Compound in Profiling

Compound Information

Test on : DRx, RBC

Compound Name
DRx, RBC : Gefitinib

Inchikey
Same : XGALLCVXEZPNRQ-N
DRx, RBC : XGALLCVXEZPNRQ-UHFFFAOYSA-N

ChemSpider
DRx, RBC : 110217

Pubchem CID
DRx, RBC : 123631

ChEMBL
DRx, RBC : CHEMBL939

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

Other

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC
NAK	4	4	1
Aur	3	3	3
CAMKK	2	2	2
PEK	4	2	-
IRE	2	1	-
IKK	4	4	4
NEK	11	9	8
WEE	3	3	1
PLK	4	4	3
SgK496	1	1	1
NKF1	3	2	-
NKF4	2	1	-
ULK	5	4	3
TLK	2	2	1
TTK	1	1	1
Haspin	1	-	1
TOPK	1	-	1
WNK	4	-	2

Other - NAK

Bioactivity
Kinase	DRx	RBC
AAK1	inactive (10001nM)	-
BIKE	inactive (10001nM)	-
GAK	active (13nM)	-
MPSK1	inactive (10001nM)	inactive (96.84%)

Other - Aur

Bioactivity
Kinase	DRx	RBC
AurA	inactive (10001nM)	inactive (95.27%)
AurB	inactive (10001nM)	inactive (105.68%)
AurC	inactive (10001nM)	inactive (89.74%)

Other - CAMKK

Bioactivity
Kinase	DRx	RBC
CaMKK1	inactive (10001nM)	inactive (93.77%)
CaMKK2	inactive (10001nM)	inactive (102.66%)

Other - PEK

Bioactivity
Kinase	DRx	RBC
HRI	inactive (10001nM)	-
PKR	inactive (10001nM)	-

Other - IRE

Bioactivity
Kinase	DRx	RBC
IRE1	inactive (10001nM)	-

Other - IKK

Bioactivity
Kinase	DRx	RBC
IKKa	inactive (10001nM)	inactive (94.87%)
IKKb	inactive (10001nM)	inactive (86.54%)
IKKe	inactive (10001nM)	inactive (89.85%)
TBK1	inactive (10001nM)	inactive (83.12%)

Other - NEK

Bioactivity
Kinase	DRx	RBC
NEK1	inactive (10001nM)	inactive (90.42%)
NEK11	inactive (10001nM)	inactive (108.83%)
NEK2	inactive (10001nM)	inactive (98.44%)
NEK3	inactive (10001nM)	inactive (94.44%)
NEK4	inactive (10001nM)	inactive (103.13%)
NEK5	inactive (10001nM)	-
NEK6	inactive (10001nM)	inactive (89.9%)
NEK7	inactive (10001nM)	inactive (96.9%)
NEK9	inactive (10001nM)	inactive (99.33%)

Other - WEE

Bioactivity
Kinase	DRx	RBC
MYT1	inactive (10001nM)	-
Wee1	inactive (10001nM)	inactive (93.76%)
Wee1B	inactive (10001nM)	-

Other - PLK

Bioactivity
Kinase	DRx	RBC
PLK1	inactive (10001nM)	inactive (96.99%)
PLK2	inactive (10001nM)	inactive (100.48%)
PLK3	inactive (10001nM)	inactive (103.02%)
PLK4	inactive (10001nM)	-

Other - SgK496

Bioactivity
Kinase	DRx	RBC
SgK496	inactive (10001nM)	inactive (101.21%)

Other - NKF1

Bioactivity
Kinase	DRx	RBC
SBK	active (560nM)	-
SgK110	inactive (10001nM)	-

Other - NKF4

Bioactivity
Kinase	DRx	RBC
CLIK1	inactive (10001nM)	-

Other - ULK

Bioactivity
Kinase	DRx	RBC
Fused	inactive (5700nM)	-
ULK1	inactive (10001nM)	inactive (93%)
ULK2	inactive (10001nM)	inactive (103.63%)
ULK3	inactive (10001nM)	inactive (107.59%)

Other - TLK

Bioactivity
Kinase	DRx	RBC
TLK1	inactive (10001nM)	-
TLK2	inactive (10001nM)	inactive (80.44%)

Other - TTK

Bioactivity
Kinase	DRx	RBC
TTK	inactive (10001nM)	inactive (96.32%)

Other - Haspin

Bioactivity
Kinase	DRx	RBC
Haspin	-	inactive (84.05%)

Other - TOPK

Bioactivity
Kinase	DRx	RBC
PBK	-	inactive (101.69%)

Other - WNK

Bioactivity
Kinase	DRx	RBC
Wnk2	-	inactive (97.23%)
Wnk3	-	inactive (102.14%)

TK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC
Abl	2	2	2
ALK	2	2	2
Axl	3	3	3
Src	11	11	11
Tec	5	5	5
PDGFR	5	5	5
Csk	2	2	2
DDR	2	2	1
EGFR	4	4	3
Eph	14	13	12
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	4
Met	2	2	2
Musk	1	1	1
Ret	1	1	1
Sev	1	1	1
Syk	2	2	2
Tie	2	2	1
Ack	2	2	1
Trk	3	3	3

TK - Abl

Bioactivity
Kinase	DRx	RBC
ABL1	active (2200nM)	inactive (86.35%)
ABL2	active (1600nM)	inactive (71.98%)

TK - ALK

Bioactivity
Kinase	DRx	RBC
ALK	inactive (10001nM)	inactive (98.75%)
LTK	inactive (5500nM)	inactive (90.35%)

TK - Axl

Bioactivity
Kinase	DRx	RBC
AXL	active (1800nM)	inactive (88.8%)
MER	inactive (10001nM)	inactive (95.91%)
TYRO3	inactive (10001nM)	inactive (94.86%)

TK - Src

Bioactivity
Kinase	DRx	RBC
BLK	active (1200nM)	inactive (87.71%)
BRK	inactive (10001nM)	inactive (77.22%)
FGR	active (2600nM)	inactive (70.15%)
FRK	active (2000nM)	inactive (97.87%)
FYN	inactive (10001nM)	inactive (92.17%)
HCK	inactive (4400nM)	inactive (73.33%)
LCK	active (630nM)	inactive (68.44%)
LYN	active (990nM)	inactive (57.09%)
SRC	inactive (3800nM)	inactive (79%)
SRM	inactive (10001nM)	inactive (96.36%)
YES	inactive (10001nM)	inactive (74.36%)

TK - Tec

Bioactivity
Kinase	DRx	RBC
BMX	inactive (10001nM)	inactive (102.44%)
BTK	inactive (10001nM)	inactive (60.56%)
ITK	inactive (10001nM)	inactive (99.94%)
TEC	inactive (10001nM)	inactive (103.98%)
TXK	inactive (6000nM)	inactive (83.21%)

TK - PDGFR

Bioactivity
Kinase	DRx	RBC
FMS	inactive (10001nM)	inactive (110.38%)
FLT3	inactive (3100nM)	inactive (56.47%)
KIT	inactive (10001nM)	inactive (96.04%)
PDGFRa	inactive (10001nM)	inactive (97%)
PDGFRb	inactive (10001nM)	inactive (93.89%)

TK - Csk

Bioactivity
Kinase	DRx	RBC
CSK	inactive (10001nM)	inactive (95.4%)
CTK	inactive (10001nM)	inactive (86.38%)

TK - DDR

Bioactivity
Kinase	DRx	RBC
DDR1	inactive (10001nM)	-
DDR2	inactive (10001nM)	inactive (116.76%)

