Showing entry for D(1B) dopamine receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008708
Protein NameD(1B) dopamine receptor
Uniport IdP21918
GeneDRD5
Gene Id1816
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04728 Dopaminergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007190 activation of adenylate cyclase activity
Biological Process GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
Biological Process GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Process GO:0008306 associative learning
Biological Process GO:0006874 cellular calcium ion homeostasis
Biological Process GO:0071870 cellular response to catecholamine stimulus
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0007212 dopamine receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0060292 long-term synaptic depression
Biological Process GO:0045776 negative regulation of blood pressure
Biological Process GO:0033861 negative regulation of NAD(P)H oxidase activity
Biological Process GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
Biological Process GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
Biological Process GO:0045762 positive regulation of adenylate cyclase activity
Biological Process GO:0072593 reactive oxygen species metabolic process
Biological Process GO:0045924 regulation of female receptivity
Biological Process GO:0001992 regulation of systemic arterial blood pressure by vasopressin
Biological Process GO:0001975 response to amphetamine
Biological Process GO:0042220 response to cocaine
Biological Process GO:0046960 sensitization
Biological Process GO:0001963 synaptic transmission, dopaminergic
Biological Process GO:0019226 transmission of nerve impulse
Biological Process GO:0042060 wound healing
molecular function GO:0035240 dopamine binding
molecular function GO:0004952 dopamine neurotransmitter receptor activity
molecular function GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs
molecular function GO:0004930 G protein-coupled receptor activity
cellular component GO:0031526 brush border membrane
cellular component GO:0060170 ciliary membrane
cellular component GO:0005929 cilium
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0097730 non-motile cilium
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375280 Amine ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-390651 Dopamine receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-5663205 Infectious disease
R-HSA-9658195 Leishmania infection
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664433 Leishmania parasite growth and survival
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003431 BXGD000190 Antisocial Personality Disorder Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005587 BXGD000316 Depression, Bipolar Mental Disorders
C0005747 BXGD000332 Blepharospasm Eye Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006325 BXGD000393 Bruxism Stomatognathic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011573 BXGD000730 Endogenous depression Mental Disorders
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0023374 BXGD001639 Lesch-Nyhan Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0024713 BXGD001799 Manic Disorder Mental Disorders
C0025193 BXGD001831 Melancholia Mental Disorders
C0027651 BXGD002009 Neoplasms Neoplasms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029121 BXGD002112 Oppositional Defiant Disorder Mental Disorders
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033958 BXGD002446 Psychosis, Brief Reactive Mental Disorders
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036337 BXGD002598 Schizoaffective Disorder Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036349 BXGD002604 Paranoid Schizophrenia Mental Disorders
C0036358 BXGD002606 Schizophreniform Disorders Mental Disorders
C0038580 BXGD002771 Substance Dependence Chemically-Induced Disorders; Mental Disorders
C0040485 BXGD002871 Torticollis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040517 BXGD002872 Gilles de la Tourette syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0041671 BXGD002930 Attention Deficit Disorder Mental Disorders
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0086133 BXGD003265 Depressive Syndrome Mental Disorders
C0149654 BXGD003343 Conduct Disorder Mental Disorders
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0152116 BXGD003545 Spasmodic torticollis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0282126 BXGD006796 Depression, Neurotic Mental Disorders
C0338831 BXGD007216 Manic Mental Disorders
C0349785 BXGD007955 Torticollis, Psychogenic Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0424101 BXGD008519 Inattention
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0426785 BXGD008575 Torticollis, Intermittent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0740858 BXGD010012 Substance abuse problem Chemically-Induced Disorders; Mental Disorders
C0743332 BXGD010081 Focal Dystonia Nervous System Diseases
C0751771 BXGD010582 Sleep Bruxism Nervous System Diseases; Mental Disorders; Stomatognathic Diseases
C0865424 BXGD011288 Adult attention deficit hyperactivity disorder Mental Disorders
C0949445 BXGD011575 Cervical Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1321905 BXGD012450 Minimal Brain Dysfunction Mental Disorders
C1510472 BXGD013170 Drug Dependence Chemically-Induced Disorders; Mental Disorders
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1839839 BXGD014416 MAJOR AFFECTIVE DISORDER 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders
C1852197 BXGD015264 MAJOR AFFECTIVE DISORDER 1 Mental Disorders
C1853237 BXGD015319 Isolated cases
C1956097 BXGD016617 Wolf-Hirschhorn Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1969363 BXGD016773 Middle age onset
C1970943 BXGD016852 MAJOR AFFECTIVE DISORDER 4 Mental Disorders
C1970945 BXGD016853 MAJOR AFFECTIVE DISORDER 6 Mental Disorders
C2700438 BXGD017469 MAJOR AFFECTIVE DISORDER 7 Mental Disorders
C2700439 BXGD017470 MAJOR AFFECTIVE DISORDER 8 Mental Disorders
C2700440 BXGD017471 MAJOR AFFECTIVE DISORDER 9 Mental Disorders
C2930898 BXGD017913 Benign essential blepharospasm Eye Diseases
C3160718 BXGD018468 PARKINSON DISEASE, LATE-ONSET
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C4692845 BXGD023591 BLEPHAROSPASM, BENIGN ESSENTIAL, SUSCEPTIBILITY TO
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000286 L-DOPA 197.19
BXGC0000538 (R)-Norepinephrine 169.18
BXGC0000651 Harmalan 184.24
BXGC0000982 L-Homocysteine 135.19
BXGC0001545 Harmine 212.25
BXGC0003196 Aripiprazole 448.39
BXGC0005683 Quercetin 302.24
BXGC0005867 Serotonin 176.22
BXGC0005871 Dopamine 153.18
BXGC0005874 Racemethionine 149.21
BXGC0005919 Biochanin A 284.27
BXGC0006183 L-Cystine 240.3
BXGC0017369 N-Methyllaurotetanine 341.16
BXGC0023978 (-)-Corydalmine 341.16
BXGC0024722 Stepholidine 327.15
BXGC0027701 Tetrahydropalmatine 355.18
BXGC0028612 Canadine 339.15
BXGC0030248 2-(4-Hydroxyphenyl)Chromen-4-One 238.06
BXGC0035881 Leonotinin 346.18
BXGC0038837 Pseudohypericin 520.08
BXGC0040582 nantenine 339.15
BXGC0042462 Cysteine 121.02
BXGC0043578 5-Hydroxy-2-(2-Phenylethyl)Chromen-4-One 266.09
BXGC0045812 Trifluoperazine 407.16
BXGC0047185 (S)-3-Hydroxyl-2,9,10-Trimethoxytetrahyrdooxyprotoberberine 341.16
BXGC0047439 14-(S)-2-Hydroxyl-3,9,10-Trimethoxytetrahyrdooxyprotoberberine 341.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein