Compound in Profiling

Compound Information

Test on : RBC

Compound Name : Aloisine

Inchikey : WVMANZPBOBRWCB-UHFFFAOYSA-N

ChemSpider : 2875180

Pubchem CID : 3641059

ChEMBL : CHEMBL306498

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDK1	1	1
Akt	3	3
DMPK	7	5
GRK	7	6
RSK	8	8
PKA	5	3
PKC	9	9
PKG	2	3
PKN	3	2
SGK	3	3
NDR	4	1

AGC - PDK1

Bioactivity
Kinase	RBC
PDK1	inactive (102.13%)

AGC - Akt

Bioactivity
Kinase	RBC
AKT1	inactive (112.75%)
AKT2	inactive (93.79%)
AKT3	inactive (101.98%)

AGC - DMPK

Bioactivity
Kinase	RBC
DMPK1	inactive (84.27%)
MRCKa	inactive (99.67%)
MRCKb	inactive (92.54%)
ROCK1	inactive (99.86%)
ROCK2	inactive (97.25%)

AGC - GRK

Bioactivity
Kinase	RBC
BARK1	inactive (78.49%)
BARK2	inactive (95.6%)
GPRK4	inactive (96.75%)
GPRK5	inactive (104.78%)
GPRK6	inactive (88.35%)
GPRK7	inactive (94.09%)

AGC - RSK

Bioactivity
Kinase	RBC
MSK1	inactive (104.21%)
MSK2	inactive (89.43%)
p70S6K	inactive (108.38%)
p70S6Kb	inactive (99.7%)
RSK2	inactive (88.04%)
RSK4	inactive (78.22%)
RSK1	inactive (89.82%)
RSK3	inactive (93.02%)

AGC - PKA

Bioactivity
Kinase	RBC
PKACg	-
PRKX	inactive (102.36%)
PKACa	inactive (96.64%)

AGC - PKC

Bioactivity
Kinase	RBC
PKCa	inactive (92.72%)
PKCd	inactive (92.79%)
PKCe	inactive (101.51%)
PKCh	inactive (102.74%)
PKCg	inactive (94.41%)
PKCi	inactive (72.84%)
PKCt	inactive (107.35%)
PKCz	inactive (93.94%)
PKCb	inactive (106.33%)

AGC - PKG

Bioactivity
Kinase	RBC
PKG2	inactive (93.92%)
PKG1	inactive (92.73%)

AGC - PKN

Bioactivity
Kinase	RBC
PKN1	inactive (89.11%)
PKN2	inactive (88.63%)

AGC - SGK

Bioactivity
Kinase	RBC
SGK1	inactive (88.44%)
SGK2	inactive (116.02%)
SGK3	inactive (98.61%)

AGC - NDR

Bioactivity
Kinase	RBC
NDR1	active (0%)

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Abl	2	2
Ack	2	1
ALK	2	2
Axl	3	3
Src	11	11
Tec	5	5
PDGFR	5	5
Csk	2	2
DDR	2	1
EGFR	4	3
Eph	14	12
FAK	2	2
Fer	2	2
FGFR	4	4
VEGFR	3	3
InsR	3	3
JakA	4	4
Musk	1	1
Ret	1	1
Met	2	2
Sev	1	1
Syk	2	2
Tie	2	1
Trk	3	3

TK - Abl

Bioactivity
Kinase	RBC
ABL1	inactive (83.38%)
ABL2	inactive (70.5%)

TK - Ack

Bioactivity
Kinase	RBC
ACK	inactive (51.24%)

TK - ALK

Bioactivity
Kinase	RBC
ALK	inactive (96.67%)
LTK	inactive (83.91%)

TK - Axl

Bioactivity
Kinase	RBC
AXL	inactive (110.3%)
MER	inactive (92.63%)
TYRO3	inactive (98.6%)

TK - Src

Bioactivity
Kinase	RBC
BLK	inactive (96.67%)
BRK	active (30.42%)
SRC	inactive (58.84%)
FGR	inactive (57.14%)
FRK	inactive (86.5%)
FYN	inactive (61.26%)
HCK	inactive (94.37%)
LCK	inactive (84.96%)
SRM	inactive (96.72%)
YES	active (45.73%)
LYN	inactive (85.48%)

TK - Tec

Bioactivity
Kinase	RBC
BMX	inactive (82.21%)
BTK	inactive (64.74%)
ITK	inactive (99.44%)
TEC	inactive (133.94%)
TXK	inactive (72.66%)

