Showing entry for (-)-Corydalmine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0023978
Compound Name(-)-Corydalmine
Structure
FormulaC20H23NO4
InchiKeyDIHXHTWYVOYYDC-INIZCTEOSA-N
SMILESCOc1cc2c(cc1OC)CCN1[C@H]2Cc2ccc(c(c2C1)OC)O
InchiInChI=1S/C20H23NO4/c1-23-18-9-13-6-7-21-11-15-12(4-5-17(22)20(15)25-3)8-16(21)14(13)10-19(18)24-2/h4-5,9-10,16,22H,6-8,11H2,1-3H3/t16-/m0/s1
IUPAC(13aS)-2,3,9-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-10-ol
Molecular Weight341.16
Pubchem Id161665
Chembl IdCHEMBL448891
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50424075
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT007950 Tissue factor reviewed Receptor F3 - 152 - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 - 18730 - -
reviewed BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 - 21270 - -
reviewed BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 - - - 1350
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A - - - 190
reviewed BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 50 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 305 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A 149 - - -
CHEMBL CHEMBL448891
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Ki '=' 149 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Emax '=' 31 %
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Imax '=' 60 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 305 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 '=' 21270 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Inhibition '=' 98 %
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 EC50 '=' 1350 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki '=' 50 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 533 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki '>' 1000 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '=' 1713 nM
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Inhibition '=' 97 %
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB IC50 '>' 20000 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 '>' 20000 nM
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A EC50 '=' 190 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 '=' 18730 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Inhibition '=' 68 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Inhibition '=' 88 %
P21918 BXGT008708 D(1B) dopamine receptor reviewed G-protein coupled receptor DRD5 Ki '=' 242 nM
P13726 BXGT007950 Tissue factor reviewed Receptor F3 IC50 '=' 152 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Activity '=' 85 %
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Emax '=' 156 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Imax '=' 82 %
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki '=' 107 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB Activity '=' 92 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00301 Cherimoya Annona cherimola Fruits
BXGF00446 Sugar apple Annona squamosa Fruits
BXGF01060 Baccharis grandicapitulata Baccharis grandicapitulata Others
BXGF01079 Renealmia alpinia Renealmia alpinia Human Edible Plant
BXGF01207 Morella pensylvanica Morella pensylvanica Others
BXGF01276 Delphinium giraldii Delphinium giraldii Medicinal Plant
BXGF01337 Stellaria media Stellaria media Medicinal Plant
BXGF01493 Curcuma aeruginosa Curcuma aeruginosa Medicinal Plant
BXGF01603 Piper brachystachyum Piper brachystachyum Medicinal Plant
BXGF01688 Tephroseris kirilowii Tephroseris kirilowii Medicinal Plant
BXGF01731 Corydalis turtschaninovii Corydalis turtschaninovii Human Edible Plant
BXGF01967 Senecio congestus Senecio congestus Medicinal Plant
BXGF02124 Papaver pseudocanescens Papaver pseudocanescens Others
BXGF02242 Sideritis dasygnaphala Sideritis dasygnaphala Others
BXGF02382 Gutierrezia dracunculoides Gutierrezia dracunculoides Others
BXGF02423 Psidium acutangulum Psidium acutangulum Human Edible Plant
BXGF02440 Beesia calthifolia Beesia calthifolia Others
BXGF02483 Bursera kerberi Bursera kerberi Others
BXGF02514 Helenium integrifolium Helenium integrifolium Others
BXGF02543 Rhododendron mucronulatum Rhododendron mucronulatum Medicinal Plant
BXGF02570 Euonymus fortunei Euonymus fortunei Medicinal Plant
BXGF02613 Phlomis crinita Phlomis crinita Medicinal Plant
BXGF02653 Macaranga bicolor Macaranga bicolor Others
BXGF02665 Crotalaria stolzii Crotalaria stolzii Others
BXGF02682 Selinum libanotis Selinum libanotis Others
BXGF02718 Melampodium leucanthum Melampodium leucanthum Others
BXGF02734 Clerodendrum trichotomum Clerodendrum trichotomum Medicinal Plant
BXGF02750 Juniperus scopulorum Juniperus scopulorum Medicinal Plant
BXGF02785 Clinacanthus nutans Clinacanthus nutans Medicinal Plant
BXGF02827 Alstonia angustiloba Alstonia angustiloba Others
BXGF02840 Lasianthaea podocephala Lasianthaea podocephala Others
BXGF02855 Eucalyptus albens Eucalyptus albens Others
BXGF02908 Pellacalyx axillaris Pellacalyx axillaris Others
BXGF02950 Boschniakia rossica Boschniakia rossica Medicinal Plant
BXGF03407 Stephania pierrei Stephania pierrei Medicinal Plant
BXGF03583 Epimedium koreanum Epimedium koreanum Medicinal Plant
BXGF03640 Fibraurea recisa Fibraurea recisa Medicinal Plant
BXGF03817 Coffea liberica var. dewevrei Coffea liberica var. dewevrei Medicinal Plant
BXGF04006 Corydalis ternata Corydalis ternata Others
BXGF04011 Botrychium ternatum Botrychium ternatum Medicinal Plant
BXGF04832 Crescentia cujete Crescentia cujete Medicinal Plant
BXGF04902 Lupinus cosentinii Lupinus cosentinii Others
BXGF05318 Hedysarum gmelini Hedysarum gmelini Others
BXGF05465 Euploca racemosa Euploca racemosa Others
BXGF05994 Corydalis yanhusuo Corydalis yanhusuo Medicinal Plant
BXGF06271 Artemisia pectinata Artemisia pectinata Others
BXGF06307 Zephyranthes flava Zephyranthes flava Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease