Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC, Millipore : DNA-PK Inhibitor III

Inchikey
Same : YHKSBKQXCWHTQL-N
RBC, Millipore : YHKSBKQXCWHTQL-UHFFFAOYSA-N

ChemSpider
RBC, Millipore : 8035009

Pubchem CID
RBC, Millipore : 9859309

ChEMBL
RBC, Millipore : CHEMBL1317546

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (111.01%)	inactive (115%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (103.22%)	inactive (101%)
AKT2	inactive (96.23%)	inactive (134%)
AKT3	inactive (106.85%)	inactive (106%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (104.92%)	inactive (112%)
MRCKa	inactive (100.45%)	inactive (105%)
MRCKb	inactive (87.17%)	inactive (100%)
ROCK1	inactive (92.94%)	inactive (120%)
ROCK2	inactive (94.7%)	inactive (92%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (98.96%)	-
BARK2	inactive (89.13%)	-
GPRK4	inactive (106.01%)	-
GPRK5	inactive (107.88%)	inactive (105%)
GPRK6	inactive (100.21%)	inactive (95%)
GPRK7	inactive (100.39%)	inactive (95%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (105.18%)	inactive (133%)
MSK2	inactive (103.07%)	inactive (92%)
p70S6K	inactive (95.16%)	inactive (55%)
p70S6Kb	inactive (101.01%)	-
RSK2	inactive (101.37%)	inactive (64%)
RSK4	inactive (95.13%)	inactive (128%)
RSK1	inactive (92.44%)	inactive (105%)
RSK3	inactive (98.64%)	inactive (121%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	-	-
PRKX	inactive (104.67%)	inactive (106%)
PKACa	inactive (101.52%)	inactive (87%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (73.36%)	inactive (101%)
PKCd	inactive (97.41%)	inactive (101%)
PKCe	inactive (93.44%)	inactive (91%)
PKCh	inactive (99.32%)	inactive (92%)
PKCg	inactive (98.68%)	inactive (109%)
PKCi	inactive (96.26%)	inactive (84%)
PKCt	inactive (99.52%)	inactive (109%)
PKCz	inactive (110.65%)	inactive (107%)
PKCb	inactive (97.85%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (106.55%)	-
PKG1	inactive (100.47%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (107.55%)	-
PKN2	inactive (94.82%)	inactive (100%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (97.21%)	inactive (109%)
SGK2	inactive (101.25%)	inactive (105%)
SGK3	inactive (104.91%)	inactive (113%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	active (0%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (98.92%)	inactive (108%)
ABL2	inactive (104.28%)	inactive (110%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (101.23%)	inactive (94%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (105.71%)	inactive (80%)
LTK	inactive (101.62%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (96.3%)	inactive (110%)
MER	inactive (100.86%)	inactive (115%)
TYRO3	inactive (89.15%)	inactive (86%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (102.32%)	inactive (126%)
BRK	inactive (104.46%)	inactive (108%)
SRC	inactive (103.52%)	inactive (86%)
FGR	inactive (95.61%)	inactive (110%)
FRK	inactive (91.62%)	inactive (109%)
FYN	inactive (102.67%)	inactive (80%)
HCK	inactive (116.38%)	inactive (84%)
LCK	inactive (100.01%)	inactive (138%)
SRM	inactive (94.71%)	-
YES	inactive (100.13%)	inactive (113%)
LYN	inactive (105.98%)	inactive (105%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (90.62%)	inactive (85%)
BTK	inactive (107.91%)	inactive (91%)
ITK	inactive (97.04%)	inactive (97%)
TEC	inactive (139.4%)	-
TXK	inactive (102.63%)	inactive (85%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (102.32%)	inactive (116%)
FLT3	inactive (102.02%)	inactive (102%)
FMS	inactive (100.21%)	inactive (123%)
PDGFRb	inactive (105.21%)	inactive (112%)
PDGFRa	inactive (94.71%)	inactive (121%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (99.07%)	inactive (120%)
CTK	inactive (92.07%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (104.3%)	inactive (112%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (97.41%)	inactive (120%)
ErbB2	inactive (98.15%)	-
ErbB4	inactive (107.34%)	inactive (93%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (93.96%)	inactive (94%)
EphA2	inactive (107.04%)	inactive (102%)
EphA3	inactive (107.66%)	inactive (107%)
EphA4	inactive (101.1%)	inactive (119%)
EphA5	inactive (108.82%)	inactive (117%)
EphA6	-	-
EphA7	inactive (95.48%)	inactive (101%)
EphA8	inactive (100.89%)	inactive (100%)
EphB1	inactive (102.96%)	inactive (93%)
EphB2	inactive (82.51%)	inactive (117%)
EphB3	inactive (92.32%)	inactive (105%)
EphB4	inactive (97.62%)	inactive (109%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (107.08%)	inactive (120%)
PYK2	inactive (101.71%)	inactive (124%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (90.39%)	inactive (113%)
FES	inactive (100.25%)	inactive (133%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (91.36%)	inactive (97%)
FGFR2	inactive (107.94%)	inactive (120%)
FGFR3	inactive (105.09%)	inactive (98%)
FGFR4	inactive (107.76%)	inactive (126%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (97.09%)	inactive (106%)
FLT4	inactive (112.3%)	inactive (93%)
KDR	inactive (97.67%)	inactive (106%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (105.52%)	inactive (148%)
IRR	inactive (96.74%)	inactive (113%)
INSR	inactive (93.99%)	inactive (122%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (104.25%)	-
JAK2	inactive (93.62%)	inactive (102%)
JAK3	inactive (103.59%)	inactive (102%)
TYK2	inactive (109.92%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (93.92%)	inactive (105%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	inactive (102.8%)	inactive (99%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (104.25%)	inactive (91%)
MET	inactive (121.69%)	inactive (115%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (101.75%)	inactive (94%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (92.63%)	inactive (129%)
ZAP70	inactive (99.51%)	inactive (84%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (101.21%)	inactive (79%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (97.22%)	inactive (106%)
TRKB	inactive (92.07%)	inactive (84%)
TRKC	inactive (100.97%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (102.54%)	-
ALK2	inactive (107.21%)	-
ALK4	inactive (100.17%)	inactive (129%)
TGFbR1	inactive (96.62%)	inactive (83%)
TGFbR2	inactive (131.67%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (93.58%)	-
BRAF	inactive (93.85%)	-
RAF1	inactive (96.17%)	inactive (83%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (111.07%)	inactive (105%)
IRAK4	inactive (120.03%)	inactive (95%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (93.63%)	inactive (104%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (96.1%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (112.26%)	inactive (89%)
MLK2	inactive (104.47%)	-
MLK3	inactive (94.81%)	-
TAK1	inactive (98.58%)	inactive (93%)
ZAK	inactive (97.81%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (103.4%)	inactive (95%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (92.78%)	inactive (97%)
BRSK1	inactive (97.59%)	inactive (93%)
BRSK2	inactive (100.06%)	inactive (110%)
CHK1	inactive (103.05%)	inactive (96%)
LKB1	inactive (103.31%)	inactive (97%)
MARK1	inactive (96.7%)	inactive (93%)
MARK3	inactive (107.84%)	-
MARK4	inactive (99.4%)	-
MELK	inactive (102.48%)	inactive (90%)
PASK	inactive (95.03%)	inactive (127%)
QIK	inactive (87.02%)	-
NuaK2	inactive (103.6%)	-
MARK2	inactive (107.12%)	inactive (93%)
AMPKa1	-	inactive (102%)
AMPKa2	-	inactive (114%)
SIK	-	inactive (90%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (102.26%)	inactive (108%)
CaMK1b	inactive (102.53%)	-
CaMK1d	inactive (96.89%)	inactive (98%)
CaMK1g	inactive (100.89%)	-
CaMK4	inactive (92.97%)	inactive (97%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (103.6%)	-
CaMK2b	inactive (105.27%)	inactive (89%)
CaMK2d	inactive (100.2%)	inactive (102%)
CaMK2g	inactive (90.21%)	inactive (103%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (104.06%)	inactive (94%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (92.81%)	inactive (111%)
DAPK2	inactive (106.34%)	inactive (100%)
DRAK1	inactive (95.88%)	inactive (124%)
DAPK3	inactive (98.11%)	inactive (106%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (101.43%)	inactive (75%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (102.55%)	inactive (100%)
MAPKAPK3	inactive (105.02%)	inactive (131%)
MAPKAPK5	inactive (96.95%)	inactive (77%)
MNK1	inactive (102%)	-
MNK2	inactive (90.65%)	inactive (105%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (91.14%)	inactive (83%)
skMLCK	inactive (98.63%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (96.54%)	-
PHKg2	inactive (98.07%)	inactive (107%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (97.15%)	inactive (82%)
PIM2	inactive (116.83%)	inactive (91%)
PIM3	inactive (115.18%)	inactive (96%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (102.28%)	inactive (92%)
PKD3	inactive (98.4%)	-
PKD2	inactive (97.42%)	inactive (93%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (106.95%)	inactive (98%)
TSSK2	inactive (101.69%)	inactive (89%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (108.65%)	inactive (92%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (99.38%)	inactive (92%)