TK - PDGFR

Bioactivity
Kinase	RBC
KIT	inactive (82.86%)
FLT3	active (47.82%)
FMS	active (37.67%)
PDGFRb	inactive (95.9%)
PDGFRa	inactive (90.25%)

TK - Csk

Bioactivity
Kinase	RBC
CSK	inactive (87.02%)
CTK	inactive (100.92%)

TK - DDR

Bioactivity
Kinase	RBC
DDR2	inactive (94.28%)

TK - EGFR

Bioactivity
Kinase	RBC
EGFR	inactive (102.52%)
ErbB2	inactive (96.44%)
ErbB4	inactive (109.15%)

TK - Eph

Bioactivity
Kinase	RBC
EphA1	inactive (67.88%)
EphA2	inactive (87.88%)
EphA3	inactive (91.89%)
EphA4	inactive (85.52%)
EphA5	inactive (91.62%)
EphA6	-
EphA7	inactive (97.96%)
EphA8	inactive (102.94%)
EphB1	inactive (76.03%)
EphB2	inactive (88.84%)
EphB3	inactive (99.8%)
EphB4	inactive (89.5%)

TK - FAK

Bioactivity
Kinase	RBC
FAK	inactive (81.73%)
PYK2	inactive (100.12%)

TK - Fer

Bioactivity
Kinase	RBC
FER	inactive (59.77%)
FES	inactive (66.01%)

TK - FGFR

Bioactivity
Kinase	RBC
FGFR1	inactive (83.3%)
FGFR2	inactive (89.51%)
FGFR3	inactive (86.81%)
FGFR4	inactive (92.48%)

TK - VEGFR

Bioactivity
Kinase	RBC
FLT1	inactive (102.79%)
FLT4	inactive (81.07%)
KDR	inactive (88.76%)

TK - InsR

Bioactivity
Kinase	RBC
IGF1R	inactive (83.9%)
IRR	inactive (83.15%)
INSR	inactive (97.55%)

TK - JakA

Bioactivity
Kinase	RBC
JAK1	inactive (67.06%)
JAK2	inactive (77.93%)
JAK3	inactive (92.78%)
TYK2	active (38.78%)

TK - Musk

Bioactivity
Kinase	RBC
MUSK	inactive (95.43%)

TK - Ret

Bioactivity
Kinase	RBC
RET	inactive (56.34%)

TK - Met

Bioactivity
Kinase	RBC
RON	inactive (103.82%)
MET	inactive (86.8%)

TK - Sev

Bioactivity
Kinase	RBC
ROS	active (37.47%)

TK - Syk

Bioactivity
Kinase	RBC
SYK	active (47.47%)
ZAP70	inactive (74.23%)

TK - Tie

Bioactivity
Kinase	RBC
TIE2	inactive (96.3%)

TK - Trk

Bioactivity
Kinase	RBC
TRKA	inactive (108.78%)
TRKB	inactive (73.42%)
TRKC	inactive (84.41%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STKR	12	5
RAF	5	3
IRAK	4	2
LISK	4	1
LRRK	2	1
MLK	10	5
RIPK	5	1

TKL - STKR

Bioactivity
Kinase	RBC
ALK1	inactive (76.98%)
ALK2	inactive (86.94%)
ALK4	inactive (111.64%)
TGFbR1	inactive (95.04%)
TGFbR2	inactive (74.78%)

TKL - RAF

Bioactivity
Kinase	RBC
ARAF	inactive (94.07%)
BRAF	inactive (99.37%)
RAF1	inactive (99.87%)

TKL - IRAK

Bioactivity
Kinase	RBC
IRAK1	inactive (64.31%)
IRAK4	inactive (163.16%)

TKL - LISK

Bioactivity
Kinase	RBC
LIMK1	inactive (65.31%)

TKL - LRRK

Bioactivity
Kinase	RBC
LRRK2	inactive (83.01%)

TKL - MLK

Bioactivity
Kinase	RBC
MLK1	active (39.78%)
MLK2	inactive (82.7%)
MLK3	active (39.4%)
TAK1	inactive (90.64%)
ZAK	inactive (83.6%)

TKL - RIPK

Bioactivity
Kinase	RBC
RIPK2	inactive (70.96%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CAMKL	20	13
CAMK1	5	5
CAMK2	4	4
RAD53	1	1
DAPK	5	4
DCAMKL	3	1
MAPKAPK	5	5
MLCK	5	2
PHK	2	2
PIM	3	3
PKD	3	3
TSSK	5	2
STK33	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC
NuaK1	active (24.97%)
BRSK1	inactive (89.05%)
BRSK2	inactive (90.76%)
CHK1	inactive (93.09%)
LKB1	inactive (74.49%)
MARK1	inactive (92.92%)
MARK3	inactive (91.25%)
MARK4	inactive (88.28%)
MELK	inactive (84.41%)
PASK	inactive (97.58%)
QIK	inactive (98.35%)
NuaK2	inactive (68.03%)
MARK2	inactive (83.05%)

CAMK - CAMK1

Bioactivity
Kinase	RBC
CaMK1a	inactive (90.94%)
CaMK1b	inactive (120.03%)
CaMK1d	inactive (97.94%)
CaMK1g	inactive (101.8%)
CaMK4	inactive (97.58%)

CAMK - CAMK2

Bioactivity
Kinase	RBC
CaMK2a	inactive (99.97%)
CaMK2b	inactive (97.65%)
CaMK2d	inactive (93.27%)
CaMK2g	inactive (106.64%)

CAMK - RAD53

Bioactivity
Kinase	RBC
CHK2	inactive (72.82%)

CAMK - DAPK

Bioactivity
Kinase	RBC
DAPK1	inactive (90.64%)
DAPK2	inactive (100.62%)
DRAK1	inactive (95.54%)
DAPK3	inactive (101.76%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC
DCLK2	inactive (101.28%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC
MAPKAPK2	inactive (90.22%)
MAPKAPK3	inactive (98.57%)
MAPKAPK5	inactive (95.27%)
MNK1	inactive (97.65%)
MNK2	inactive (99.26%)

CAMK - MLCK

Bioactivity
Kinase	RBC
smMLCK	inactive (96.85%)
skMLCK	inactive (101.74%)

CAMK - PHK

Bioactivity
Kinase	RBC
PHKg1	inactive (89.4%)
PHKg2	inactive (106.3%)

CAMK - PIM

Bioactivity
Kinase	RBC
PIM1	inactive (96.99%)
PIM2	inactive (114.55%)
PIM3	inactive (90.92%)

CAMK - PKD

Bioactivity
Kinase	RBC
PKD1	inactive (92.88%)
PKD3	inactive (88.47%)
PKD2	inactive (101.06%)

CAMK - TSSK

Bioactivity
Kinase	RBC
TSSK1	inactive (65.31%)
TSSK2	inactive (93.68%)

CAMK - STK33

Bioactivity
Kinase	RBC
STK33	inactive (84.61%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STE11	8	3
STE-Unique	2	2
STE20	31	23
STE7	7	3

STE - STE11

Bioactivity
Kinase	RBC
MAP3K5	inactive (94.98%)
MAP3K2	inactive (90.88%)
MAP3K3	inactive (99.77%)

STE - STE-Unique

Bioactivity
Kinase	RBC
COT	inactive (98.22%)
NIK	inactive (104.68%)

STE - STE20

Bioactivity
Kinase	RBC
GCK	inactive (65.1%)
HGK	inactive (66.47%)
KHS1	inactive (63.82%)
LOK	inactive (95.37%)
MINK	inactive (84.44%)
MST1	inactive (82.2%)
MST2	inactive (87.02%)
MST3	inactive (87.26%)
MST4	inactive (75.78%)
OSR1	inactive (101.62%)
PAK1	inactive (83.65%)
PAK2	inactive (97.5%)
PAK3	inactive (106.11%)
PAK4	inactive (106.56%)
PAK5	inactive (88.08%)
PAK6	inactive (96.83%)
SLK	inactive (76.19%)
YSK1	inactive (90.31%)
STLK3	inactive (77.83%)
TAO1	inactive (87.03%)
TAO2	inactive (90.05%)
TAO3	inactive (102.92%)
MYO3B	active (0%)

STE - STE7

Bioactivity
Kinase	RBC
MAP2K1	inactive (88.66%)
MAP2K2	inactive (79.45%)
MAP2K6	inactive (96.02%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Aur	3	3
CAMKK	2	2
Haspin	1	1
IKK	4	4
NEK	11	8
TOPK	1	1
PLK	4	3
SgK496	1	1
NAK	4	1
TTK	1	1
ULK	5	3
WEE	3	1
WNK	4	2
TLK	2	1

Other - Aur

Bioactivity
Kinase	RBC
AurA	active (25.45%)
AurB	inactive (64.5%)
AurC	inactive (55.83%)

Other - CAMKK

Bioactivity
Kinase	RBC
CaMKK1	inactive (105.08%)
CaMKK2	inactive (79.15%)

Other - Haspin

Bioactivity
Kinase	RBC
Haspin	inactive (79.98%)

Other - IKK

Bioactivity
Kinase	RBC
IKKa	inactive (97.26%)
IKKb	inactive (101.56%)
IKKe	inactive (100.26%)
TBK1	inactive (81.42%)

Other - NEK

Bioactivity
Kinase	RBC
NEK1	inactive (86.88%)
NEK11	inactive (93.62%)
NEK2	inactive (115.16%)
NEK4	inactive (81.28%)
NEK6	inactive (110.62%)
NEK7	inactive (106.72%)
NEK9	inactive (106.43%)
NEK3	inactive (99.1%)

Other - TOPK

Bioactivity
Kinase	RBC
PBK	inactive (80.58%)

Other - PLK

Bioactivity
Kinase	RBC
PLK1	inactive (104.27%)
PLK2	inactive (94.94%)
PLK3	inactive (91.53%)

Other - SgK496

Bioactivity
Kinase	RBC
SgK496	inactive (97.56%)

Other - NAK

Bioactivity
Kinase	RBC
MPSK1	inactive (58.71%)

Other - TTK

Bioactivity
Kinase	RBC
TTK	inactive (87.9%)

Other - ULK

Bioactivity
Kinase	RBC
ULK1	inactive (87.87%)
ULK2	inactive (107.96%)
ULK3	active (0%)

Other - WEE

Bioactivity
Kinase	RBC
Wee1	inactive (85.93%)

Other - WNK

Bioactivity
Kinase	RBC
Wnk2	inactive (112.26%)
Wnk3	inactive (88.44%)

Other - TLK

Bioactivity
Kinase	RBC
TLK2	active (0%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK1	7	6
VRK	3	1

CK1 - CK1

Bioactivity
Kinase	RBC
CK1d	inactive (94.74%)
CK1g1	inactive (93.32%)
CK1g2	inactive (92.55%)
CK1g3	inactive (89.21%)
CK1a	inactive (92.89%)
CK1e	inactive (108.92%)

CK1 - VRK

Bioactivity
Kinase	RBC
VRK1	inactive (95.54%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK2	3	2
CLK	4	4
DYRK	10	9
MAPK	14	10
GSK	2	2
SRPK	3	3

CMGC - CK2

Bioactivity
Kinase	RBC
CK2a1	inactive (97.78%)
CK2a2	inactive (94.11%)

CMGC - CLK

Bioactivity
Kinase	RBC
CLK1	inactive (101.95%)
CLK2	inactive (85.32%)
CLK3	inactive (116.4%)
CLK4	inactive (73.15%)

CMGC - DYRK

Bioactivity
Kinase	RBC
DYRK1A	inactive (102.17%)
DYRK1B	inactive (94.53%)
DYRK2	inactive (92.86%)
DYRK3	inactive (96.14%)
DYRK4	inactive (97.66%)
HIPK1	inactive (109.05%)
HIPK2	inactive (108.97%)
HIPK3	inactive (99.86%)
HIPK4	inactive (118.75%)

CMGC - MAPK

Bioactivity
Kinase	RBC
Erk1	inactive (110.69%)
Erk2	inactive (103.33%)
JNK3	inactive (97.22%)
NLK	inactive (88.44%)
p38a	inactive (112.06%)
p38b	inactive (100.21%)
p38d	inactive (99.1%)
p38g	inactive (102.1%)
JNK1	inactive (74.54%)
JNK2	inactive (84.8%)

CMGC - GSK

Bioactivity
Kinase	RBC
GSK3A	inactive (55.76%)
GSK3B	inactive (70.16%)

CMGC - SRPK

Bioactivity
Kinase	RBC
MSSK1	inactive (97.94%)
SRPK1	inactive (100.34%)
SRPK2	inactive (105.1%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDHK	5	1

Atypical - PDHK

Bioactivity
Kinase	RBC
PDHK1	inactive (102.13%)