TK - EGFR

Bioactivity
Kinase	DRx	RBC
EGFR	active (1nM)	active (2.97%)
ErbB2	inactive (3500nM)	active (34.2%)
ErbB3	active (790nM)	-
ErbB4	active (410nM)	active (24.15%)

TK - Eph

Bioactivity
Kinase	DRx	RBC
EphA1	inactive (4000nM)	inactive (87.38%)
EphA2	inactive (10001nM)	inactive (85.71%)
EphA3	inactive (5500nM)	inactive (94.45%)
EphA4	inactive (10001nM)	inactive (90.23%)
EphA5	active (1500nM)	inactive (95.8%)
EphA6	active (590nM)	active (28.94%)
EphA7	inactive (10001nM)	inactive (74.31%)
EphA8	active (1800nM)	inactive (84.51%)
EphB1	active (1300nM)	inactive (94.76%)
EphB2	inactive (10001nM)	inactive (87.65%)
EphB3	inactive (10001nM)	inactive (57.52%)
EphB4	active (2500nM)	inactive (70.85%)
EphB6	inactive (3200nM)	-

TK - FAK

Bioactivity
Kinase	DRx	RBC
FAK	inactive (10001nM)	inactive (102.59%)
PYK2	inactive (10001nM)	inactive (98.87%)

TK - Fer

Bioactivity
Kinase	DRx	RBC
FER	inactive (10001nM)	inactive (94.11%)
FES	inactive (10001nM)	inactive (110.93%)

TK - FGFR

Bioactivity
Kinase	DRx	RBC
FGFR1	inactive (10001nM)	inactive (96.4%)
FGFR2	inactive (10001nM)	inactive (98.73%)
FGFR3	inactive (10001nM)	inactive (79.32%)
FGFR4	inactive (10001nM)	inactive (92.38%)

TK - VEGFR

Bioactivity
Kinase	DRx	RBC
FLT1	inactive (10001nM)	inactive (98.32%)
FLT4	inactive (10001nM)	inactive (92.15%)
KDR	inactive (10001nM)	inactive (95.24%)

TK - InsR

Bioactivity
Kinase	DRx	RBC
IGF1R	inactive (10001nM)	inactive (92.33%)
INSR	inactive (10001nM)	inactive (106.69%)
IRR	inactive (10001nM)	inactive (111.76%)

TK - JakA

Bioactivity
Kinase	DRx	RBC
JAK1	inactive (10001nM)	inactive (101.53%)
JAK2	inactive (10001nM)	inactive (99.85%)
JAK3	inactive (10001nM)	inactive (96.64%)
TYK2	inactive (10001nM)	inactive (101.66%)

TK - Met

Bioactivity
Kinase	DRx	RBC
MET	inactive (10001nM)	inactive (92.36%)
RON	inactive (10001nM)	inactive (97.71%)

TK - Musk

Bioactivity
Kinase	DRx	RBC
MUSK	inactive (10001nM)	inactive (98.12%)

TK - Ret

Bioactivity
Kinase	DRx	RBC
RET	inactive (10001nM)	inactive (76.94%)

TK - Sev

Bioactivity
Kinase	DRx	RBC
ROS	inactive (10001nM)	inactive (92.33%)

TK - Syk

Bioactivity
Kinase	DRx	RBC
SYK	inactive (10001nM)	inactive (104.18%)
ZAP70	inactive (10001nM)	inactive (96.47%)

TK - Tie

Bioactivity
Kinase	DRx	RBC
TIE1	inactive (10001nM)	-
TIE2	inactive (10001nM)	inactive (96.18%)

TK - Ack

Bioactivity
Kinase	DRx	RBC
TNK1	inactive (10001nM)	-
ACK	inactive (10001nM)	inactive (72.8%)

TK - Trk

Bioactivity
Kinase	DRx	RBC
TRKA	inactive (10001nM)	inactive (103.32%)
TRKB	inactive (10001nM)	inactive (98.16%)
TRKC	inactive (10001nM)	inactive (102.82%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC
STKR	12	10	5
RIPK	5	4	1
RAF	5	2	3
MLK	10	8	5
IRAK	4	3	2
LISK	4	3	1
LRRK	2	1	1