MAP3K2	inactive (108.89%)	-
MAP3K3	inactive (107.64%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (99.4%)	-
NIK	inactive (82.63%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (116.48%)	inactive (91%)
HGK	inactive (96.94%)	-
KHS1	inactive (101.8%)	-
LOK	inactive (101.38%)	inactive (102%)
MINK	inactive (94.28%)	inactive (108%)
MST1	inactive (102.28%)	inactive (85%)
MST2	inactive (98.9%)	inactive (121%)
MST3	inactive (99.04%)	inactive (70%)
MST4	inactive (99.52%)	-
OSR1	inactive (115.38%)	-
PAK1	inactive (93.72%)	-
PAK2	inactive (98.81%)	inactive (104%)
PAK3	inactive (93.95%)	inactive (70%)
PAK4	inactive (103.04%)	inactive (100%)
PAK5	inactive (102.34%)	inactive (97%)
PAK6	inactive (93.66%)	inactive (95%)
SLK	inactive (105.07%)	-
YSK1	inactive (90.88%)	-
STLK3	inactive (90.93%)	-
TAO1	inactive (99.44%)	inactive (103%)
TAO2	inactive (106.84%)	inactive (92%)
TAO3	inactive (98.4%)	inactive (101%)
MYO3B	active (0%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (95.2%)	inactive (102%)
MAP2K2	inactive (99.76%)	-
MAP2K6	inactive (94.21%)	inactive (75%)
MAP2K7	-	inactive (104%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (132.41%)	inactive (109%)
AurB	inactive (91.45%)	inactive (100%)
AurC	inactive (103.99%)	inactive (106%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (123.81%)	-
CaMKK2	inactive (114.68%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (79.56%)	inactive (78%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (96.21%)	inactive (114%)
IKKb	inactive (103.16%)	inactive (104%)
IKKe	inactive (105.45%)	-
TBK1	inactive (99.05%)	inactive (74%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (114.03%)	-
NEK11	inactive (98.56%)	inactive (109%)
NEK2	inactive (81.32%)	inactive (84%)
NEK4	inactive (102.58%)	-
NEK6	inactive (96.5%)	inactive (114%)
NEK7	inactive (101.06%)	inactive (98%)
NEK9	inactive (93.92%)	-
NEK3	inactive (103.49%)	inactive (116%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (113.46%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (94.31%)	inactive (91%)
PLK2	inactive (104.32%)	inactive (103%)
PLK3	inactive (98.09%)	inactive (90%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (95.31%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (110.39%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (102.61%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (94.84%)	-
ULK2	inactive (114.2%)	inactive (106%)
ULK3	active (0%)	inactive (106%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (97.51%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (100.75%)	inactive (117%)
Wnk3	inactive (104.04%)	inactive (104%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	active (0%)	inactive (103%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (100.11%)	inactive (89%)
CK1g1	inactive (91.84%)	inactive (97%)
CK1g2	inactive (101.82%)	inactive (99%)
CK1g3	inactive (101%)	inactive (121%)
CK1a	inactive (110.35%)	-
CK1e	inactive (96.23%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (98.07%)	-
VRK2	-	inactive (107%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (101.2%)	inactive (81%)
CK2a2	inactive (98.77%)	inactive (128%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (109.83%)	-
CLK2	inactive (102.25%)	inactive (119%)
CLK3	inactive (100.71%)	inactive (85%)
CLK4	inactive (111.06%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (98.02%)	-
DYRK1B	inactive (99.94%)	-
DYRK2	inactive (101%)	inactive (108%)
DYRK3	inactive (93.87%)	-
DYRK4	inactive (95.59%)	-
HIPK1	inactive (93.87%)	inactive (97%)
HIPK2	inactive (106.13%)	inactive (100%)
HIPK3	inactive (101.09%)	inactive (95%)
HIPK4	inactive (100.78%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (102.66%)	inactive (91%)
Erk2	inactive (97.58%)	inactive (113%)
JNK3	inactive (78.43%)	inactive (88%)
NLK	inactive (95.56%)	inactive (97%)
p38a	inactive (97.09%)	inactive (110%)
p38b	inactive (99.8%)	inactive (106%)
p38d	inactive (104.19%)	inactive (113%)
p38g	inactive (78.71%)	inactive (110%)
JNK1	inactive (96.82%)	inactive (104%)
JNK2	inactive (104.55%)	inactive (101%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (100.87%)	inactive (125%)
GSK3B	inactive (121.5%)	inactive (101%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (103.73%)	inactive (121%)
SRPK1	inactive (90.73%)	inactive (98%)
SRPK2	inactive (98.59%)	inactive (98%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (111.01%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (86%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (117%)