Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC, Millipore : pd 174265

Inchikey
Same : WUPUZEMRHDROEO-N
RBC, Millipore : WUPUZEMRHDROEO-UHFFFAOYSA-N

ChemSpider
RBC, Millipore : 4547

Pubchem CID
RBC, Millipore : 4709

ChEMBL
RBC, Millipore : CHEMBL188762

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (107.37%)	inactive (111%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (95.84%)	inactive (99%)
AKT2	inactive (102.28%)	inactive (135%)
AKT3	inactive (94.37%)	inactive (102%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (92%)	inactive (112%)
MRCKa	inactive (100.79%)	inactive (109%)
MRCKb	inactive (113.68%)	inactive (89%)
ROCK1	inactive (99.49%)	inactive (115%)
ROCK2	inactive (86.08%)	inactive (89%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (111.67%)	-
BARK2	inactive (99.24%)	-
GPRK4	inactive (96.17%)	-
GPRK5	inactive (107.15%)	inactive (114%)
GPRK6	inactive (97.65%)	inactive (97%)
GPRK7	inactive (105.12%)	inactive (96%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (90.05%)	inactive (113%)
MSK2	inactive (106.26%)	inactive (94%)
p70S6K	inactive (91.25%)	inactive (111%)
p70S6Kb	inactive (94.86%)	-
RSK2	inactive (94.98%)	inactive (120%)
RSK4	inactive (90.64%)	inactive (124%)
RSK1	inactive (88.74%)	inactive (99%)
RSK3	inactive (87.23%)	inactive (119%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	inactive (95.52%)	-
PRKX	inactive (95.72%)	inactive (89%)
PKACa	inactive (94.57%)	inactive (88%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (96.53%)	inactive (100%)
PKCd	inactive (93.82%)	inactive (101%)
PKCe	inactive (99.67%)	inactive (79%)
PKCh	inactive (89.29%)	inactive (85%)
PKCg	inactive (102.17%)	inactive (109%)
PKCi	inactive (106.46%)	inactive (100%)
PKCt	inactive (96.26%)	inactive (96%)
PKCz	inactive (95.75%)	inactive (116%)
PKCb	inactive (101.01%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (110.42%)	-
PKG1	inactive (101.02%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (100.71%)	-
PKN2	inactive (105.52%)	inactive (90%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (84.56%)	inactive (107%)
SGK2	inactive (96.22%)	inactive (105%)
SGK3	inactive (92.77%)	inactive (105%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	inactive (100.08%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (98.89%)	inactive (90%)
ABL2	inactive (96.57%)	inactive (96%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (93.5%)	inactive (70%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (83.09%)	inactive (81%)
LTK	inactive (80.97%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (125.61%)	inactive (83%)
MER	inactive (83.92%)	inactive (108%)
TYRO3	inactive (101.19%)	inactive (90%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (90.68%)	inactive (112%)
BRK	inactive (57.22%)	inactive (80%)
SRC	inactive (93.63%)	inactive (88%)
FGR	inactive (93.24%)	inactive (102%)
FRK	inactive (66.85%)	inactive (94%)
FYN	inactive (107.4%)	inactive (85%)
HCK	inactive (93.01%)	inactive (82%)
LCK	inactive (93.15%)	inactive (79%)
SRM	inactive (99.37%)	-
YES	inactive (86.99%)	inactive (85%)
LYN	inactive (82.61%)	active (28%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (98.68%)	inactive (79%)
BTK	inactive (89.45%)	inactive (95%)
ITK	inactive (89.65%)	inactive (106%)
TEC	inactive (102.98%)	-
TXK	inactive (90.48%)	inactive (108%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (90.44%)	inactive (109%)
FLT3	inactive (94.08%)	inactive (120%)
FMS	inactive (98.87%)	inactive (94%)
PDGFRb	inactive (97.97%)	inactive (96%)
PDGFRa	inactive (107.48%)	inactive (117%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (89.51%)	inactive (104%)
CTK	inactive (93.38%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (108.75%)	inactive (92%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	active (2.17%)	active (-3%)
ErbB2	active (34.01%)	-
ErbB4	inactive (82.34%)	inactive (59%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (89.52%)	inactive (71%)
EphA2	inactive (100.89%)	inactive (105%)
EphA3	inactive (105.88%)	inactive (105%)
EphA4	inactive (94.35%)	inactive (106%)
EphA5	inactive (100.8%)	inactive (101%)
EphA6	inactive (79.54%)	-
EphA7	inactive (102.35%)	inactive (92%)
EphA8	inactive (96.65%)	inactive (97%)
EphB1	inactive (93.27%)	inactive (97%)
EphB2	inactive (95.14%)	inactive (105%)
EphB3	inactive (89.43%)	inactive (111%)
EphB4	inactive (93.44%)	inactive (81%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (99.44%)	inactive (131%)
PYK2	inactive (99%)	inactive (126%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (95.6%)	inactive (106%)
FES	inactive (101.56%)	inactive (115%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (108.23%)	inactive (108%)
FGFR2	inactive (99.77%)	inactive (105%)
FGFR3	inactive (93.17%)	inactive (118%)
FGFR4	inactive (95.2%)	inactive (120%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (86.88%)	inactive (86%)
FLT4	inactive (91.49%)	inactive (85%)
KDR	inactive (96.47%)	inactive (95%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (87.55%)	inactive (132%)
IRR	inactive (98.44%)	inactive (111%)
INSR	inactive (100.95%)	inactive (110%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (96.6%)	-
JAK2	inactive (102.9%)	inactive (89%)
JAK3	inactive (98.29%)	inactive (99%)
TYK2	inactive (90.23%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (87.84%)	inactive (96%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	inactive (106.23%)	inactive (86%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (97.24%)	inactive (90%)
MET	inactive (103.01%)	inactive (99%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (97.47%)	inactive (92%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (94.28%)	inactive (125%)
ZAP70	inactive (112.6%)	inactive (86%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (91.23%)	inactive (81%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (95.76%)	inactive (97%)
TRKB	inactive (77.09%)	inactive (77%)
TRKC	inactive (95.81%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (97.39%)	-
ALK2	inactive (93.75%)	-
ALK4	inactive (96.52%)	inactive (125%)
TGFbR1	inactive (100.96%)	inactive (75%)
TGFbR2	inactive (116.15%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (93.42%)	-
BRAF	inactive (93.01%)	-
RAF1	inactive (98.42%)	inactive (77%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (92.67%)	inactive (89%)
IRAK4	inactive (79.82%)	inactive (96%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (88.71%)	inactive (97%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (92.36%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (92.68%)	inactive (89%)
MLK2	inactive (91.21%)	-
MLK3	inactive (97.05%)	-
TAK1	inactive (94%)	inactive (92%)
ZAK	inactive (95.98%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (71.41%)	active (50%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (87.34%)	inactive (99%)
BRSK1	inactive (83.33%)	inactive (55%)
BRSK2	inactive (94.35%)	inactive (97%)
CHK1	inactive (114.06%)	inactive (85%)
LKB1	inactive (102.51%)	inactive (96%)
MARK1	inactive (98.46%)	inactive (84%)
MARK3	inactive (86.13%)	-
MARK4	inactive (80.2%)	-
MELK	inactive (93.38%)	inactive (90%)
PASK	inactive (88.67%)	inactive (85%)
QIK	inactive (98.69%)	-
NuaK2	inactive (77.45%)	-
MARK2	inactive (73.54%)	inactive (94%)
AMPKa1	-	inactive (103%)
AMPKa2	-	inactive (105%)
SIK	-	inactive (68%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (88.86%)	inactive (96%)
CaMK1b	inactive (96%)	-
CaMK1d	inactive (103.69%)	inactive (112%)
CaMK1g	inactive (92.06%)	-
CaMK4	inactive (102.95%)	inactive (123%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (85.7%)	-
CaMK2b	inactive (104.75%)	inactive (90%)
CaMK2d	inactive (112.54%)	inactive (109%)
CaMK2g	inactive (105.38%)	inactive (100%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (87.13%)	inactive (95%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (99.36%)	inactive (80%)
DAPK2	inactive (120.87%)	inactive (98%)
DRAK1	inactive (88.72%)	inactive (95%)
DAPK3	inactive (104.36%)	inactive (75%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (89.04%)	inactive (79%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (87.1%)	inactive (88%)
MAPKAPK3	inactive (90.22%)	inactive (89%)
MAPKAPK5	inactive (105.06%)	inactive (74%)
MNK1	inactive (82.76%)	-
MNK2	inactive (55.64%)	active (30%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (95.45%)	inactive (68%)
skMLCK	inactive (96.36%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (92.37%)	-
PHKg2	inactive (109.03%)	inactive (90%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (85.28%)	inactive (80%)
PIM2	inactive (90.35%)	inactive (104%)
PIM3	inactive (76.63%)	inactive (92%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (97.85%)	inactive (85%)
PKD3	inactive (85.92%)	-
PKD2	inactive (85.1%)	inactive (105%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (73.23%)	inactive (93%)
TSSK2	inactive (82.85%)	inactive (95%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (94.06%)	inactive (91%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (101.51%)	inactive (108%)
