Showing entry for 2,4-Dichlorophenoxyacetic Acid


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0026845
Compound Name2,4-Dichlorophenoxyacetic Acid
Structure
FormulaC8H6Cl2O3
InchiKeyOVSKIKFHRZPJSS-UHFFFAOYSA-N
SMILESOC(=O)COc1ccc(cc1Cl)Cl
InchiInChI=1S/C8H6Cl2O3/c9-5-1-2-7(6(10)3-5)13-4-8(11)12/h1-3H,4H2,(H,11,12)
IUPAC2-(2,4-dichlorophenoxy)acetic acid
Molecular Weight219.97
Pubchem Id1486
Chembl IdCHEMBL367623
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB CFA
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q570C0 BXGT015108 Protein TRANSPORT INHIBITOR RESPONSE 1 reviewed TIR1 - - - - -
Q8KSC8 BXGT018452 (R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase reviewed rdpA - - - - -
Q8GZ29 BXGT018189 Indole-3-acetic acid-amido synthetase GH3.15 reviewed GH3.15 - - - - -
Binding DB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
CHEMBL CHEMBL367623
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 104 %
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 86349 nM
P52904 BXGT010963 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial reviewed - Inhibition '=' 18 %
P52902 BXGT010962 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial reviewed - Inhibition '=' 18 %
P52904 BXGT010963 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial reviewed - Inhibition '=' 27 %
P52902 BXGT010962 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial reviewed - Inhibition '=' 27 %
P52904 BXGT010963 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial reviewed - IC50 '>' 4530000 nM
P52902 BXGT010962 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial reviewed - IC50 '>' 4530000 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 111 %
P52904 BXGT010963 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial reviewed - Inhibition '=' 48 %
P52902 BXGT010962 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial reviewed - Inhibition '=' 48 %
Q8VCA0 BXGT018913 Solute carrier family 22 member 19 reviewed - Slc22a19 Activity '=' 25 %
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 25118 nM
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short reviewed - GNAS Potency - 22387 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 1122 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 39810 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 35481 nM
P52904 BXGT010963 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial reviewed - Inhibition '=' 8 %
P52902 BXGT010962 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial reviewed - Inhibition '=' 8 %
Q4U2R8 BXGT014891 Solute carrier family 22 member 6 reviewed Transporter SLC22A6 Activity - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 3548 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 66824 nM
P52904 BXGT010963 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial reviewed - Inhibition '=' 12 %
P52902 BXGT010962 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial reviewed - Inhibition '=' 12 %
P52904 BXGT010963 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial reviewed - GI '=' 97 %
P52902 BXGT010962 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial reviewed - GI '=' 97 %
P49759 BXGT010734 Dual specificity protein kinase CLK1 reviewed Kinase CLK1 Activity '=' 21 %
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 reviewed Kinase PLK1 Potency - 29934 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF04334 Carapichea ipecacuanha Carapichea ipecacuanha Medicinal Plant
BXGF05040 prionosciadium watsoni prionosciadium watsoni Others
BXGF05303 Lagerstroemia indica Lagerstroemia indica Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease