Compound in Profiling

Compound Information

Test on : DRx, RBC, Metz

Compound Name
DRx, RBC, Metz : Dasatinib

Inchikey
Same : ZBNZXTGUTAYRHI-N
DRx, RBC, Metz : ZBNZXTGUTAYRHI-UHFFFAOYSA-N

ChemSpider
DRx, RBC, Metz : 2323020

Pubchem CID
DRx, RBC, Metz : 3062316

ChEMBL
DRx, RBC, Metz : CHEMBL1421

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

Other

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
NAK	4	4	1	-
Aur	3	3	3	2
CAMKK	2	2	2	1
PEK	4	2	-	-
IRE	2	1	-	-
IKK	4	4	4	4
NEK	11	9	8	2
WEE	3	3	1	1
PLK	4	4	3	3
SgK496	1	1	1	-
NKF1	3	2	-	-
NKF4	2	1	-	-
ULK	5	4	3	-
TLK	2	2	1	-
TTK	1	1	1	-
Haspin	1	-	1	-
TOPK	1	-	1	1
WNK	4	-	2	-
CDC7	1	-	-	1

Other - NAK

Bioactivity
Kinase	DRx	RBC	Metz
AAK1	inactive (10001nM)	-	-
BIKE	inactive (10001nM)	-	-
GAK	active (2.6nM)	-	-
MPSK1	inactive (10001nM)	inactive (96.9%)	-

Other - Aur

Bioactivity
Kinase	DRx	RBC	Metz
AurA	inactive (9300nM)	inactive (93.22%)	inactive (>1000nM)
AurB	inactive (10001nM)	inactive (92.53%)	inactive (1258.93nM)
AurC	inactive (10001nM)	inactive (84.82%)	-

Other - CAMKK

Bioactivity
Kinase	DRx	RBC	Metz
CaMKK1	inactive (10001nM)	inactive (99.75%)	-
CaMKK2	inactive (10001nM)	inactive (101.46%)	inactive (>2511.89nM)

Other - PEK

Bioactivity
Kinase	DRx	RBC	Metz
HRI	inactive (10001nM)	-	-
PKR	inactive (10001nM)	-	-

Other - IRE

Bioactivity
Kinase	DRx	RBC	Metz
IRE1	inactive (10001nM)	-	-

Other - IKK

Bioactivity
Kinase	DRx	RBC	Metz
IKKa	inactive (10001nM)	inactive (95.05%)	inactive (>3981.07nM)
IKKb	inactive (10001nM)	inactive (94.03%)	inactive (>3162.28nM)
IKKe	inactive (10001nM)	inactive (90.01%)	inactive (>3162.28nM)
TBK1	inactive (10001nM)	inactive (90.77%)	inactive (>3162.28nM)

Other - NEK

Bioactivity
Kinase	DRx	RBC	Metz
NEK1	inactive (10001nM)	inactive (89.81%)	-
NEK11	active (470nM)	active (21.66%)	-
NEK2	inactive (6500nM)	inactive (102.56%)	inactive (>6309.57nM)
NEK3	inactive (10001nM)	inactive (94.1%)	-
NEK4	inactive (10001nM)	inactive (90.71%)	inactive (>6309.57nM)
NEK5	inactive (10001nM)	-	-
NEK6	inactive (10001nM)	inactive (86.19%)	-
NEK7	inactive (10001nM)	inactive (90.99%)	-
NEK9	inactive (10001nM)	inactive (98.3%)	-

Other - WEE

Bioactivity
Kinase	DRx	RBC	Metz
MYT1	active (130nM)	-	-
Wee1	inactive (7000nM)	inactive (92.61%)	-
Wee1B	active (200nM)	-	-

Other - PLK

Bioactivity
Kinase	DRx	RBC	Metz
PLK1	inactive (10001nM)	inactive (98.05%)	inactive (>7943.28nM)
PLK2	inactive (10001nM)	inactive (97.99%)	-
PLK3	inactive (10001nM)	inactive (105.02%)	inactive (>7943.28nM)
PLK4	inactive (10001nM)	-	inactive (1995.26nM)

Other - SgK496

Bioactivity
Kinase	DRx	RBC	Metz
SgK496	inactive (10001nM)	inactive (99.35%)	-

Other - NKF1

Bioactivity
Kinase	DRx	RBC	Metz
SBK	active (1200nM)	-	-
SgK110	inactive (10001nM)	-	-

Other - NKF4

Bioactivity
Kinase	DRx	RBC	Metz
CLIK1	active (770nM)	-	-

Other - ULK

Bioactivity
Kinase	DRx	RBC	Metz
Fused	active (210nM)	-	-
ULK1	inactive (10001nM)	inactive (85.49%)	-
ULK2	inactive (10001nM)	inactive (94.18%)	-
ULK3	inactive (4600nM)	inactive (102.87%)	-

Other - TLK

Bioactivity
Kinase	DRx	RBC	Metz
TLK1	inactive (10001nM)	-	-
TLK2	inactive (10001nM)	inactive (94.4%)	-

Other - TTK

Bioactivity
Kinase	DRx	RBC	Metz
TTK	inactive (10001nM)	inactive (104.91%)	-

Other - Haspin

Bioactivity
Kinase	DRx	RBC	Metz
Haspin	-	inactive (91.94%)	-

Other - TOPK

Bioactivity
Kinase	DRx	RBC	Metz
PBK	-	inactive (101.05%)	inactive (>10000nM)

Other - WNK

Bioactivity
Kinase	DRx	RBC	Metz
Wnk2	-	inactive (83.9%)	-
Wnk3	-	inactive (88.07%)	-

Other - CDC7

Bioactivity
Kinase	DRx	RBC	Metz
CDC7	-	-	inactive (>1258.93nM)

TK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
Abl	2	2	2	1
ALK	2	2	2	2
Axl	3	3	3	2
Src	11	11	11	9
Tec	5	5	5	3
PDGFR	5	5	5	5
Csk	2	2	2	1
DDR	2	2	1	-
EGFR	4	4	3	3
Eph	14	13	12	1
FAK	2	2	2	2
Fer	2	2	2	2
FGFR	4	4	4	2
VEGFR	3	3	3	3
InsR	3	3	3	2
JakA	4	4	4	3
Met	2	2	2	2
Musk	1	1	1	-
Ret	1	1	1	1
Sev	1	1	1	1
Syk	2	2	2	1
Tie	2	2	1	-
Ack	2	2	1	1
Trk	3	3	3	3

TK - Abl

Bioactivity
Kinase	DRx	RBC	Metz
ABL1	active (0.03nM)	active (2.77%)	-
ABL2	active (0.17nM)	active (2.74%)	-

TK - ALK

Bioactivity
Kinase	DRx	RBC	Metz
ALK	inactive (10001nM)	inactive (109.91%)	inactive (>5011.87nM)
LTK	inactive (10001nM)	inactive (97.75%)	inactive (>2511.89nM)

TK - Axl

Bioactivity
Kinase	DRx	RBC	Metz
AXL	inactive (10001nM)	inactive (61.36%)	inactive (1995.26nM)
MER	inactive (10001nM)	inactive (103.38%)	-
TYRO3	inactive (10001nM)	inactive (87.6%)	inactive (>1258.93nM)

TK - Src

Bioactivity
Kinase	DRx	RBC	Metz
BLK	active (0.21nM)	active (3.04%)	-
BRK	active (7.8nM)	active (4.59%)	active (5.01nM)
FGR	active (0.5nM)	active (1.7%)	-
FRK	active (0.31nM)	active (-0.88%)	-
FYN	active (0.79nM)	active (1.96%)	-
HCK	active (0.35nM)	active (0.79%)	active (0.32nM)
LCK	active (0.2nM)	active (0.31%)	-
LYN	active (0.57nM)	active (0.43%)	-
SRC	active (0.21nM)	active (3.52%)	-
SRM	active (13nM)	active (16.98%)	active (0.63nM)
YES	active (0.3nM)	active (1.94%)	-

TK - Tec

Bioactivity
Kinase	DRx	RBC	Metz
BMX	active (1.4nM)	active (2.53%)	-
BTK	active (1.4nM)	active (2.09%)	-
ITK	inactive (10001nM)	inactive (102.72%)	inactive (>1584.89nM)
TEC	active (13nM)	active (11.28%)	-
TXK	active (2.1nM)	active (1.37%)	-

TK - PDGFR

Bioactivity
Kinase	DRx	RBC	Metz
FMS	active (0.58nM)	active (0.77%)	inactive (>6.31nM)
FLT3	inactive (4800nM)	inactive (71.02%)	inactive (>1995.26nM)
KIT	active (0.81nM)	active (3.27%)	inactive (>3162.28nM)
PDGFRa	active (0.47nM)	active (1.82%)	active (10nM)
PDGFRb	active (0.63nM)	active (2.48%)	active (1.26nM)

TK - Csk

Bioactivity
Kinase	DRx	RBC	Metz
CSK	active (1nM)	active (7.11%)	-
CTK	inactive (10001nM)	inactive (79.03%)	inactive (>1995.26nM)

TK - DDR

Bioactivity
Kinase	DRx	RBC	Metz
DDR1	active (0.69nM)	-	-
DDR2	active (3.2nM)	active (0.24%)	-

TK - EGFR

Bioactivity
Kinase	DRx	RBC	Metz
EGFR	active (120nM)	active (21.08%)	inactive (>1000nM)
ErbB2	active (1400nM)	inactive (79.85%)	active (158.49nM)
ErbB3	active (18nM)	-	-
ErbB4	active (55nM)	active (4.03%)	active (39.81nM)

TK - Eph

Bioactivity
Kinase	DRx	RBC	Metz
EphA1	active (4.1nM)	active (2.72%)	-
EphA2	active (0.85nM)	active (6.82%)	active (3.98nM)
EphA3	active (0.09nM)	active (3.46%)	-
EphA4	active (1.2nM)	active (1.63%)	-
EphA5	active (0.24nM)	active (0.24%)	-
EphA6	active (2100nM)	inactive (50.45%)	-
EphA7	inactive (10001nM)	inactive (94.32%)	-
EphA8	active (0.24nM)	active (4.13%)	-
EphB1	active (0.45nM)	active (4.8%)	-
EphB2	active (0.39nM)	active (-0.19%)	-
EphB3	active (6.9nM)	active (0.99%)	-
EphB4	active (0.34nM)	active (1.17%)	-
EphB6	active (0.04nM)	-	-

TK - FAK

Bioactivity
Kinase	DRx	RBC	Metz
FAK	inactive (10001nM)	inactive (103.4%)	inactive (>3981.07nM)
PYK2	inactive (10001nM)	inactive (97.74%)	inactive (>1584.89nM)

TK - Fer

Bioactivity
Kinase	DRx	RBC	Metz
FER	inactive (10001nM)	inactive (95.86%)	inactive (>1584.89nM)
FES	inactive (10001nM)	inactive (110.14%)	inactive (1995.26nM)

TK - FGFR

Bioactivity
Kinase	DRx	RBC	Metz
FGFR1	inactive (3700nM)	inactive (88.45%)	inactive (1995.26nM)
FGFR2	active (1400nM)	inactive (73.67%)	-
FGFR3	inactive (3900nM)	inactive (86.17%)	inactive (1258.93nM)
FGFR4	inactive (10001nM)	inactive (91.11%)	-

TK - VEGFR

Bioactivity
Kinase	DRx	RBC	Metz
FLT1	inactive (5000nM)	inactive (97.29%)	inactive (>1995.26nM)
FLT4	inactive (10001nM)	inactive (92.08%)	inactive (>5011.87nM)
KDR	active (2900nM)	inactive (102.69%)	inactive (1258.93nM)

TK - InsR

Bioactivity
Kinase	DRx	RBC	Metz
IGF1R	inactive (10001nM)	inactive (97.48%)	inactive (>1995.26nM)
INSR	inactive (10001nM)	inactive (97.23%)	inactive (>5011.87nM)
IRR	inactive (10001nM)	inactive (96.89%)	-

TK - JakA

Bioactivity
Kinase	DRx	RBC	Metz
JAK1	inactive (10001nM)	inactive (100.97%)	-
JAK2	active (1000nM)	inactive (98.1%)	inactive (1258.93nM)
JAK3	active (640nM)	inactive (93.43%)	inactive (>3981.07nM)
TYK2	active (1800nM)	inactive (95.56%)	inactive (>1995.26nM)

TK - Met

Bioactivity
Kinase	DRx	RBC	Metz
MET	inactive (10001nM)	inactive (88.05%)	inactive (>3162.28nM)
RON	inactive (10001nM)	inactive (105.71%)	inactive (>3162.28nM)

TK - Musk

Bioactivity
Kinase	DRx	RBC	Metz
MUSK	inactive (10001nM)	inactive (105.64%)	-

TK - Ret

Bioactivity
Kinase	DRx	RBC	Metz
RET	active (730nM)	active (45.99%)	inactive (>1000nM)

TK - Sev

Bioactivity
Kinase	DRx	RBC	Metz
ROS	inactive (10001nM)	inactive (88.88%)	inactive (>2511.89nM)

TK - Syk

Bioactivity
Kinase	DRx	RBC	Metz
SYK	active (2900nM)	inactive (65.46%)	active (199.53nM)
ZAP70	inactive (10001nM)	inactive (117.42%)	-

TK - Tie

Bioactivity
Kinase	DRx	RBC	Metz
TIE1	inactive (10001nM)	-	-
TIE2	inactive (10001nM)	inactive (91.28%)	-

TK - Ack

Bioactivity
Kinase	DRx	RBC	Metz
TNK1	inactive (10001nM)	-	-
ACK	active (5.6nM)	active (2.62%)	active (2.51nM)

TK - Trk

Bioactivity
Kinase	DRx	RBC	Metz
TRKA	inactive (10001nM)	inactive (97.19%)	inactive (>2511.89nM)
TRKB	inactive (10001nM)	inactive (96.45%)	inactive (>3981.07nM)
TRKC	inactive (10001nM)	inactive (65.29%)	inactive (>2511.89nM)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
STKR	12	10	5	1
RIPK	5	4	1	-
RAF	5	2	3	1
MLK	10	8	5	2
IRAK	4	3	2	2
LISK	4	3	1	1
LRRK	2	1	1	1

TKL - STKR

Bioactivity
Kinase	DRx	RBC	Metz
ALK2	active (620nM)	inactive (196.97%)	active (79.43nM)
ALK4	active (330nM)	inactive (108.71%)	-
ACTR2	active (210nM)	-	-
ACTR2B	active (570nM)	-	-
ALK1	active (460nM)	active (15.93%)	-
BMPR1A	inactive (7000nM)	-	-
BMPR1B	active (53nM)	-	-
BMPR2	inactive (10001nM)	-	-
TGFbR1	active (230nM)	inactive (76.74%)	-
TGFbR2	active (2900nM)	inactive (98.29%)	-

TKL - RIPK

Bioactivity
Kinase	DRx	RBC	Metz
SgK288	inactive (10001nM)	-	-
RIPK1	inactive (10001nM)	-	-
RIPK2	active (31nM)	active (25.2%)	-
ANKRD3	inactive (10001nM)	-	-

TKL - RAF

Bioactivity
Kinase	DRx	RBC	Metz
BRAF	active (500nM)	inactive (52.13%)	-
RAF1	active (570nM)	active (39.66%)	-
ARAF	-	active (33.76%)	-

TKL - MLK

Bioactivity
Kinase	DRx	RBC	Metz
DLK	inactive (10001nM)	-	-
LZK	inactive (5300nM)	-	-
MLK1	inactive (10001nM)	inactive (99.56%)	-
MLK2	inactive (10001nM)	inactive (93.68%)	inactive (2511.89nM)
MLK3	inactive (10001nM)	inactive (87.5%)	-
TAK1	inactive (3700nM)	inactive (87.31%)	-
HH498	active (11nM)	-	-
ZAK	active (45nM)	active (8.63%)	active (50.12nM)

TKL - IRAK

Bioactivity
Kinase	DRx	RBC	Metz
IRAK1	inactive (10001nM)	inactive (98.15%)	inactive (>7943.28nM)
IRAK3	inactive (10001nM)	-	-
IRAK4	inactive (10001nM)	inactive (88.46%)	inactive (5011.87nM)

TKL - LISK

Bioactivity
Kinase	DRx	RBC	Metz
LIMK1	active (570nM)	active (16.71%)	active (251.19nM)
LIMK2	active (86nM)	-	-
TESK1	active (33nM)	-	-

TKL - LRRK

Bioactivity
Kinase	DRx	RBC	Metz
LRRK2	inactive (10001nM)	inactive (99.42%)	inactive (>2511.89nM)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
ABC1	5	2	-	-
PIKK	6	1	-	-
RIO	3	3	-	-
Alpha	6	1	-	1
PDHK	5	-	1	-

Atypical - ABC1

Bioactivity
Kinase	DRx	RBC	Metz
ADCK3	active (190nM)	-	-
ADCK4	inactive (10001nM)	-	-

Atypical - PIKK

Bioactivity
Kinase	DRx	RBC	Metz
FRAP	inactive (10001nM)	-	-

Atypical - RIO

Bioactivity
Kinase	DRx	RBC	Metz
RIOK1	inactive (10001nM)	-	-
RIOK2	inactive (10001nM)	-	-
RIOK3	inactive (10001nM)	-	-

Atypical - Alpha

Bioactivity
Kinase	DRx	RBC	Metz
ChaK2	inactive (10001nM)	-	-
eEF2K	-	-	inactive (>3981.07nM)

Atypical - PDHK

Bioactivity
Kinase	DRx	RBC	Metz
PDHK1	-	inactive (94.13%)	-

AGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
Akt	3	3	3	3
DMPK	7	7	5	3
GRK	7	3	6	1
NDR	4	4	1	-
MAST	5	1	-	-
PDK1	1	1	1	1
PKA	5	3	3	2
PKN	3	2	2	1
PKC	9	5	9	5
PKG	2	2	3	2
RSK	8	1	8	4
SGK	3	1	3	1
YANK	3	3	-	-

AGC - Akt

Bioactivity
Kinase	DRx	RBC	Metz
AKT1	inactive (10001nM)	inactive (96.7%)	inactive (>7943.28nM)
AKT2	inactive (10001nM)	inactive (94.1%)	inactive (>7943.28nM)
AKT3	inactive (10001nM)	inactive (89.91%)	inactive (>10000nM)

AGC - DMPK

Bioactivity
Kinase	DRx	RBC	Metz
CRIK	inactive (10001nM)	-	-
DMPK1	active (1300nM)	inactive (106.83%)	-
DMPK2	active (1200nM)	-	-
MRCKa	active (2000nM)	inactive (99.22%)	inactive (6309.57nM)
MRCKb	active (2100nM)	inactive (98.84%)	-
ROCK1	inactive (10001nM)	inactive (105.37%)	inactive (>6309.57nM)
ROCK2	inactive (10001nM)	inactive (90.06%)	inactive (>6309.57nM)

