Compound in Profiling

Compound Information

Test on : RBC

Compound Name : GSK-3beta Inhibitor XI

Inchikey : ZDEJZKULWCZIHL-UHFFFAOYSA-N

ChemSpider : 8196286

Pubchem CID : 10020713

ChEMBL : CHEMBL272629

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDK1	1	1
Akt	3	3
DMPK	7	5
GRK	7	6
RSK	8	8
PKA	5	3
PKC	9	9
PKG	2	3
PKN	3	2
SGK	3	3
NDR	4	1

AGC - PDK1

Bioactivity
Kinase	RBC
PDK1	inactive (92.24%)

AGC - Akt

Bioactivity
Kinase	RBC
AKT1	inactive (98.61%)
AKT2	inactive (113.92%)
AKT3	inactive (101.31%)

AGC - DMPK

Bioactivity
Kinase	RBC
DMPK1	inactive (99.58%)
MRCKa	inactive (78.62%)
MRCKb	inactive (101.78%)
ROCK1	inactive (90.24%)
ROCK2	inactive (95.97%)

AGC - GRK

Bioactivity
Kinase	RBC
BARK1	inactive (113.78%)
BARK2	inactive (99.89%)
GPRK4	inactive (90.13%)
GPRK5	inactive (115.75%)
GPRK6	inactive (102.25%)
GPRK7	inactive (117.82%)

AGC - RSK

Bioactivity
Kinase	RBC
MSK1	inactive (73.91%)
MSK2	inactive (100.98%)
p70S6K	inactive (90.15%)
p70S6Kb	inactive (94.72%)
RSK2	inactive (91.34%)
RSK4	inactive (73.04%)
RSK1	inactive (94.77%)
RSK3	inactive (73.16%)

AGC - PKA

Bioactivity
Kinase	RBC
PKACg	-
PRKX	inactive (106.49%)
PKACa	inactive (87.7%)

AGC - PKC

Bioactivity
Kinase	RBC
PKCa	inactive (91.11%)
PKCd	inactive (97.02%)
PKCe	inactive (101.81%)
PKCh	inactive (81.6%)
PKCg	inactive (93.07%)
PKCi	inactive (86.97%)
PKCt	inactive (81.73%)
PKCz	inactive (88.47%)
PKCb	inactive (102.43%)

AGC - PKG

Bioactivity
Kinase	RBC
PKG2	inactive (117.63%)
PKG1	inactive (131.21%)

AGC - PKN

Bioactivity
Kinase	RBC
PKN1	inactive (97.77%)
PKN2	inactive (83.27%)

AGC - SGK

Bioactivity
Kinase	RBC
SGK1	inactive (91.19%)
SGK2	inactive (96.89%)
SGK3	inactive (124.16%)

AGC - NDR

Bioactivity
Kinase	RBC
NDR1	active (0%)

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Abl	2	2
Ack	2	1
ALK	2	2
Axl	3	3
Src	11	11
Tec	5	5
PDGFR	5	5
Csk	2	2
DDR	2	1
EGFR	4	3
Eph	14	12
FAK	2	2
Fer	2	2
FGFR	4	4
VEGFR	3	3
InsR	3	3
JakA	4	4
Musk	1	1
Ret	1	1
Met	2	2
Sev	1	1
Syk	2	2
Tie	2	1
Trk	3	3

TK - Abl

Bioactivity
Kinase	RBC
ABL1	inactive (98.88%)
ABL2	inactive (83.73%)

TK - Ack

Bioactivity
Kinase	RBC
ACK	inactive (90.7%)

TK - ALK

Bioactivity
Kinase	RBC
ALK	inactive (104.53%)
LTK	inactive (90.86%)

TK - Axl

Bioactivity
Kinase	RBC
AXL	inactive (103.99%)
MER	inactive (78.73%)
TYRO3	inactive (93.68%)

TK - Src

Bioactivity
Kinase	RBC
BLK	inactive (87.14%)
BRK	inactive (101.26%)
SRC	inactive (78.86%)
FGR	inactive (107.69%)
FRK	inactive (88.34%)
FYN	inactive (107.03%)
HCK	inactive (63.45%)
LCK	inactive (95.85%)
SRM	inactive (95.93%)
YES	inactive (80.15%)
LYN	inactive (112.33%)

TK - Tec

Bioactivity
Kinase	RBC
BMX	inactive (97.77%)
BTK	inactive (93.66%)
ITK	inactive (84.65%)
TEC	inactive (119.82%)
TXK	inactive (75.32%)

TK - PDGFR

Bioactivity
Kinase	RBC
KIT	inactive (93.01%)
FLT3	inactive (87.83%)
FMS	inactive (98.42%)
PDGFRb	inactive (102.49%)
PDGFRa	inactive (112.66%)

TK - Csk

Bioactivity
Kinase	RBC
CSK	inactive (86.92%)
CTK	inactive (95.54%)

TK - DDR

Bioactivity
Kinase	RBC
DDR2	inactive (94.63%)

TK - EGFR

Bioactivity
Kinase	RBC
EGFR	inactive (95.86%)
ErbB2	inactive (106.06%)
ErbB4	inactive (115.2%)

TK - Eph

Bioactivity
Kinase	RBC
EphA1	inactive (73.9%)
EphA2	inactive (105.22%)
EphA3	inactive (101.63%)
EphA4	inactive (99.5%)
EphA5	inactive (99.37%)
EphA6	-
EphA7	inactive (104.88%)
EphA8	inactive (86.91%)
EphB1	inactive (108.76%)
EphB2	inactive (78.26%)
EphB3	inactive (86.62%)
EphB4	inactive (95.16%)

TK - FAK

Bioactivity
Kinase	RBC
FAK	inactive (100.52%)
PYK2	inactive (94.01%)

TK - Fer

Bioactivity
Kinase	RBC
FER	inactive (99.2%)
FES	inactive (120.9%)

TK - FGFR

Bioactivity
Kinase	RBC
FGFR1	inactive (81.18%)
FGFR2	inactive (102.88%)
FGFR3	inactive (78.71%)
FGFR4	inactive (91.52%)

TK - VEGFR

Bioactivity
Kinase	RBC
FLT1	inactive (89.4%)
FLT4	inactive (92.3%)
KDR	inactive (82.06%)

TK - InsR

Bioactivity
Kinase	RBC
IGF1R	inactive (98.37%)
IRR	inactive (93.21%)
INSR	inactive (92.93%)

TK - JakA

Bioactivity
Kinase	RBC
JAK1	inactive (116.87%)
JAK2	inactive (97.81%)
JAK3	inactive (134.23%)
TYK2	inactive (96.88%)

TK - Musk

Bioactivity
Kinase	RBC
MUSK	inactive (67.15%)

TK - Ret

Bioactivity
Kinase	RBC
RET	inactive (54.53%)

TK - Met

Bioactivity
Kinase	RBC
RON	inactive (96.12%)
MET	inactive (120.57%)

TK - Sev

Bioactivity
Kinase	RBC
ROS	inactive (106.33%)

TK - Syk

Bioactivity
Kinase	RBC
SYK	inactive (60%)
ZAP70	inactive (87.78%)

TK - Tie

Bioactivity
Kinase	RBC
TIE2	inactive (103.13%)

TK - Trk

Bioactivity
Kinase	RBC
TRKA	inactive (88.09%)
TRKB	inactive (99.7%)
TRKC	inactive (79.66%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STKR	12	5
RAF	5	3
IRAK	4	2
LISK	4	1
LRRK	2	1
MLK	10	5
RIPK	5	1

TKL - STKR

Bioactivity
Kinase	RBC
ALK1	inactive (104.97%)
ALK2	inactive (96.99%)
ALK4	inactive (100.14%)
TGFbR1	inactive (98.49%)
TGFbR2	inactive (122.03%)

TKL - RAF

Bioactivity
Kinase	RBC
ARAF	inactive (93.55%)
BRAF	inactive (99.54%)
RAF1	inactive (100.01%)

TKL - IRAK

Bioactivity
Kinase	RBC
IRAK1	inactive (76.56%)
IRAK4	inactive (129.21%)

TKL - LISK

Bioactivity
Kinase	RBC
LIMK1	inactive (96.37%)

TKL - LRRK

Bioactivity
Kinase	RBC
LRRK2	inactive (90.01%)

TKL - MLK

Bioactivity
Kinase	RBC
MLK1	inactive (85.49%)
MLK2	inactive (91.31%)
MLK3	inactive (80.83%)
TAK1	inactive (95.54%)
ZAK	inactive (96.37%)

TKL - RIPK

Bioactivity
Kinase	RBC
RIPK2	inactive (90.94%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CAMKL	20	13
CAMK1	5	5
CAMK2	4	4
RAD53	1	1
DAPK	5	4
DCAMKL	3	1
MAPKAPK	5	5
MLCK	5	2
PHK	2	2
PIM	3	3
PKD	3	3
TSSK	5	2
STK33	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC
NuaK1	inactive (59.43%)
BRSK1	inactive (89.17%)
BRSK2	inactive (90.36%)
CHK1	inactive (141.17%)
LKB1	inactive (83.07%)
MARK1	inactive (94.98%)
MARK3	inactive (87.84%)
MARK4	inactive (93.86%)
MELK	inactive (100.74%)
PASK	inactive (97.11%)
QIK	inactive (100.65%)
NuaK2	inactive (92.27%)
MARK2	inactive (97.49%)

CAMK - CAMK1

Bioactivity
Kinase	RBC
CaMK1a	inactive (101.16%)
CaMK1b	inactive (94.87%)
CaMK1d	inactive (95.11%)
CaMK1g	inactive (101.24%)
CaMK4	inactive (95.64%)

CAMK - CAMK2

Bioactivity
Kinase	RBC
CaMK2a	inactive (107.77%)
CaMK2b	inactive (97.56%)
CaMK2d	inactive (100.54%)
CaMK2g	inactive (90.6%)

CAMK - RAD53

Bioactivity
Kinase	RBC
CHK2	inactive (97.7%)

CAMK - DAPK

Bioactivity
Kinase	RBC
DAPK1	inactive (74.36%)
DAPK2	inactive (88.41%)
DRAK1	inactive (93.62%)
DAPK3	inactive (80.16%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC
DCLK2	inactive (90.12%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC
MAPKAPK2	inactive (90.97%)
MAPKAPK3	inactive (102.58%)
MAPKAPK5	inactive (98.63%)
MNK1	inactive (100.27%)
MNK2	inactive (69.06%)

CAMK - MLCK

Bioactivity
Kinase	RBC
smMLCK	inactive (74.04%)
skMLCK	inactive (81.14%)

CAMK - PHK

Bioactivity
Kinase	RBC
PHKg1	inactive (87.21%)
PHKg2	inactive (101.73%)

CAMK - PIM

Bioactivity
Kinase	RBC
PIM1	active (43.9%)
PIM2	inactive (92.67%)
PIM3	active (16.66%)

CAMK - PKD

Bioactivity
Kinase	RBC
PKD1	inactive (106.53%)
PKD3	inactive (78.17%)
PKD2	inactive (117.82%)

CAMK - TSSK

Bioactivity
Kinase	RBC
TSSK1	inactive (94.9%)
TSSK2	inactive (118.59%)

CAMK - STK33

Bioactivity
Kinase	RBC
STK33	inactive (82.83%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STE11	8	3
STE-Unique	2	2
STE20	31	23
STE7	7	3

STE - STE11

Bioactivity
Kinase	RBC
MAP3K5	inactive (88.91%)
MAP3K2	inactive (96.93%)
MAP3K3	inactive (88.27%)

STE - STE-Unique

Bioactivity
Kinase	RBC
COT	inactive (96.96%)
NIK	inactive (78.1%)

STE - STE20

Bioactivity
Kinase	RBC
GCK	inactive (67.43%)
HGK	active (36.44%)
KHS1	active (37.54%)
LOK	inactive (103.77%)
MINK	inactive (84.75%)
MST1	inactive (83.63%)
MST2	inactive (74.43%)
MST3	inactive (72.05%)
MST4	inactive (78.68%)
OSR1	inactive (100.8%)
PAK1	inactive (100.51%)
PAK2	inactive (105.02%)
PAK3	inactive (92.85%)
PAK4	inactive (110.59%)
PAK5	inactive (88.18%)
PAK6	inactive (78.18%)
SLK	inactive (106.41%)
YSK1	inactive (78.92%)
STLK3	inactive (111.16%)
TAO1	inactive (132.33%)
TAO2	inactive (88.11%)
TAO3	inactive (88.17%)
MYO3B	active (0%)

STE - STE7

Bioactivity
Kinase	RBC
MAP2K1	inactive (106.29%)
MAP2K2	inactive (90.31%)
MAP2K6	inactive (91.06%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Aur	3	3
CAMKK	2	2
Haspin	1	1
IKK	4	4
NEK	11	8
TOPK	1	1
PLK	4	3
SgK496	1	1
NAK	4	1
TTK	1	1
ULK	5	3
WEE	3	1
WNK	4	2
TLK	2	1