TKL - STKR

Bioactivity
Kinase	DRx	RBC
ALK2	inactive (10001nM)	inactive (105.63%)
ALK4	inactive (10001nM)	inactive (99.64%)
ACTR2	inactive (10001nM)	-
ACTR2B	inactive (10001nM)	-
ALK1	inactive (10001nM)	inactive (96.86%)
BMPR1A	inactive (10001nM)	-
BMPR1B	inactive (10001nM)	-
BMPR2	inactive (10001nM)	-
TGFbR1	inactive (10001nM)	inactive (99.58%)
TGFbR2	inactive (10001nM)	inactive (93.77%)

TKL - RIPK

Bioactivity
Kinase	DRx	RBC
SgK288	inactive (10001nM)	-
RIPK1	inactive (10001nM)	-
RIPK2	active (530nM)	active (33.98%)
ANKRD3	inactive (10001nM)	-

TKL - RAF

Bioactivity
Kinase	DRx	RBC
BRAF	inactive (10001nM)	inactive (95.81%)
RAF1	inactive (10001nM)	inactive (90.93%)
ARAF	-	inactive (95.27%)

TKL - MLK

Bioactivity
Kinase	DRx	RBC
DLK	inactive (10001nM)	-
LZK	inactive (10001nM)	-
MLK1	inactive (10001nM)	inactive (109.52%)
MLK2	inactive (10001nM)	inactive (108.75%)
MLK3	inactive (10001nM)	inactive (102.32%)
TAK1	inactive (10001nM)	inactive (91.33%)
HH498	inactive (10001nM)	-
ZAK	inactive (10001nM)	inactive (96.17%)

TKL - IRAK

Bioactivity
Kinase	DRx	RBC
IRAK1	active (69nM)	inactive (57.64%)
IRAK3	active (1500nM)	-
IRAK4	active (540nM)	inactive (78.79%)

TKL - LISK

Bioactivity
Kinase	DRx	RBC
LIMK1	inactive (10001nM)	inactive (89.98%)
LIMK2	inactive (10001nM)	-
TESK1	inactive (10001nM)	-

TKL - LRRK

Bioactivity
Kinase	DRx	RBC
LRRK2	inactive (10001nM)	inactive (107.6%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC
ABC1	5	2	-
PIKK	6	1	-
RIO	3	3	-
Alpha	6	1	-
PDHK	5	-	1

Atypical - ABC1

Bioactivity
Kinase	DRx	RBC
ADCK3	inactive (10001nM)	-
ADCK4	inactive (10001nM)	-

Atypical - PIKK

Bioactivity
Kinase	DRx	RBC
FRAP	inactive (10001nM)	-

Atypical - RIO

Bioactivity
Kinase	DRx	RBC
RIOK1	inactive (10001nM)	-
RIOK2	inactive (10001nM)	-
RIOK3	inactive (10001nM)	-

Atypical - Alpha

Bioactivity
Kinase	DRx	RBC
ChaK2	inactive (10001nM)	-

Atypical - PDHK

Bioactivity
Kinase	DRx	RBC
PDHK1	-	inactive (88.16%)

AGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC
Akt	3	3	3
DMPK	7	7	5
GRK	7	3	6
NDR	4	4	1
MAST	5	1	-
PDK1	1	1	1
PKA	5	3	3
PKN	3	2	2
PKC	9	5	9
PKG	2	2	3
RSK	8	1	8
SGK	3	1	3
YANK	3	3	-

AGC - Akt

Bioactivity
Kinase	DRx	RBC
AKT1	inactive (10001nM)	inactive (94.14%)
AKT2	inactive (10001nM)	inactive (111.08%)
AKT3	inactive (10001nM)	inactive (84.59%)

AGC - DMPK

Bioactivity
Kinase	DRx	RBC
CRIK	active (1300nM)	-
DMPK1	inactive (6900nM)	inactive (90.09%)
DMPK2	inactive (10001nM)	-
MRCKa	inactive (10001nM)	inactive (87.78%)
MRCKb	inactive (10001nM)	inactive (98.96%)
ROCK1	inactive (10001nM)	inactive (105.65%)
ROCK2	inactive (10001nM)	inactive (90.75%)

AGC - GRK

Bioactivity
Kinase	DRx	RBC
RHOK	inactive (10001nM)	-
GPRK4	inactive (10001nM)	inactive (91.01%)
GPRK7	inactive (10001nM)	inactive (96.18%)
BARK1	-	inactive (93.33%)
BARK2	-	inactive (97.93%)
GPRK5	-	inactive (94.88%)
GPRK6	-	inactive (99.6%)

AGC - NDR

Bioactivity
Kinase	DRx	RBC
LATS1	inactive (10001nM)	-
LATS2	inactive (10001nM)	-
NDR1	inactive (10001nM)	inactive (105.13%)
NDR2	inactive (10001nM)	-

AGC - MAST

Bioactivity
Kinase	DRx	RBC
MAST1	inactive (10001nM)	-

AGC - PDK1

Bioactivity
Kinase	DRx	RBC
PDK1	inactive (10001nM)	inactive (88.16%)

AGC - PKA

Bioactivity
Kinase	DRx	RBC
PKACa	inactive (10001nM)	inactive (96.28%)
PKACb	inactive (10001nM)	-
PRKX	inactive (10001nM)	inactive (110.5%)
PKACg	-	inactive (107.18%)

AGC - PKN

Bioactivity
Kinase	DRx	RBC
PKN1	inactive (10001nM)	inactive (105.11%)
PKN2	inactive (10001nM)	inactive (93.08%)

AGC - PKC

Bioactivity
Kinase	DRx	RBC
PKCd	inactive (10001nM)	inactive (106%)
PKCe	inactive (10001nM)	inactive (97.3%)
PKCh	inactive (10001nM)	inactive (110.93%)
PKCi	inactive (10001nM)	inactive (96.87%)
PKCt	inactive (10001nM)	inactive (85.88%)
PKCa	-	inactive (93.63%)
PKCg	-	inactive (84.15%)
PKCz	-	inactive (92.47%)
PKCb	-	inactive (100.44%)

AGC - PKG

Bioactivity
Kinase	DRx	RBC
PKG1	inactive (10001nM)	inactive (87.53%)
PKG2	inactive (10001nM)	inactive (94.76%)

AGC - RSK

Bioactivity
Kinase	DRx	RBC
p70S6K	inactive (10001nM)	inactive (93.87%)
MSK1	-	inactive (100.45%)
MSK2	-	inactive (104.47%)
p70S6Kb	-	inactive (100.6%)
RSK2	-	inactive (100.01%)
RSK4	-	inactive (95.25%)
RSK1	-	inactive (97.28%)
RSK3	-	inactive (82.35%)

AGC - SGK

Bioactivity
Kinase	DRx	RBC
SGK3	inactive (10001nM)	inactive (98.35%)
SGK1	-	inactive (131.23%)
SGK2	-	inactive (117.01%)

AGC - YANK

Bioactivity
Kinase	DRx	RBC
YANK1	inactive (10001nM)	-
YANK2	inactive (10001nM)	-
YANK3	inactive (10001nM)	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC
CAMKL	20	19	13
CAMK1	5	4	5
CAMK2	4	4	4
CASK	1	1	-
RAD53	1	1	1
DAPK	5	5	4
DCAMKL	3	3	1
MAPKAPK	5	4	5
MLCK	5	4	2
PHK	2	2	2
PIM	3	3	3
PKD	3	3	3
STK33	1	1	-
TSSK	5	1	2

CAMK - CAMKL

Bioactivity
Kinase	DRx	RBC
AMPKa1	inactive (10001nM)	-
AMPKa2	inactive (10001nM)	-
NuaK1	inactive (10001nM)	inactive (99.06%)
BRSK1	inactive (10001nM)	inactive (92.5%)
BRSK2	inactive (10001nM)	inactive (103.09%)
CHK1	inactive (10001nM)	inactive (95.27%)
HUNK	inactive (10001nM)	-
LKB1	inactive (10001nM)	inactive (106.26%)
MARK1	inactive (10001nM)	inactive (116.22%)
MARK2	inactive (10001nM)	inactive (119.2%)
MARK3	inactive (10001nM)	inactive (94.55%)
MARK4	inactive (10001nM)	inactive (94.21%)
MELK	inactive (10001nM)	inactive (77.75%)
NIM1	inactive (10001nM)	-
QSK	inactive (10001nM)	-
SIK	inactive (10001nM)	-
QIK	active (2100nM)	active (49.34%)
NuaK2	inactive (4600nM)	inactive (96.03%)
SNRK	inactive (10001nM)	-
PASK	-	inactive (97.94%)

CAMK - CAMK1

Bioactivity
Kinase	DRx	RBC
CaMK1a	inactive (10001nM)	inactive (101.56%)
CaMK1d	inactive (10001nM)	inactive (88.64%)
CaMK1g	inactive (10001nM)	inactive (103.44%)
CaMK4	inactive (10001nM)	inactive (93.3%)
CaMK1b	-	inactive (108.09%)

CAMK - CAMK2

Bioactivity
Kinase	DRx	RBC
CaMK2a	inactive (10001nM)	inactive (94.45%)
CaMK2b	inactive (10001nM)	inactive (95.43%)
CaMK2d	inactive (10001nM)	inactive (92.43%)
CaMK2g	inactive (10001nM)	inactive (128.23%)

CAMK - CASK

Bioactivity
Kinase	DRx	RBC
CASK	inactive (10001nM)	-

CAMK - RAD53

Bioactivity
Kinase	DRx	RBC
CHK2	active (800nM)	inactive (83.95%)

CAMK - DAPK

Bioactivity
Kinase	DRx	RBC
DAPK1	inactive (10001nM)	inactive (108.61%)
DAPK2	inactive (10001nM)	inactive (93.17%)
DAPK3	inactive (5700nM)	inactive (95.66%)
DRAK1	active (2000nM)	inactive (95.96%)
DRAK2	inactive (3800nM)	-

CAMK - DCAMKL

Bioactivity
Kinase	DRx	RBC
DCLK1	inactive (10001nM)	-
DCLK2	inactive (10001nM)	inactive (100.85%)
DCLK3	active (2900nM)	-

CAMK - MAPKAPK

Bioactivity
Kinase	DRx	RBC
MAPKAPK2	inactive (10001nM)	inactive (97.5%)
MAPKAPK5	inactive (10001nM)	inactive (92.66%)
MNK1	active (290nM)	active (41.86%)
MNK2	active (1200nM)	inactive (54.09%)
MAPKAPK3	-	inactive (99.61%)

CAMK - MLCK

Bioactivity
Kinase	DRx	RBC
caMLCK	inactive (10001nM)	-
smMLCK	inactive (10001nM)	inactive (89.7%)
skMLCK	active (1900nM)	inactive (99.24%)
SgK085	inactive (10001nM)	-

CAMK - PHK

Bioactivity
Kinase	DRx	RBC
PHKg1	inactive (3700nM)	inactive (68.81%)
PHKg2	active (2700nM)	inactive (93.88%)

CAMK - PIM

Bioactivity
Kinase	DRx	RBC
PIM1	inactive (10001nM)	inactive (86.45%)
PIM2	inactive (10001nM)	inactive (96.22%)
PIM3	inactive (5800nM)	inactive (74.62%)