AGC - GRK

Bioactivity
Kinase	DRx	RBC	Metz
RHOK	inactive (10001nM)	-	-
GPRK4	inactive (10001nM)	inactive (94.15%)	-
GPRK7	inactive (10001nM)	inactive (102.6%)	-
BARK1	-	inactive (96.96%)	-
BARK2	-	inactive (101.53%)	-
GPRK5	-	inactive (105.6%)	inactive (>3981.07nM)
GPRK6	-	inactive (100.73%)	-

AGC - NDR

Bioactivity
Kinase	DRx	RBC	Metz
LATS1	inactive (10001nM)	-	-
LATS2	inactive (10001nM)	-	-
NDR1	inactive (10001nM)	inactive (101.48%)	-
NDR2	inactive (10001nM)	-	-

AGC - MAST

Bioactivity
Kinase	DRx	RBC	Metz
MAST1	inactive (10001nM)	-	-

AGC - PDK1

Bioactivity
Kinase	DRx	RBC	Metz
PDK1	inactive (10001nM)	inactive (94.13%)	inactive (>3981.07nM)

AGC - PKA

Bioactivity
Kinase	DRx	RBC	Metz
PKACa	inactive (10001nM)	inactive (101.59%)	inactive (>3981.07nM)
PKACb	inactive (10001nM)	-	-
PRKX	inactive (10001nM)	inactive (105.03%)	inactive (>2511.89nM)
PKACg	-	inactive (114.3%)	-

AGC - PKN

Bioactivity
Kinase	DRx	RBC	Metz
PKN1	inactive (10001nM)	inactive (90.01%)	-
PKN2	inactive (10001nM)	inactive (103.29%)	inactive (5011.87nM)

AGC - PKC

Bioactivity
Kinase	DRx	RBC	Metz
PKCd	inactive (10001nM)	inactive (99.57%)	inactive (>7943.28nM)
PKCe	inactive (10001nM)	inactive (102.31%)	-
PKCh	inactive (10001nM)	inactive (105.8%)	-
PKCi	inactive (10001nM)	inactive (100.83%)	inactive (>5011.87nM)
PKCt	inactive (10001nM)	inactive (97.28%)	inactive (>2511.89nM)
PKCa	-	inactive (103.01%)	-
PKCg	-	inactive (86.19%)	inactive (>7943.28nM)
PKCz	-	inactive (100.58%)	inactive (>7943.28nM)
PKCb	-	inactive (88.86%)	-

AGC - PKG

Bioactivity
Kinase	DRx	RBC	Metz
PKG1	inactive (10001nM)	inactive (84.62%)	inactive (>1995.26nM)
PKG2	inactive (10001nM)	inactive (104.4%)	inactive (>1584.89nM)

AGC - RSK

Bioactivity
Kinase	DRx	RBC	Metz
p70S6K	inactive (10001nM)	inactive (102.41%)	inactive (>6309.57nM)
MSK1	-	inactive (100.61%)	inactive (>1995.26nM)
MSK2	-	inactive (106.81%)	-
p70S6Kb	-	inactive (101.47%)	-
RSK2	-	inactive (99.83%)	inactive (>3981.07nM)
RSK4	-	inactive (101.23%)	-
RSK1	-	inactive (96.24%)	-
RSK3	-	inactive (93.9%)	-

AGC - SGK

Bioactivity
Kinase	DRx	RBC	Metz
SGK3	inactive (10001nM)	inactive (101.99%)	-
SGK1	-	inactive (131.93%)	inactive (>7943.28nM)
SGK2	-	inactive (106.62%)	-

AGC - YANK

Bioactivity
Kinase	DRx	RBC	Metz
YANK1	inactive (10001nM)	-	-
YANK2	inactive (10001nM)	-	-
YANK3	inactive (10001nM)	-	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
CAMKL	20	19	13	9
CAMK1	5	4	5	2
CAMK2	4	4	4	4
CASK	1	1	-	-
RAD53	1	1	1	1
DAPK	5	5	4	2
DCAMKL	3	3	1	1
MAPKAPK	5	4	5	4
MLCK	5	4	2	-
PHK	2	2	2	1
PIM	3	3	3	3
PKD	3	3	3	2
STK33	1	1	-	1
TSSK	5	1	2	2

CAMK - CAMKL

Bioactivity
Kinase	DRx	RBC	Metz
AMPKa1	inactive (10001nM)	-	inactive (>5011.87nM)
AMPKa2	inactive (10001nM)	-	-
NuaK1	inactive (10001nM)	inactive (110.42%)	-
BRSK1	inactive (10001nM)	inactive (102.96%)	inactive (>10000nM)
BRSK2	inactive (10001nM)	inactive (99.18%)	-
CHK1	inactive (10001nM)	inactive (95.99%)	inactive (>6309.57nM)
HUNK	inactive (10001nM)	-	-
LKB1	inactive (10001nM)	inactive (107.79%)	-
MARK1	inactive (10001nM)	inactive (106.86%)	-
MARK2	inactive (10001nM)	inactive (109.6%)	inactive (>7943.28nM)
MARK3	inactive (10001nM)	inactive (97.78%)	inactive (>5011.87nM)
MARK4	inactive (10001nM)	inactive (90.93%)	inactive (>5011.87nM)
MELK	inactive (10001nM)	inactive (81.38%)	inactive (>1995.26nM)
NIM1	inactive (10001nM)	-	-
QSK	active (28nM)	-	-
SIK	active (3.9nM)	-	-
QIK	active (6.4nM)	active (1.91%)	active (0.79nM)
NuaK2	inactive (10001nM)	inactive (100.84%)	-
SNRK	inactive (10001nM)	-	-
PASK	-	inactive (109.65%)	-

CAMK - CAMK1

Bioactivity
Kinase	DRx	RBC	Metz
CaMK1a	inactive (10001nM)	inactive (105.77%)	inactive (>6309.57nM)
CaMK1d	inactive (10001nM)	inactive (104.74%)	inactive (>2511.89nM)
CaMK1g	inactive (10001nM)	inactive (104.01%)	-
CaMK4	inactive (10001nM)	inactive (91.32%)	-
CaMK1b	-	inactive (102.39%)	-

CAMK - CAMK2

Bioactivity
Kinase	DRx	RBC	Metz
CaMK2a	inactive (10001nM)	inactive (103.21%)	inactive (>5011.87nM)
CaMK2b	inactive (10001nM)	inactive (97.31%)	inactive (>7943.28nM)
CaMK2d	inactive (10001nM)	inactive (109.11%)	inactive (>6309.57nM)
CaMK2g	inactive (10001nM)	inactive (103.32%)	inactive (>6309.57nM)

CAMK - CASK

Bioactivity
Kinase	DRx	RBC	Metz
CASK	inactive (10001nM)	-	-

CAMK - RAD53

Bioactivity
Kinase	DRx	RBC	Metz
CHK2	inactive (10001nM)	inactive (103.19%)	inactive (>5011.87nM)

CAMK - DAPK

Bioactivity
Kinase	DRx	RBC	Metz
DAPK1	inactive (10001nM)	inactive (121.98%)	-
DAPK2	inactive (10001nM)	inactive (91.22%)	-
DAPK3	inactive (10001nM)	inactive (106.96%)	inactive (>2511.89nM)
DRAK1	inactive (10001nM)	inactive (106.96%)	inactive (>3981.07nM)
DRAK2	inactive (10001nM)	-	-

CAMK - DCAMKL

Bioactivity
Kinase	DRx	RBC	Metz
DCLK1	inactive (10001nM)	-	inactive (>10000nM)
DCLK2	inactive (10001nM)	inactive (99.83%)	-
DCLK3	inactive (10001nM)	-	-

CAMK - MAPKAPK

Bioactivity
Kinase	DRx	RBC	Metz
MAPKAPK2	inactive (10001nM)	inactive (99.53%)	inactive (>7943.28nM)
MAPKAPK5	inactive (10001nM)	inactive (94.94%)	inactive (>1584.89nM)
MNK1	inactive (10001nM)	inactive (91.34%)	-
MNK2	inactive (10001nM)	inactive (100.27%)	inactive (>10000nM)
MAPKAPK3	-	inactive (100.9%)	inactive (>10000nM)

CAMK - MLCK

Bioactivity
Kinase	DRx	RBC	Metz
caMLCK	inactive (10001nM)	-	-
smMLCK	inactive (10001nM)	inactive (92.29%)	-
skMLCK	inactive (3500nM)	inactive (97.31%)	-
SgK085	inactive (10001nM)	-	-

CAMK - PHK

Bioactivity
Kinase	DRx	RBC	Metz
PHKg1	inactive (10001nM)	inactive (94.33%)	-
PHKg2	inactive (10001nM)	inactive (101.21%)	inactive (>5011.87nM)

CAMK - PIM

Bioactivity
Kinase	DRx	RBC	Metz
PIM1	inactive (10001nM)	inactive (102.17%)	inactive (>6309.57nM)
PIM2	inactive (10001nM)	inactive (112.82%)	inactive (>1584.89nM)
PIM3	inactive (10001nM)	inactive (96.26%)	inactive (>7943.28nM)

CAMK - PKD

Bioactivity
Kinase	DRx	RBC	Metz
PKD1	inactive (10001nM)	inactive (98.94%)	-
PKD2	inactive (10001nM)	inactive (93.01%)	inactive (>10000nM)
PKD3	inactive (10001nM)	inactive (89.94%)	inactive (>3981.07nM)

CAMK - STK33

Bioactivity
Kinase	DRx	RBC	Metz
STK33	inactive (10001nM)	inactive (88.69%)	-

CAMK - TSSK

Bioactivity
Kinase	DRx	RBC	Metz
TSSK1	inactive (10001nM)	inactive (93.77%)	inactive (>1584.89nM)
TSSK2	-	inactive (93.88%)	inactive (>1584.89nM)

STE

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
STE11	8	8	3	-
STE20	31	27	23	9
STE7	7	7	3	2
STE-Unique	2	-	2	-

STE - STE11

Bioactivity
Kinase	DRx	RBC	Metz
MAP3K5	inactive (10001nM)	inactive (97.25%)	-
MAP3K6	inactive (10001nM)	-	-
MAP3K1	inactive (10001nM)	-	-
MAP3K7	inactive (10001nM)	-	-
MAP3K2	active (140nM)	inactive (100.02%)	-
MAP3K3	active (280nM)	inactive (87.79%)	-
MAP3K4	active (310nM)	-	-
MAP3K8	active (79nM)	-	-

STE - STE20

Bioactivity
Kinase	DRx	RBC	Metz
HPK1	active (980nM)	-	-
LOK	active (1200nM)	inactive (51.97%)	-
GCK	active (1300nM)	inactive (79.44%)	inactive (>1584.89nM)
KHS2	active (640nM)	-	-
HGK	inactive (3100nM)	active (49.2%)	inactive (>3162.28nM)
KHS1	active (45nM)	active (3.07%)	active (15.85nM)
MINK	active (430nM)	active (46.54%)	active (794.33nM)
MST1	inactive (3800nM)	inactive (96.32%)	-
MST2	inactive (10001nM)	inactive (90.65%)	inactive (>6309.57nM)
MST3	inactive (10001nM)	inactive (103.89%)	-
MST4	active (1900nM)	inactive (84.13%)	-
MYO3A	inactive (10001nM)	-	-
MYO3B	inactive (10001nM)	inactive (84.82%)	-
OSR1	inactive (10001nM)	inactive (99.86%)	-
PAK1	inactive (10001nM)	inactive (102.2%)	inactive (>10000nM)
PAK2	inactive (10001nM)	inactive (113%)	-
PAK3	inactive (10001nM)	inactive (104.62%)	-
PAK4	inactive (10001nM)	inactive (98.71%)	inactive (>5011.87nM)
PAK6	inactive (10001nM)	inactive (135.67%)	-
PAK5	inactive (10001nM)	inactive (91.06%)	-
SLK	active (720nM)	inactive (81.1%)	active (630.96nM)
STLK3	inactive (10001nM)	inactive (92.8%)	-
TAO1	inactive (10001nM)	inactive (101.17%)	active (1000nM)
TAO2	inactive (5400nM)	inactive (86.68%)	-
TAO3	active (2300nM)	inactive (95.32%)	-
TNIK	active (2000nM)	-	-
YSK1	inactive (3400nM)	inactive (83.83%)	-

STE - STE7

Bioactivity
Kinase	DRx	RBC	Metz
MAP2K1	active (1000nM)	inactive (119.91%)	active (630.96nM)
MAP2K2	active (1400nM)	inactive (102.09%)	inactive (1584.89nM)
MAP2K3	inactive (10001nM)	-	-
MAP2K4	inactive (10001nM)	-	-
MAP2K5	active (3.3nM)	-	-
MAP2K6	inactive (10001nM)	inactive (95.15%)	-
MAP2K7	inactive (10001nM)	-	-

STE - STE-Unique

Bioactivity
Kinase	DRx	RBC	Metz
COT	-	inactive (97.56%)	-
NIK	-	inactive (97.49%)	-

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
CDK	20	8	-	7
CDKL	5	4	-	-
CLK	4	4	4	2
CK2	3	2	2	1
DYRK	10	8	9	6
MAPK	14	14	10	8
GSK	2	2	2	2
RCK	3	2	-	-
SRPK	3	3	3	1

CMGC - CDK

Bioactivity
Kinase	DRx	RBC	Metz
PITSLRE	inactive (10001nM)	-	-
CHED	inactive (10001nM)	-	-
CDK11	inactive (10001nM)	-	-
PCTAIRE1	inactive (10001nM)	-	-
PCTAIRE2	inactive (10001nM)	-	-
PCTAIRE3	inactive (10001nM)	-	-
PFTAIRE2	inactive (10001nM)	-	-
PFTAIRE1	inactive (10001nM)	-	-
CDC2	-	-	inactive (>7943.28nM)
CDK2	-	-	inactive (>7943.28nM)
CDK5	-	-	inactive (>7943.28nM)
CDK8	-	-	inactive (>3981.07nM)
CDK7	-	-	inactive (>3981.07nM)
CDK9	-	-	inactive (>1584.89nM)

