Compound in Profiling

Compound Information

Test on : RBC

Compound Name : -

Inchikey : YUWFTONEHHSMEI-CZUORRHYSA-N

CANNOT FIND

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDK1	1	1
Akt	3	3
DMPK	7	5
GRK	7	6
RSK	8	8
PKA	5	3
PKC	9	9
PKG	2	3
PKN	3	2
SGK	3	3
NDR	4	1

AGC - PDK1

Bioactivity
Kinase	RBC
PDK1	inactive (86.82%)

AGC - Akt

Bioactivity
Kinase	RBC
AKT1	inactive (93.05%)
AKT2	inactive (89.75%)
AKT3	inactive (88.91%)

AGC - DMPK

Bioactivity
Kinase	RBC
DMPK1	inactive (100.18%)
MRCKa	inactive (77.75%)
MRCKb	inactive (87.43%)
ROCK1	inactive (99.67%)
ROCK2	inactive (97.73%)

AGC - GRK

Bioactivity
Kinase	RBC
BARK1	inactive (103.07%)
BARK2	inactive (96.6%)
GPRK4	inactive (94.39%)
GPRK5	inactive (104.75%)
GPRK6	inactive (94.96%)
GPRK7	inactive (94.68%)

AGC - RSK

Bioactivity
Kinase	RBC
MSK1	inactive (95.57%)
MSK2	inactive (98.49%)
p70S6K	inactive (90.63%)
p70S6Kb	inactive (103.94%)
RSK2	inactive (94.93%)
RSK4	inactive (101.59%)
RSK1	inactive (92.35%)
RSK3	inactive (95.74%)

AGC - PKA

Bioactivity
Kinase	RBC
PKACg	inactive (105.82%)
PRKX	inactive (100.07%)
PKACa	inactive (99.66%)

AGC - PKC

Bioactivity
Kinase	RBC
PKCa	inactive (99.33%)
PKCd	inactive (90.07%)
PKCe	inactive (96.78%)
PKCh	inactive (101.2%)
PKCg	inactive (120.5%)
PKCi	inactive (93.03%)
PKCt	inactive (102.23%)
PKCz	inactive (102.15%)
PKCb	inactive (93.57%)

AGC - PKG

Bioactivity
Kinase	RBC
PKG2	inactive (96.96%)
PKG1	inactive (76.82%)

AGC - PKN

Bioactivity
Kinase	RBC
PKN1	inactive (99.12%)
PKN2	inactive (99.24%)

AGC - SGK

Bioactivity
Kinase	RBC
SGK1	inactive (96.25%)
SGK2	inactive (97.15%)
SGK3	inactive (95.51%)

AGC - NDR

Bioactivity
Kinase	RBC
NDR1	inactive (87.94%)

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Abl	2	2
Ack	2	1
ALK	2	2
Axl	3	3
Src	11	11
Tec	5	5
PDGFR	5	5
Csk	2	2
DDR	2	1
EGFR	4	3
Eph	14	12
FAK	2	2
Fer	2	2
FGFR	4	4
VEGFR	3	3
InsR	3	3
JakA	4	4
Musk	1	1
Ret	1	1
Met	2	2
Sev	1	1
Syk	2	2
Tie	2	1
Trk	3	3

TK - Abl

Bioactivity
Kinase	RBC
ABL1	inactive (88.98%)
ABL2	inactive (90.45%)

TK - Ack

Bioactivity
Kinase	RBC
ACK	inactive (96.54%)

TK - ALK

Bioactivity
Kinase	RBC
ALK	-
LTK	inactive (95.66%)

TK - Axl

Bioactivity
Kinase	RBC
AXL	inactive (100.7%)
MER	inactive (67.71%)
TYRO3	inactive (101.93%)

TK - Src

Bioactivity
Kinase	RBC
BLK	inactive (96.77%)
BRK	active (48.33%)
SRC	inactive (98.62%)
FGR	inactive (70.24%)
FRK	inactive (87.18%)
FYN	inactive (92.72%)
HCK	inactive (88.65%)
LCK	inactive (81.82%)
SRM	inactive (105.23%)
YES	inactive (82.09%)
LYN	inactive (75.54%)

TK - Tec

Bioactivity
Kinase	RBC
BMX	inactive (93.59%)
BTK	inactive (98.57%)
ITK	inactive (96.93%)
TEC	inactive (119.4%)
TXK	inactive (100.7%)

TK - PDGFR

Bioactivity
Kinase	RBC
KIT	active (39.17%)
FLT3	inactive (82.12%)
FMS	inactive (51.12%)
PDGFRb	-
PDGFRa	inactive (92.23%)

TK - Csk

Bioactivity
Kinase	RBC
CSK	inactive (99.96%)
CTK	inactive (96.79%)

TK - DDR

Bioactivity
Kinase	RBC
DDR2	inactive (67.61%)

TK - EGFR

Bioactivity
Kinase	RBC
EGFR	inactive (88.13%)
ErbB2	inactive (116.46%)
ErbB4	-

TK - Eph

Bioactivity
Kinase	RBC
EphA1	inactive (96.93%)
EphA2	inactive (104.19%)
EphA3	inactive (98.54%)
EphA4	inactive (93.37%)
EphA5	inactive (81.77%)
EphA6	inactive (77.74%)
EphA7	inactive (86.35%)
EphA8	inactive (104.69%)
EphB1	inactive (95.54%)
EphB2	inactive (90.79%)
EphB3	inactive (93.72%)
EphB4	inactive (89.42%)

TK - FAK

Bioactivity
Kinase	RBC
FAK	inactive (99.55%)
PYK2	inactive (88.04%)

TK - Fer

Bioactivity
Kinase	RBC
FER	inactive (74.07%)
FES	inactive (96.01%)

TK - FGFR

Bioactivity
Kinase	RBC
FGFR1	inactive (75.36%)
FGFR2	inactive (91.27%)
FGFR3	inactive (84.46%)
FGFR4	inactive (73.92%)

TK - VEGFR

Bioactivity
Kinase	RBC
FLT1	inactive (65.17%)
FLT4	active (38.52%)
KDR	active (19.71%)

TK - InsR

Bioactivity
Kinase	RBC
IGF1R	inactive (77%)
IRR	inactive (98.38%)
INSR	inactive (92.38%)

TK - JakA

Bioactivity
Kinase	RBC
JAK1	inactive (99.21%)
JAK2	inactive (96.94%)
JAK3	inactive (88.94%)
TYK2	inactive (95.19%)

TK - Musk

Bioactivity
Kinase	RBC
MUSK	inactive (100.97%)

TK - Ret

Bioactivity
Kinase	RBC
RET	active (8.42%)

TK - Met

Bioactivity
Kinase	RBC
RON	inactive (89.33%)
MET	inactive (73.63%)

TK - Sev

Bioactivity
Kinase	RBC
ROS	inactive (97.59%)

TK - Syk

Bioactivity
Kinase	RBC
SYK	inactive (97.51%)
ZAP70	inactive (101.83%)

TK - Tie

Bioactivity
Kinase	RBC
TIE2	inactive (86.99%)

TK - Trk

Bioactivity
Kinase	RBC
TRKA	inactive (93.19%)
TRKB	inactive (101.9%)
TRKC	inactive (89.04%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STKR	12	5
RAF	5	3
IRAK	4	2
LISK	4	1
LRRK	2	1
MLK	10	5
RIPK	5	1

TKL - STKR

Bioactivity
Kinase	RBC
ALK1	inactive (100.33%)
ALK2	inactive (100.56%)
ALK4	inactive (99.56%)
TGFbR1	inactive (101.59%)
TGFbR2	inactive (109.11%)

TKL - RAF

Bioactivity
Kinase	RBC
ARAF	inactive (87.51%)
BRAF	inactive (95.09%)
RAF1	inactive (85.39%)

TKL - IRAK

Bioactivity
Kinase	RBC
IRAK1	inactive (106.06%)
IRAK4	inactive (92.01%)

TKL - LISK

Bioactivity
Kinase	RBC
LIMK1	inactive (81.63%)

TKL - LRRK

Bioactivity
Kinase	RBC
LRRK2	inactive (94.1%)

TKL - MLK

Bioactivity
Kinase	RBC
MLK1	inactive (88.85%)
MLK2	inactive (102.56%)
MLK3	inactive (89.18%)
TAK1	inactive (102.52%)
ZAK	inactive (103.47%)

TKL - RIPK

Bioactivity
Kinase	RBC
RIPK2	inactive (84.79%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CAMKL	20	13
CAMK1	5	5
CAMK2	4	4
RAD53	1	1
DAPK	5	4
DCAMKL	3	1
MAPKAPK	5	5
MLCK	5	2
PHK	2	2
PIM	3	3
PKD	3	3
TSSK	5	2
STK33	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC
NuaK1	inactive (92.31%)
BRSK1	inactive (98.52%)
BRSK2	inactive (96.67%)
CHK1	inactive (76.99%)
LKB1	inactive (87.25%)
MARK1	inactive (97.55%)
MARK3	inactive (95.31%)
MARK4	inactive (110.34%)
MELK	inactive (86.77%)
PASK	inactive (87.71%)
QIK	inactive (101.35%)
NuaK2	inactive (123.19%)
MARK2	inactive (96.17%)

CAMK - CAMK1

Bioactivity
Kinase	RBC
CaMK1a	inactive (96.72%)
CaMK1b	inactive (95.4%)
CaMK1d	inactive (96.84%)
CaMK1g	inactive (103.39%)
CaMK4	inactive (99.11%)

CAMK - CAMK2

Bioactivity
Kinase	RBC
CaMK2a	inactive (97.52%)
CaMK2b	inactive (94.91%)
CaMK2d	inactive (89.37%)
CaMK2g	inactive (90.52%)

CAMK - RAD53

Bioactivity
Kinase	RBC
CHK2	inactive (79.96%)

CAMK - DAPK

Bioactivity
Kinase	RBC
DAPK1	inactive (104.41%)
DAPK2	inactive (107.92%)
DRAK1	inactive (98.98%)
DAPK3	inactive (88.77%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC
DCLK2	inactive (96.39%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC
MAPKAPK2	inactive (101.29%)
MAPKAPK3	inactive (95.81%)
MAPKAPK5	inactive (92.18%)
MNK1	inactive (95.24%)
MNK2	inactive (81.26%)

CAMK - MLCK

Bioactivity
Kinase	RBC
smMLCK	inactive (97.37%)
skMLCK	inactive (99.93%)

CAMK - PHK

Bioactivity
Kinase	RBC
PHKg1	inactive (91.26%)
PHKg2	inactive (84.05%)

CAMK - PIM

Bioactivity
Kinase	RBC
PIM1	inactive (101.56%)
PIM2	inactive (100.93%)
PIM3	inactive (81.28%)

CAMK - PKD

Bioactivity
Kinase	RBC
PKD1	inactive (92.89%)
PKD3	inactive (93.39%)
PKD2	inactive (94.34%)

CAMK - TSSK

Bioactivity
Kinase	RBC
TSSK1	inactive (80.36%)
TSSK2	inactive (98.73%)

CAMK - STK33

Bioactivity
Kinase	RBC
STK33	inactive (88.05%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STE11	8	3
STE-Unique	2	2
STE20	31	23
STE7	7	3

STE - STE11

Bioactivity
Kinase	RBC
MAP3K5	inactive (102.49%)
MAP3K2	inactive (89.49%)
MAP3K3	inactive (95.31%)

STE - STE-Unique

Bioactivity
Kinase	RBC
COT	inactive (104.18%)
NIK	inactive (108.87%)

STE - STE20

Bioactivity
Kinase	RBC
GCK	inactive (83.1%)
HGK	inactive (86.45%)
KHS1	inactive (54.6%)
LOK	active (34.96%)
MINK	inactive (90.13%)
MST1	inactive (92.78%)
MST2	inactive (84.98%)
MST3	inactive (91.73%)
MST4	inactive (86.89%)
OSR1	inactive (96.49%)
PAK1	inactive (93.79%)
PAK2	inactive (81.45%)
PAK3	inactive (94.66%)
PAK4	inactive (95.66%)
PAK5	inactive (84.55%)
PAK6	inactive (106.49%)
SLK	inactive (80%)
YSK1	inactive (92.6%)
STLK3	inactive (87.98%)
TAO1	inactive (92.2%)
TAO2	inactive (94.53%)
TAO3	inactive (95.87%)
MYO3B	inactive (76.17%)

STE - STE7

Bioactivity
Kinase	RBC
MAP2K1	inactive (99.16%)
MAP2K2	inactive (99.85%)
MAP2K6	inactive (106.35%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Aur	3	3
CAMKK	2	2
Haspin	1	1
IKK	4	4
NEK	11	8
TOPK	1	1
PLK	4	3
SgK496	1	1
NAK	4	1
TTK	1	1
ULK	5	3
WEE	3	1
WNK	4	2
TLK	2	1

