Compound in Profiling

Compound Information

Test on : RBC, Metz, Millipore

Compound Name
RBC, Metz : Z-Semaxanib
Millipore : Semaxanib

Inchikey
Same : WUWDLXZGHZSWQZ-N
RBC, Metz : WUWDLXZGHZSWQZ-UHFFFAOYSA-N
Millipore : WUWDLXZGHZSWQZ-WQLSENKSSA-N

ChemSpider
RBC, Metz : 109638
Millipore : 4486260

Pubchem CID
RBC, Metz : 123015
Millipore : 5329098

ChEMBL
RBC, Metz : CHEMBL2002702
Millipore : CHEMBL276711

RBC, Metz	Millipore

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
PDK1	1	1	1	1
Akt	3	3	3	3
DMPK	7	5	3	5
GRK	7	6	1	3
RSK	8	8	4	7
PKA	5	3	2	2
PKC	9	9	5	8
PKG	2	3	2	-
PKN	3	2	1	1
SGK	3	3	1	3
NDR	4	1	-	-

AGC - PDK1

Bioactivity
Kinase	RBC	Metz	Millipore
PDK1	inactive (94.21%)	inactive (1995.26nM)	inactive (95%)

AGC - Akt

Bioactivity
Kinase	RBC	Metz	Millipore
AKT1	inactive (90.09%)	inactive (>7943.28nM)	inactive (89%)
AKT2	inactive (93.46%)	inactive (>7943.28nM)	inactive (114%)
AKT3	inactive (99.36%)	inactive (>10000nM)	inactive (101%)

AGC - DMPK

Bioactivity
Kinase	RBC	Metz	Millipore
DMPK1	inactive (101.12%)	-	inactive (84%)
MRCKa	inactive (92.3%)	inactive (>10000nM)	inactive (119%)
MRCKb	inactive (116.04%)	-	inactive (99%)
ROCK1	inactive (100.32%)	inactive (5011.87nM)	inactive (110%)
ROCK2	inactive (92.71%)	inactive (>7943.28nM)	inactive (88%)

AGC - GRK

Bioactivity
Kinase	RBC	Metz	Millipore
BARK1	inactive (92.01%)	-	-
BARK2	inactive (98.92%)	-	-
GPRK4	inactive (81.85%)	-	-
GPRK5	inactive (101.17%)	-	inactive (93%)
GPRK6	inactive (84.55%)	-	inactive (81%)
GPRK7	inactive (76.33%)	-	inactive (74%)

AGC - RSK

Bioactivity
Kinase	RBC	Metz	Millipore
MSK1	inactive (76.61%)	inactive (>1995.26nM)	inactive (95%)
MSK2	inactive (78.42%)	-	inactive (61%)
p70S6K	inactive (78.11%)	active (125.89nM)	active (38%)
p70S6Kb	inactive (106.11%)	-	-
RSK2	inactive (50.91%)	active (158.49nM)	active (26%)
RSK4	active (39%)	-	active (38%)
RSK1	active (44.05%)	-	active (27%)
RSK3	active (35.25%)	-	inactive (51%)

AGC - PKA

Bioactivity
Kinase	RBC	Metz	Millipore
PKACg	inactive (87.63%)	-	-
PRKX	inactive (101%)	inactive (>1584.89nM)	inactive (94%)
PKACa	inactive (93.13%)	inactive (>7943.28nM)	inactive (89%)

AGC - PKC

Bioactivity
Kinase	RBC	Metz	Millipore
PKCa	inactive (95.62%)	-	inactive (100%)
PKCd	inactive (91.67%)	inactive (>7943.28nM)	inactive (95%)
PKCe	inactive (102.65%)	-	inactive (82%)
PKCh	inactive (94.66%)	-	inactive (96%)
PKCg	inactive (106.73%)	inactive (>7943.28nM)	inactive (106%)
PKCi	inactive (97.5%)	-	inactive (79%)
PKCt	inactive (98.51%)	-	inactive (103%)
PKCz	inactive (89.88%)	inactive (>7943.28nM)	inactive (103%)
PKCb	inactive (109%)	-	-

AGC - PKG

Bioactivity
Kinase	RBC	Metz	Millipore
PKG2	inactive (92.68%)	inactive (>1584.89nM)	-
PKG1	inactive (76.15%)	inactive (>1995.26nM)	-

AGC - PKN

Bioactivity
Kinase	RBC	Metz	Millipore
PKN1	inactive (96.39%)	-	-
PKN2	inactive (95.62%)	inactive (1258.93nM)	inactive (108%)

AGC - SGK

Bioactivity
Kinase	RBC	Metz	Millipore
SGK1	inactive (82.63%)	inactive (1995.26nM)	inactive (84%)
SGK2	inactive (94.43%)	-	inactive (80%)
SGK3	inactive (97.22%)	-	inactive (91%)

AGC - NDR

Bioactivity
Kinase	RBC	Metz	Millipore
NDR1	inactive (101.01%)	-	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
Abl	2	2	1	2
Ack	2	1	1	1
ALK	2	2	2	1
Axl	3	3	2	3
Src	11	11	9	10
Tec	5	5	3	4
PDGFR	5	5	5	5
Csk	2	2	1	1
DDR	2	1	-	1
EGFR	4	3	3	2
Eph	14	12	1	11
FAK	2	2	2	2
Fer	2	2	2	2
FGFR	4	4	2	4
VEGFR	3	3	3	3
InsR	3	3	2	3
JakA	4	4	3	2
Musk	1	1	-	1
Ret	1	1	1	1
Met	2	2	2	2
Sev	1	1	1	1
Syk	2	2	1	2
Tie	2	1	-	1
Trk	3	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Metz	Millipore
ABL1	inactive (95.24%)	inactive (>630.96nM)	inactive (81%)
ABL2	inactive (90.32%)	-	inactive (88%)

TK - Ack

Bioactivity
Kinase	RBC	Metz	Millipore
ACK	inactive (75.85%)	-	inactive (52%)

TK - ALK

Bioactivity
Kinase	RBC	Metz	Millipore
ALK	active (47.41%)	active (199.53nM)	active (37%)
LTK	active (28.19%)	-	-

TK - Axl

Bioactivity
Kinase	RBC	Metz	Millipore
AXL	inactive (77.2%)	active (39.81nM)	active (31%)
MER	inactive (68.34%)	-	active (4%)
TYRO3	inactive (81.02%)	inactive (>1995.26nM)	inactive (68%)

TK - Src

Bioactivity
Kinase	RBC	Metz	Millipore
BLK	inactive (71.53%)	active (100nM)	inactive (65%)
BRK	inactive (83.59%)	inactive (>2511.89nM)	inactive (103%)
SRC	inactive (86.54%)	inactive (1995.26nM)	inactive (78%)
FGR	inactive (69.6%)	-	inactive (53%)
FRK	inactive (92.58%)	inactive (1584.89nM)	inactive (89%)
FYN	inactive (92.09%)	active (794.33nM)	inactive (75%)
HCK	inactive (85.47%)	-	inactive (60%)
LCK	inactive (81.03%)	active (1000nM)	inactive (83%)
SRM	inactive (96.14%)	inactive (>1584.89nM)	-
YES	inactive (53.64%)	-	inactive (58%)
LYN	inactive (84.22%)	active (501.19nM)	active (46%)

TK - Tec

Bioactivity
Kinase	RBC	Metz	Millipore
BMX	inactive (94.18%)	-	inactive (87%)
BTK	inactive (90.85%)	inactive (>1258.93nM)	inactive (89%)
ITK	inactive (89.88%)	active (398.11nM)	inactive (66%)
TEC	inactive (125.37%)	-	-
TXK	inactive (93.41%)	-	inactive (103%)

TK - PDGFR

Bioactivity
Kinase	RBC	Metz	Millipore
KIT	active (31.52%)	inactive (>1258.93nM)	active (11%)
FLT3	active (3.07%)	active (5.01nM)	active (1%)
FMS	active (28.53%)	active (19.95nM)	active (2%)
PDGFRb	inactive (64.84%)	-	active (43%)
PDGFRa	inactive (83.22%)	-	active (15%)

TK - Csk

Bioactivity
Kinase	RBC	Metz	Millipore
CSK	inactive (99.39%)	-	inactive (121%)
CTK	inactive (104.76%)	inactive (>1995.26nM)	-

TK - DDR

Bioactivity
Kinase	RBC	Metz	Millipore
DDR2	inactive (100.6%)	-	inactive (110%)

TK - EGFR

Bioactivity
Kinase	RBC	Metz	Millipore
EGFR	inactive (91.7%)	inactive (>1995.26nM)	inactive (114%)
ErbB2	inactive (103.04%)	inactive (>1584.89nM)	-
ErbB4	inactive (80.75%)	inactive (>3981.07nM)	inactive (105%)

TK - Eph

Bioactivity
Kinase	RBC	Metz	Millipore
EphA1	inactive (95.16%)	-	inactive (90%)
EphA2	inactive (103.8%)	inactive (>3162.28nM)	inactive (95%)
EphA3	inactive (95.93%)	-	inactive (101%)
EphA4	inactive (90.84%)	-	inactive (107%)
EphA5	inactive (87.38%)	-	inactive (99%)
EphA6	inactive (81.05%)	-	-
EphA7	inactive (86.92%)	-	inactive (85%)
EphA8	inactive (90.72%)	-	inactive (113%)
EphB1	inactive (88.77%)	-	inactive (102%)
EphB2	inactive (82.11%)	-	inactive (108%)
EphB3	inactive (92.83%)	-	inactive (113%)
EphB4	inactive (89.18%)	-	inactive (121%)

TK - FAK

Bioactivity
Kinase	RBC	Metz	Millipore
FAK	inactive (61.48%)	inactive (>1584.89nM)	inactive (52%)
PYK2	inactive (66%)	active (316.23nM)	active (34%)

TK - Fer

Bioactivity
Kinase	RBC	Metz	Millipore
FER	inactive (53.39%)	active (316.23nM)	inactive (100%)
FES	inactive (90.52%)	inactive (>1995.26nM)	inactive (92%)

TK - FGFR

Bioactivity
Kinase	RBC	Metz	Millipore
FGFR1	inactive (77.21%)	inactive (1258.93nM)	inactive (65%)
FGFR2	inactive (85.5%)	-	inactive (66%)
FGFR3	inactive (75.29%)	active (794.33nM)	inactive (80%)
FGFR4	inactive (69.27%)	-	inactive (124%)

TK - VEGFR

Bioactivity
Kinase	RBC	Metz	Millipore
FLT1	inactive (69.87%)	active (19.95nM)	active (3%)
FLT4	inactive (64.43%)	active (316.23nM)	active (1%)
KDR	inactive (67.4%)	active (100nM)	active (4%)

TK - InsR

Bioactivity
Kinase	RBC	Metz	Millipore
IGF1R	inactive (80.97%)	inactive (>1000nM)	inactive (119%)
IRR	inactive (74.16%)	-	inactive (65%)
INSR	inactive (78.18%)	active (158.49nM)	active (30%)

TK - JakA

Bioactivity
Kinase	RBC	Metz	Millipore
JAK1	inactive (84.9%)	-	-
JAK2	inactive (84.47%)	active (199.53nM)	inactive (108%)
JAK3	inactive (93.99%)	active (630.96nM)	inactive (98%)
TYK2	inactive (86.94%)	active (1000nM)	-

TK - Musk

Bioactivity
Kinase	RBC	Metz	Millipore
MUSK	inactive (85.35%)	-	inactive (76%)

TK - Ret

Bioactivity
Kinase	RBC	Metz	Millipore
RET	active (17.64%)	active (31.62nM)	active (12%)

TK - Met

Bioactivity
Kinase	RBC	Metz	Millipore
RON	inactive (90.51%)	-	inactive (105%)
MET	inactive (83.81%)	inactive (>3162.28nM)	inactive (101%)

TK - Sev

Bioactivity
Kinase	RBC	Metz	Millipore
ROS	inactive (91.37%)	inactive (>1995.26nM)	inactive (100%)

TK - Syk

Bioactivity
Kinase	RBC	Metz	Millipore
SYK	inactive (92.46%)	active (794.33nM)	inactive (121%)
ZAP70	inactive (93.5%)	-	inactive (95%)

TK - Tie

Bioactivity
Kinase	RBC	Metz	Millipore
TIE2	inactive (89.94%)	-	inactive (74%)

