Compound in Profiling

Compound Information

Test on : RBC

Compound Name : HMS3229I22

Inchikey : ZXVUBPLDUMSDOE-UHFFFAOYSA-N

ChemSpider : 21395908

Pubchem CID : 16760525

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDK1	1	1
Akt	3	3
DMPK	7	5
GRK	7	6
RSK	8	8
PKA	5	3
PKC	9	9
PKG	2	3
PKN	3	2
SGK	3	3
NDR	4	1

AGC - PDK1

Bioactivity
Kinase	RBC
PDK1	inactive (92.06%)

AGC - Akt

Bioactivity
Kinase	RBC
AKT1	inactive (101.42%)
AKT2	inactive (105.21%)
AKT3	inactive (99.63%)

AGC - DMPK

Bioactivity
Kinase	RBC
DMPK1	inactive (108.67%)
MRCKa	inactive (102.63%)
MRCKb	inactive (97.99%)
ROCK1	inactive (96.33%)
ROCK2	inactive (97.96%)

AGC - GRK

Bioactivity
Kinase	RBC
BARK1	inactive (104.74%)
BARK2	inactive (105.72%)
GPRK4	inactive (110.01%)
GPRK5	inactive (98.19%)
GPRK6	inactive (108.03%)
GPRK7	inactive (116.06%)

AGC - RSK

Bioactivity
Kinase	RBC
MSK1	inactive (99.58%)
MSK2	inactive (111.07%)
p70S6K	inactive (104.68%)
p70S6Kb	inactive (100.19%)
RSK2	inactive (99.01%)
RSK4	inactive (101.23%)
RSK1	inactive (86.06%)
RSK3	inactive (95.28%)

AGC - PKA

Bioactivity
Kinase	RBC
PKACg	inactive (110.65%)
PRKX	inactive (103.44%)
PKACa	inactive (102.11%)

AGC - PKC

Bioactivity
Kinase	RBC
PKCa	inactive (99.47%)
PKCd	inactive (94.13%)
PKCe	inactive (99.1%)
PKCh	inactive (97.88%)
PKCg	inactive (95.45%)
PKCi	inactive (95.88%)
PKCt	inactive (106.82%)
PKCz	inactive (102.19%)
PKCb	inactive (103.6%)

AGC - PKG

Bioactivity
Kinase	RBC
PKG2	inactive (111.49%)
PKG1	inactive (101.41%)

AGC - PKN

Bioactivity
Kinase	RBC
PKN1	inactive (107.65%)
PKN2	inactive (103.28%)

AGC - SGK

Bioactivity
Kinase	RBC
SGK1	inactive (107.67%)
SGK2	inactive (101.16%)
SGK3	inactive (106.79%)

AGC - NDR

Bioactivity
Kinase	RBC
NDR1	inactive (97.69%)

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Abl	2	2
Ack	2	1
ALK	2	2
Axl	3	3
Src	11	11
Tec	5	5
PDGFR	5	5
Csk	2	2
DDR	2	1
EGFR	4	3
Eph	14	12
FAK	2	2
Fer	2	2
FGFR	4	4
VEGFR	3	3
InsR	3	3
JakA	4	4
Musk	1	1
Ret	1	1
Met	2	2
Sev	1	1
Syk	2	2
Tie	2	1
Trk	3	3

TK - Abl

Bioactivity
Kinase	RBC
ABL1	inactive (102.78%)
ABL2	inactive (98.88%)

TK - Ack

Bioactivity
Kinase	RBC
ACK	inactive (95.4%)

TK - ALK

Bioactivity
Kinase	RBC
ALK	inactive (96.39%)
LTK	inactive (101.83%)

TK - Axl

Bioactivity
Kinase	RBC
AXL	inactive (105.57%)
MER	inactive (97.93%)
TYRO3	inactive (100.86%)

TK - Src

Bioactivity
Kinase	RBC
BLK	inactive (104.8%)
BRK	inactive (89.78%)
SRC	inactive (93.47%)
FGR	inactive (98.07%)
FRK	inactive (104.09%)
FYN	inactive (101.68%)
HCK	inactive (96.55%)
LCK	inactive (101.68%)
SRM	inactive (106%)
YES	inactive (103.88%)
LYN	inactive (103.88%)

TK - Tec

Bioactivity
Kinase	RBC
BMX	inactive (101.03%)
BTK	inactive (94.97%)
ITK	inactive (100.96%)
TEC	inactive (110.54%)
TXK	inactive (97.02%)

TK - PDGFR

Bioactivity
Kinase	RBC
KIT	inactive (84.22%)
FLT3	inactive (111.06%)
FMS	inactive (97.18%)
PDGFRb	inactive (98.89%)
PDGFRa	inactive (101.19%)

TK - Csk

Bioactivity
Kinase	RBC
CSK	inactive (91.47%)
CTK	inactive (92.68%)

TK - DDR

Bioactivity
Kinase	RBC
DDR2	inactive (95.79%)

TK - EGFR

Bioactivity
Kinase	RBC
EGFR	inactive (92.69%)
ErbB2	inactive (97.6%)
ErbB4	inactive (99.78%)

TK - Eph

Bioactivity
Kinase	RBC
EphA1	inactive (102.7%)
EphA2	inactive (100.93%)
EphA3	inactive (103.14%)
EphA4	inactive (99.04%)
EphA5	inactive (99.63%)
EphA6	inactive (93.36%)
EphA7	inactive (108.8%)
EphA8	inactive (104.11%)
EphB1	inactive (95.93%)
EphB2	inactive (97.45%)
EphB3	inactive (95.87%)
EphB4	inactive (99.46%)

TK - FAK

Bioactivity
Kinase	RBC
FAK	inactive (100.77%)
PYK2	inactive (107.88%)

TK - Fer

Bioactivity
Kinase	RBC
FER	inactive (99.69%)
FES	inactive (102.5%)

TK - FGFR

Bioactivity
Kinase	RBC
FGFR1	inactive (105.12%)
FGFR2	inactive (109.76%)
FGFR3	inactive (101.07%)
FGFR4	inactive (108.68%)

TK - VEGFR

Bioactivity
Kinase	RBC
FLT1	inactive (84.39%)
FLT4	inactive (89.81%)
KDR	inactive (100.04%)

TK - InsR

Bioactivity
Kinase	RBC
IGF1R	inactive (104.46%)
IRR	inactive (94.3%)
INSR	inactive (98.22%)

TK - JakA

Bioactivity
Kinase	RBC
JAK1	inactive (107.91%)
JAK2	inactive (102.59%)
JAK3	inactive (100.63%)
TYK2	inactive (100.31%)

TK - Musk

Bioactivity
Kinase	RBC
MUSK	inactive (94.83%)

TK - Ret

Bioactivity
Kinase	RBC
RET	inactive (105.49%)

TK - Met

Bioactivity
Kinase	RBC
RON	inactive (92.46%)
MET	inactive (108.63%)

TK - Sev

Bioactivity
Kinase	RBC
ROS	inactive (96.78%)

TK - Syk

Bioactivity
Kinase	RBC
SYK	inactive (97.64%)
ZAP70	inactive (94.99%)

TK - Tie

Bioactivity
Kinase	RBC
TIE2	inactive (103.89%)

TK - Trk

Bioactivity
Kinase	RBC
TRKA	inactive (105.16%)
TRKB	inactive (100%)
TRKC	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STKR	12	5
RAF	5	3
IRAK	4	2
LISK	4	1
LRRK	2	1
MLK	10	5
RIPK	5	1

TKL - STKR

Bioactivity
Kinase	RBC
ALK1	inactive (106.92%)
ALK2	inactive (72.87%)
ALK4	inactive (96.49%)
TGFbR1	inactive (100.86%)
TGFbR2	inactive (104.33%)

TKL - RAF

Bioactivity
Kinase	RBC
ARAF	inactive (103.92%)
BRAF	inactive (95.2%)
RAF1	inactive (92.91%)

TKL - IRAK

Bioactivity
Kinase	RBC
IRAK1	inactive (103.69%)
IRAK4	inactive (92.9%)

TKL - LISK

Bioactivity
Kinase	RBC
LIMK1	inactive (102.1%)

TKL - LRRK

Bioactivity
Kinase	RBC
LRRK2	inactive (99.97%)

TKL - MLK

Bioactivity
Kinase	RBC
MLK1	inactive (99.47%)
MLK2	inactive (85.43%)
MLK3	inactive (102.7%)
TAK1	inactive (99.73%)
ZAK	inactive (93.19%)

TKL - RIPK

Bioactivity
Kinase	RBC
RIPK2	inactive (81.28%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CAMKL	20	13
CAMK1	5	5
CAMK2	4	4
RAD53	1	1
DAPK	5	4
DCAMKL	3	1
MAPKAPK	5	5
MLCK	5	2
PHK	2	2
PIM	3	3
PKD	3	3
TSSK	5	2
STK33	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC
NuaK1	inactive (97.25%)
BRSK1	inactive (97.02%)
BRSK2	inactive (100.47%)
CHK1	inactive (103.65%)
LKB1	inactive (96.09%)
MARK1	inactive (100.08%)
MARK3	inactive (97.05%)
MARK4	inactive (100.81%)
MELK	inactive (83.26%)
PASK	inactive (98.33%)
QIK	inactive (100.74%)
NuaK2	inactive (76.65%)
MARK2	inactive (105.38%)

CAMK - CAMK1

Bioactivity
Kinase	RBC
CaMK1a	inactive (108.45%)
CaMK1b	inactive (103.73%)
CaMK1d	inactive (120.02%)
CaMK1g	inactive (97.71%)
CaMK4	inactive (107.6%)

CAMK - CAMK2

Bioactivity
Kinase	RBC
CaMK2a	inactive (103.95%)
CaMK2b	inactive (101.37%)
CaMK2d	inactive (97.73%)
CaMK2g	inactive (99.56%)

CAMK - RAD53

Bioactivity
Kinase	RBC
CHK2	inactive (98.49%)

CAMK - DAPK

Bioactivity
Kinase	RBC
DAPK1	inactive (109.14%)
DAPK2	inactive (104.63%)
DRAK1	inactive (104.3%)
DAPK3	inactive (109.77%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC
DCLK2	inactive (96.48%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC
MAPKAPK2	inactive (102.79%)
MAPKAPK3	inactive (102.4%)
MAPKAPK5	inactive (96.64%)
MNK1	inactive (105.9%)
MNK2	inactive (106.36%)

CAMK - MLCK

Bioactivity
Kinase	RBC
smMLCK	inactive (98.67%)
skMLCK	inactive (100.77%)

CAMK - PHK

Bioactivity
Kinase	RBC
PHKg1	inactive (93.82%)
PHKg2	inactive (100.51%)

CAMK - PIM

Bioactivity
Kinase	RBC
PIM1	inactive (105.17%)
PIM2	inactive (104.03%)
PIM3	inactive (95.35%)

CAMK - PKD

Bioactivity
Kinase	RBC
PKD1	inactive (101.26%)
PKD3	inactive (97.7%)
PKD2	inactive (126.31%)

CAMK - TSSK

Bioactivity
Kinase	RBC
TSSK1	inactive (94.93%)
TSSK2	inactive (104.4%)

CAMK - STK33

Bioactivity
Kinase	RBC
STK33	inactive (92.97%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STE11	8	3
STE-Unique	2	2
STE20	31	23
STE7	7	3

STE - STE11

Bioactivity
Kinase	RBC
MAP3K5	inactive (99%)
MAP3K2	inactive (83.99%)
MAP3K3	inactive (99.83%)

STE - STE-Unique

Bioactivity
Kinase	RBC
COT	inactive (99.82%)
NIK	inactive (110.66%)

STE - STE20

Bioactivity
Kinase	RBC
GCK	inactive (86.08%)
HGK	inactive (88.9%)
KHS1	inactive (93.78%)
LOK	inactive (97.68%)
MINK	inactive (95.2%)
MST1	inactive (93.08%)
MST2	inactive (111.39%)
MST3	inactive (90.29%)
MST4	inactive (102.33%)
OSR1	inactive (103.49%)
PAK1	inactive (97.36%)
PAK2	inactive (103.18%)
PAK3	inactive (105.28%)
PAK4	inactive (95.22%)
PAK5	inactive (102.59%)
PAK6	inactive (101.47%)
SLK	inactive (99.24%)
YSK1	inactive (95.7%)
STLK3	inactive (94.55%)
TAO1	inactive (105.69%)
TAO2	inactive (99.84%)
TAO3	inactive (90.19%)
MYO3B	inactive (106.54%)

STE - STE7

Bioactivity
Kinase	RBC
MAP2K1	inactive (98.38%)
MAP2K2	inactive (105.97%)
MAP2K6	inactive (98.14%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Aur	3	3
CAMKK	2	2
Haspin	1	1
IKK	4	4
NEK	11	8
TOPK	1	1
PLK	4	3
SgK496	1	1
NAK	4	1
TTK	1	1
ULK	5	3
WEE	3	1
WNK	4	2
TLK	2	1

Other - Aur

Bioactivity
Kinase	RBC
AurA	inactive (101.39%)
AurB	inactive (103.15%)
AurC	inactive (94.99%)

Other - CAMKK

Bioactivity
Kinase	RBC
CaMKK1	inactive (109.4%)
CaMKK2	inactive (80.43%)

Other - Haspin

Bioactivity
Kinase	RBC
Haspin	inactive (99.02%)

Other - IKK

Bioactivity
Kinase	RBC
IKKa	inactive (99.59%)
IKKb	inactive (97.01%)
IKKe	inactive (94.27%)
TBK1	inactive (94.04%)

Other - NEK

Bioactivity
Kinase	RBC
NEK1	inactive (93.41%)
NEK11	inactive (104.83%)
NEK2	inactive (88.1%)
NEK4	inactive (94.59%)
NEK6	inactive (101.49%)
NEK7	inactive (89.21%)
NEK9	inactive (96.03%)
NEK3	inactive (93.17%)

Other - TOPK

Bioactivity
Kinase	RBC
PBK	inactive (116.44%)

Other - PLK

Bioactivity
Kinase	RBC
PLK1	inactive (96.44%)
PLK2	inactive (100.74%)
PLK3	inactive (99.64%)

Other - SgK496

Bioactivity
Kinase	RBC
SgK496	inactive (100.06%)

Other - NAK

Bioactivity
Kinase	RBC
MPSK1	inactive (98.53%)

Other - TTK

Bioactivity
Kinase	RBC
TTK	inactive (85.51%)

Other - ULK

Bioactivity
Kinase	RBC
ULK1	inactive (99.78%)
ULK2	inactive (112.15%)
ULK3	inactive (101.1%)

Other - WEE

Bioactivity
Kinase	RBC
Wee1	inactive (88.93%)

Other - WNK

Bioactivity
Kinase	RBC
Wnk2	inactive (108.96%)
Wnk3	inactive (99.21%)

Other - TLK

Bioactivity
Kinase	RBC
TLK2	inactive (98.86%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK1	7	6
VRK	3	1

CK1 - CK1

Bioactivity
Kinase	RBC
CK1d	inactive (105.61%)
CK1g1	inactive (109.36%)
CK1g2	inactive (102.54%)
CK1g3	inactive (103.96%)
CK1a	inactive (91.07%)
CK1e	inactive (101.71%)

CK1 - VRK

Bioactivity
Kinase	RBC
VRK1	inactive (87.19%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK2	3	2
CLK	4	4
DYRK	10	9
MAPK	14	10
GSK	2	2
SRPK	3	3

CMGC - CK2

Bioactivity
Kinase	RBC
CK2a1	inactive (101.06%)
CK2a2	inactive (92.21%)

CMGC - CLK

Bioactivity
Kinase	RBC
CLK1	inactive (99.24%)
CLK2	inactive (101.31%)
CLK3	inactive (99.35%)
CLK4	inactive (91.97%)

CMGC - DYRK

Bioactivity
Kinase	RBC
DYRK1A	inactive (96.66%)
DYRK1B	inactive (101.14%)
DYRK2	inactive (119.13%)
DYRK3	inactive (127.61%)
DYRK4	inactive (98.13%)
HIPK1	inactive (107.18%)
HIPK2	inactive (108.95%)
HIPK3	inactive (115.51%)
HIPK4	inactive (110.05%)

CMGC - MAPK

Bioactivity
Kinase	RBC
Erk1	inactive (97.11%)
Erk2	inactive (87.5%)
JNK3	inactive (111.58%)
NLK	inactive (99.43%)
p38a	inactive (98.08%)
p38b	inactive (104.43%)
p38d	inactive (109.19%)
p38g	inactive (95.56%)
JNK1	inactive (87.32%)
JNK2	active (33.9%)

CMGC - GSK

Bioactivity
Kinase	RBC
GSK3A	inactive (97.23%)
GSK3B	inactive (97.5%)

CMGC - SRPK

Bioactivity
Kinase	RBC
MSSK1	inactive (95.69%)
SRPK1	inactive (102.22%)
SRPK2	inactive (99.24%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDHK	5	1

Atypical - PDHK

Bioactivity
Kinase	RBC
PDHK1	inactive (92.06%)