CAMK - PKD

Bioactivity
Kinase	DRx	RBC
PKD1	inactive (3500nM)	inactive (85.4%)
PKD2	inactive (10001nM)	inactive (73.78%)
PKD3	inactive (10001nM)	inactive (76.27%)

CAMK - STK33

Bioactivity
Kinase	DRx	RBC
STK33	inactive (10001nM)	inactive (90.43%)

CAMK - TSSK

Bioactivity
Kinase	DRx	RBC
TSSK1	inactive (10001nM)	inactive (89.98%)
TSSK2	-	inactive (91.51%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC
STE11	8	8	3
STE20	31	27	23
STE7	7	7	3
STE-Unique	2	-	2

STE - STE11

Bioactivity
Kinase	DRx	RBC
MAP3K5	inactive (10001nM)	inactive (102.87%)
MAP3K6	inactive (10001nM)	-
MAP3K1	inactive (10001nM)	-
MAP3K7	inactive (10001nM)	-
MAP3K2	inactive (3300nM)	inactive (108.9%)
MAP3K3	active (2100nM)	inactive (106.57%)
MAP3K4	inactive (10001nM)	-
MAP3K8	active (240nM)	-

STE - STE20

Bioactivity
Kinase	DRx	RBC
HPK1	inactive (10001nM)	-
LOK	active (470nM)	active (38.59%)
GCK	inactive (10001nM)	inactive (103.53%)
KHS2	inactive (10001nM)	-
HGK	inactive (10001nM)	inactive (97.78%)
KHS1	inactive (10001nM)	inactive (79.95%)
MINK	active (1800nM)	inactive (102.32%)
MST1	inactive (10001nM)	inactive (100.73%)
MST2	inactive (10001nM)	inactive (93.57%)
MST3	inactive (10001nM)	inactive (102.15%)
MST4	inactive (10001nM)	inactive (106.07%)
MYO3A	inactive (10001nM)	-
MYO3B	inactive (10001nM)	inactive (91.41%)
OSR1	inactive (10001nM)	inactive (101.19%)
PAK1	inactive (10001nM)	inactive (104.06%)
PAK2	inactive (10001nM)	inactive (100.18%)
PAK3	inactive (10001nM)	inactive (105.75%)
PAK4	inactive (10001nM)	inactive (90.22%)
PAK6	inactive (10001nM)	inactive (104.59%)
PAK5	inactive (10001nM)	inactive (97.39%)
SLK	active (920nM)	inactive (83.71%)
STLK3	inactive (10001nM)	inactive (93.52%)
TAO1	inactive (10001nM)	inactive (103.35%)
TAO2	inactive (10001nM)	inactive (106.16%)
TAO3	inactive (10001nM)	inactive (99.52%)
TNIK	inactive (6900nM)	-
YSK1	inactive (10001nM)	inactive (97.38%)

STE - STE7

Bioactivity
Kinase	DRx	RBC
MAP2K1	inactive (10001nM)	inactive (106.69%)
MAP2K2	inactive (10001nM)	inactive (101.76%)
MAP2K3	inactive (10001nM)	-
MAP2K4	inactive (10001nM)	-
MAP2K5	active (600nM)	-
MAP2K6	inactive (10001nM)	inactive (90.13%)
MAP2K7	inactive (10001nM)	-

STE - STE-Unique

Bioactivity
Kinase	DRx	RBC
COT	-	inactive (95.73%)
NIK	-	inactive (103.54%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC
CDK	20	8	-
CDKL	5	4	-
CLK	4	4	4
CK2	3	2	2
DYRK	10	8	9
MAPK	14	14	10
GSK	2	2	2
RCK	3	2	-
SRPK	3	3	3

CMGC - CDK

Bioactivity
Kinase	DRx	RBC
PITSLRE	inactive (10001nM)	-
CHED	inactive (10001nM)	-
CDK11	inactive (10001nM)	-
PCTAIRE1	inactive (10001nM)	-
PCTAIRE2	inactive (10001nM)	-
PCTAIRE3	inactive (10001nM)	-
PFTAIRE2	inactive (10001nM)	-
PFTAIRE1	inactive (10001nM)	-

CMGC - CDKL

Bioactivity
Kinase	DRx	RBC
CDKL1	inactive (10001nM)	-
CDKL2	inactive (10001nM)	-
CDKL3	inactive (10001nM)	-
CDKL5	inactive (10001nM)	-

CMGC - CLK

Bioactivity
Kinase	DRx	RBC
CLK1	inactive (10001nM)	inactive (105.34%)
CLK2	inactive (10001nM)	inactive (94.8%)
CLK3	inactive (10001nM)	inactive (105.68%)
CLK4	inactive (10001nM)	inactive (106.81%)

CMGC - CK2

Bioactivity
Kinase	DRx	RBC
CK2a1	inactive (10001nM)	inactive (113.94%)
CK2a2	inactive (10001nM)	inactive (88.61%)

CMGC - DYRK

Bioactivity
Kinase	DRx	RBC
DYRK1A	inactive (10001nM)	inactive (101.21%)
DYRK1B	inactive (10001nM)	inactive (91.87%)
DYRK2	inactive (10001nM)	inactive (98.2%)
HIPK1	inactive (10001nM)	inactive (97.55%)
HIPK2	inactive (10001nM)	inactive (99.71%)
HIPK3	inactive (10001nM)	inactive (102.72%)
HIPK4	active (310nM)	inactive (90.36%)
PRP4	inactive (10001nM)	-
DYRK3	-	inactive (84.98%)
DYRK4	-	inactive (104.94%)

CMGC - MAPK

Bioactivity
Kinase	DRx	RBC
Erk1	inactive (10001nM)	inactive (100.48%)
Erk2	inactive (10001nM)	inactive (103.1%)
Erk3	active (1600nM)	-
Erk4	inactive (3100nM)	-
Erk5	inactive (10001nM)	-
Erk7	inactive (10001nM)	-
JNK1	inactive (10001nM)	inactive (93.07%)
JNK2	active (1700nM)	inactive (95.46%)
JNK3	inactive (3200nM)	inactive (101.5%)
NLK	inactive (4200nM)	inactive (91.1%)
p38a	inactive (10001nM)	inactive (74.59%)
p38b	inactive (10001nM)	inactive (95.15%)
p38d	inactive (10001nM)	inactive (94.68%)
p38g	inactive (10001nM)	inactive (97.45%)

CMGC - GSK

Bioactivity
Kinase	DRx	RBC
GSK3A	inactive (10001nM)	inactive (99.73%)
GSK3B	inactive (10001nM)	inactive (100.3%)

CMGC - RCK

Bioactivity
Kinase	DRx	RBC
ICK	inactive (10001nM)	-
MAK	inactive (10001nM)	-

CMGC - SRPK

Bioactivity
Kinase	DRx	RBC
SRPK1	inactive (10001nM)	inactive (98.31%)
SRPK2	inactive (10001nM)	inactive (99.49%)
MSSK1	inactive (10001nM)	inactive (102.83%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC
CK1	7	7	6
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	DRx	RBC
CK1a	inactive (10001nM)	inactive (98.63%)
CK1a2	inactive (10001nM)	-
CK1d	inactive (3200nM)	inactive (90.37%)
CK1e	active (430nM)	inactive (106.23%)
CK1g1	inactive (10001nM)	inactive (99.48%)
CK1g2	inactive (10001nM)	inactive (98.09%)
CK1g3	inactive (10001nM)	inactive (103.42%)

CK1 - VRK

Bioactivity
Kinase	DRx	RBC
VRK2	inactive (10001nM)	-
VRK1	-	inactive (99.26%)