TK - Trk

Bioactivity
Kinase	RBC	Metz	Millipore
TRKA	active (42.83%)	active (251.19nM)	active (1%)
TRKB	active (23.68%)	active (501.19nM)	active (40%)
TRKC	active (6.15%)	active (19.95nM)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
STKR	12	5	1	2
RAF	5	3	1	1
IRAK	4	2	2	2
LISK	4	1	1	1
LRRK	2	1	1	-
MLK	10	5	2	2
RIPK	5	1	-	1

TKL - STKR

Bioactivity
Kinase	RBC	Metz	Millipore
ALK1	inactive (104.23%)	-	-
ALK2	inactive (96.14%)	-	-
ALK4	inactive (100.54%)	-	inactive (112%)
TGFbR1	inactive (96.99%)	-	inactive (95%)
TGFbR2	inactive (113.87%)	-	-

TKL - RAF

Bioactivity
Kinase	RBC	Metz	Millipore
ARAF	inactive (115.89%)	-	-
BRAF	inactive (111.24%)	-	-
RAF1	inactive (113.34%)	-	inactive (92%)

TKL - IRAK

Bioactivity
Kinase	RBC	Metz	Millipore
IRAK1	inactive (98.66%)	inactive (1995.26nM)	inactive (76%)
IRAK4	active (45.85%)	active (1000nM)	active (39%)

TKL - LISK

Bioactivity
Kinase	RBC	Metz	Millipore
LIMK1	inactive (99.33%)	inactive (>10000nM)	inactive (112%)

TKL - LRRK

Bioactivity
Kinase	RBC	Metz	Millipore
LRRK2	active (13.95%)	-	-

TKL - MLK

Bioactivity
Kinase	RBC	Metz	Millipore
MLK1	active (39.5%)	-	active (10%)
MLK2	inactive (101.89%)	-	-
MLK3	active (17.59%)	-	-
TAK1	inactive (75.4%)	-	inactive (76%)
ZAK	inactive (94.7%)	inactive (>7943.28nM)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Metz	Millipore
RIPK2	inactive (81.38%)	-	inactive (94%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
CAMKL	20	13	9	12
CAMK1	5	5	2	3
CAMK2	4	4	4	3
RAD53	1	1	1	1
DAPK	5	4	2	4
DCAMKL	3	1	1	1
MAPKAPK	5	5	4	4
MLCK	5	2	-	1
PHK	2	2	1	1
PIM	3	3	3	3
PKD	3	3	2	2
TSSK	5	2	2	2
STK33	1	-	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Metz	Millipore
NuaK1	active (26.44%)	-	active (35%)
BRSK1	inactive (83.89%)	inactive (2511.89nM)	inactive (75%)
BRSK2	inactive (87.14%)	-	inactive (100%)
CHK1	inactive (71.87%)	inactive (>7943.28nM)	inactive (72%)
LKB1	inactive (87.61%)	-	inactive (103%)
MARK1	inactive (83.36%)	-	inactive (65%)
MARK3	inactive (80.26%)	inactive (1995.26nM)	-
MARK4	inactive (85.77%)	-	-
MELK	inactive (77.94%)	inactive (>1584.89nM)	inactive (56%)
PASK	inactive (99.68%)	-	inactive (111%)
QIK	inactive (89.44%)	-	-
NuaK2	inactive (126.46%)	-	-
MARK2	inactive (88.07%)	inactive (1584.89nM)	inactive (78%)
AMPKa1	-	inactive (>7943.28nM)	inactive (55%)
AMPKa2	-	-	inactive (70%)
SIK	-	-	inactive (115%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Metz	Millipore
CaMK1a	inactive (103.86%)	inactive (5011.87nM)	inactive (86%)
CaMK1b	inactive (91.08%)	-	-
CaMK1d	inactive (94.56%)	-	inactive (102%)
CaMK1g	inactive (100.75%)	-	-
CaMK4	inactive (96.51%)	-	inactive (104%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Metz	Millipore
CaMK2a	inactive (84.54%)	-	-
CaMK2b	inactive (93.98%)	inactive (6309.57nM)	inactive (81%)
CaMK2d	inactive (83.79%)	active (630.96nM)	active (38%)
CaMK2g	inactive (84.81%)	active (794.33nM)	active (32%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Metz	Millipore
CHK2	active (21.48%)	active (79.43nM)	active (18%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Metz	Millipore
DAPK1	inactive (108.93%)	-	inactive (95%)
DAPK2	inactive (101.31%)	-	inactive (91%)
DRAK1	inactive (52.94%)	active (125.89nM)	active (26%)
DAPK3	inactive (91.78%)	inactive (>1258.93nM)	inactive (88%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Metz	Millipore
DCLK2	inactive (95.81%)	-	inactive (90%)
DCLK1	-	inactive (>10000nM)	-

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Metz	Millipore
MAPKAPK2	inactive (100.28%)	inactive (>7943.28nM)	inactive (100%)
MAPKAPK3	inactive (99.04%)	inactive (>10000nM)	inactive (140%)
MAPKAPK5	inactive (88.87%)	inactive (>1584.89nM)	inactive (78%)
MNK1	inactive (105.14%)	-	-
MNK2	inactive (76.89%)	inactive (>10000nM)	inactive (100%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Metz	Millipore
smMLCK	inactive (68.73%)	-	active (32%)
skMLCK	active (43.02%)	-	-

CAMK - PHK

Bioactivity
Kinase	RBC	Metz	Millipore
PHKg1	active (44.56%)	-	-
PHKg2	inactive (88.97%)	active (1000nM)	inactive (70%)

CAMK - PIM

Bioactivity
Kinase	RBC	Metz	Millipore
PIM1	inactive (95.75%)	inactive (>10000nM)	inactive (83%)
PIM2	inactive (100.76%)	inactive (>1584.89nM)	inactive (121%)
PIM3	inactive (87.93%)	inactive (>7943.28nM)	inactive (100%)

CAMK - PKD

Bioactivity
Kinase	RBC	Metz	Millipore
PKD1	inactive (85.33%)	-	inactive (78%)
PKD3	inactive (81.64%)	inactive (5011.87nM)	-
PKD2	inactive (90.82%)	inactive (5011.87nM)	inactive (94%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Metz	Millipore
TSSK1	inactive (87.21%)	inactive (>1584.89nM)	inactive (91%)
TSSK2	inactive (94.06%)	inactive (>1584.89nM)	inactive (97%)

CAMK - STK33

Bioactivity
Kinase	RBC	Metz	Millipore
STK33	inactive (72.09%)	-	inactive (69%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
STE11	8	3	-	1
STE-Unique	2	2	-	-
STE20	31	23	9	14
STE7	7	3	2	3

STE - STE11

Bioactivity
Kinase	RBC	Metz	Millipore
MAP3K5	inactive (98.28%)	-	inactive (82%)
MAP3K2	inactive (95.84%)	-	-
MAP3K3	inactive (94.18%)	-	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Metz	Millipore
COT	inactive (116.22%)	-	-
NIK	inactive (99%)	-	-

STE - STE20

Bioactivity
Kinase	RBC	Metz	Millipore
GCK	inactive (71.32%)	inactive (1584.89nM)	inactive (57%)
HGK	active (48.78%)	active (199.53nM)	-
KHS1	active (39.69%)	active (501.19nM)	-
LOK	inactive (71.86%)	-	inactive (86%)
MINK	inactive (80.31%)	inactive (1258.93nM)	inactive (71%)
MST1	active (46.5%)	-	inactive (51%)
MST2	inactive (64.04%)	active (630.96nM)	inactive (70%)
MST3	inactive (99.66%)	-	inactive (96%)
MST4	inactive (95.24%)	-	-
OSR1	inactive (91.79%)	-	-
PAK1	inactive (95.75%)	inactive (>10000nM)	-
PAK2	inactive (66.52%)	-	inactive (108%)
PAK3	inactive (95.93%)	-	inactive (107%)
PAK4	inactive (72.35%)	inactive (>5011.87nM)	inactive (91%)
PAK5	inactive (85.15%)	-	inactive (95%)
PAK6	inactive (107.75%)	-	inactive (94%)
SLK	inactive (88.82%)	inactive (1584.89nM)	-
YSK1	inactive (100.74%)	-	-
STLK3	inactive (94.86%)	-	-
TAO1	inactive (108.57%)	inactive (>10000nM)	inactive (108%)
TAO2	inactive (107.41%)	-	inactive (117%)
TAO3	inactive (76.7%)	-	inactive (101%)
MYO3B	inactive (75.76%)	-	-

STE - STE7

Bioactivity
Kinase	RBC	Metz	Millipore
MAP2K1	inactive (81.94%)	-	active (41%)
MAP2K2	inactive (93.18%)	-	-
MAP2K6	inactive (102.93%)	-	inactive (60%)
MAP2K7	-	-	inactive (81%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
Aur	3	3	2	3
CAMKK	2	2	1	-
Haspin	1	1	-	1
IKK	4	4	4	3
NEK	11	8	2	5
TOPK	1	1	1	-
PLK	4	3	3	3
SgK496	1	1	-	-
NAK	4	1	-	-
TTK	1	1	-	-
ULK	5	3	-	2
WEE	3	1	1	-
WNK	4	2	-	2
TLK	2	1	-	1
CDC7	1	-	1	-

Other - Aur

Bioactivity
Kinase	RBC	Metz	Millipore
AurA	inactive (77.62%)	active (501.19nM)	active (29%)
AurB	active (9.65%)	active (39.81nM)	active (6%)
AurC	active (47.52%)	-	inactive (56%)

Other - CAMKK

Bioactivity
Kinase	RBC	Metz	Millipore
CaMKK1	inactive (82.97%)	-	-
CaMKK2	inactive (81.6%)	-	-

Other - Haspin

Bioactivity
Kinase	RBC	Metz	Millipore
Haspin	inactive (95.67%)	-	inactive (100%)

Other - IKK

Bioactivity
Kinase	RBC	Metz	Millipore
IKKa	inactive (98.28%)	inactive (>3981.07nM)	inactive (93%)
IKKb	inactive (102.07%)	inactive (>3162.28nM)	inactive (111%)
IKKe	inactive (72.78%)	-	-
TBK1	inactive (67.39%)	-	inactive (70%)

Other - NEK

Bioactivity
Kinase	RBC	Metz	Millipore
NEK1	inactive (96.36%)	-	-
NEK11	inactive (110.82%)	-	inactive (88%)
NEK2	inactive (87.99%)	inactive (>10000nM)	inactive (83%)
NEK4	inactive (79.09%)	inactive (>6309.57nM)	-
NEK6	inactive (95.14%)	-	inactive (108%)
NEK7	inactive (106.5%)	-	inactive (101%)
NEK9	inactive (97.3%)	-	-
NEK3	inactive (88.81%)	-	inactive (116%)

Other - TOPK

Bioactivity
Kinase	RBC	Metz	Millipore
PBK	inactive (88.29%)	inactive (>10000nM)	-

Other - PLK

Bioactivity
Kinase	RBC	Metz	Millipore
PLK1	inactive (104.17%)	inactive (>7943.28nM)	inactive (92%)
PLK2	inactive (106.34%)	-	inactive (103%)
PLK3	inactive (96.58%)	inactive (>7943.28nM)	inactive (102%)
PLK4	-	active (398.11nM)	-

Other - SgK496

Bioactivity
Kinase	RBC	Metz	Millipore
SgK496	inactive (93.89%)	-	-

Other - NAK

Bioactivity
Kinase	RBC	Metz	Millipore
MPSK1	inactive (94.19%)	-	-

Other - TTK

Bioactivity
Kinase	RBC	Metz	Millipore
TTK	inactive (93.58%)	-	-

Other - ULK

Bioactivity
Kinase	RBC	Metz	Millipore
ULK1	inactive (75.6%)	-	-
ULK2	inactive (120.16%)	-	inactive (100%)
ULK3	inactive (60.17%)	-	inactive (53%)

Other - WEE

Bioactivity
Kinase	RBC	Metz	Millipore
Wee1	inactive (93.3%)	-	-

Other - WNK

Bioactivity
Kinase	RBC	Metz	Millipore
Wnk2	inactive (105.92%)	-	inactive (111%)
Wnk3	inactive (100.05%)	-	inactive (110%)

Other - TLK

Bioactivity
Kinase	RBC	Metz	Millipore
TLK2	inactive (98.47%)	-	inactive (105%)

Other - CDC7

Bioactivity
Kinase	RBC	Metz	Millipore
CDC7	-	inactive (>1258.93nM)	-

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
CK1	7	6	5	4
VRK	3	1	-	1

CK1 - CK1

Bioactivity
Kinase	RBC	Metz	Millipore
CK1d	active (37.8%)	active (316.23nM)	active (13%)
CK1g1	inactive (86.92%)	inactive (>6309.57nM)	inactive (70%)
CK1g2	inactive (70.2%)	inactive (1995.26nM)	inactive (51%)
CK1g3	inactive (78.52%)	inactive (3981.07nM)	inactive (83%)
CK1a	inactive (70.96%)	inactive (1995.26nM)	-
CK1e	active (47.1%)	-	-

CK1 - VRK

Bioactivity
Kinase	RBC	Metz	Millipore
VRK1	inactive (98.95%)	-	-
VRK2	-	-	inactive (98%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
CK2	3	2	1	2
CLK	4	4	2	2
DYRK	10	9	6	4
MAPK	14	10	8	10
GSK	2	2	2	2
SRPK	3	3	1	3
CDK	20	-	7	-

CMGC - CK2

Bioactivity
Kinase	RBC	Metz	Millipore
CK2a1	inactive (73.55%)	inactive (>6309.57nM)	inactive (100%)
CK2a2	inactive (98.56%)	-	inactive (120%)

CMGC - CLK

Bioactivity
Kinase	RBC	Metz	Millipore
CLK1	inactive (94.07%)	-	-
CLK2	inactive (69.21%)	active (398.11nM)	active (49%)
CLK3	inactive (91.34%)	-	inactive (80%)
CLK4	inactive (80.75%)	active (398.11nM)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Metz	Millipore
DYRK1A	inactive (94.15%)	inactive (>6309.57nM)	-
DYRK1B	inactive (95.31%)	-	-
DYRK2	inactive (101.04%)	-	inactive (91%)
DYRK3	inactive (93.48%)	inactive (>6309.57nM)	-
DYRK4	inactive (103.92%)	inactive (>7943.28nM)	-
HIPK1	inactive (98.19%)	-	inactive (94%)
HIPK2	inactive (82.37%)	inactive (>3162.28nM)	inactive (80%)
HIPK3	inactive (95.34%)	-	inactive (95%)
HIPK4	inactive (99.4%)	inactive (>7943.28nM)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Metz	Millipore
Erk1	inactive (98.73%)	-	inactive (88%)
Erk2	inactive (99.77%)	inactive (>7943.28nM)	inactive (98%)
JNK3	inactive (90.63%)	-	inactive (87%)
NLK	inactive (92.23%)	-	inactive (100%)
p38a	inactive (104.34%)	-	inactive (79%)
p38b	inactive (93.74%)	-	inactive (97%)
p38d	inactive (98.29%)	inactive (>7943.28nM)	inactive (124%)
p38g	inactive (100.51%)	inactive (>6309.57nM)	inactive (111%)
JNK1	inactive (105%)	inactive (>3162.28nM)	inactive (115%)
JNK2	inactive (97.67%)	inactive (>3981.07nM)	inactive (102%)

CMGC - GSK

Bioactivity
Kinase	RBC	Metz	Millipore
GSK3A	inactive (91.4%)	inactive (>7943.28nM)	inactive (106%)
GSK3B	inactive (102.11%)	inactive (>6309.57nM)	inactive (93%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Metz	Millipore
MSSK1	inactive (94.29%)	-	inactive (99%)
SRPK1	inactive (99.16%)	inactive (>7943.28nM)	inactive (104%)
SRPK2	inactive (91.84%)	-	inactive (93%)

CMGC - CDK

Bioactivity
Kinase	RBC	Metz	Millipore
CDC2	-	inactive (>7943.28nM)	-
CDK2	-	inactive (>7943.28nM)	-
CDK5	-	inactive (>10000nM)	-
CDK8	-	-	-
CDK7	-	-	-
CDK9	-	-	-
CDK11	-	inactive (>100000nM)	-

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz	Millipore
PDHK	5	1	-	-
Alpha	6	-	1	1
PIKK	6	-	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Metz	Millipore
PDHK1	inactive (94.21%)	-	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Metz	Millipore
eEF2K	-	inactive (>3981.07nM)	inactive (92%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Metz	Millipore
FRAP	-	-	inactive (111%)