Other - Aur

Bioactivity
Kinase	RBC
AurA	inactive (107.17%)
AurB	inactive (101.39%)
AurC	inactive (113.44%)

Other - CAMKK

Bioactivity
Kinase	RBC
CaMKK1	inactive (106.64%)
CaMKK2	inactive (115.49%)

Other - Haspin

Bioactivity
Kinase	RBC
Haspin	inactive (91.94%)

Other - IKK

Bioactivity
Kinase	RBC
IKKa	inactive (100.76%)
IKKb	inactive (87.29%)
IKKe	inactive (90.03%)
TBK1	inactive (98.78%)

Other - NEK

Bioactivity
Kinase	RBC
NEK1	inactive (91.92%)
NEK11	inactive (107.55%)
NEK2	inactive (97.49%)
NEK4	inactive (85.11%)
NEK6	inactive (94.23%)
NEK7	inactive (95.37%)
NEK9	inactive (93.36%)
NEK3	inactive (97.51%)

Other - TOPK

Bioactivity
Kinase	RBC
PBK	inactive (94.87%)

Other - PLK

Bioactivity
Kinase	RBC
PLK1	inactive (102.74%)
PLK2	inactive (103.76%)
PLK3	inactive (91.08%)

Other - SgK496

Bioactivity
Kinase	RBC
SgK496	inactive (78.04%)

Other - NAK

Bioactivity
Kinase	RBC
MPSK1	inactive (90.27%)

Other - TTK

Bioactivity
Kinase	RBC
TTK	inactive (94.53%)

Other - ULK

Bioactivity
Kinase	RBC
ULK1	inactive (102.2%)
ULK2	inactive (96.66%)
ULK3	active (0%)

Other - WEE

Bioactivity
Kinase	RBC
Wee1	inactive (96.19%)

Other - WNK

Bioactivity
Kinase	RBC
Wnk2	inactive (104.18%)
Wnk3	inactive (91.29%)

Other - TLK

Bioactivity
Kinase	RBC
TLK2	active (0%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK1	7	6
VRK	3	1

CK1 - CK1

Bioactivity
Kinase	RBC
CK1d	inactive (99.37%)
CK1g1	inactive (100.84%)
CK1g2	inactive (66.01%)
CK1g3	inactive (106.62%)
CK1a	inactive (66.99%)
CK1e	inactive (93.92%)

CK1 - VRK

Bioactivity
Kinase	RBC
VRK1	inactive (86.4%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK2	3	2
CLK	4	4
DYRK	10	9
MAPK	14	10
GSK	2	2
SRPK	3	3

CMGC - CK2

Bioactivity
Kinase	RBC
CK2a1	inactive (78.86%)
CK2a2	-

CMGC - CLK

Bioactivity
Kinase	RBC
CLK1	inactive (88.45%)
CLK2	inactive (98.92%)
CLK3	inactive (67.81%)
CLK4	inactive (99.97%)

CMGC - DYRK

Bioactivity
Kinase	RBC
DYRK1A	inactive (107.64%)
DYRK1B	inactive (93.25%)
DYRK2	inactive (81.67%)
DYRK3	inactive (79.63%)
DYRK4	inactive (98.42%)
HIPK1	inactive (84.15%)
HIPK2	inactive (96.58%)
HIPK3	inactive (89.15%)
HIPK4	inactive (104.41%)

CMGC - MAPK

Bioactivity
Kinase	RBC
Erk1	inactive (94.46%)
Erk2	inactive (81.94%)
JNK3	inactive (87.97%)
NLK	inactive (91.24%)
p38a	inactive (106.56%)
p38b	inactive (104.61%)
p38d	inactive (96.48%)
p38g	inactive (86.78%)
JNK1	inactive (99.55%)
JNK2	inactive (100.29%)

CMGC - GSK

Bioactivity
Kinase	RBC
GSK3A	active (8.56%)
GSK3B	active (25.18%)

CMGC - SRPK

Bioactivity
Kinase	RBC
MSSK1	inactive (91.15%)
SRPK1	inactive (97.99%)
SRPK2	inactive (97.93%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDHK	5	1

Atypical - PDHK

Bioactivity
Kinase	RBC
PDHK1	inactive (92.24%)