%)
ROCK2	inactive (99.01%)

AGC - GRK

Bioactivity
Kinase	RBC
BARK1	inactive (99.31%)
BARK2	inactive (102.53%)
GPRK4	inactive (95.47%)
GPRK5	inactive (97.11%)
GPRK6	inactive (91.37%)
GPRK7	inactive (101.79%)

AGC - RSK

Bioactivity
Kinase	RBC
MSK1	inactive (103.73%)
MSK2	inactive (109.61%)
p70S6K	inactive (95.91%)
p70S6Kb	inactive (97.96%)
RSK2	inactive (95.55%)
RSK4	inactive (100.81%)
RSK1	inactive (100.91%)
RSK3	inactive (90.53%)

AGC - PKA

Bioactivity
Kinase	RBC
PKACg	inactive (126.55%)
PRKX	inactive (93.75%)
PKACa	inactive (99.4%)

AGC - PKC

Bioactivity
Kinase	RBC
PKCa	inactive (100.89%)
PKCd	inactive (103.49%)
PKCe	inactive (112.99%)
PKCh	inactive (100.5%)
PKCg	inactive (99.12%)
PKCi	inactive (94.57%)
PKCt	inactive (117.13%)
PKCz	inactive (94.31%)
PKCb	inactive (97.01%)

AGC - PKG

Bioactivity
Kinase	RBC
PKG2	inactive (94.81%)
PKG1	inactive (93.95%)

AGC - PKN

Bioactivity
Kinase	RBC
PKN1	inactive (99.46%)
PKN2	inactive (97.94%)

AGC - SGK

Bioactivity
Kinase	RBC
SGK1	inactive (101.56%)
SGK2	inactive (102.77%)
SGK3	inactive (103.08%)

AGC - NDR

Bioactivity
Kinase	RBC
NDR1	inactive (97.47%)

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Abl	2	2
Ack	2	1
ALK	2	2
Axl	3	3
Src	11	11
Tec	5	5
PDGFR	5	5
Csk	2	2
DDR	2	1
EGFR	4	3
Eph	14	12
FAK	2	2
Fer	2	2
FGFR	4	4
VEGFR	3	3
InsR	3	3
JakA	4	4
Musk	1	1
Ret	1	1
Met	2	2
Sev	1	1
Syk	2	2
Tie	2	1
Trk	3	3

TK - Abl

Bioactivity
Kinase	RBC
ABL1	inactive (99.29%)
ABL2	inactive (99.99%)

TK - Ack

Bioactivity
Kinase	RBC
ACK	inactive (100.93%)

TK - ALK

Bioactivity
Kinase	RBC
ALK	inactive (92.71%)
LTK	inactive (72.71%)

TK - Axl

Bioactivity
Kinase	RBC
AXL	inactive (94.31%)
MER	inactive (77.72%)
TYRO3	inactive (101.5%)

TK - Src

Bioactivity
Kinase	RBC
BLK	inactive (100.12%)
BRK	inactive (91.06%)
SRC	inactive (96.27%)
FGR	inactive (98.94%)
FRK	inactive (97.57%)
FYN	inactive (94%)
HCK	inactive (96.71%)
LCK	inactive (100.61%)
SRM	inactive (106.42%)
YES	inactive (96.56%)
LYN	inactive (101.47%)

TK - Tec

Bioactivity
Kinase	RBC
BMX	inactive (96.43%)
BTK	inactive (109.29%)
ITK	inactive (97.69%)
TEC	inactive (123.16%)
TXK	inactive (101.92%)

TK - PDGFR

Bioactivity
Kinase	RBC
KIT	inactive (93.54%)
FLT3	inactive (68.88%)
FMS	inactive (104.45%)
PDGFRb	inactive (107.28%)
PDGFRa	inactive (94.38%)

TK - Csk

Bioactivity
Kinase	RBC
CSK	inactive (101.08%)
CTK	inactive (93.97%)

TK - DDR

Bioactivity
Kinase	RBC
DDR2	inactive (96.78%)

TK - EGFR

Bioactivity
Kinase	RBC
EGFR	inactive (96.53%)
ErbB2	inactive (99.68%)
ErbB4	inactive (105.22%)

TK - Eph

Bioactivity
Kinase	RBC
EphA1	inactive (95.31%)
EphA2	inactive (102.39%)
EphA3	inactive (103.88%)
EphA4	inactive (103.1%)
EphA5	inactive (94.24%)
EphA6	inactive (104.86%)
EphA7	inactive (102.93%)
EphA8	inactive (89.38%)
EphB1	inactive (97.52%)
EphB2	inactive (104.16%)
EphB3	inactive (94.49%)
EphB4	inactive (90.56%)

TK - FAK

Bioactivity
Kinase	RBC
FAK	inactive (97.52%)
PYK2	inactive (69.25%)

TK - Fer

Bioactivity
Kinase	RBC
FER	inactive (96.49%)
FES	inactive (98.17%)

TK - FGFR

Bioactivity
Kinase	RBC
FGFR1	inactive (84.68%)
FGFR2	inactive (100.13%)
FGFR3	inactive (92.94%)
FGFR4	inactive (88.61%)

TK - VEGFR

Bioactivity
Kinase	RBC
FLT1	inactive (86.51%)
FLT4	inactive (82.45%)
KDR	inactive (101.05%)

TK - InsR

Bioactivity
Kinase	RBC
IGF1R	inactive (100.21%)
IRR	inactive (101.25%)
INSR	inactive (91.46%)

TK - JakA

Bioactivity
Kinase	RBC
JAK1	inactive (98.44%)
JAK2	inactive (86.75%)
JAK3	active (46.88%)
TYK2	active (22.83%)

TK - Musk

Bioactivity
Kinase	RBC
MUSK	active (47.12%)

TK - Ret

Bioactivity
Kinase	RBC
RET	inactive (96.84%)

TK - Met

Bioactivity
Kinase	RBC
RON	inactive (100.33%)
MET	inactive (103.56%)

TK - Sev

Bioactivity
Kinase	RBC
ROS	inactive (95.17%)

TK - Syk

Bioactivity
Kinase	RBC
SYK	inactive (96.04%)
ZAP70	inactive (118.99%)

TK - Tie

Bioactivity
Kinase	RBC
TIE2	inactive (101.54%)

TK - Trk

Bioactivity
Kinase	RBC
TRKA	inactive (105.15%)
TRKB	inactive (98.36%)
TRKC	inactive (67.1%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STKR	12	5
RAF	5	3
IRAK	4	2
LISK	4	1
LRRK	2	1
MLK	10	5
RIPK	5	1

TKL - STKR

Bioactivity
Kinase	RBC
ALK1	inactive (102.76%)
ALK2	inactive (91.14%)
ALK4	inactive (93.49%)
TGFbR1	inactive (99.37%)
TGFbR2	inactive (132.98%)

TKL - RAF

Bioactivity
Kinase	RBC
ARAF	inactive (101.09%)
BRAF	inactive (95.07%)
RAF1	inactive (97.5%)

TKL - IRAK

Bioactivity
Kinase	RBC
IRAK1	inactive (61.14%)
IRAK4	inactive (106.77%)

TKL - LISK

Bioactivity
Kinase	RBC
LIMK1	inactive (92.72%)

TKL - LRRK

Bioactivity
Kinase	RBC
LRRK2	inactive (70.08%)

TKL - MLK

Bioactivity
Kinase	RBC
MLK1	inactive (64.36%)
MLK2	inactive (99.31%)
MLK3	active (23.75%)
TAK1	inactive (74.4%)
ZAK	inactive (100.12%)

TKL - RIPK

Bioactivity
Kinase	RBC
RIPK2	inactive (78.38%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CAMKL	20	13
CAMK1	5	5
CAMK2	4	4
RAD53	1	1
DAPK	5	4
DCAMKL	3	1
MAPKAPK	5	5
MLCK	5	2
PHK	2	2
PIM	3	3
PKD	3	3
TSSK	5	2
STK33	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC
NuaK1	active (41.29%)
BRSK1	inactive (88.99%)
BRSK2	inactive (90.38%)
CHK1	inactive (100.87%)
LKB1	inactive (96.56%)
MARK1	inactive (79.47%)
MARK3	inactive (82.61%)
MARK4	inactive (88.38%)
MELK	inactive (97.02%)
PASK	inactive (106.37%)
QIK	inactive (92.82%)
NuaK2	inactive (121.53%)
MARK2	inactive (87.69%)

CAMK - CAMK1

Bioactivity
Kinase	RBC
CaMK1a	inactive (100.84%)
CaMK1b	inactive (101.4%)
CaMK1d	inactive (100.09%)
CaMK1g	inactive (98.98%)
CaMK4	inactive (100.96%)

CAMK - CAMK2

Bioactivity
Kinase	RBC
CaMK2a	inactive (85.18%)
CaMK2b	inactive (92.56%)
CaMK2d	inactive (93.56%)
CaMK2g	inactive (96.47%)

CAMK - RAD53

Bioactivity
Kinase	RBC
CHK2	inactive (75.25%)

CAMK - DAPK

Bioactivity
Kinase	RBC
DAPK1	active (40.94%)
DAPK2	inactive (91.85%)
DRAK1	inactive (73.39%)
DAPK3	inactive (51.32%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC
DCLK2	inactive (96.72%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC
MAPKAPK2	inactive (102.07%)
MAPKAPK3	inactive (102.93%)
MAPKAPK5	inactive (96.04%)
MNK1	inactive (60.28%)
MNK2	inactive (57.24%)

CAMK - MLCK

Bioactivity
Kinase	RBC
smMLCK	inactive (89.76%)
skMLCK	inactive (99.6%)

CAMK - PHK

Bioactivity
Kinase	RBC
PHKg1	inactive (91.48%)
PHKg2	inactive (94.67%)

CAMK - PIM

Bioactivity
Kinase	RBC
PIM1	inactive (59.5%)
PIM2	active (41.7%)
PIM3	active (4.96%)

CAMK - PKD

Bioactivity
Kinase	RBC
PKD1	inactive (86.22%)
PKD3	inactive (82.15%)
PKD2	inactive (86.84%)

CAMK - TSSK

Bioactivity
Kinase	RBC
TSSK1	inactive (112.06%)
TSSK2	inactive (105.94%)

CAMK - STK33

Bioactivity
Kinase	RBC
STK33	inactive (78.79%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STE11	8	3
STE-Unique	2	2
STE20	31	23
STE7	7	3

STE - STE11

Bioactivity
Kinase	RBC
MAP3K5	inactive (101.81%)
MAP3K2	inactive (90.67%)
MAP3K3	inactive (81%)

STE - STE-Unique

Bioactivity
Kinase	RBC
COT	inactive (88.32%)
NIK	inactive (94.75%)

STE - STE20

Bioactivity
Kinase	RBC
GCK	active (37.99%)
HGK	active (43.41%)
KHS1	active (47.05%)
LOK	inactive (88.58%)
MINK	inactive (79.8%)
MST1	inactive (93.3%)
MST2	inactive (97.06%)
MST3	inactive (87.61%)
MST4	inactive (97.79%)
OSR1	inactive (103.89%)
PAK1	inactive (95.65%)
PAK2	inactive (97.02%)
PAK3	inactive (97.61%)
PAK4	inactive (113.82%)
PAK5	inactive (98.73%)
PAK6	inactive (103.03%)
SLK	inactive (94.11%)
YSK1	inactive (104.3%)
STLK3	inactive (102.11%)
TAO1	inactive (93.32%)
TAO2	inactive (95.22%)
TAO3	inactive (93.15%)
MYO3B	inactive (96.66%)

STE - STE7

Bioactivity
Kinase	RBC
MAP2K1	inactive (93.72%)
MAP2K2	inactive (105.45%)
MAP2K6	inactive (103.44%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Aur	3	3
CAMKK	2	2
Haspin	1	1
IKK	4	4
NEK	11	8
TOPK	1	1
PLK	4	3
SgK496	1	1
NAK	4	1
TTK	1	1
ULK	5	3
WEE	3	1
WNK	4	2
TLK	2	1

Other - Aur

Bioactivity
Kinase	RBC
AurA	inactive (78.55%)
AurB	inactive (82.47%)
AurC	inactive (88%)

