Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC : 856436-16-3
Millipore : JAK3 Inhibitor VI

Inchikey
Same : ZUDPNBZMAJGYTE-N
RBC : ZUDPNBZMAJGYTE-UHFFFAOYSA-N
Millipore : ZUDPNBZMAJGYTE-HYMQDMCPSA-N

ChemSpider
RBC : 21465183
Millipore : 21395909

Pubchem CID
RBC : 24906278
Millipore : 16760524

ChEMBL
RBC : -
Millipore : CHEMBL2397013

RBC	Millipore

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	active (46.88%)	active (6%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (100.86%)	inactive (96%)
AKT2	inactive (101.67%)	inactive (131%)
AKT3	inactive (91.16%)	inactive (68%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (106.88%)	inactive (125%)
MRCKa	inactive (98.36%)	inactive (95%)
MRCKb	inactive (90.23%)	inactive (66%)
ROCK1	active (38.06%)	inactive (86%)
ROCK2	active (17.29%)	active (10%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (100.77%)	-
BARK2	inactive (95.43%)	-
GPRK4	inactive (86.4%)	-
GPRK5	inactive (82.99%)	inactive (76%)
GPRK6	inactive (76.86%)	inactive (81%)
GPRK7	inactive (67.56%)	active (41%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (54.21%)	inactive (60%)
MSK2	active (48.98%)	active (23%)
p70S6K	active (26.65%)	active (8%)
p70S6Kb	inactive (92.53%)	-
RSK2	active (24.85%)	active (11%)
RSK4	active (10.77%)	active (10%)
RSK1	active (0.91%)	active (3%)
RSK3	active (7.21%)	active (10%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	inactive (102.38%)	-
PRKX	active (43.52%)	active (37%)
PKACa	inactive (83.22%)	inactive (61%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (86.72%)	inactive (87%)
PKCd	active (36.05%)	inactive (54%)
PKCe	inactive (66.99%)	inactive (69%)
PKCh	inactive (83.9%)	inactive (92%)
PKCg	inactive (78.08%)	inactive (67%)
PKCi	inactive (92.03%)	inactive (88%)
PKCt	inactive (114.56%)	active (28%)
PKCz	inactive (101.52%)	inactive (91%)
PKCb	inactive (72.88%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	active (2.21%)	-
PKG1	inactive (60.57%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	active (14.38%)	-
PKN2	inactive (70.87%)	active (15%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	active (25.95%)	active (25%)
SGK2	active (28.13%)	active (12%)
SGK3	inactive (63.64%)	inactive (58%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	inactive (60%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (61.97%)	active (39%)
ABL2	inactive (67.23%)	inactive (59%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (79.44%)	inactive (57%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (76.02%)	inactive (63%)
LTK	inactive (67.57%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (80.75%)	active (8%)
MER	inactive (66.4%)	active (8%)
TYRO3	inactive (71.66%)	inactive (55%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (53.63%)	active (12%)
BRK	inactive (86.3%)	inactive (85%)
SRC	inactive (58.86%)	inactive (68%)
FGR	active (34.37%)	active (11%)
FRK	inactive (95.15%)	inactive (69%)
FYN	active (32.67%)	active (37%)
HCK	inactive (65.04%)	active (40%)
LCK	inactive (70.65%)	active (38%)
SRM	inactive (104.7%)	-
YES	active (35.03%)	active (14%)
LYN	active (30.32%)	active (10%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (89.34%)	active (50%)
BTK	inactive (88.69%)	inactive (90%)
ITK	inactive (55.5%)	active (46%)
TEC	inactive (105.06%)	-
TXK	inactive (75.73%)	inactive (53%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (86.09%)	inactive (104%)
FLT3	active (1.61%)	active (0%)
FMS	inactive (92.47%)	active (42%)
PDGFRb	active (32.26%)	inactive (71%)
PDGFRa	inactive (56.02%)	inactive (93%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (80.5%)	inactive (108%)
CTK	inactive (96.56%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (98.46%)	inactive (110%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (104.4%)	inactive (115%)
ErbB2	inactive (102.54%)	-
ErbB4	inactive (93.04%)	inactive (100%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (98.15%)	inactive (87%)
EphA2	inactive (103.76%)	inactive (104%)
EphA3	inactive (96.79%)	inactive (105%)
EphA4	inactive (98.42%)	inactive (112%)
EphA5	inactive (101.82%)	inactive (102%)
EphA6	inactive (77.05%)	-
EphA7	inactive (95.61%)	inactive (92%)
EphA8	inactive (99.43%)	inactive (92%)
EphB1	inactive (91.21%)	inactive (81%)
EphB2	inactive (100.33%)	inactive (112%)
EphB3	inactive (90.28%)	inactive (101%)
EphB4	inactive (99.05%)	inactive (96%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (93.79%)	inactive (93%)
PYK2	inactive (89.96%)	inactive (84%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (77.12%)	inactive (97%)
FES	inactive (87.75%)	inactive (93%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (69.53%)	active (28%)
FGFR2	inactive (70.91%)	active (49%)
FGFR3	inactive (64.61%)	active (46%)
FGFR4	inactive (98.9%)	inactive (122%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	active (30.09%)	active (2%)
FLT4	active (5.12%)	active (2%)
KDR	active (24.71%)	active (5%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (103.54%)	inactive (143%)
IRR	inactive (89.09%)	inactive (122%)
INSR	inactive (101.5%)	inactive (71%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (60.32%)	-
JAK2	inactive (58.01%)	active (40%)
JAK3	active (4.79%)	active (6%)
TYK2	active (20.37%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	active (6.09%)	active (25%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	active (18.04%)	active (13%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (80.01%)	inactive (67%)
MET	inactive (103.31%)	inactive (62%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (86.24%)	inactive (85%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (72.45%)	inactive (90%)
ZAP70	inactive (96.5%)	inactive (98%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (94.64%)	active (34%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	active (8.96%)	active (1%)
TRKB	active (7.65%)	active (6%)
TRKC	active (2.64%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (101.96%)	-
ALK2	inactive (108.15%)	-
ALK4	inactive (137.56%)	inactive (64%)
TGFbR1	inactive (107%)	inactive (58%)
TGFbR2	inactive (86.48%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (141.73%)	-
BRAF	inactive (112.04%)	-
RAF1	inactive (120.91%)	inactive (69%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	active (14.45%)	active (1%)
IRAK4	active (8.32%)	active (3%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (95.19%)	inactive (83%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	active (6.23%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	active (18.59%)	active (6%)
MLK2	active (39.81%)	-
MLK3	active (8.73%)	-
TAK1	active (9.69%)	active (10%)
ZAK	inactive (57.15%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (52.87%)	active (30%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	active (5.27%)	active (10%)
BRSK1	active (19.7%)	active (1%)
BRSK2	active (15.93%)	active (10%)
CHK1	active (5.97%)	active (10%)
LKB1	active (34.81%)	inactive (90%)
MARK1	active (3.26%)	active (1%)
MARK3	active (3.87%)	-
MARK4	active (1.56%)	-
MELK	active (4.63%)	active (4%)
PASK	active (32.03%)	active (40%)
QIK	inactive (66.62%)	-
NuaK2	active (43.72%)	-
MARK2	active (3.25%)	active (1%)
AMPKa1	-	active (6%)
AMPKa2	-	active (5%)
SIK	-	active (36%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (94.66%)	inactive (81%)
CaMK1b	inactive (98.89%)	-
CaMK1d	inactive (83.47%)	inactive (52%)
CaMK1g	inactive (94.81%)	-
CaMK4	inactive (93.43%)	inactive (103%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	active (16.79%)	-
CaMK2b	active (29.45%)	active (13%)
CaMK2d	active (32.13%)	active (8%)
CaMK2g	inactive (78.48%)	active (12%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	active (26.3%)	active (24%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (82.27%)	inactive (94%)
DAPK2	inactive (113.29%)	inactive (85%)
DRAK1	active (5.2%)	active (1%)
DAPK3	inactive (99.6%)	inactive (91%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (87.85%)	inactive (71%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (100.35%)	inactive (83%)
MAPKAPK3	inactive (100.86%)	inactive (116%)
MAPKAPK5	inactive (83.69%)	active (43%)
MNK1	inactive (79.5%)	-
MNK2	inactive (72.99%)	active (47%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	active (41.73%)	active (23%)
skMLCK	active (5.85%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	active (9.56%)	-
PHKg2	active (46.97%)	active (22%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	active (41.78%)	active (35%)
PIM2	inactive (87.39%)	active (13%)
PIM3	active (7.61%)	inactive (63%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	active (2.07%)	active (6%)
PKD3	active (1.85%)	-
PKD2	active (2.2%)	active (25%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	active (39.61%)	active (21%)
TSSK2	inactive (97.49%)	inactive (88%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	active (14.96%)	active (24%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (91.23%)	inactive (61%)
MAP3K2	inactive (58.41%)	-
MAP3K3	inactive (62.96%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (104.45%)	-
NIK	inactive (123.51%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	active (4.84%)	active (3%)
HGK	active (0.63%)	-
KHS1	active (6.03%)	-
LOK	active (15.32%)	active (8%)
MINK	active (1.72%)	active (6%)
MST1	active (4.24%)	active (2%)
MST2	active (2.72%)	active (5%)
MST3	active (23.5%)	active (12%)
MST4	active (27.29%)	-
OSR1	inactive (99.69%)	-
PAK1	inactive (78.68%)	-
PAK2	inactive (86.3%)	inactive (86%)
PAK3	inactive (82.94%)	inactive (55%)
PAK4	inactive (90.83%)	inactive (68%)
PAK5	inactive (97.82%)	inactive (66%)
PAK6	inactive (92.63%)	inactive (64%)
SLK	inactive (51.97%)	-
YSK1	active (47.19%)	-
STLK3	inactive (95.89%)	-
TAO1	active (22.59%)	active (8%)
TAO2	inactive (72.41%)	active (50%)
TAO3	active (21.13%)	active (13%)
MYO3B	inactive (50.89%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (81.26%)	active (9%)
MAP2K2	inactive (77.68%)	-
MAP2K6	inactive (78.81%)	active (22%)
MAP2K7	-	inactive (70%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	active (39.22%)	active (4%)
AurB	active (8.5%)	active (4%)
AurC	active (48.54%)	inactive (53%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	active (23.77%)	-
CaMKK2	active (10.11%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	active (22.54%)	active (9%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (60.34%)	active (5%)
IKKb	inactive (69.23%)	inactive (51%)
IKKe	active (14.86%)	-
TBK1	active (4.45%)	active (1%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (71.97%)	-
NEK11	inactive (107.55%)	active (40%)
NEK2	inactive (82.59%)	inactive (65%)
NEK4	active (26.12%)	-
NEK6	inactive (100.74%)	inactive (90%)
NEK7	inactive (91.25%)	inactive (101%)
NEK9	inactive (66.26%)	-
NEK3	inactive (100.81%)	inactive (98%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (91.26%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (97.35%)	inactive (77%)
PLK2	inactive (92.87%)	inactive (87%)
PLK3	inactive (99.11%)	inactive (92%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (84.85%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	active (44.28%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (54.4%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	active (11.54%)	-
ULK2	active (48.11%)	active (46%)
ULK3	active (41.69%)	active (37%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (69.43%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (107.41%)	inactive (80%)
Wnk3	inactive (82.63%)	inactive (99%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	inactive (50.83%)	active (38%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (92.57%)	inactive (73%)
CK1g1	inactive (104.07%)	inactive (90%)
CK1g2	inactive (95.46%)	inactive (79%)
CK1g3	inactive (87.88%)	inactive (92%)
CK1a	inactive (87.71%)	-
CK1e	inactive (72.9%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (86.78%)	-
VRK2	-	inactive (88%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (73.98%)	inactive (69%)
CK2a2	-	inactive (105%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	active (4.07%)	-
CLK2	active (0.33%)	active (1%)
CLK3	inactive (63.97%)	active (7%)
CLK4	active (8.92%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	active (5.06%)	-
DYRK1B	active (5%)	-
DYRK2	active (3.11%)	active (-5%)
DYRK3	active (30.4%)	-
DYRK4	inactive (93.42%)	-
HIPK1	inactive (106.64%)	active (45%)
HIPK2	inactive (60.3%)	active (8%)
HIPK3	inactive (66.35%)	active (10%)
HIPK4	inactive (58.66%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (71.81%)	active (25%)
Erk2	inactive (80.67%)	inactive (65%)
JNK3	inactive (111.29%)	active (18%)
NLK	inactive (94.64%)	inactive (75%)
p38a	inactive (97.58%)	inactive (87%)
p38b	inactive (104.49%)	inactive (83%)
p38d	inactive (98.23%)	inactive (73%)
p38g	inactive (98.96%)	inactive (83%)
JNK1	inactive (86.78%)	inactive (65%)
JNK2	inactive (60.77%)	inactive (80%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	active (11.3%)	active (12%)
GSK3B	active (16.72%)	active (14%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (94.09%)	inactive (91%)
SRPK1	inactive (94.33%)	inactive (98%)
SRPK2	inactive (97.3%)	inactive (96%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	active (46.88%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (83%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (107%)