Showing entry for Rap guanine nucleotide exchange factor 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005378
Protein NameRap guanine nucleotide exchange factor 3
Uniport IdO95398
GeneRAPGEF3
Gene Id10411
DomaincNMP_binding; DEP; RasGEF; RasGEF_N
Pfam PF00027   PF00610   PF00617   PF00618  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04015 Rap1 signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.1 Immune system hsa04670 Leukocyte transendothelial migration
5. Organismal Systems 5.6 Nervous system hsa04720 Long-term potentiation
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001525 angiogenesis
Biological Process GO:0019933 cAMP-mediated signaling
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0061028 establishment of endothelial barrier
Biological Process GO:0034242 negative regulation of syncytium formation by plasma membrane fusion
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:1901985 positive regulation of protein acetylation
Biological Process GO:0046827 positive regulation of protein export from nucleus
Biological Process GO:0051496 positive regulation of stress fiber assembly
Biological Process GO:0060143 positive regulation of syncytium formation by plasma membrane fusion
Biological Process GO:0032486 Rap protein signal transduction
Biological Process GO:2000249 regulation of actin cytoskeleton reorganization
Biological Process GO:0050796 regulation of insulin secretion
Biological Process GO:0007165 signal transduction
molecular function GO:0030552 cAMP binding
molecular function GO:0005085 guanyl-nucleotide exchange factor activity
molecular function GO:0019904 protein domain specific binding
molecular function GO:0017034 Rap guanyl-nucleotide exchange factor activity
cellular component GO:0012505 endomembrane system
cellular component GO:0070062 extracellular exosome
cellular component GO:0030175 filopodium
cellular component GO:0030027 lamellipodium
cellular component GO:0016020 membrane
cellular component GO:0005902 microvillus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1280218 Adaptive Immune System
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-163685 Integration of energy metabolism
R-HSA-168256 Immune System
R-HSA-354192 Integrin signaling
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392517 Rap1 signalling
R-HSA-422356 Regulation of insulin secretion
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76009 Platelet Aggregation (Plug Formation)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0018129 BXGD001175 Graft Rejection
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030201 BXGD002194 Pain, Postoperative Pathological Conditions, Signs and Symptoms
C0032617 BXGD002367 Polyuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035585 BXGD002561 Rickettsia Infections Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0149678 BXGD003346 Epstein-Barr Virus Infections Infections
C0149978 BXGD003397 Adenocarcinoma of rectum Digestive System Diseases; Neoplasms
C0151468 BXGD003424 Thyroid Gland Follicular Adenoma Neoplasms; Endocrine System Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0162699 BXGD003976 Tick-Borne Infections Infections
C0162700 BXGD003977 Tick-Borne Diseases Infections
C0205682 BXGD004105 Waist-Hip Ratio
C0205696 BXGD004107 Anaplastic carcinoma Neoplasms
C0206682 BXGD004237 Follicular thyroid carcinoma Neoplasms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0856742 BXGD011111 Post MI Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1290807 BXGD012195 Diarrheal disorder Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1527303 BXGD013265 Chronic Airflow Obstruction Respiratory Tract Diseases
C1565662 BXGD013402 Acute Kidney Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2931367 BXGD018010 Thyroid cancer, follicular Neoplasms
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2945695 BXGD018187 Limb ischemia
C2985280 BXGD018223 Blood Protein Measurement
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3873567 BXGD019863 Peripheral neuropathy due to and following chemotherapy Nervous System Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4553639 BXGD023545 Arterial Injury, CTCAE
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0000284 alpha-Tocopherol 430.71
BXGC0000383 (S)-Naringenin 272.25
BXGC0000500 2,4-Dihydroxybenzoic acid 154.12
BXGC0000505 Protocatechuic acid 154.12
