Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC, Millipore : NG 52

Inchikey
Same : XZEFMZCNXDQXOZ-N
RBC, Millipore : XZEFMZCNXDQXOZ-UHFFFAOYSA-N

ChemSpider
RBC, Millipore : 2754

Pubchem CID
RBC, Millipore : 2856

ChEMBL
RBC, Millipore : CHEMBL311228

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (96.77%)	inactive (96%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (102.7%)	inactive (111%)
AKT2	inactive (92.44%)	inactive (95%)
AKT3	inactive (99.88%)	inactive (95%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (98.52%)	inactive (124%)
MRCKa	inactive (83.89%)	inactive (108%)
MRCKb	inactive (109.11%)	inactive (85%)
ROCK1	inactive (100.68%)	inactive (113%)
ROCK2	inactive (97.53%)	inactive (83%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (95.97%)	-
BARK2	inactive (90.5%)	-
GPRK4	inactive (93.49%)	-
GPRK5	inactive (99.35%)	inactive (92%)
GPRK6	inactive (88.76%)	inactive (90%)
GPRK7	inactive (88.73%)	inactive (76%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (87%)	inactive (62%)
MSK2	inactive (83.75%)	inactive (57%)
p70S6K	inactive (93.27%)	active (36%)
p70S6Kb	inactive (96.96%)	-
RSK2	inactive (60.1%)	active (15%)
RSK4	inactive (74.78%)	active (34%)
RSK1	inactive (69.15%)	active (6%)
RSK3	inactive (62.05%)	active (50%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	-	-
PRKX	inactive (96.44%)	inactive (82%)
PKACa	inactive (99.47%)	inactive (96%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (78.65%)	inactive (101%)
PKCd	inactive (89.12%)	inactive (96%)
PKCe	inactive (93.63%)	inactive (75%)
PKCh	inactive (99.44%)	inactive (87%)
PKCg	inactive (93.56%)	inactive (99%)
PKCi	inactive (100.53%)	inactive (110%)
PKCt	inactive (91.45%)	inactive (69%)
PKCz	inactive (97.75%)	inactive (100%)
PKCb	inactive (99.68%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (82.68%)	-
PKG1	inactive (92.18%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (100.72%)	-
PKN2	inactive (90.77%)	inactive (86%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (114.5%)	inactive (89%)
SGK2	inactive (97.39%)	inactive (105%)
SGK3	inactive (97.05%)	inactive (107%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	active (0%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (73.29%)	inactive (73%)
ABL2	inactive (60.73%)	inactive (52%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (70.81%)	active (14%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (91.79%)	inactive (81%)
LTK	inactive (85.28%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (91.27%)	inactive (94%)
MER	inactive (89.68%)	inactive (54%)
TYRO3	inactive (92.67%)	inactive (118%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (91.15%)	inactive (79%)
BRK	inactive (90.18%)	inactive (105%)
SRC	inactive (68.86%)	inactive (54%)
FGR	inactive (61.55%)	active (48%)
FRK	inactive (94.23%)	inactive (75%)
FYN	inactive (60.44%)	active (21%)
HCK	inactive (77.96%)	active (41%)
LCK	inactive (84.87%)	active (48%)
SRM	inactive (85.14%)	-
YES	active (33.66%)	active (27%)
LYN	inactive (80.25%)	active (20%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (92.52%)	inactive (58%)
BTK	inactive (86.33%)	inactive (72%)
ITK	inactive (96.01%)	inactive (76%)
TEC	inactive (113.01%)	-
TXK	inactive (78.11%)	inactive (68%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (76.28%)	inactive (108%)
FLT3	active (15.13%)	active (20%)
FMS	inactive (94.76%)	inactive (83%)
PDGFRb	inactive (94.73%)	inactive (108%)
PDGFRa	inactive (96.44%)	inactive (105%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (98.19%)	inactive (101%)
CTK	inactive (93.33%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (93.25%)	inactive (94%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (91.53%)	inactive (98%)
ErbB2	inactive (96.19%)	-
ErbB4	inactive (100.81%)	inactive (94%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (94.06%)	inactive (86%)
EphA2	inactive (93.32%)	inactive (82%)
EphA3	inactive (90.34%)	inactive (82%)
EphA4	inactive (87.48%)	inactive (110%)
EphA5	inactive (91.72%)	inactive (102%)
EphA6	-	-
EphA7	inactive (87.06%)	inactive (83%)
EphA8	inactive (98.19%)	inactive (97%)
EphB1	inactive (76.86%)	inactive (81%)
EphB2	inactive (89.85%)	inactive (102%)
EphB3	inactive (118.98%)	inactive (108%)
EphB4	inactive (82.02%)	inactive (67%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (68.86%)	active (46%)
PYK2	inactive (84.97%)	inactive (56%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (79.52%)	inactive (94%)
FES	inactive (66.22%)	inactive (58%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (84.16%)	inactive (87%)
FGFR2	inactive (94.48%)	inactive (101%)
FGFR3	inactive (95.09%)	inactive (106%)
FGFR4	inactive (86.51%)	inactive (114%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (93.35%)	inactive (68%)
FLT4	inactive (92.59%)	active (42%)
KDR	inactive (103.34%)	inactive (85%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (90.04%)	inactive (103%)
IRR	inactive (82.46%)	inactive (96%)
INSR	inactive (97.27%)	inactive (83%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (102.71%)	-
JAK2	inactive (100.73%)	inactive (92%)
JAK3	active (24.68%)	inactive (111%)
TYK2	inactive (105.38%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (58.6%)	inactive (75%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	inactive (82.91%)	inactive (93%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (101.4%)	inactive (74%)
MET	inactive (83.87%)	inactive (87%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (101.5%)	inactive (77%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (85.13%)	inactive (79%)
ZAP70	inactive (98.29%)	inactive (98%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (97.36%)	inactive (91%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (98.24%)	active (24%)
TRKB	inactive (66.11%)	active (8%)
TRKC	active (30.66%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (103.49%)	-
ALK2	inactive (80.29%)	-
ALK4	inactive (101.39%)	inactive (103%)
TGFbR1	inactive (97.68%)	inactive (79%)
TGFbR2	inactive (70.2%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (107.38%)	-
BRAF	inactive (97.01%)	-
RAF1	inactive (104.76%)	inactive (70%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (101.2%)	inactive (76%)
IRAK4	inactive (95.2%)	active (44%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (105.4%)	inactive (96%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (72.83%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	active (27.24%)	active (11%)
MLK2	inactive (90.34%)	-
MLK3	inactive (51.05%)	-
TAK1	inactive (92.71%)	inactive (77%)
ZAK	inactive (96.62%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (84.27%)	inactive (77%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (67.31%)	inactive (75%)
BRSK1	inactive (93.15%)	inactive (89%)
BRSK2	inactive (95.02%)	inactive (118%)
CHK1	inactive (87.1%)	active (38%)
LKB1	inactive (76.07%)	inactive (96%)
MARK1	inactive (87.63%)	active (50%)
MARK3	inactive (92.35%)	-
MARK4	inactive (88.09%)	-
MELK	inactive (59.7%)	inactive (56%)
PASK	inactive (92.66%)	inactive (113%)
QIK	inactive (106.69%)	-
NuaK2	inactive (89.81%)	-
MARK2	inactive (98.72%)	inactive (80%)
AMPKa1	-	inactive (76%)
AMPKa2	-	inactive (88%)
SIK	-	inactive (90%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (71.24%)	inactive (87%)
CaMK1b	inactive (100.49%)	-
CaMK1d	inactive (98.06%)	inactive (94%)
CaMK1g	inactive (98.74%)	-
CaMK4	inactive (100.71%)	inactive (103%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (99.14%)	-
CaMK2b	inactive (95.87%)	inactive (75%)
CaMK2d	inactive (84.2%)	active (19%)
CaMK2g	inactive (105.8%)	active (13%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (78.55%)	inactive (64%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (78.85%)	inactive (89%)
DAPK2	inactive (92.8%)	inactive (104%)
DRAK1	inactive (96.78%)	inactive (106%)
DAPK3	inactive (102.11%)	inactive (103%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (97.75%)	inactive (103%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (98.91%)	inactive (91%)
MAPKAPK3	inactive (91.02%)	inactive (116%)
MAPKAPK5	inactive (68.58%)	inactive (105%)
MNK1	inactive (98.7%)	-
MNK2	inactive (94.79%)	inactive (95%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (87.82%)	inactive (90%)
skMLCK	inactive (96.26%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (75.78%)	-
PHKg2	inactive (93.18%)	inactive (52%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (93.89%)	inactive (115%)
PIM2	inactive (96.97%)	inactive (137%)
PIM3	inactive (90.36%)	inactive (84%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (99.18%)	inactive (77%)
PKD3	inactive (88.42%)	-
PKD2	inactive (88.11%)	inactive (96%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (91.88%)	inactive (94%)
TSSK2	inactive (107.29%)	inactive (88%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (68.05%)	inactive (78%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (113.91%)	inactive (90%)
MAP3K2	inactive (97.62%)	-
MAP3K3	inactive (97.39%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (92.16%)	-
NIK	inactive (97.36%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (87.61%)	active (35%)
HGK	inactive (75.48%)	-
KHS1	inactive (81.48%)	-
LOK	inactive (86.9%)	inactive (89%)
MINK	inactive (86.31%)	inactive (98%)
MST1	inactive (93.08%)	inactive (61%)
MST2	inactive (94.56%)	inactive (71%)
MST3	inactive (87.68%)	inactive (62%)
MST4	inactive (87.88%)	-
OSR1	inactive (97.75%)	-
PAK1	inactive (97.14%)	-
PAK2	inactive (105.68%)	inactive (109%)
PAK3	inactive (96.68%)	inactive (111%)
PAK4	inactive (104.52%)	inactive (62%)
PAK5	inactive (80.39%)	inactive (80%)
PAK6	-	active (43%)
SLK	inactive (84.84%)	-
YSK1	inactive (92.87%)	-
STLK3	inactive (100.16%)	-
TAO1	inactive (94.44%)	inactive (87%)
TAO2	inactive (97.19%)	inactive (70%)
TAO3	inactive (91.77%)	inactive (93%)
MYO3B	active (0%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (92.78%)	inactive (81%)
MAP2K2	inactive (97.58%)	-
MAP2K6	inactive (88.92%)	inactive (73%)
MAP2K7	-	inactive (80%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (107.52%)	inactive (88%)
AurB	inactive (105.57%)	active (13%)
AurC	inactive (92.06%)	inactive (74%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (88.17%)	-
CaMKK2	inactive (68.21%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (94.7%)	inactive (80%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (96.06%)	inactive (114%)
IKKb	inactive (102.48%)	inactive (102%)
IKKe	inactive (97.57%)	-
TBK1	inactive (89.25%)	inactive (57%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (90.35%)	-
NEK11	inactive (109.24%)	active (43%)
NEK2	inactive (97.6%)	inactive (85%)
NEK4	inactive (89.1%)	-
NEK6	inactive (100.89%)	inactive (118%)
NEK7	inactive (93.85%)	inactive (102%)
NEK9	inactive (81.1%)	-
NEK3	inactive (92.59%)	inactive (76%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (101.1%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	active (44.1%)	active (30%)
PLK2	inactive (95.85%)	inactive (61%)
PLK3	active (48.53%)	inactive (93%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (96.96%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (89.84%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (82.53%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (77.59%)	-
ULK2	inactive (89.02%)	inactive (68%)
ULK3	active (0%)	active (42%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (98.94%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (93.6%)	inactive (90%)
Wnk3	inactive (77.68%)	inactive (88%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	active (0%)	inactive (82%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	active (48.51%)	active (37%)
CK1g1	active (16.03%)	active (8%)
CK1g2	active (20.61%)	active (4%)
CK1g3	active (6.89%)	inactive (56%)
CK1a	inactive (62.35%)	-
CK1e	inactive (65.38%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (96.34%)	-
VRK2	-	inactive (71%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (83.76%)	inactive (89%)
CK2a2	inactive (91.77%)	inactive (108%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (77.93%)	-
CLK2	active (25.01%)	active (19%)
CLK3	inactive (77.76%)	inactive (55%)
CLK4	active (36.06%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (88.63%)	-
DYRK1B	inactive (78.82%)	-
DYRK2	inactive (93.86%)	inactive (95%)
DYRK3	inactive (97.23%)	-
DYRK4	inactive (91.19%)	-
HIPK1	inactive (99.83%)	inactive (98%)
HIPK2	inactive (93.27%)	inactive (89%)
HIPK3	inactive (99.91%)	inactive (97%)
HIPK4	inactive (94.64%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (110.92%)	inactive (92%)
Erk2	inactive (106.92%)	inactive (117%)
JNK3	inactive (101.32%)	inactive (64%)
NLK	inactive (101.94%)	inactive (88%)
p38a	inactive (90.72%)	inactive (84%)
p38b	inactive (92.25%)	inactive (101%)
p38d	inactive (98.96%)	inactive (103%)
p38g	inactive (101.54%)	inactive (96%)
JNK1	inactive (94.79%)	inactive (103%)
JNK2	inactive (101.33%)	inactive (97%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (103.21%)	inactive (98%)
GSK3B	inactive (95.98%)	inactive (122%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	active (47.71%)	inactive (61%)
SRPK1	inactive (61.75%)	active (41%)
SRPK2	active (37.05%)	active (27%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (96.77%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (95%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (114%)