Showing entry for Thymidine kinase, cytosolic


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006166
Protein NameThymidine kinase, cytosolic
Uniport IdP04183
GeneTK1
Gene Id7083
DomainTK
Pfam PF00265  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00240 Pyrimidine metabolism
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00983 Drug metabolism - other enzymes
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071897 DNA biosynthetic process
Biological Process GO:0006139 nucleobase-containing compound metabolic process
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0043097 pyrimidine nucleoside salvage
Biological Process GO:0046104 thymidine metabolic process
molecular function GO:0005524 ATP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0004797 thymidine kinase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-15869 Metabolism of nucleotides
R-HSA-1640170 Cell Cycle
R-HSA-453279 Mitotic G1 phase and G1/S transition
R-HSA-69205 G1/S-Specific Transcription
R-HSA-69206 G1/S Transition
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-73614 Pyrimidine salvage
R-HSA-8956321 Nucleotide salvage
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010273 BXGD000658 Craniofacial Dysostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019207 BXGD001303 Hepatoma, Morris Digestive System Diseases; Neoplasms
C0019208 BXGD001304 Hepatoma, Novikoff Digestive System Diseases; Neoplasms
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020217 BXGD001365 Hydatidiform Mole Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0023904 BXGD001721 Liver Neoplasms, Experimental Digestive System Diseases; Neoplasms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0032227 BXGD002336 Pleural effusion disorder Respiratory Tract Diseases
C0032320 BXGD002350 Pneumoperitoneum Digestive System Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0080032 BXGD003105 Pleural Effusion, Malignant Neoplasms; Respiratory Tract Diseases
C0086404 BXGD003278 Experimental Hepatoma Digestive System Diseases; Neoplasms
C0149521 BXGD003328 Pancreatitis, Chronic Digestive System Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152171 BXGD003552 Idiopathic pulmonary hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0205851 BXGD004132 Germ cell tumor Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0238462 BXGD004937 Medullary carcinoma of thyroid Neoplasms; Endocrine System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0278689 BXGD006563 Recurrent ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349631 BXGD007938 Richter's syndrome Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0427460 BXGD008616 Red cell distribution width determination
C0524587 BXGD009232 Mean Corpuscular Volume (result)
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677607 BXGD009721 Hashimoto Disease Endocrine System Diseases
C0677932 BXGD009736 Progressive Neoplastic Disease
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0685938 BXGD009829 Malignant neoplasm of gastrointestinal tract Digestive System Diseases; Neoplasms
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1335177 BXGD012771 Ovarian Serous Adenocarcinoma Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1851585 BXGD015222 MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931196 BXGD017974 Craniofacial dysostosis type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C2986665 BXGD018237 Early-Stage Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3539781 BXGD019086 Progressive cGVHD
C4721579 BXGD023759 Secondary malignant neoplasm of colon and/or rectum Digestive System Diseases; Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4733092 BXGD023907 estrogen receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000759 Arabinan 243.22
BXGC0002588 Magnesium 24.31
BXGC0013263 Deoxyuridine 228.07
BXGC0020706 Dithioerythritol 154.01
BXGC0025658 Vinblastine 810.42
BXGC0027421 Paclitaxel 853.33
BXGC0027565 Deoxyadenosine 251.1
BXGC0030428 Deoxycytidine 227.09
BXGC0035032 Deoxyguanosine 267.1
BXGC0049801 Thymidine 242.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein