Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC, Millipore : -

Inchikey
Same : WXUJAQBSBZLVEV-N
RBC, Millipore : WXUJAQBSBZLVEV-UHFFFAOYSA-N

ChemSpider
RBC, Millipore : 4925373

Pubchem CID
RBC, Millipore : 6419741

ChEMBL
RBC, Millipore : -

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (89.04%)	inactive (56%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (101.79%)	inactive (110%)
AKT2	inactive (120.66%)	inactive (96%)
AKT3	inactive (94.31%)	inactive (84%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (101.2%)	inactive (110%)
MRCKa	inactive (92.7%)	inactive (99%)
MRCKb	inactive (94.77%)	inactive (82%)
ROCK1	inactive (95.87%)	inactive (109%)
ROCK2	inactive (93.16%)	inactive (88%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (107.14%)	-
BARK2	inactive (108.62%)	-
GPRK4	inactive (100.8%)	-
GPRK5	inactive (94.43%)	inactive (83%)
GPRK6	inactive (82.11%)	inactive (82%)
GPRK7	inactive (96.24%)	inactive (84%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (87.6%)	inactive (63%)
MSK2	inactive (61.29%)	inactive (53%)
p70S6K	inactive (70.6%)	inactive (68%)
p70S6Kb	inactive (74.71%)	-
RSK2	active (47.41%)	inactive (57%)
RSK4	active (33.37%)	active (37%)
RSK1	active (31.08%)	active (33%)
RSK3	active (32.73%)	inactive (58%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	-	-
PRKX	inactive (87.77%)	inactive (80%)
PKACa	inactive (98.2%)	inactive (82%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (66.55%)	inactive (97%)
PKCd	inactive (64.97%)	inactive (79%)
PKCe	inactive (84.9%)	inactive (105%)
PKCh	inactive (74.81%)	inactive (85%)
PKCg	inactive (116.7%)	inactive (71%)
PKCi	inactive (82.28%)	inactive (102%)
PKCt	inactive (88.94%)	inactive (71%)
PKCz	inactive (84.76%)	inactive (113%)
PKCb	inactive (94.66%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (64.12%)	-
PKG1	inactive (93.82%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (76.43%)	-
PKN2	inactive (95.47%)	inactive (69%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (69.02%)	inactive (66%)
SGK2	inactive (75.25%)	inactive (52%)
SGK3	inactive (110.72%)	inactive (87%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	active (0%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (85.62%)	inactive (80%)
ABL2	inactive (79.94%)	inactive (91%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	active (41.31%)	active (38%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (84.62%)	inactive (77%)
LTK	inactive (80.81%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (91.74%)	inactive (86%)
MER	inactive (53.92%)	active (37%)
TYRO3	inactive (88.83%)	inactive (95%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (73.95%)	inactive (57%)
BRK	inactive (88.95%)	inactive (81%)
SRC	inactive (88.4%)	inactive (100%)
FGR	inactive (94.82%)	inactive (75%)
FRK	inactive (96.8%)	inactive (87%)
FYN	inactive (97.74%)	inactive (51%)
HCK	inactive (94.55%)	inactive (54%)
LCK	inactive (87.11%)	inactive (61%)
SRM	inactive (100.33%)	-
YES	inactive (79.94%)	inactive (90%)
LYN	inactive (94.81%)	inactive (57%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (91.71%)	inactive (54%)
BTK	inactive (83.9%)	inactive (70%)
ITK	inactive (71.36%)	inactive (85%)
TEC	inactive (96.67%)	-
TXK	inactive (76.44%)	inactive (71%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	active (38.05%)	active (11%)
FLT3	active (9.86%)	active (18%)
FMS	inactive (64.86%)	active (26%)
PDGFRb	inactive (68.44%)	inactive (88%)
PDGFRa	inactive (84.42%)	inactive (96%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (83.29%)	inactive (97%)
CTK	inactive (99.81%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (96.45%)	inactive (85%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (92.65%)	inactive (108%)
ErbB2	inactive (109.16%)	-
ErbB4	inactive (101.76%)	inactive (87%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (72.45%)	inactive (74%)
EphA2	inactive (102.23%)	inactive (87%)
EphA3	inactive (105.06%)	inactive (91%)
EphA4	inactive (98.61%)	inactive (98%)
EphA5	inactive (92.04%)	inactive (105%)
EphA6	-	-
EphA7	inactive (78.81%)	inactive (86%)
EphA8	inactive (97.52%)	inactive (88%)
EphB1	inactive (93.96%)	inactive (90%)
EphB2	inactive (86.12%)	inactive (112%)
EphB3	inactive (79.71%)	inactive (121%)
EphB4	inactive (105.41%)	inactive (82%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (56.91%)	inactive (57%)
PYK2	inactive (70.14%)	active (32%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	active (47.9%)	inactive (78%)
