Showing entry for Deoxyguanosine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0035032
Compound NameDeoxyguanosine
Structure
FormulaC10H13N5O4
InchiKeyYKBGVTZYEHREMT-KVQBGUIXSA-N
SMILESOC[C@H]1O[C@H](C[C@@H]1O)n1cnc2c1[nH]c(=N)nc2O
InchiInChI=1S/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/m0/s1
IUPAC2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
Molecular Weight267.1
Pubchem Id135398592
Chembl IdCHEMBL68908
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB GNG
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P02701 BXGT005926 Avidin reviewed AVD - - - 205000 -
P27707 BXGT009201 Deoxycytidine kinase reviewed DCK Kinase - - - -
P9WP01 BXGT012432 Purine nucleoside phosphorylase reviewed punA - - - - -
O34925 BXGT004505 Purine nucleoside phosphorylase DeoD-type reviewed deoD - - - - -
Q82Y41 BXGT017428 Cytidine and deoxycytidylate deaminase zinc-binding region unreviewed NE0047 - - - - 91000
P24021 BXGT008942 Nuclease S1 reviewed nucS - - - - -
Binding DB 50422404
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 - 115000 - -
reviewed BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 - 364000 - -
CHEMBL CHEMBL68908
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P27707 BXGT009201 Deoxycytidine kinase reviewed Kinase DCK Kcat '=' 0 /s
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 10322 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 501 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 5804 nM
P27707 BXGT009201 Deoxycytidine kinase reviewed Kinase DCK Km '=' 41000 nM
P27707 BXGT009201 Deoxycytidine kinase reviewed Kinase DCK Ratio '=' 0 /s/microM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 90 %
Q0H0G8 BXGT013083 Deoxyguanosine kinase unreviewed - dgk Kcat '=' 0 /s
Q0H0G8 BXGT013083 Deoxyguanosine kinase unreviewed - dgk Kcat/Km '=' 5 10'5/M/s
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 ID50 '=' 300 uM
Q0H0G8 BXGT013083 Deoxyguanosine kinase unreviewed - dgk Vmax '=' 1 U/mg
Q0H0G8 BXGT013083 Deoxyguanosine kinase unreviewed - dgk Km '=' 1100 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 IC50 '=' 364000 nM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 29092 nM
P27707 BXGT009201 Deoxycytidine kinase reviewed Kinase DCK Kcat '=' 2 /s
P27707 BXGT009201 Deoxycytidine kinase reviewed Kinase DCK Km '=' 181000 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 20587 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 IC50 '=' 115000 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Activity - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 3981 nM
P27707 BXGT009201 Deoxycytidine kinase reviewed Kinase DCK Ratio '=' 0 /s/microM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 6513 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 6309 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 85 %
P00491 BXGT005555 Purine nucleoside phosphorylase reviewed Enzyme PNP Activity '=' 65 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00101 Flaxseed Linum usitatissimum Herbs and Spices
BXGF00337 Ginkgo nuts Ginkgo biloba Herbs and Spices
BXGF03811 Euryale ferox Euryale ferox Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease