acompound

Showing entry for Oroxylin A

General Compound Information
BXGC Id	BXGC0039271
Compound Name	Oroxylin A
Structure
Formula	C16H12O5
InchiKey	LKOJGSWUMISDOF-UHFFFAOYSA-N
SMILES	COc1c(O)cc2c(c1O)c(=O)cc(o2)c1ccccc1
Inchi	InChI=1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3
IUPAC	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one
Molecular Weight	284.07
Pubchem Id	5320315
Chembl Id	CHEMBL183513

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1

Binding DB

50430091

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT009938	Receptor-type tyrosine-protein kinase FLT3	reviewed	Kinase	FLT3	-	1480	-	-

CHEMBL

CHEMBL183513

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	reviewed	-	CREB1	AC50	'='	2200	nM
P05412	BXGT006354	Transcription factor AP-1	reviewed	Transcription factor	JUN	FC	'='	1	-
P05412	BXGT006354	Transcription factor AP-1	reviewed	Transcription factor	JUN	FC	'='	1	-
P05412	BXGT006354	Transcription factor AP-1	reviewed	Transcription factor	JUN	AC50	-	-	-
P35030	BXGT009784	Trypsin-3	reviewed	Enzyme	PRSS3	Activity	-	-	-
P07478	BXGT006630	Trypsin-2	reviewed	Enzyme	PRSS2	Activity	-	-	-
P07477	BXGT006629	Trypsin-1	reviewed	Enzyme	PRSS1	Activity	-	-	-
P35030	BXGT009784	Trypsin-3	reviewed	Enzyme	PRSS3	IC50	'='	61000	nM
P07478	BXGT006630	Trypsin-2	reviewed	Enzyme	PRSS2	IC50	'='	61000	nM
P07477	BXGT006629	Trypsin-1	reviewed	Enzyme	PRSS1	IC50	'='	61000	nM
P08183	BXGT006741	ATP-dependent translocase ABCB1	reviewed	Transporter	ABCB1	Inhibition	-	-	-
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	reviewed	-	CREB1	FC	'='	1	-
P08047	BXGT006720	Transcription factor Sp1	reviewed	Nucleic acid binding	SP1	Activity	-	-	-
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	reviewed	-	CREB1	FC	'='	2	-
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	reviewed	-	CREB1	AC50	-	-	-
P36888	BXGT009938	Receptor-type tyrosine-protein kinase FLT3	reviewed	Kinase	FLT3	IC50	'='	1480	nM
P29477	BXGT009355	Nitric oxide synthase, inducible	reviewed	-	Nos2	Inhibition	'='	26	%

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00149	Peach	Prunus persica	Fruits
BXGF00889	Petrosimonia monandra	Petrosimonia monandra	Others
BXGF01555	Scutellaria amoena	Scutellaria amoena	Medicinal Plant
BXGF01886	Crambe hispanica subsp. abyssinica	Crambe hispanica subsp. abyssinica	Human Edible Plant
BXGF01911	Bupleurum scorzonerifolium	Bupleurum scorzonerifolium	Medicinal Plant
BXGF01929	Uvaria acuminata	Uvaria acuminata	Medicinal Plant
BXGF02047	Vitex rotundifolia	Vitex rotundifolia	Medicinal Plant
BXGF02087	Utricularia vulgaris	Utricularia vulgaris	Medicinal Plant
BXGF02325	Helichrysum lindleyi	Helichrysum lindleyi	Others
BXGF02359	Eucommia ulmoides	Eucommia ulmoides	Medicinal Plant
BXGF02490	Stizophyllum riparium	Stizophyllum riparium	Others
BXGF02846	Kalmia latifolia	Kalmia latifolia	Medicinal Plant
BXGF02895	Caesalpinia tinctoria	Caesalpinia tinctoria	Medicinal Plant
BXGF02991	Scutellaria viscidula	Scutellaria viscidula	Medicinal Plant
BXGF03018	Anthemis auriculata	Anthemis auriculata	Medicinal Plant
BXGF03356	Clathrotropis brachypetala	Clathrotropis brachypetala	Others
BXGF03391	Dioscorea tokoro	Dioscorea tokoro	Medicinal Plant
BXGF03483	Senecio speciosus	Senecio speciosus	Medicinal Plant
BXGF03530	Kopsia hainanensis	Kopsia hainanensis	Others
BXGF03584	Dalbergia nigra	Dalbergia nigra	Others
BXGF03599	Andropogon jwarancusa	Andropogon jwarancusa	Medicinal Plant
BXGF03786	Euphorbia sapinii	Euphorbia sapinii	Others
BXGF04155	Vincetoxicum amplexicaule	Vincetoxicum amplexicaule	Others
BXGF04691	Oroxylum indicum	Oroxylum indicum	Medicinal Plant
BXGF04750	Scutellaria baicalensis	Scutellaria baicalensis	Medicinal Plant
BXGF04906	Andrographis herba	Andrographis herba	Others
BXGF05002	Scutellaria balcalensis	Scutellaria balcalensis	Others
BXGF05185	Parinari campestris	Parinari campestris	Human Edible Plant
BXGF06151	Scutellaria lateriflora	Scutellaria lateriflora	Others

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}