acompound

Showing entry for Hypoxanthine

General Compound Information
BXGC Id	BXGC0002786
Compound Name	Hypoxanthine
Structure
Formula	C5H4N4O
InchiKey	FDGQSTZJBFJUBT-UHFFFAOYSA-N
SMILES	OC1=NC=NC2=C1NC=N2
Inchi	InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
IUPAC	7H-purin-6-ol
Molecular Weight	136.11
Pubchem Id	790
Chembl Id	CHEMBL1427

Targets of Information Source

DrugBank

DB04076

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
P00491	BXGT005555	Purine nucleoside phosphorylase	reviewed	Enzyme	PNP	experimental	-

PDB

HPA

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
P55859	BXGT011128	Purine nucleoside phosphorylase	reviewed	PNP	-	-	-	-	-
P0ACP7	BXGT007269	HTH-type transcriptional repressor PurR	reviewed	purR	-	-	-	-	-
P55859	BXGT011128	Purine nucleoside phosphorylase	reviewed	PNP	-	2500	-	-	-
O54051	BXGT004718	Xanthine dehydrogenase	unreviewed	xdhB	-	-	-	-	-
Q8I3X4	BXGT018215	Purine nucleoside phosphorylase	unreviewed	PF3D7_0513300	-	-	-	-	-
Q9BMI9	BXGT020101	Purine nucleoside phosphorylase	unreviewed		-	-	-	-	-
Q8DTU4	BXGT018037	Purine nucleoside phosphorylase	unreviewed	punA	-	-	-	-	-
P80457	BXGT011911	Xanthine dehydrogenase/oxidase	reviewed	XDH	-	-	-	-	-
Q9HZK1	BXGT020678	S-methyl-5'-thioinosine phosphorylase	reviewed	PA3004	-	-	-	-	-
P20035	BXGT008540	Hypoxanthine-guanine-xanthine phosphoribosyltransferase	reviewed	LACZ	-	-	-	-	-
Q9I6Y4	BXGT020775	Adenine deaminase	reviewed	PA0148	-	-	-	-	-
P9WP01	BXGT012432	Purine nucleoside phosphorylase	reviewed	punA	-	-	-	-	-
O34925	BXGT004505	Purine nucleoside phosphorylase DeoD-type	reviewed	deoD	-	-	-	-	-
B9JYS2	BXGT002335	Purine nucleoside phosphorylase	unreviewed	Avi_0263	-	-	-	-	-
Q6CSZ6	BXGT016227	Purine nucleoside phosphorylase	unreviewed	KLLA0_C16621g	-	-	-	-	-
K2JXG0	BXGT003772	Purine nucleoside phosphorylase DeoD-type	unreviewed	deoD	-	-	-	-	-
P56463	BXGT011172	Purine nucleoside phosphorylase DeoD-type	reviewed	deoD	-	-	-	-	-
A0A0U3AGT1	BXGT000619	Purine nucleoside phosphorylase	unreviewed		-	-	-	-	-
P07741	BXGT006666	Adenine phosphoribosyltransferase	reviewed	APRT	-	-	-	-	-
Q8IJA9	BXGT018285	Adenosine deaminase	unreviewed	PF3D7_1029600	-	-	-	-	-

Binding DB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM

CHEMBL

CHEMBL1427

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P00492	BXGT005556	Hypoxanthine-guanine phosphoribosyltransferase	reviewed	Enzyme	HPRT1	Km	'='	3100	nM
P85973	BXGT012080	Purine nucleoside phosphorylase	reviewed	-	Pnp	Ratio	'='	3	-
P55859	BXGT011128	Purine nucleoside phosphorylase	reviewed	-	PNP	Kd	'='	1250	nM
P00352	BXGT005510	Retinal dehydrogenase 1	reviewed	Enzyme	ALDH1A1	Potency	'='	39810	nM
P00492	BXGT005556	Hypoxanthine-guanine phosphoribosyltransferase	reviewed	Enzyme	HPRT1	Km	'='	3400	nM
P85973	BXGT012080	Purine nucleoside phosphorylase	reviewed	-	Pnp	Ki	'='	17000	nM
O97447	BXGT005436	Putative fructose-1,6-bisphosphate aldolase	unreviewed	-	ald	Potency	'='	19905	nM
P55859	BXGT011128	Purine nucleoside phosphorylase	reviewed	-	PNP	Kieq	'='	2500	nM
P55859	BXGT011128	Purine nucleoside phosphorylase	reviewed	-	PNP	Kd	'='	680	nM
Q9F4F7	BXGT020344	4'-phosphopantetheinyl transferase ffp	reviewed	-	ffp	Potency	'='	79432	nM
Q9NPD5	BXGT021151	Solute carrier organic anion transporter family member 1B3	reviewed	Transporter	SLCO1B3	Inhibition	'='	92	%
P00491	BXGT005555	Purine nucleoside phosphorylase	reviewed	Enzyme	PNP	Inhibition	'='	78	%
Q9Y6L6	BXGT022334	Solute carrier organic anion transporter family member 1B1	reviewed	Transporter	SLCO1B1	Inhibition	'='	92	%

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00015	Wild celery	Apium graveolens	Herbs and Spices
BXGF00022	Oat	Avena sativa	Cereals and cereal products
BXGF00038	Tea	Camellia sinensis	Teas
BXGF00059	Arabica coffee	Coffea arabica	Coffee and coffee products
BXGF00085	Soy bean	Glycine max	Soy
BXGF00125	Rice	Oryza sativa	Cereals and cereal products
BXGF00175	Potato	Solanum tuberosum	Vegetables
BXGF00246	Red beetroot	Beta vulgaris var. rubra	Vegetables
BXGF00522	Narrowleaf cattail	Typha angustifolia	Vegetables
BXGF01185	Aloe vera	Aloe vera	Medicinal Plant
BXGF01323	Pinellia pedatisecta	Pinellia pedatisecta	Medicinal Plant
BXGF01333	Leontice robustum	Leontice robustum	Medicinal Plant
BXGF01347	Fritillaria delavayi	Fritillaria delavayi	Medicinal Plant
BXGF01413	Fritillaria verticillata	Fritillaria verticillata	Medicinal Plant
BXGF01479	Fritillaria cirrhosa	Fritillaria cirrhosa	Medicinal Plant
BXGF01776	Fritillaria prezewalskii	Fritillaria prezewalskii	Others
BXGF01900	Aloe ferox	Aloe ferox	Medicinal Plant
BXGF01913	Fritillaria unibracteata	Fritillaria unibracteata	Medicinal Plant
BXGF02567	Lycium chinense	Lycium chinense	Medicinal Plant
BXGF03359	Amomum melegueta	Amomum melegueta	Medicinal Plant
BXGF03439	Fritillaria przewalskii	Fritillaria przewalskii	Medicinal Plant
BXGF03811	Euryale ferox	Euryale ferox	Medicinal Plant
BXGF03879	Arisaema heterophyllum	Arisaema heterophyllum	Medicinal Plant
BXGF04103	Fritillaria taipaiensis	Fritillaria taipaiensis	Others
BXGF04471	Otholobium glandulosum	Otholobium glandulosum	Medicinal Plant
BXGF04483	Terminalia brachystemma	Terminalia brachystemma	Others
BXGF04494	Raoulia australis	Raoulia australis	Others
BXGF04507	Anacyclus monanthos	Anacyclus monanthos	Others
BXGF04516	Ulmus campestris	Ulmus campestris	Medicinal Plant
BXGF04554	Corydalis tashiroi	Corydalis tashiroi	Others
BXGF04562	Senecio chionophilus	Senecio chionophilus	Others
BXGF04585	Arisaema amurense	Arisaema amurense	Medicinal Plant
BXGF04592	Prunus speciosa	Prunus speciosa	Others
BXGF04600	Typha orientalis	Typha orientalis	Medicinal Plant
BXGF04612	Mikania cordifolia	Mikania cordifolia	Medicinal Plant
BXGF04619	Hakea trifurcata	Hakea trifurcata	Others
BXGF04624	Astragalus siculus	Astragalus siculus	Others
BXGF04631	Aloe spicata	Aloe spicata	Medicinal Plant
BXGF04652	Guizotia scabra	Guizotia scabra	Medicinal Plant
BXGF04669	Euphorbia cuneata	Euphorbia cuneata	Medicinal Plant
BXGF04672	Arum palaestinum	Arum palaestinum	Medicinal Plant
BXGF04926	Aloe africana	Aloe africana	Medicinal Plant
BXGF05297	Isatis tinctoria	Isatis tinctoria	Medicinal Plant
BXGF05330	Arum ternatum thunb	Arum ternatum thunb	Others
BXGF05499	Arisaema erubescens	Arisaema erubescens	Medicinal Plant
BXGF05571	Ziziphus jujuba	Ziziphus jujuba	Medicinal Plant
BXGF05962	Rehmannia glutinosa	Rehmannia glutinosa	Medicinal Plant
BXGF06143	Persicaria tinctoria	Persicaria tinctoria	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}