FES	inactive (117.27%)	inactive (79%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (55.2%)	active (41%)
FGFR2	inactive (91.31%)	inactive (72%)
FGFR3	inactive (85.03%)	inactive (76%)
FGFR4	inactive (78.55%)	inactive (102%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (57.99%)	active (16%)
FLT4	inactive (56.65%)	active (0%)
KDR	inactive (66.6%)	active (10%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (76.76%)	active (9%)
IRR	active (20.7%)	active (5%)
INSR	active (17.85%)	active (10%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (101.76%)	-
JAK2	inactive (116.64%)	inactive (97%)
JAK3	inactive (140.11%)	inactive (83%)
TYK2	inactive (85.37%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (54.43%)	inactive (72%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	active (41.97%)	inactive (59%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (102.32%)	inactive (73%)
MET	inactive (93.38%)	inactive (146%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (76.96%)	inactive (97%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (84.94%)	inactive (60%)
ZAP70	inactive (87.85%)	inactive (97%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (78.94%)	inactive (98%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (89.78%)	active (21%)
TRKB	active (49.03%)	active (48%)
TRKC	active (26.12%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (108.79%)	-
ALK2	inactive (103.46%)	-
ALK4	inactive (102.83%)	inactive (97%)
TGFbR1	inactive (96.29%)	inactive (91%)
TGFbR2	inactive (95.85%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (93.8%)	-
BRAF	inactive (101%)	-
RAF1	inactive (108.07%)	inactive (68%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (83.13%)	inactive (76%)
IRAK4	inactive (84.84%)	inactive (61%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (74.71%)	inactive (71%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (61.31%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (72.5%)	active (33%)
MLK2	inactive (82.47%)	-
MLK3	inactive (57.48%)	-
TAK1	inactive (63.38%)	inactive (55%)
ZAK	inactive (78.73%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (67.52%)	inactive (79%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	active (12.1%)	active (15%)
BRSK1	active (22.55%)	active (32%)
BRSK2	active (29.72%)	active (23%)
CHK1	active (24.64%)	active (18%)
LKB1	active (45.22%)	inactive (84%)
MARK1	active (36.72%)	active (25%)
MARK3	active (29.82%)	-
MARK4	active (26.82%)	-
MELK	active (32.6%)	active (27%)
PASK	active (33.63%)	inactive (57%)
QIK	inactive (91.86%)	-
NuaK2	inactive (80.13%)	-
MARK2	active (34.69%)	active (40%)
AMPKa1	-	active (49%)
AMPKa2	-	active (38%)
SIK	-	inactive (83%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (83.34%)	inactive (61%)
CaMK1b	inactive (105.24%)	-
CaMK1d	inactive (91.91%)	inactive (71%)
CaMK1g	inactive (94.66%)	-
CaMK4	inactive (89.75%)	inactive (61%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (55.08%)	-
CaMK2b	inactive (58.22%)	active (22%)
CaMK2d	active (36.73%)	active (12%)
CaMK2g	inactive (52.32%)	active (15%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	active (21.23%)	active (23%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	active (26.61%)	inactive (57%)
DAPK2	active (43.83%)	active (9%)
DRAK1	active (36.56%)	active (10%)
DAPK3	active (29.61%)	active (27%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (82.28%)	inactive (96%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (98.94%)	inactive (79%)
MAPKAPK3	inactive (88.73%)	inactive (86%)
MAPKAPK5	inactive (123.19%)	inactive (97%)
MNK1	inactive (56.26%)	-
MNK2	active (35.04%)	active (32%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	active (15.53%)	active (11%)
skMLCK	active (33.71%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (70.79%)	-
PHKg2	inactive (108.31%)	inactive (95%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	active (1.43%)	active (6%)
PIM2	active (34.43%)	active (5%)
PIM3	active (4.48%)	active (14%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (61.42%)	active (41%)
PKD3	active (47.67%)	-
PKD2	inactive (69.38%)	inactive (90%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (84.44%)	inactive (83%)
TSSK2	inactive (99.13%)	inactive (83%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (52.26%)	inactive (79%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (97.85%)	inactive (99%)
MAP3K2	inactive (97.87%)	-
MAP3K3	inactive (86.92%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (100.24%)	-
NIK	inactive (83.01%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (51.79%)	inactive (58%)
HGK	active (21.23%)	-
KHS1	active (13.47%)	-
LOK	inactive (69%)	inactive (70%)
MINK	active (48.19%)	inactive (77%)
MST1	active (42.66%)	active (40%)
MST2	active (41.02%)	inactive (68%)
MST3	active (48.37%)	inactive (56%)
MST4	inactive (69.44%)	-
OSR1	inactive (97.17%)	-
PAK1	inactive (93.92%)	-
PAK2	inactive (99.04%)	inactive (98%)
PAK3	inactive (100.1%)	inactive (96%)
PAK4	inactive (97.06%)	inactive (81%)
PAK5	inactive (79.99%)	inactive (109%)
PAK6	inactive (85.49%)	inactive (98%)
SLK	inactive (87.83%)	-
YSK1	inactive (72.51%)	-
STLK3	inactive (103.98%)	-
TAO1	inactive (134.62%)	inactive (78%)
TAO2	inactive (89.36%)	inactive (88%)
TAO3	inactive (66.9%)	inactive (69%)
MYO3B	active (0%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (101.61%)	inactive (59%)
MAP2K2	inactive (85.91%)	-
MAP2K6	inactive (65.72%)	inactive (69%)
MAP2K7	-	active (42%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	active (34.84%)	active (14%)
AurB	active (25.18%)	active (3%)
AurC	active (47.6%)	active (37%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (63.53%)	-
CaMKK2	inactive (77.18%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	active (33.51%)	active (8%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (100.28%)	inactive (63%)
IKKb	inactive (95.85%)	inactive (94%)
IKKe	inactive (102.88%)	-
TBK1	inactive (81.89%)	inactive (53%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (75.19%)	-
NEK11	inactive (99.02%)	active (36%)
NEK2	inactive (87.49%)	inactive (77%)
NEK4	inactive (88.43%)	-
NEK6	inactive (88.71%)	inactive (98%)
NEK7	inactive (80.32%)	inactive (100%)
NEK9	inactive (77.4%)	-
NEK3	inactive (89.28%)	inactive (77%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (72.38%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (50.79%)	inactive (62%)
PLK2	inactive (63.76%)	active (38%)
PLK3	active (48.22%)	inactive (55%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (105.92%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (70.91%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (79.04%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (97.2%)	-
ULK2	inactive (95.45%)	inactive (103%)
ULK3	active (0%)	inactive (80%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (94.65%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (86.64%)	inactive (82%)
Wnk3	inactive (79.1%)	inactive (74%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	active (0%)	inactive (74%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	active (17.19%)	active (15%)
CK1g1	inactive (68.36%)	inactive (58%)
CK1g2	inactive (63.42%)	active (40%)
CK1g3	inactive (87%)	active (46%)
CK1a	inactive (51.59%)	-
CK1e	active (18.88%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (78.08%)	-
VRK2	-	inactive (93%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (52.61%)	inactive (60%)
CK2a2	inactive (53.37%)	inactive (81%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (84%)	-
CLK2	inactive (94.7%)	inactive (51%)
CLK3	active (48.17%)	inactive (70%)
CLK4	inactive (99.01%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (89.1%)	-
DYRK1B	inactive (65.9%)	-
DYRK2	inactive (64.12%)	inactive (68%)
DYRK3	inactive (85.8%)	-
DYRK4	inactive (106.54%)	-
HIPK1	inactive (82.63%)	inactive (77%)
HIPK2	inactive (94.38%)	active (30%)
HIPK3	inactive (66.93%)	inactive (61%)
HIPK4	inactive (98.49%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (87.83%)	inactive (86%)
Erk2	inactive (124.65%)	inactive (109%)
JNK3	inactive (96.03%)	active (25%)
NLK	inactive (87.92%)	inactive (89%)
p38a	inactive (100.68%)	inactive (93%)
p38b	inactive (94.53%)	inactive (90%)
p38d	inactive (106.92%)	inactive (93%)
p38g	inactive (85.93%)	inactive (95%)
JNK1	inactive (83.93%)	inactive (89%)
JNK2	inactive (65.3%)	inactive (67%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	active (10.37%)	active (7%)
GSK3B	active (30.83%)	active (26%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (75.73%)	inactive (82%)
SRPK1	inactive (95.42%)	inactive (91%)
SRPK2	inactive (80.22%)	inactive (103%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (89.04%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (78%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (75%)