CMGC - CDKL

Bioactivity
Kinase	DRx	RBC	Metz
CDKL1	inactive (10001nM)	-	-
CDKL2	inactive (10001nM)	-	-
CDKL3	inactive (10001nM)	-	-
CDKL5	inactive (10001nM)	-	-

CMGC - CLK

Bioactivity
Kinase	DRx	RBC	Metz
CLK1	inactive (10001nM)	inactive (102.24%)	-
CLK2	inactive (10001nM)	inactive (87.18%)	inactive (>3162.28nM)
CLK3	inactive (10001nM)	inactive (95.25%)	-
CLK4	inactive (10001nM)	inactive (91.44%)	inactive (>2511.89nM)

CMGC - CK2

Bioactivity
Kinase	DRx	RBC	Metz
CK2a1	inactive (10001nM)	inactive (105.07%)	inactive (>6309.57nM)
CK2a2	inactive (10001nM)	inactive (103.46%)	-

CMGC - DYRK

Bioactivity
Kinase	DRx	RBC	Metz
DYRK1A	inactive (10001nM)	inactive (105.65%)	inactive (>3981.07nM)
DYRK1B	inactive (10001nM)	inactive (98.39%)	inactive (>2511.89nM)
DYRK2	inactive (10001nM)	inactive (113.47%)	-
HIPK1	inactive (10001nM)	inactive (99.48%)	-
HIPK2	inactive (10001nM)	inactive (97.11%)	inactive (>3162.28nM)
HIPK3	inactive (10001nM)	inactive (100.21%)	-
HIPK4	inactive (10001nM)	inactive (98.36%)	inactive (>7943.28nM)
PRP4	inactive (10001nM)	-	-
DYRK3	-	inactive (108.74%)	inactive (1258.93nM)
DYRK4	-	inactive (100.49%)	inactive (>7943.28nM)

CMGC - MAPK

Bioactivity
Kinase	DRx	RBC	Metz
Erk1	inactive (10001nM)	inactive (100.46%)	-
Erk2	inactive (10001nM)	inactive (93.25%)	inactive (>7943.28nM)
Erk3	inactive (10001nM)	-	-
Erk4	inactive (10001nM)	-	-
Erk5	inactive (10001nM)	-	-
Erk7	inactive (10001nM)	-	-
JNK1	inactive (10001nM)	inactive (105.91%)	inactive (>3981.07nM)
JNK2	inactive (10001nM)	inactive (109.51%)	inactive (>3981.07nM)
JNK3	inactive (10001nM)	inactive (100.47%)	inactive (>3162.28nM)
NLK	active (260nM)	active (27.49%)	-
p38a	active (27nM)	active (36.53%)	active (31.62nM)
p38b	active (410nM)	inactive (76.58%)	-
p38d	inactive (10001nM)	inactive (99.26%)	inactive (>7943.28nM)
p38g	inactive (10001nM)	inactive (99.88%)	inactive (>6309.57nM)

CMGC - GSK

Bioactivity
Kinase	DRx	RBC	Metz
GSK3A	inactive (10001nM)	inactive (103.41%)	inactive (>6309.57nM)
GSK3B	inactive (10001nM)	inactive (97.33%)	inactive (>5011.87nM)

CMGC - RCK

Bioactivity
Kinase	DRx	RBC	Metz
ICK	inactive (10001nM)	-	-
MAK	inactive (10001nM)	-	-

CMGC - SRPK

Bioactivity
Kinase	DRx	RBC	Metz
SRPK1	inactive (10001nM)	inactive (100.55%)	inactive (>7943.28nM)
SRPK2	inactive (10001nM)	inactive (103.76%)	-
MSSK1	inactive (10001nM)	inactive (101.86%)	-

CK1

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
CK1	7	7	6	5
VRK	3	1	1	-

CK1 - CK1

Bioactivity
Kinase	DRx	RBC	Metz
CK1a	inactive (10001nM)	inactive (98.25%)	inactive (>5011.87nM)
CK1a2	inactive (10001nM)	-	-
CK1d	inactive (10001nM)	inactive (84.09%)	inactive (>7943.28nM)
CK1e	active (1500nM)	inactive (89.5%)	-
CK1g1	inactive (10001nM)	inactive (96.56%)	inactive (>6309.57nM)
CK1g2	inactive (10001nM)	inactive (97.24%)	inactive (>7943.28nM)
CK1g3	inactive (10001nM)	inactive (97.19%)	inactive (>6309.57nM)

CK1 - VRK

Bioactivity
Kinase	DRx	RBC	Metz
VRK2	inactive (3200nM)	-	-
VRK1	-	inactive (97.72%)	-