Other - CAMKK

Bioactivity
Kinase	RBC
CaMKK1	active (45.85%)
CaMKK2	active (7.88%)

Other - Haspin

Bioactivity
Kinase	RBC
Haspin	inactive (90.94%)

Other - IKK

Bioactivity
Kinase	RBC
IKKa	inactive (114.49%)
IKKb	inactive (108.74%)
IKKe	inactive (57.35%)
TBK1	active (20.18%)

Other - NEK

Bioactivity
Kinase	RBC
NEK1	inactive (87.76%)
NEK11	inactive (82.99%)
NEK2	inactive (108.65%)
NEK4	inactive (60.38%)
NEK6	inactive (115.34%)
NEK7	inactive (105.27%)
NEK9	inactive (94.07%)
NEK3	inactive (91.77%)

Other - TOPK

Bioactivity
Kinase	RBC
PBK	inactive (97.49%)

Other - PLK

Bioactivity
Kinase	RBC
PLK1	inactive (109.98%)
PLK2	inactive (97.01%)
PLK3	inactive (93.93%)

Other - SgK496

Bioactivity
Kinase	RBC
SgK496	inactive (103.23%)

Other - NAK

Bioactivity
Kinase	RBC
MPSK1	inactive (106.49%)

Other - TTK

Bioactivity
Kinase	RBC
TTK	inactive (80.97%)

Other - ULK

Bioactivity
Kinase	RBC
ULK1	inactive (83.55%)
ULK2	inactive (93.92%)
ULK3	inactive (79.84%)

Other - WEE

Bioactivity
Kinase	RBC
Wee1	inactive (84.57%)

Other - WNK

Bioactivity
Kinase	RBC
Wnk2	inactive (105.51%)
Wnk3	inactive (95.8%)

Other - TLK

Bioactivity
Kinase	RBC
TLK2	inactive (91.21%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK1	7	6
VRK	3	1

CK1 - CK1

Bioactivity
Kinase	RBC
CK1d	inactive (100.8%)
CK1g1	inactive (99.49%)
CK1g2	inactive (93.52%)
CK1g3	inactive (96.86%)
CK1a	inactive (97.63%)
CK1e	inactive (95.99%)

CK1 - VRK

Bioactivity
Kinase	RBC
VRK1	inactive (102.63%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK2	3	2
CLK	4	4
DYRK	10	9
MAPK	14	10
GSK	2	2
SRPK	3	3

CMGC - CK2

Bioactivity
Kinase	RBC
CK2a1	active (28.28%)
CK2a2	active (13.35%)

CMGC - CLK

Bioactivity
Kinase	RBC
CLK1	inactive (93.77%)
CLK2	inactive (91.02%)
CLK3	inactive (95.43%)
CLK4	inactive (82.76%)

CMGC - DYRK

Bioactivity
Kinase	RBC
DYRK1A	inactive (55.47%)
DYRK1B	active (40.1%)
DYRK2	inactive (50.74%)
DYRK3	inactive (92.28%)
DYRK4	inactive (95.85%)
HIPK1	inactive (103.67%)
HIPK2	inactive (101.36%)
HIPK3	inactive (103.13%)
HIPK4	inactive (86.93%)

CMGC - MAPK

Bioactivity
Kinase	RBC
Erk1	inactive (102.35%)
Erk2	inactive (100.41%)
JNK3	inactive (107.68%)
NLK	inactive (96.12%)
p38a	inactive (99.03%)
p38b	inactive (105.46%)
p38d	inactive (103.63%)
p38g	inactive (102.93%)
JNK1	inactive (97.96%)
JNK2	inactive (97.45%)

CMGC - GSK

Bioactivity
Kinase	RBC
GSK3A	inactive (87.3%)
GSK3B	inactive (99.97%)

CMGC - SRPK

Bioactivity
Kinase	RBC
MSSK1	inactive (82.76%)
SRPK1	inactive (96.11%)
SRPK2	inactive (89.29%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDHK	5	1

Atypical - PDHK

Bioactivity
Kinase	RBC
PDHK1	inactive (108.47%)