Other - Aur

Bioactivity
Kinase	RBC
AurA	inactive (89.2%)
AurB	active (36.97%)
AurC	inactive (71.63%)

Other - CAMKK

Bioactivity
Kinase	RBC
CaMKK1	inactive (93.09%)
CaMKK2	inactive (91.53%)

Other - Haspin

Bioactivity
Kinase	RBC
Haspin	inactive (99.06%)

Other - IKK

Bioactivity
Kinase	RBC
IKKa	inactive (84.88%)
IKKb	inactive (100.17%)
IKKe	inactive (93.48%)
TBK1	inactive (90.02%)

Other - NEK

Bioactivity
Kinase	RBC
NEK1	inactive (91.77%)
NEK11	inactive (100.9%)
NEK2	inactive (92.34%)
NEK4	inactive (75.97%)
NEK6	inactive (104.8%)
NEK7	inactive (102.65%)
NEK9	inactive (83.32%)
NEK3	inactive (93.77%)

Other - TOPK

Bioactivity
Kinase	RBC
PBK	inactive (66.2%)

Other - PLK

Bioactivity
Kinase	RBC
PLK1	inactive (101.25%)
PLK2	inactive (104.04%)
PLK3	inactive (94.97%)

Other - SgK496

Bioactivity
Kinase	RBC
SgK496	inactive (88.6%)

Other - NAK

Bioactivity
Kinase	RBC
MPSK1	inactive (93.39%)

Other - TTK

Bioactivity
Kinase	RBC
TTK	inactive (88.61%)

Other - ULK

Bioactivity
Kinase	RBC
ULK1	inactive (83.24%)
ULK2	inactive (89.19%)
ULK3	inactive (80.73%)

Other - WEE

Bioactivity
Kinase	RBC
Wee1	inactive (92.91%)

Other - WNK

Bioactivity
Kinase	RBC
Wnk2	inactive (100.06%)
Wnk3	inactive (93.75%)

Other - TLK

Bioactivity
Kinase	RBC
TLK2	inactive (99.49%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK1	7	6
VRK	3	1

CK1 - CK1

Bioactivity
Kinase	RBC
CK1d	inactive (98.95%)
CK1g1	inactive (97.08%)
CK1g2	inactive (84.78%)
CK1g3	inactive (104.55%)
CK1a	inactive (98.85%)
CK1e	inactive (78.53%)

CK1 - VRK

Bioactivity
Kinase	RBC
VRK1	inactive (103.96%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK2	3	2
CLK	4	4
DYRK	10	9
MAPK	14	10
GSK	2	2
SRPK	3	3

CMGC - CK2

Bioactivity
Kinase	RBC
CK2a1	inactive (105.24%)
CK2a2	-

CMGC - CLK

Bioactivity
Kinase	RBC
CLK1	inactive (96.16%)
CLK2	inactive (89.5%)
CLK3	inactive (98.83%)
CLK4	inactive (94.2%)

CMGC - DYRK

Bioactivity
Kinase	RBC
DYRK1A	inactive (96.9%)
DYRK1B	inactive (104.47%)
DYRK2	inactive (108.36%)
DYRK3	inactive (99.75%)
DYRK4	inactive (106.3%)
HIPK1	inactive (96.76%)
HIPK2	inactive (97.91%)
HIPK3	inactive (96.21%)
HIPK4	inactive (93.49%)

CMGC - MAPK

Bioactivity
Kinase	RBC
Erk1	inactive (105.25%)
Erk2	inactive (100.68%)
JNK3	inactive (100.1%)
NLK	inactive (90.72%)
p38a	inactive (122.47%)
p38b	inactive (88.47%)
p38d	inactive (100.46%)
p38g	inactive (61.89%)
JNK1	inactive (107.47%)
JNK2	inactive (103.9%)

CMGC - GSK

Bioactivity
Kinase	RBC
GSK3A	inactive (98.76%)
GSK3B	inactive (91.34%)

CMGC - SRPK

Bioactivity
Kinase	RBC
MSSK1	inactive (95.84%)
SRPK1	inactive (102.28%)
SRPK2	inactive (91.08%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDHK	5	1

Atypical - PDHK

Bioactivity
Kinase	RBC
PDHK1	inactive (86.82%)