MAP3K2	inactive (76.07%)	-
MAP3K3	inactive (89.77%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (93.04%)	-
NIK	inactive (116.06%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (90.5%)	inactive (77%)
HGK	inactive (91.12%)	-
KHS1	inactive (88.98%)	-
LOK	inactive (68.72%)	active (50%)
MINK	inactive (95.82%)	inactive (83%)
MST1	inactive (97.1%)	inactive (91%)
MST2	inactive (88.05%)	inactive (121%)
MST3	inactive (101.65%)	inactive (69%)
MST4	inactive (97.62%)	-
OSR1	inactive (107.3%)	-
PAK1	inactive (96.3%)	-
PAK2	inactive (101.08%)	inactive (110%)
PAK3	inactive (104.93%)	inactive (94%)
PAK4	inactive (105.26%)	inactive (99%)
PAK5	inactive (91.63%)	inactive (97%)
PAK6	inactive (100.52%)	inactive (107%)
SLK	inactive (90.03%)	-
YSK1	inactive (102.43%)	-
STLK3	inactive (96.05%)	-
TAO1	inactive (79.06%)	inactive (96%)
TAO2	inactive (91.42%)	inactive (98%)
TAO3	inactive (89.23%)	inactive (96%)
MYO3B	inactive (134.69%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (104.61%)	inactive (93%)
MAP2K2	inactive (85.11%)	-
MAP2K6	inactive (94.52%)	inactive (77%)
MAP2K7	-	inactive (94%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (97.43%)	inactive (73%)
AurB	inactive (95.43%)	inactive (101%)
AurC	inactive (102.29%)	inactive (94%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (99.79%)	-
CaMKK2	inactive (84.27%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (95.23%)	inactive (109%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (99.27%)	inactive (121%)
IKKb	inactive (94.87%)	inactive (112%)
IKKe	inactive (94.91%)	-
TBK1	inactive (95.62%)	inactive (69%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (76.91%)	-
NEK11	inactive (103.28%)	inactive (84%)
NEK2	inactive (87.51%)	inactive (73%)
NEK4	inactive (94.71%)	-
NEK6	inactive (104.75%)	inactive (79%)
NEK7	inactive (92.75%)	inactive (89%)
NEK9	inactive (104.57%)	-
NEK3	inactive (99.64%)	inactive (109%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (96.19%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (95.32%)	inactive (93%)
PLK2	inactive (107.73%)	inactive (104%)
PLK3	inactive (93.22%)	inactive (89%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (91.32%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (99.59%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (112.58%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (103.26%)	-
ULK2	inactive (117.75%)	inactive (106%)
ULK3	inactive (97.51%)	inactive (107%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (80.24%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (106.78%)	inactive (99%)
Wnk3	inactive (99.35%)	inactive (95%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	inactive (103.73%)	inactive (103%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (96.92%)	inactive (97%)
CK1g1	inactive (98.59%)	inactive (87%)
CK1g2	inactive (98.13%)	inactive (89%)
CK1g3	inactive (91.64%)	inactive (113%)
CK1a	inactive (96.98%)	-
CK1e	inactive (98.17%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (94.44%)	-
VRK2	-	inactive (106%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (99.03%)	inactive (107%)
CK2a2	inactive (61.44%)	inactive (125%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (84.53%)	-
CLK2	inactive (101.22%)	inactive (125%)
CLK3	inactive (99.33%)	inactive (76%)
CLK4	inactive (99.37%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (89.18%)	-
DYRK1B	inactive (95.16%)	-
DYRK2	inactive (90.57%)	inactive (99%)
DYRK3	inactive (92.32%)	-
DYRK4	inactive (112.54%)	-
HIPK1	inactive (103.9%)	inactive (98%)
HIPK2	inactive (96.98%)	inactive (104%)
HIPK3	inactive (92.11%)	inactive (92%)
HIPK4	inactive (87.84%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (100.83%)	inactive (83%)
Erk2	inactive (77.74%)	inactive (93%)
JNK3	inactive (96.54%)	inactive (72%)
NLK	inactive (95.94%)	inactive (91%)
p38a	inactive (82.78%)	inactive (78%)
p38b	inactive (92.95%)	inactive (91%)
p38d	inactive (105.58%)	inactive (100%)
p38g	inactive (103.04%)	inactive (101%)
JNK1	inactive (73.7%)	inactive (94%)
JNK2	inactive (78.3%)	inactive (105%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (98.19%)	inactive (125%)
GSK3B	inactive (91.24%)	inactive (108%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (97.03%)	inactive (94%)
SRPK1	inactive (97.04%)	inactive (102%)
SRPK2	inactive (88.57%)	inactive (89%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (107.37%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (94%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (106%)