Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC, Millipore : GSK-3 Inhibitor II

Inchikey
Same : ZRHRPGSSSVYBRG-N
RBC, Millipore : ZRHRPGSSSVYBRG-UHFFFAOYSA-N

ChemSpider
RBC, Millipore : 5022186

Pubchem CID
RBC, Millipore : 6539732

ChEMBL
RBC, Millipore : CHEMBL288064

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (98.34%)	inactive (56%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (98.59%)	inactive (116%)
AKT2	inactive (100.83%)	inactive (93%)
AKT3	inactive (90.68%)	inactive (92%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (104.85%)	inactive (82%)
MRCKa	inactive (98.44%)	inactive (123%)
MRCKb	inactive (96.65%)	inactive (87%)
ROCK1	inactive (88%)	inactive (113%)
ROCK2	inactive (88.98%)	inactive (68%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (99.94%)	-
BARK2	inactive (102.93%)	-
GPRK4	inactive (99.85%)	-
GPRK5	inactive (105.98%)	inactive (89%)
GPRK6	inactive (100.44%)	inactive (89%)
GPRK7	inactive (112.25%)	inactive (88%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (97.24%)	inactive (95%)
MSK2	inactive (92.1%)	inactive (65%)
p70S6K	inactive (100.06%)	inactive (55%)
p70S6Kb	inactive (103.17%)	-
RSK2	inactive (96.43%)	active (39%)
RSK4	inactive (102.53%)	inactive (97%)
RSK1	inactive (98.58%)	active (30%)
RSK3	inactive (101.07%)	inactive (55%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	-	-
PRKX	inactive (78.21%)	inactive (57%)
PKACa	inactive (94.61%)	inactive (99%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (122.62%)	inactive (96%)
PKCd	inactive (83.7%)	inactive (100%)
PKCe	inactive (86.51%)	inactive (88%)
PKCh	inactive (99.07%)	inactive (59%)
PKCg	inactive (98.66%)	inactive (97%)
PKCi	inactive (96.39%)	inactive (109%)
PKCt	inactive (119.87%)	inactive (68%)
PKCz	inactive (96.07%)	inactive (101%)
PKCb	inactive (91.21%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (104.88%)	-
PKG1	inactive (92.15%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (98.58%)	-
PKN2	inactive (100.02%)	inactive (83%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (99.04%)	inactive (71%)
SGK2	inactive (102.46%)	inactive (84%)
SGK3	inactive (98.49%)	inactive (91%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	active (0%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (107.1%)	inactive (87%)
ABL2	inactive (110.09%)	inactive (112%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (101.08%)	inactive (75%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (101.22%)	inactive (73%)
LTK	inactive (103.03%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (99.2%)	inactive (74%)
MER	inactive (96.44%)	inactive (69%)
TYRO3	inactive (102.81%)	inactive (112%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (102.54%)	inactive (87%)
BRK	inactive (104.32%)	inactive (105%)
SRC	inactive (100.58%)	inactive (113%)
FGR	inactive (90.94%)	inactive (80%)
FRK	inactive (85.51%)	inactive (77%)
FYN	inactive (102.36%)	inactive (71%)
HCK	inactive (103.75%)	inactive (74%)
LCK	inactive (98.53%)	inactive (58%)
SRM	inactive (93.37%)	-
YES	inactive (95.68%)	inactive (96%)
LYN	inactive (102.86%)	inactive (63%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (86.56%)	inactive (63%)
BTK	inactive (95.58%)	inactive (79%)
ITK	inactive (102.32%)	inactive (93%)
TEC	inactive (105.92%)	-
TXK	inactive (96.81%)	inactive (75%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (99.82%)	inactive (97%)
FLT3	inactive (102.01%)	active (30%)
FMS	inactive (104.27%)	inactive (71%)
PDGFRb	inactive (97.69%)	inactive (99%)
PDGFRa	inactive (90.08%)	inactive (104%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (100.71%)	inactive (104%)
CTK	inactive (94.31%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (102.5%)	inactive (86%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (97.12%)	inactive (111%)
ErbB2	inactive (99.61%)	-
ErbB4	inactive (96.38%)	inactive (94%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (96.99%)	inactive (95%)
EphA2	inactive (102.18%)	inactive (90%)
EphA3	inactive (110.66%)	inactive (96%)
EphA4	inactive (105.27%)	inactive (104%)
EphA5	inactive (99.97%)	inactive (106%)
EphA6	-	-
EphA7	inactive (100.28%)	inactive (88%)
EphA8	inactive (91.48%)	inactive (89%)
EphB1	inactive (100.53%)	inactive (95%)
EphB2	inactive (87.7%)	inactive (106%)
EphB3	inactive (99.73%)	inactive (104%)
EphB4	inactive (101.15%)	inactive (84%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (106.02%)	inactive (96%)
PYK2	inactive (92.07%)	inactive (103%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (100.92%)	inactive (93%)
FES	inactive (97.96%)	inactive (88%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (92.37%)	inactive (98%)
FGFR2	inactive (101.48%)	inactive (99%)
FGFR3	inactive (105.74%)	inactive (106%)
FGFR4	inactive (97.16%)	inactive (112%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (90.96%)	active (26%)
FLT4	inactive (96.19%)	active (22%)
KDR	inactive (78.06%)	inactive (77%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (99.09%)	inactive (96%)
IRR	inactive (98.04%)	inactive (112%)
INSR	inactive (83.52%)	inactive (93%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (102.89%)	-
JAK2	inactive (106.72%)	inactive (86%)
JAK3	inactive (105.67%)	inactive (102%)
TYK2	inactive (104.83%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (94.07%)	inactive (74%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	inactive (102.99%)	inactive (93%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (103.89%)	inactive (81%)
MET	inactive (88.73%)	inactive (126%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (99.31%)	inactive (93%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (92.2%)	inactive (98%)
ZAP70	inactive (107.48%)	inactive (101%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (92.64%)	inactive (104%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (95.99%)	inactive (87%)
TRKB	inactive (91.37%)	active (32%)
TRKC	inactive (104.34%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (103.44%)	-
ALK2	inactive (97.37%)	-
ALK4	inactive (102.22%)	inactive (98%)
TGFbR1	inactive (94.37%)	inactive (82%)
TGFbR2	inactive (121.12%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (91.33%)	-
BRAF	inactive (100.14%)	-
RAF1	inactive (92.83%)	inactive (77%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (120.83%)	inactive (91%)
IRAK4	inactive (104.54%)	inactive (55%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (85.81%)	inactive (84%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (91.9%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (108.21%)	inactive (90%)
MLK2	inactive (102.24%)	-
MLK3	inactive (99.56%)	-
TAK1	inactive (101.5%)	inactive (83%)
ZAK	inactive (96.68%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (86.3%)	inactive (82%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (95.06%)	inactive (105%)
BRSK1	inactive (101.05%)	inactive (84%)
BRSK2	inactive (99.29%)	inactive (113%)
CHK1	inactive (96.34%)	inactive (57%)
LKB1	inactive (102.59%)	inactive (96%)
MARK1	inactive (111.04%)	active (4%)
MARK3	inactive (124.02%)	-
MARK4	inactive (86.79%)	-
MELK	inactive (97.71%)	active (24%)
PASK	inactive (100.09%)	inactive (108%)
QIK	inactive (100.09%)	-
NuaK2	inactive (98.95%)	-
MARK2	inactive (116.12%)	active (22%)
AMPKa1	-	active (35%)
AMPKa2	-	active (45%)
SIK	-	inactive (92%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (102.09%)	inactive (97%)
CaMK1b	inactive (101.29%)	-
CaMK1d	inactive (100.55%)	inactive (93%)
CaMK1g	inactive (95.92%)	-
CaMK4	inactive (91.59%)	inactive (106%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (92.28%)	-
CaMK2b	inactive (95.41%)	inactive (75%)
CaMK2d	inactive (96.81%)	inactive (73%)
CaMK2g	inactive (96.8%)	inactive (85%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (102.15%)	inactive (72%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (90.33%)	inactive (90%)
DAPK2	inactive (108%)	inactive (96%)
DRAK1	inactive (95.77%)	inactive (100%)
DAPK3	inactive (107.2%)	inactive (107%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (100.29%)	inactive (100%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (93.53%)	inactive (77%)
MAPKAPK3	inactive (109.33%)	inactive (111%)
MAPKAPK5	inactive (83.58%)	inactive (105%)
MNK1	inactive (108.71%)	-
MNK2	inactive (91.55%)	inactive (91%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (99.06%)	inactive (84%)
skMLCK	inactive (101.36%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (104.53%)	-
PHKg2	inactive (105.39%)	inactive (106%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (102.16%)	inactive (104%)
PIM2	inactive (102.33%)	inactive (93%)
PIM3	inactive (106.3%)	inactive (78%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (97.62%)	inactive (72%)
PKD3	inactive (98.4%)	-
PKD2	inactive (97.07%)	inactive (97%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (97.58%)	inactive (78%)
TSSK2	inactive (109.67%)	inactive (87%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (110.55%)	inactive (86%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (91.74%)	inactive (80%)
MAP3K2	inactive (106.16%)	-
MAP3K3	inactive (89.6%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (96.09%)	-
NIK	inactive (88.29%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (112.48%)	active (49%)
HGK	inactive (97.37%)	-
KHS1	inactive (99.49%)	-
LOK	inactive (93.85%)	inactive (104%)
MINK	inactive (90.16%)	inactive (98%)
MST1	inactive (101.65%)	inactive (106%)
MST2	inactive (110.25%)	active (39%)
MST3	inactive (108.3%)	active (50%)
MST4	inactive (103.46%)	-
OSR1	inactive (104.66%)	-
PAK1	inactive (94.83%)	-
PAK2	inactive (97.63%)	inactive (104%)
PAK3	inactive (92.9%)	inactive (103%)
PAK4	inactive (83.65%)	inactive (91%)
PAK5	inactive (99.26%)	inactive (91%)
PAK6	inactive (73.99%)	inactive (89%)
SLK	inactive (98.64%)	-
YSK1	inactive (96.24%)	-
STLK3	inactive (101.04%)	-
TAO1	inactive (101.11%)	inactive (63%)
TAO2	inactive (105.11%)	inactive (88%)
TAO3	inactive (103.4%)	inactive (93%)
MYO3B	active (0%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (95.4%)	inactive (69%)
MAP2K2	inactive (101.69%)	-
MAP2K6	inactive (97.04%)	inactive (100%)
MAP2K7	-	inactive (70%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (95.81%)	inactive (83%)
AurB	inactive (99.05%)	inactive (77%)
AurC	inactive (91.25%)	inactive (79%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (123.74%)	-
CaMKK2	inactive (85.07%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (95.85%)	inactive (104%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (96.5%)	inactive (80%)
IKKb	inactive (89.33%)	inactive (87%)
IKKe	inactive (101.5%)	-
TBK1	inactive (102.72%)	active (15%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (95.52%)	-
NEK11	inactive (112.59%)	inactive (103%)
NEK2	inactive (100%)	inactive (88%)
NEK4	inactive (93.68%)	-
NEK6	inactive (95.43%)	inactive (113%)
NEK7	inactive (101.55%)	inactive (101%)
NEK9	inactive (99.23%)	-
NEK3	inactive (86.88%)	inactive (84%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (62.65%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (98.64%)	inactive (72%)
PLK2	inactive (101.45%)	inactive (97%)
PLK3	inactive (96.1%)	inactive (87%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (94.75%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (109.53%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (103.14%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (97.07%)	-
ULK2	inactive (111.41%)	inactive (98%)
ULK3	active (0%)	inactive (86%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (97.22%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (99.54%)	inactive (87%)
Wnk3	inactive (101.35%)	inactive (89%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	active (0%)	inactive (83%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (102.77%)	inactive (83%)
CK1g1	inactive (91.7%)	inactive (101%)
CK1g2	inactive (99.16%)	inactive (97%)
CK1g3	inactive (75.9%)	inactive (80%)
CK1a	inactive (96.97%)	-
CK1e	inactive (94.3%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (93.08%)	-
VRK2	-	inactive (92%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (97.25%)	inactive (87%)
CK2a2	inactive (80.98%)	inactive (101%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (99.76%)	-
CLK2	inactive (103.57%)	active (12%)
CLK3	inactive (76.3%)	inactive (65%)
CLK4	inactive (90.05%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (96.44%)	-
DYRK1B	inactive (96.67%)	-
DYRK2	inactive (96.79%)	inactive (87%)
DYRK3	inactive (108.39%)	-
DYRK4	inactive (98.47%)	-
HIPK1	inactive (105.23%)	inactive (101%)
HIPK2	inactive (101.57%)	inactive (76%)
HIPK3	inactive (99.09%)	inactive (96%)
HIPK4	inactive (98.79%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (95.83%)	inactive (82%)
Erk2	inactive (106.78%)	inactive (111%)
JNK3	inactive (95.74%)	inactive (73%)
NLK	inactive (107.45%)	inactive (89%)
p38a	inactive (99.34%)	inactive (90%)
p38b	inactive (96.89%)	inactive (102%)
p38d	inactive (93.77%)	inactive (104%)
p38g	inactive (93.04%)	inactive (88%)
JNK1	inactive (84.71%)	inactive (93%)
JNK2	inactive (108.12%)	inactive (90%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	active (42.68%)	active (32%)
GSK3B	inactive (59.75%)	active (43%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (100.91%)	inactive (90%)
SRPK1	inactive (102.55%)	inactive (97%)
SRPK2	inactive (97.38%)	inactive (88%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (98.34%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (83%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (108%)