Showing entry for Glaucine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000993
Compound NameGlaucine
Structure
FormulaC21H25NO4
InchiKeyRUZIUYOSRDWYQF-UHFFFAOYSA-N
SMILESCOC1=CC2=C(C=C1OC)C1=C(OC)C(OC)=CC3=C1C(C2)N(C)CC3
InchiInChI=1S/C21H25NO4/c1-22-7-6-12-9-18(25-4)21(26-5)20-14-11-17(24-3)16(23-2)10-13(14)8-15(22)19(12)20/h9-11,15H,6-8H2,1-5H3
IUPAC4,5,15,16-tetramethoxy-10-methyl-10-azatetracyclo[7.7.1.02,?.013,1?]heptadeca-1(16),2(7),3,5,13(17),14-hexaene
Molecular Weight355.43
Pubchem Id10145
Chembl IdCHEMBL36536
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 35523
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006689 Cathepsin B reviewed Enzyme CTSB - >50000 - -
reviewed BXGT006661 Cathepsin L1 reviewed Enzyme CTSL - >50000 - -
reviewed BXGT010317 Caspase-3 reviewed Enzyme CASP3 - 907 - -
reviewed BXGT019693 Sentrin-specific protease 8 reviewed SENP8 - 5470 - -
reviewed BXGT019693 Sentrin-specific protease 8 reviewed SENP8 - >5000 - -
reviewed BXGT020423 Sentrin-specific protease 6 reviewed Enzyme SENP6 - 1860 - -
reviewed BXGT012297 Protein RecA reviewed recA - 25760 - -
reviewed BXGT005384 Tyrosyl-DNA phosphodiesterase 2 reviewed TDP2 - 4598 - -
CHEMBL CHEMBL36536
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 39810 nM
P9WHJ3 BXGT012297 Protein RecA reviewed - recA IC90 - 40200 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 39810 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 39810 nM
Q9BQF6 BXGT020111 Sentrin-specific protease 7 reviewed Enzyme SENP7 IC50 '=' 4630 nM
Q96LD8 BXGT019693 Sentrin-specific protease 8 reviewed - SENP8 IC50 '>' 5000 nM
P00811 BXGT005666 Beta-lactamase reviewed - ampC Potency '=' 50118 nM
P9WMR3 BXGT012397 Replicative DNA helicase reviewed - dnaB AC50 '=' 10340 nM
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 15848 nM
P42574 BXGT010317 Caspase-3 reviewed Enzyme CASP3 IC50 '=' 907 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 177 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 8199 nM
Q96LD8 BXGT019693 Sentrin-specific protease 8 reviewed - SENP8 IC50 '=' 5470 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 18356 nM
O95398 BXGT005378 Rap guanine nucleotide exchange factor 3 reviewed Enzyme modulator RAPGEF3 Potency - 35481 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 1032 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 11220 nM
Q9GZR1 BXGT020423 Sentrin-specific protease 6 reviewed Enzyme SENP6 IC50 '=' 1860 nM
Q962Y6 BXGT019597 Thioredoxin glutathione reductase unreviewed - TGR Potency '=' 39810 nM
P43351 BXGT010380 DNA repair protein RAD52 homolog reviewed Nucleic acid binding RAD52 AC50 '=' 2140 nM
P9WMR3 BXGT012397 Replicative DNA helicase reviewed - dnaB AC50 '=' 549 nM
O95551 BXGT005384 Tyrosyl-DNA phosphodiesterase 2 reviewed - TDP2 IC50 '=' 4598 nM
P9WHJ3 BXGT012297 Protein RecA reviewed - recA EC50 '=' 614 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 14125 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 25118 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 28183 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 8912 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00014 Custard apple Annona reticulata Fruits
BXGF00088 Barley Hordeum vulgare Cereals and cereal products
BXGF00402 Opium poppy Papaver somniferum Herbs and Spices
BXGF03079 Glaucium flavum Glaucium flavum Medicinal Plant
BXGF05994 Corydalis yanhusuo Corydalis yanhusuo Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease