Compound in Profiling

Compound Information

Test on : GPCR

Compound Name : -

Inchikey : ZQAZHQLWCKQXTD-GDNBJRDFSA-N

ChemSpider : 5021514

Pubchem CID : 6539046

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

TK

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
JakA	4	4
Fer	2	2
Abl	2	2
Csk	2	1
Tec	5	5
Src	11	10
Eph	14	6
FAK	2	1
Syk	2	2
ALK	2	2
Sev	1	1
InsR	3	3
DDR	2	1
Musk	1	1
Trk	3	3
Met	2	2
Axl	3	3
Ret	1	1
FGFR	4	4
VEGFR	3	3
PDGFR	5	5
Tie	2	1
Ack	2	2
EGFR	4	3

TK - JakA

Bioactivity
Kinase	GPCR
JAK1	inactive (-1.09%)
TYK2	inactive (6.88%)
JAK2	inactive (0.27%)
JAK3	inactive (6.44%)

TK - Fer

Bioactivity
Kinase	GPCR
FER	inactive (10.52%)
FES	inactive (-3.39%)

TK - Abl

Bioactivity
Kinase	GPCR
ABL1	inactive (11.68%)
ABL2	inactive (10.07%)

TK - Csk

Bioactivity
Kinase	GPCR
CSK	inactive (-4%)

TK - Tec

Bioactivity
Kinase	GPCR
BMX	inactive (-0.17%)
BTK	inactive (-1.09%)
TXK	inactive (-0.74%)
TEC	inactive (-2.14%)
ITK	inactive (4.72%)

TK - Src

Bioactivity
Kinase	GPCR
BRK	inactive (-1.43%)
SRM	inactive (4.16%)
FRK	inactive (0.76%)
BLK	inactive (12.03%)
LCK	inactive (4.22%)
HCK	inactive (6.24%)
FGR	inactive (11.41%)
FYN	inactive (2.57%)
SRC	inactive (0.81%)
YES	inactive (14.1%)

TK - Eph

Bioactivity
Kinase	GPCR
EphA2	inactive (-3.36%)
EphA4	inactive (-2.02%)
EphA3	inactive (-1.74%)
EphB4	inactive (-2.22%)
EphB3	inactive (-3.57%)
EphB2	inactive (-0.51%)

TK - FAK

Bioactivity
Kinase	GPCR
PYK2	inactive (17.83%)

TK - Syk

Bioactivity
Kinase	GPCR
SYK	inactive (0.6%)
ZAP70	inactive (0.18%)

TK - ALK

Bioactivity
Kinase	GPCR
LTK	inactive (9.41%)
ALK	inactive (14.24%)

TK - Sev

Bioactivity
Kinase	GPCR
ROS	inactive (8.7%)

TK - InsR

Bioactivity
Kinase	GPCR
INSR	inactive (12.74%)
IGF1R	inactive (9.94%)
IRR	inactive (-0.64%)

TK - DDR

Bioactivity
Kinase	GPCR
DDR2	inactive (0.07%)

TK - Musk

Bioactivity
Kinase	GPCR
MUSK	inactive (30.86%)

TK - Trk

Bioactivity
Kinase	GPCR
TRKA	inactive (38.27%)
TRKB	active (61.81%)
TRKC	active (87.09%)

TK - Met

Bioactivity
Kinase	GPCR
RON	inactive (4%)
MET	inactive (9.39%)

TK - Axl

Bioactivity
Kinase	GPCR
AXL	inactive (10.54%)
MER	inactive (9.21%)
TYRO3	inactive (16.8%)

TK - Ret

Bioactivity
Kinase	GPCR
RET	inactive (35.87%)

TK - FGFR

Bioactivity
Kinase	GPCR
FGFR1	inactive (6.33%)
FGFR2	inactive (21.07%)
FGFR3	inactive (21%)
FGFR4	inactive (3.59%)

TK - VEGFR

Bioactivity
Kinase	GPCR
FLT1	inactive (23.58%)
KDR	inactive (44.46%)
FLT4	inactive (32.91%)

TK - PDGFR

Bioactivity
Kinase	GPCR
FMS	active (50.62%)
KIT	active (90.86%)
FLT3	active (62.87%)
PDGFRa	active (53.21%)
PDGFRb	inactive (43.06%)

TK - Tie

Bioactivity
Kinase	GPCR
TIE2	inactive (2.44%)

TK - Ack

Bioactivity
Kinase	GPCR
ACK	inactive (0.65%)
TNK1	inactive (9.56%)

TK - EGFR

Bioactivity
Kinase	GPCR
EGFR	inactive (2.48%)
ErbB2	inactive (-3.5%)
ErbB4	inactive (-8.14%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
IRAK	4	1
RAF	5	1

TKL - IRAK

Bioactivity
Kinase	GPCR
IRAK4	inactive (0.3%)

TKL - RAF

Bioactivity
Kinase	GPCR
BRAF	inactive (0.23%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
STE20	31	12
STE7	7	1

STE - STE20

Bioactivity
Kinase	GPCR
GCK	inactive (17.7%)
MST1	active (55.29%)
MST2	inactive (42.33%)
MST4	inactive (15.63%)
HGK	active (88.32%)
MINK	active (85.3%)
LOK	inactive (9.28%)
PAK1	inactive (2.37%)
PAK3	inactive (-1.11%)
PAK2	inactive (-1.06%)
PAK5	inactive (2.88%)
PAK6	inactive (0.59%)

STE - STE7

Bioactivity
Kinase	GPCR
MAP2K1	inactive (0.96%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
CK1	7	4

CK1 - CK1

Bioactivity
Kinase	GPCR
CK1a	inactive (8.53%)
CK1g2	inactive (18.68%)
CK1g1	inactive (6.33%)
CK1g3	inactive (19.05%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
PLK	4	1
Aur	3	3
NEK	11	5
IKK	4	4
TTK	1	1

Other - PLK

Bioactivity
Kinase	GPCR
PLK1	inactive (-0.72%)

Other - Aur

Bioactivity
Kinase	GPCR
AurB	inactive (47.98%)
AurC	active (85.68%)
AurA	inactive (37.76%)

Other - NEK

Bioactivity
Kinase	GPCR
NEK1	inactive (0.52%)
NEK2	inactive (0.19%)
NEK9	inactive (1.67%)
NEK7	inactive (-0.23%)
NEK6	inactive (-0.83%)

Other - IKK

Bioactivity
Kinase	GPCR
TBK1	inactive (4.75%)
IKKe	inactive (2.23%)
IKKb	inactive (1.17%)
IKKa	inactive (2.59%)

Other - TTK

Bioactivity
Kinase	GPCR
TTK	inactive (35.67%)

AGC

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
GRK	7	2
PDK1	1	1
RSK	8	7
Akt	3	3
SGK	3	3
PKC	9	5
PKG	2	2
PKA	5	1
DMPK	7	4

AGC - GRK

Bioactivity
Kinase	GPCR
GPRK7	inactive (2.76%)
GPRK6	inactive (9.44%)

AGC - PDK1

Bioactivity
Kinase	GPCR
PDK1	inactive (39.59%)

AGC - RSK

Bioactivity
Kinase	GPCR
MSK1	inactive (8.47%)
MSK2	inactive (17.66%)
RSK1	inactive (14.46%)
RSK2	inactive (14.59%)
RSK4	inactive (20.68%)
RSK3	inactive (23.45%)
p70S6K	inactive (2.17%)

AGC - Akt

Bioactivity
Kinase	GPCR
AKT2	inactive (-0.17%)
AKT1	inactive (-1.45%)
AKT3	inactive (-0.18%)

AGC - SGK

Bioactivity
Kinase	GPCR
SGK1	inactive (18.37%)
SGK3	inactive (2.1%)
SGK2	inactive (2.83%)

AGC - PKC

Bioactivity
Kinase	GPCR
PKCh	inactive (-1.17%)
PKCg	inactive (2.57%)
PKCa	inactive (0.38%)
PKCt	inactive (3.24%)
PKCi	inactive (0.02%)

AGC - PKG

Bioactivity
Kinase	GPCR
PKG2	inactive (8.25%)
PKG1	inactive (3.66%)

AGC - PKA

Bioactivity
Kinase	GPCR
PRKX	inactive (4.84%)

AGC - DMPK

Bioactivity
Kinase	GPCR
ROCK1	inactive (5.13%)
ROCK2	inactive (9.54%)
MRCKb	inactive (3.4%)
MRCKa	inactive (0.16%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
RAD53	1	1
DCAMKL	3	1
CAMK1	5	2
PHK	2	2
CAMK2	4	2
MAPKAPK	5	5
PKD	3	3
CAMKL	20	13
TSSK	5	2
DAPK	5	1
PIM	3	3

CAMK - RAD53

Bioactivity
Kinase	GPCR
CHK2	inactive (14.46%)

CAMK - DCAMKL

Bioactivity
Kinase	GPCR
DCLK2	inactive (2.32%)

CAMK - CAMK1

Bioactivity
Kinase	GPCR
CaMK4	inactive (-0.89%)
CaMK1d	inactive (-0.55%)

CAMK - PHK

Bioactivity
Kinase	GPCR
PHKg1	inactive (29.9%)
PHKg2	inactive (19.6%)

CAMK - CAMK2

Bioactivity
Kinase	GPCR
CaMK2d	inactive (3.2%)
CaMK2a	inactive (-2.07%)

CAMK - MAPKAPK

Bioactivity
Kinase	GPCR
MAPKAPK5	inactive (1.08%)
MAPKAPK2	inactive (-0.57%)
MAPKAPK3	inactive (-0.11%)
MNK2	inactive (3.41%)
MNK1	inactive (3.04%)

CAMK - PKD

Bioactivity
Kinase	GPCR
PKD3	inactive (9.13%)
PKD1	inactive (15.92%)
PKD2	inactive (11.28%)

CAMK - CAMKL

Bioactivity
Kinase	GPCR
MARK4	inactive (28.16%)
MARK3	inactive (19.84%)
MARK1	inactive (32.78%)
QIK	inactive (-0.55%)
SIK	inactive (-0.38%)
NuaK1	inactive (34.03%)
BRSK1	inactive (18.87%)
BRSK2	inactive (31.15%)
MELK	inactive (41.87%)
CHK1	inactive (10.05%)
PASK	inactive (-1.37%)
AMPKa1	inactive (9.79%)
AMPKa2	inactive (4.96%)

CAMK - TSSK

Bioactivity
Kinase	GPCR
TSSK2	inactive (1.13%)
TSSK1	inactive (5.46%)

CAMK - DAPK

Bioactivity
Kinase	GPCR
DAPK1	inactive (1.66%)

CAMK - PIM

Bioactivity
Kinase	GPCR
PIM2	inactive (0.33%)
PIM3	inactive (1.7%)
PIM1	inactive (2.86%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
MAPK	14	6
GSK	2	2
SRPK	3	2
CLK	4	2
DYRK	10	5
CK2	3	1

CMGC - MAPK

Bioactivity
Kinase	GPCR
JNK2	inactive (3.67%)
p38a	inactive (3.43%)
p38b	inactive (7.87%)
p38d	inactive (-1.14%)
Erk2	inactive (-2.06%)
Erk1	inactive (0.88%)

CMGC - GSK

Bioactivity
Kinase	GPCR
GSK3A	inactive (7.04%)
GSK3B	inactive (9.04%)

CMGC - SRPK

Bioactivity
Kinase	GPCR
SRPK1	inactive (1.41%)
MSSK1	inactive (-1.15%)

CMGC - CLK

Bioactivity
Kinase	GPCR
CLK3	inactive (1.28%)
CLK2	inactive (2.45%)

CMGC - DYRK

Bioactivity
Kinase	GPCR
HIPK1	inactive (-1.35%)
HIPK4	inactive (2.56%)
DYRK1B	inactive (12.7%)
DYRK1A	inactive (11.46%)
DYRK2	inactive (3.79%)

CMGC - CK2

Bioactivity
Kinase	GPCR
CK2a1	inactive (7.42%)