Compound in Profiling

Compound Information

Test on : GPCR

Compound Name : -

Inchikey : ZOVGOJSKGVLAJH-UHFFFAOYSA-N

ChemSpider : 5021557

Pubchem CID : 6539089

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

TK

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
JakA	4	4
Fer	2	2
Abl	2	2
Csk	2	1
Tec	5	5
Src	11	10
Eph	14	6
FAK	2	1
Syk	2	2
ALK	2	2
Sev	1	1
InsR	3	3
DDR	2	1
Musk	1	1
Trk	3	3
Met	2	2
Axl	3	3
Ret	1	1
FGFR	4	4
VEGFR	3	3
PDGFR	5	5
Tie	2	1
Ack	2	2
EGFR	4	3

TK - JakA

Bioactivity
Kinase	GPCR
JAK1	inactive (2.13%)
TYK2	inactive (4.08%)
JAK2	inactive (1.02%)
JAK3	inactive (13.47%)

TK - Fer

Bioactivity
Kinase	GPCR
FER	inactive (-10.83%)
FES	inactive (0.22%)

TK - Abl

Bioactivity
Kinase	GPCR
ABL1	inactive (10.74%)
ABL2	inactive (3.31%)

TK - Csk

Bioactivity
Kinase	GPCR
CSK	inactive (-0.3%)

TK - Tec

Bioactivity
Kinase	GPCR
BMX	inactive (0.67%)
BTK	inactive (-2.23%)
TXK	inactive (3.21%)
TEC	inactive (5.32%)
ITK	inactive (1.2%)

TK - Src

Bioactivity
Kinase	GPCR
BRK	inactive (-0.34%)
SRM	inactive (0.39%)
FRK	inactive (-0.01%)
BLK	inactive (10.77%)
LCK	inactive (3.08%)
HCK	inactive (21.19%)
FGR	inactive (22.19%)
FYN	active (53.68%)
SRC	inactive (34.16%)
YES	inactive (16.91%)

TK - Eph

Bioactivity
Kinase	GPCR
EphA2	inactive (-2.69%)
EphA4	inactive (10.3%)
EphA3	inactive (1.81%)
EphB4	inactive (-0.62%)
EphB3	inactive (0.79%)
EphB2	inactive (7.99%)

TK - FAK

Bioactivity
Kinase	GPCR
PYK2	inactive (18.78%)

TK - Syk

Bioactivity
Kinase	GPCR
SYK	inactive (-2.05%)
ZAP70	inactive (0.33%)

TK - ALK

Bioactivity
Kinase	GPCR
LTK	inactive (-1.87%)
ALK	inactive (-1.23%)

TK - Sev

Bioactivity
Kinase	GPCR
ROS	inactive (3.7%)

TK - InsR

Bioactivity
Kinase	GPCR
INSR	inactive (-0.37%)
IGF1R	inactive (-2.3%)
IRR	inactive (-2.31%)

TK - DDR

Bioactivity
Kinase	GPCR
DDR2	inactive (3.39%)

TK - Musk

Bioactivity
Kinase	GPCR
MUSK	inactive (21.58%)

TK - Trk

Bioactivity
Kinase	GPCR
TRKA	inactive (15.55%)
TRKB	inactive (31.21%)
TRKC	inactive (41.47%)

TK - Met

Bioactivity
Kinase	GPCR
RON	inactive (2.41%)
MET	inactive (9.33%)

TK - Axl

Bioactivity
Kinase	GPCR
AXL	inactive (6.57%)
MER	inactive (1.33%)
TYRO3	inactive (5.36%)

TK - Ret

Bioactivity
Kinase	GPCR
RET	inactive (49.14%)

TK - FGFR

Bioactivity
Kinase	GPCR
FGFR1	inactive (1.07%)
FGFR2	inactive (6.9%)
FGFR3	inactive (5.3%)
FGFR4	inactive (-0.62%)

TK - VEGFR

Bioactivity
Kinase	GPCR
FLT1	inactive (11.08%)
KDR	active (56.03%)
FLT4	inactive (44.27%)

TK - PDGFR

Bioactivity
Kinase	GPCR
FMS	inactive (3.69%)
KIT	inactive (6.13%)
FLT3	inactive (6.23%)
PDGFRa	active (62.49%)
PDGFRb	active (72.35%)

TK - Tie

Bioactivity
Kinase	GPCR
TIE2	inactive (0.79%)

TK - Ack

Bioactivity
Kinase	GPCR
ACK	inactive (0.03%)
TNK1	inactive (10.3%)

TK - EGFR

Bioactivity
Kinase	GPCR
EGFR	inactive (5.03%)
ErbB2	inactive (3.86%)
ErbB4	inactive (7.73%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
IRAK	4	1
RAF	5	1

TKL - IRAK

Bioactivity
Kinase	GPCR
IRAK4	inactive (-0.85%)

TKL - RAF

Bioactivity
Kinase	GPCR
BRAF	inactive (43.53%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
STE20	31	12
STE7	7	1

STE - STE20

Bioactivity
Kinase	GPCR
GCK	inactive (3.15%)
MST1	active (80.18%)
MST2	active (77.13%)
MST4	inactive (7.27%)
HGK	inactive (18.75%)
MINK	inactive (13.1%)
LOK	inactive (4.55%)
PAK1	inactive (3.48%)
PAK3	inactive (0.96%)
PAK2	inactive (-0.42%)
PAK5	inactive (0.12%)
PAK6	inactive (1.5%)

STE - STE7

Bioactivity
Kinase	GPCR
MAP2K1	inactive (43.14%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
CK1	7	4

CK1 - CK1

Bioactivity
Kinase	GPCR
CK1a	inactive (7.84%)
CK1g2	inactive (3.6%)
CK1g1	inactive (4.11%)
CK1g3	inactive (8.37%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
PLK	4	1
Aur	3	3
NEK	11	5
IKK	4	4
TTK	1	1

Other - PLK

Bioactivity
Kinase	GPCR
PLK1	inactive (0.88%)

Other - Aur

Bioactivity
Kinase	GPCR
AurB	inactive (21.01%)
AurC	inactive (42.99%)
AurA	active (56.25%)

Other - NEK

Bioactivity
Kinase	GPCR
NEK1	inactive (1.29%)
NEK2	inactive (0.85%)
NEK9	inactive (8.02%)
NEK7	inactive (2.36%)
NEK6	inactive (0.2%)

Other - IKK

Bioactivity
Kinase	GPCR
TBK1	active (63.35%)
IKKe	active (59.74%)
IKKb	inactive (0.5%)
IKKa	inactive (3.43%)

Other - TTK

Bioactivity
Kinase	GPCR
TTK	active (79.2%)

AGC

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
GRK	7	2
PDK1	1	1
RSK	8	7
Akt	3	3
SGK	3	3
PKC	9	5
PKG	2	2
PKA	5	1
DMPK	7	4

AGC - GRK

Bioactivity
Kinase	GPCR
GPRK7	inactive (-0.41%)
GPRK6	inactive (9.38%)

AGC - PDK1

Bioactivity
Kinase	GPCR
PDK1	active (58.15%)

AGC - RSK

Bioactivity
Kinase	GPCR
MSK1	inactive (0.97%)
MSK2	inactive (6.02%)
RSK1	inactive (3.49%)
RSK2	inactive (4.41%)
RSK4	inactive (9.45%)
RSK3	inactive (6.29%)
p70S6K	inactive (2.2%)

AGC - Akt

Bioactivity
Kinase	GPCR
AKT2	inactive (0.25%)
AKT1	inactive (-0.56%)
AKT3	inactive (2.3%)

AGC - SGK

Bioactivity
Kinase	GPCR
SGK1	inactive (8.72%)
SGK3	inactive (3.04%)
SGK2	inactive (3.3%)

AGC - PKC

Bioactivity
Kinase	GPCR
PKCh	inactive (-0.08%)
PKCg	inactive (3.43%)
PKCa	inactive (0.27%)
PKCt	inactive (0.9%)
PKCi	inactive (-0.82%)

AGC - PKG

Bioactivity
Kinase	GPCR
PKG2	inactive (22.03%)
PKG1	inactive (11.85%)

AGC - PKA

Bioactivity
Kinase	GPCR
PRKX	inactive (3.07%)

AGC - DMPK

Bioactivity
Kinase	GPCR
ROCK1	inactive (5.01%)
ROCK2	inactive (10.29%)
MRCKb	inactive (1.07%)
MRCKa	inactive (-2.01%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
RAD53	1	1
DCAMKL	3	1
CAMK1	5	2
PHK	2	2
CAMK2	4	2
MAPKAPK	5	5
PKD	3	3
CAMKL	20	13
TSSK	5	2
DAPK	5	1
PIM	3	3

CAMK - RAD53

Bioactivity
Kinase	GPCR
CHK2	inactive (5.93%)

CAMK - DCAMKL

Bioactivity
Kinase	GPCR
DCLK2	inactive (1.76%)

CAMK - CAMK1

Bioactivity
Kinase	GPCR
CaMK4	inactive (-0.51%)
CaMK1d	inactive (1.92%)

CAMK - PHK

Bioactivity
Kinase	GPCR
PHKg1	inactive (29.88%)
PHKg2	inactive (3.4%)

CAMK - CAMK2

Bioactivity
Kinase	GPCR
CaMK2d	inactive (12.19%)
CaMK2a	inactive (4.28%)

CAMK - MAPKAPK

Bioactivity
Kinase	GPCR
MAPKAPK5	inactive (-0.16%)
MAPKAPK2	inactive (-1.03%)
MAPKAPK3	inactive (2.07%)
MNK2	inactive (9.44%)
MNK1	inactive (3.37%)

CAMK - PKD

Bioactivity
Kinase	GPCR
PKD3	inactive (9.82%)
PKD1	inactive (13.9%)
PKD2	inactive (11.83%)

CAMK - CAMKL

Bioactivity
Kinase	GPCR
MARK4	inactive (42.56%)
MARK3	inactive (36.61%)
MARK1	active (52.47%)
QIK	inactive (36.05%)
SIK	inactive (27.67%)
NuaK1	active (58.6%)
BRSK1	inactive (37.74%)
BRSK2	active (52.25%)
MELK	active (72.66%)
CHK1	inactive (-3.69%)
PASK	inactive (0.43%)
AMPKa1	active (72.32%)
AMPKa2	inactive (33.68%)

CAMK - TSSK

Bioactivity
Kinase	GPCR
TSSK2	inactive (-0.69%)
TSSK1	inactive (10.98%)

CAMK - DAPK

Bioactivity
Kinase	GPCR
DAPK1	inactive (0.07%)

CAMK - PIM

Bioactivity
Kinase	GPCR
PIM2	inactive (4.28%)
PIM3	inactive (14.17%)
PIM1	inactive (18.91%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
MAPK	14	6
GSK	2	2
SRPK	3	2
CLK	4	2
DYRK	10	5
CK2	3	1

CMGC - MAPK

Bioactivity
Kinase	GPCR
JNK2	inactive (8.39%)
p38a	inactive (1.84%)
p38b	inactive (9.13%)
p38d	inactive (0.83%)
Erk2	inactive (42.1%)
Erk1	inactive (16.57%)

CMGC - GSK

Bioactivity
Kinase	GPCR
GSK3A	active (65.21%)
GSK3B	active (66.84%)

CMGC - SRPK

Bioactivity
Kinase	GPCR
SRPK1	inactive (-1.91%)
MSSK1	inactive (-1.79%)

CMGC - CLK

Bioactivity
Kinase	GPCR
CLK3	inactive (9.15%)
CLK2	active (61.89%)

CMGC - DYRK

Bioactivity
Kinase	GPCR
HIPK1	inactive (13.14%)
HIPK4	inactive (4.55%)
DYRK1B	inactive (1%)
DYRK1A	inactive (7.83%)
DYRK2	inactive (9.64%)

CMGC - CK2

Bioactivity
Kinase	GPCR
CK2a1	inactive (23.51%)