Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC, Millipore : JNJ-10198409

Inchikey
Same : ZDNURMVOKAERHZ-N
RBC, Millipore : ZDNURMVOKAERHZ-UHFFFAOYSA-N

ChemSpider
RBC, Millipore : 7973136

Pubchem CID
RBC, Millipore : 9797370

ChEMBL
RBC, Millipore : CHEMBL120077

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (95.95%)	inactive (104%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (93.3%)	inactive (107%)
AKT2	inactive (95.28%)	inactive (96%)
AKT3	inactive (96.1%)	inactive (88%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (108.82%)	inactive (123%)
MRCKa	inactive (119.08%)	inactive (116%)
MRCKb	inactive (99.25%)	inactive (84%)
ROCK1	inactive (87.46%)	inactive (122%)
ROCK2	inactive (95.24%)	inactive (90%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (92.96%)	-
BARK2	inactive (98.39%)	-
GPRK4	inactive (97.11%)	-
GPRK5	inactive (95.84%)	inactive (96%)
GPRK6	inactive (89.37%)	inactive (89%)
GPRK7	inactive (100.86%)	inactive (89%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (96.02%)	inactive (121%)
MSK2	inactive (99.79%)	inactive (96%)
p70S6K	inactive (99.13%)	inactive (63%)
p70S6Kb	inactive (100.47%)	-
RSK2	inactive (94.73%)	inactive (63%)
RSK4	inactive (93.65%)	inactive (105%)
RSK1	inactive (84.1%)	inactive (93%)
RSK3	inactive (91.39%)	inactive (112%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	inactive (102%)	-
PRKX	inactive (102.73%)	inactive (89%)
PKACa	inactive (92.84%)	inactive (89%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (99.19%)	inactive (104%)
PKCd	inactive (111.26%)	inactive (102%)
PKCe	inactive (87.93%)	inactive (90%)
PKCh	inactive (92.14%)	inactive (102%)
PKCg	inactive (102.44%)	inactive (104%)
PKCi	inactive (95.5%)	inactive (87%)
PKCt	inactive (107.78%)	inactive (92%)
PKCz	inactive (99.7%)	inactive (111%)
PKCb	inactive (103.2%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (92.47%)	-
PKG1	inactive (95.2%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (106.24%)	-
PKN2	inactive (92%)	inactive (93%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (99.85%)	inactive (70%)
SGK2	inactive (98.58%)	inactive (109%)
SGK3	inactive (92.68%)	inactive (91%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	inactive (113.08%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	active (44.02%)	active (12%)
ABL2	active (21.44%)	active (12%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	active (15.07%)	active (6%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (102.58%)	inactive (74%)
LTK	inactive (93.34%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (96.1%)	inactive (71%)
MER	inactive (78.69%)	inactive (95%)
TYRO3	inactive (97.19%)	inactive (87%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (74.2%)	active (14%)
BRK	inactive (80.97%)	inactive (78%)
SRC	inactive (63.37%)	active (44%)
FGR	active (47.25%)	active (20%)
FRK	inactive (67.95%)	active (25%)
FYN	inactive (73.4%)	active (16%)
HCK	inactive (61.91%)	active (22%)
LCK	active (41.29%)	active (24%)
SRM	inactive (99.9%)	-
YES	inactive (61.3%)	active (17%)
LYN	inactive (60.25%)	active (6%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (74.8%)	active (24%)
BTK	active (40.8%)	active (22%)
ITK	inactive (85.51%)	inactive (86%)
TEC	inactive (94.97%)	-
TXK	inactive (60.59%)	inactive (64%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	active (27.9%)	active (0%)
FLT3	active (25%)	active (47%)
FMS	active (19.98%)	active (1%)
PDGFRb	active (45.32%)	active (11%)
PDGFRa	active (33.4%)	active (2%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	active (44.92%)	inactive (80%)
CTK	inactive (92.06%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (109.99%)	inactive (96%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (83.28%)	inactive (120%)
ErbB2	inactive (101.18%)	-
ErbB4	inactive (96.51%)	inactive (94%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (101.92%)	inactive (81%)
EphA2	inactive (93.75%)	inactive (95%)
EphA3	inactive (94.47%)	inactive (83%)
EphA4	inactive (93.34%)	inactive (97%)
EphA5	inactive (93.4%)	inactive (103%)
EphA6	inactive (82.74%)	-
EphA7	inactive (98.03%)	inactive (88%)
EphA8	inactive (94.24%)	inactive (69%)
EphB1	inactive (100.31%)	inactive (83%)
EphB2	inactive (94.85%)	inactive (101%)
EphB3	inactive (97.21%)	inactive (112%)
EphB4	inactive (95.31%)	inactive (77%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (88.25%)	inactive (96%)
PYK2	inactive (98.01%)	inactive (79%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (94%)	inactive (100%)
FES	inactive (95.61%)	inactive (94%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (99.18%)	inactive (91%)
FGFR2	inactive (100.42%)	inactive (91%)
FGFR3	inactive (99.64%)	inactive (111%)
FGFR4	inactive (91.64%)	inactive (117%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (82.59%)	inactive (62%)
FLT4	inactive (82.56%)	active (42%)
KDR	inactive (98.74%)	inactive (75%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (93.88%)	inactive (105%)
IRR	inactive (99.17%)	inactive (99%)
INSR	inactive (100.82%)	inactive (114%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (97.6%)	-
JAK2	inactive (107.11%)	inactive (93%)
JAK3	inactive (98.6%)	inactive (102%)
TYK2	inactive (81.33%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (82.68%)	inactive (63%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	inactive (83.57%)	inactive (64%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (99.13%)	inactive (89%)
MET	inactive (97.8%)	inactive (92%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (97.47%)	inactive (85%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (103.31%)	inactive (117%)
ZAP70	inactive (95.28%)	inactive (99%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (92.46%)	inactive (87%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (98.79%)	inactive (69%)
TRKB	inactive (102.39%)	inactive (56%)
TRKC	inactive (72.6%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (102.07%)	-
ALK2	inactive (107.18%)	-
ALK4	inactive (92.85%)	inactive (117%)
TGFbR1	inactive (100.93%)	inactive (78%)
TGFbR2	inactive (100.29%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (98.9%)	-
BRAF	inactive (93.77%)	-
RAF1	-	inactive (64%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (97.81%)	inactive (73%)
IRAK4	inactive (70%)	inactive (76%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	active (23.29%)	active (13%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (82.31%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (90.01%)	inactive (68%)
MLK2	inactive (87.09%)	-
MLK3	inactive (93.94%)	-
TAK1	inactive (94.02%)	inactive (84%)
ZAK	active (44.65%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (76.34%)	active (30%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (88.5%)	inactive (87%)
BRSK1	inactive (89.28%)	inactive (97%)
BRSK2	inactive (92.08%)	inactive (104%)
CHK1	inactive (92.4%)	inactive (72%)
LKB1	inactive (103.84%)	inactive (96%)
MARK1	inactive (96.07%)	inactive (73%)
MARK3	inactive (69.93%)	-
MARK4	inactive (70.62%)	-
MELK	inactive (72.11%)	active (47%)
PASK	inactive (93.29%)	inactive (90%)
QIK	active (38.61%)	-
NuaK2	inactive (94.58%)	-
MARK2	inactive (77.2%)	inactive (90%)
AMPKa1	-	inactive (80%)
AMPKa2	-	inactive (92%)
SIK	-	active (4%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (98.41%)	inactive (97%)
CaMK1b	inactive (97.99%)	-
CaMK1d	inactive (89.84%)	inactive (93%)
CaMK1g	inactive (101.31%)	-
CaMK4	inactive (106.37%)	inactive (120%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (95.65%)	-
CaMK2b	inactive (101.12%)	inactive (87%)
CaMK2d	inactive (103.25%)	inactive (95%)
CaMK2g	inactive (100.84%)	inactive (99%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (96.52%)	inactive (82%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (90.74%)	inactive (83%)
DAPK2	inactive (86.7%)	inactive (99%)
DRAK1	inactive (86.98%)	inactive (92%)
DAPK3	inactive (100.21%)	inactive (73%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (88.2%)	inactive (109%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (97.22%)	inactive (75%)
MAPKAPK3	inactive (90.85%)	inactive (99%)
MAPKAPK5	inactive (82.31%)	active (47%)
MNK1	inactive (89.77%)	-
MNK2	inactive (91.53%)	inactive (73%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (101.93%)	inactive (73%)
skMLCK	inactive (86.36%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (88.96%)	-
PHKg2	inactive (120.93%)	inactive (87%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (97.25%)	inactive (78%)
PIM2	inactive (119.37%)	inactive (101%)
PIM3	inactive (95.35%)	inactive (91%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (93.64%)	inactive (78%)
PKD3	inactive (93.07%)	-
PKD2	inactive (96.31%)	inactive (107%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (71.74%)	inactive (77%)
TSSK2	inactive (75.15%)	inactive (85%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (99.46%)	inactive (93%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (99.87%)	inactive (74%)
MAP3K2	inactive (84.46%)	-
MAP3K3	inactive (102.72%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (99.87%)	-
NIK	inactive (104.58%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (103.11%)	inactive (78%)
HGK	inactive (55.49%)	-
KHS1	inactive (89.03%)	-
LOK	inactive (89.01%)	inactive (59%)
MINK	inactive (83.63%)	inactive (74%)
MST1	inactive (91.5%)	inactive (83%)
MST2	inactive (92.97%)	inactive (98%)
MST3	inactive (99.87%)	inactive (61%)
MST4	inactive (97%)	-
OSR1	inactive (120.59%)	-
PAK1	inactive (96.91%)	-
PAK2	inactive (99.63%)	inactive (95%)
PAK3	inactive (93.07%)	inactive (71%)
PAK4	inactive (89.93%)	inactive (91%)
PAK5	inactive (93.21%)	inactive (90%)
PAK6	inactive (84.82%)	inactive (98%)
SLK	inactive (95.4%)	-
YSK1	inactive (103.25%)	-
STLK3	inactive (105.34%)	-
TAO1	inactive (76.32%)	inactive (89%)
TAO2	inactive (97.15%)	inactive (94%)
TAO3	inactive (91.5%)	inactive (97%)
MYO3B	inactive (106.6%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (90.06%)	inactive (108%)
MAP2K2	inactive (99.8%)	-
MAP2K6	inactive (87.02%)	inactive (78%)
MAP2K7	-	inactive (109%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (94.6%)	active (47%)
AurB	inactive (79.18%)	active (43%)
AurC	inactive (94.46%)	inactive (90%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (81.5%)	-
CaMKK2	inactive (86.85%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (84.79%)	inactive (61%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (91.43%)	inactive (109%)
IKKb	inactive (98.19%)	inactive (101%)
IKKe	inactive (93.31%)	-
TBK1	inactive (100.53%)	inactive (52%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (93.01%)	-
NEK11	inactive (98.86%)	inactive (96%)
NEK2	inactive (92.95%)	inactive (82%)
NEK4	inactive (100.99%)	-
NEK6	inactive (104.51%)	inactive (93%)
NEK7	inactive (100.46%)	inactive (92%)
NEK9	inactive (101.95%)	-
NEK3	inactive (97.14%)	inactive (114%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (86.81%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (102.26%)	inactive (65%)
PLK2	inactive (97.09%)	inactive (97%)
PLK3	inactive (94.9%)	inactive (90%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (93.32%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (96.82%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (84.14%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (102.8%)	-
ULK2	inactive (97.26%)	inactive (98%)
ULK3	inactive (96.52%)	inactive (98%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (93%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (103.82%)	inactive (78%)
Wnk3	inactive (104.17%)	inactive (85%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	inactive (102.97%)	inactive (95%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (99.94%)	inactive (76%)
CK1g1	inactive (77.78%)	inactive (84%)
CK1g2	inactive (89.72%)	inactive (83%)
CK1g3	inactive (94.96%)	inactive (92%)
CK1a	inactive (96.06%)	-
CK1e	inactive (94.33%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (89.86%)	-
VRK2	-	inactive (96%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (96.61%)	inactive (82%)
CK2a2	inactive (104.98%)	inactive (123%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (102.45%)	-
CLK2	inactive (84.29%)	inactive (108%)
CLK3	inactive (96.55%)	inactive (59%)
CLK4	inactive (77.71%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (90.3%)	-
DYRK1B	inactive (101.62%)	-
DYRK2	inactive (95.34%)	inactive (96%)
DYRK3	inactive (84.38%)	-
DYRK4	inactive (92.63%)	-
HIPK1	inactive (96.39%)	inactive (94%)
HIPK2	inactive (102.53%)	inactive (97%)
HIPK3	inactive (99.97%)	inactive (91%)
HIPK4	inactive (90.02%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (93.66%)	inactive (84%)
Erk2	inactive (85.08%)	inactive (103%)
JNK3	inactive (102.29%)	inactive (53%)
NLK	inactive (74.11%)	inactive (54%)
p38a	inactive (94.33%)	inactive (69%)
p38b	inactive (83%)	inactive (60%)
p38d	inactive (99.75%)	inactive (102%)
p38g	inactive (100.87%)	inactive (100%)
JNK1	inactive (85.19%)	inactive (95%)
JNK2	inactive (75.9%)	inactive (101%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (101.1%)	inactive (115%)
GSK3B	inactive (96.6%)	inactive (92%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (99.7%)	inactive (114%)
SRPK1	inactive (101.19%)	inactive (94%)
SRPK2	inactive (87.84%)	inactive (93%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (95.95%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (90%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (110%)