BXGC0000805 Bis(2-furanylmethyl) disulfide 226.32
BXGC0000952 6-Oxocamphor 457.91
BXGC0000988 3' 5'-cyclic AMP 329.21
BXGC0000993 Glaucine 355.43
BXGC0001080 Xanthoangelol B 408.49
BXGC0001172 Xanthoangelol F 406.51
BXGC0001497 Berberrubine 322.33
BXGC0001742 Eupafolin 316.26
BXGC0001782 Sennoside B 862.74
BXGC0001843 Bergaptol 202.17
BXGC0001879 Chlorogenic acid 354.31
BXGC0002064 Amentoflavone 538.46
BXGC0002144 Tetradecanoic acid 228.37
BXGC0002605 Adenosine 267.24
BXGC0002794 N-Methylaniline 107.15
BXGC0003060 o-Xylenol 122.16
BXGC0003255 Lochnocarpol A 408.49
BXGC0003450 Gibberellins 346.37
BXGC0003696 Quercetin 3-O-methyl-ether 316.26
BXGC0004322 xi-3-Hydroxy-5-phenylpentanoic acid O-beta-D-Glucopyranoside 356.37
BXGC0005319 Garcinone E 464.55
BXGC0005682 3,3',4,4'-Tetrahydroxylignan 302.36
BXGC0005793 Baicalein 270.24
BXGC0005881 Urea 60.06
BXGC0006034 Phytomenadione 450.7
BXGC0006193 Ellagic acid 302.19
BXGC0006306 Myricetin 318.24
BXGC0006362 Estrone 270.37
BXGC0006372 Ergocalciferol 396.65
BXGC0006635 Luteolin 286.24
BXGC0007368 Luteolin 7-glucoside 448.38
BXGC0007835 (-)-3-Isothujone 152.23
BXGC0008168 7-Methylchrysin 268.26
BXGC0008181 Morusin 420.45
BXGC0008824 Astragalin 448.38
BXGC0009332 Pelanin 356.5
BXGC0009649 Dihydrocapsaicin 307.43
BXGC0009984 Pyrafoline D 347.45
BXGC0009993 (R)-Mahanine 347.45
BXGC0010010 3,8''-Biapigenin 538.46
BXGC0011421 3-Hydroxy-1-(4-hydroxyphenyl)-1-propanone 166.17
BXGC0012292 Creatinine 113.12
BXGC0012321 Menatetrenone 444.66
BXGC0012496 13-epi-sclareol 308.27
BXGC0015314 1-(2,6-Dihydroxyphenyl)Dodecan-1-One 292.2
BXGC0016291 Suksdorfin 388.15
BXGC0016692 Wogonin 284.07
BXGC0017003 Decursin 328.13
BXGC0017933 Sulfuretin 270.05
BXGC0018252 Embelin 294.18
BXGC0020995 6-[(3E,5E,7S)-5,7-Dimethyl-2-Oxonona-3,5-Dienyl]-2,4-Dihydroxy-3-Methylbenzaldehyde 316.17
BXGC0022009 (9R)-9-[(9R)-2-Carboxy-4-Hydroxy-10-Oxo-5-[(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracen-9-Yl]-4-Hydroxy-10-Oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracene-2-Carboxylic Acid 862.2
BXGC0022169 2-[(1S,6R)-6-(2,4-Dihydroxybenzoyl)-5-(2,4-Dihydroxyphenyl)-3-Methylcyclohex-2-En-1-Yl]-1,3,5A,8-Tetrahydroxy-10A-(3-Methylbut-2-Enyl)-[1]Benzofuro[3,2-B]Chromen-11-One 708.22
BXGC0023321 Quercetin Dihydrate 302.04
BXGC0023633 Kamebanin 334.21
BXGC0023895 (1R,4Ar,7R)-7-Ethenyl-1,4A,7-Trimethyl-3,4,4B,5,6,9,10,10A-Octahydro-2H-Phenanthrene-1-Carboxylic Acid 302.22
BXGC0024428 3-(1H-Benzimidazol-2-Yl)-7-(Diethylamino)Chromen-2-One 333.15
BXGC0024665 Vitamin K 1 450.35
BXGC0025200 2-Anilinonaphthalene-1,4-Dione 249.08
BXGC0025757 Calcimycin 523.27
BXGC0025862 Levothyroxine 776.69
BXGC0025876 Acetoside 624.21
BXGC0025979 Alisol B 472.36
BXGC0026480 Osajin 404.16
BXGC0026607 epiberberine 336.12
BXGC0027249 Deoxyvasicinone 186.08
BXGC0027639 sanggenon A 436.15
BXGC0027965 (+)-cis-Khellactone 262.08
BXGC0028067 Enniatin B 639.41
BXGC0028589 5,6,7,8-Tetrahydroxy-2-(4-Hydroxyphenyl)Chromen-4-One 302.04
BXGC0029205 Sphaeropsidin A 346.18
BXGC0029598 2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyloxan-2-Yl]Oxychromen-4-One;Hydrate 448.1
BXGC0029707 Byakangelicin 334.11
BXGC0029721 Sclerotiorin 390.12
BXGC0030094 Paroxypropione 150.07
BXGC0030384 Vitamin A Palmitate 524.46
BXGC0030714 Daphnoretin 352.06
BXGC0030879 Mesodihydroguaiaretic Acid 330.18
BXGC0031659 delta-Tocopherol 402.35
BXGC0031717 Purpurin 256.04
BXGC0034502 Sumaresinolic acid 472.36
BXGC0034894 Oleic Acid 282.26
BXGC0037407 Lithocholic Acid 376.3
BXGC0037599 Tanshinone Iia 294.13
BXGC0038895 Emodic Acid 300.03
BXGC0040358 Lobaric Acid 456.18
BXGC0040779 Gerontoxanthone I 396.16
BXGC0041119 Methyl (1S,4As,7As)-7-(Hydroxymethyl)-1-[3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-1,4A,5,7A-Tetrahydrocyclopenta[C]Pyran-4-Carboxylate 388.14
BXGC0042336 7-Amino-4-Hydroxynaphthalene-2-Sulfonic Acid 239.03
BXGC0042852 Skimmianine 259.08
BXGC0044087 Uridine 244.07
BXGC0044200 Menadione 172.05
BXGC0046510 Tpck 351.07
BXGC0047404 Androstenedone 284.18
BXGC0047867 Dalfampridine 94.05
BXGC0048801 Sid24823998 254.09
BXGC0050184 Myricitrin 464.1
BXGC0050651 Cryptotanshinone 296.14
BXGC0051756 [8,8-Dimethyl-9-[(Z)-2-Methylbut-2-Enoyl]Oxy-2-Oxo-9,10-Dihydropyrano[2,3-F]Chromen-10-Yl] (Z)-2-Methylbut-2-Enoate 426.17
BXGC0052109 Cardamomin 270.09
BXGC0052948 Tanshinone I 276.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein