Showing entry for Trypsin-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006630
Protein NameTrypsin-2
Uniport IdP07478
GenePRSS2
Gene Id5645
DomainTrypsin
Pfam PF00089  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
5. Organismal Systems 5.4 Digestive system hsa04974 Protein digestion and absorption
6. Human Diseases 6.9 Infectious diseases: Viral hsa05164 Influenza A
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019730 antimicrobial humoral response
Biological Process GO:0030574 collagen catabolic process
Biological Process GO:0007586 digestion
Biological Process GO:0022617 extracellular matrix disassembly
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0045785 positive regulation of cell adhesion
Biological Process GO:0030307 positive regulation of cell growth
Biological Process GO:0006508 proteolysis
molecular function GO:0005509 calcium ion binding
molecular function GO:0004252 serine-type endopeptidase activity
cellular component GO:0035578 azurophil granule lumen
cellular component GO:0031012 extracellular matrix
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
Reactome
Pathway Id Pathway Name
R-HSA-1442490 Collagen degradation
R-HSA-1461973 Defensins
R-HSA-1462054 Alpha-defensins
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1474244 Extracellular matrix organization
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-6798695 Neutrophil degranulation
R-HSA-6803157 Antimicrobial peptides
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0023518 BXGD001677 Leukocytosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030286 BXGD002201 Pancreatic Diseases Digestive System Diseases
C0030299 BXGD002205 Pancreatic Pseudocyst Digestive System Diseases; Neoplasms
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032227 BXGD002336 Pleural effusion disorder Respiratory Tract Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0038034 BXGD002731 Sporotrichosis Infections; Skin and Connective Tissue Diseases
C0038238 BXGD002741 Steatorrhea Digestive System Diseases; Nutritional and Metabolic Diseases
C0039103 BXGD002791 Synovitis Musculoskeletal Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0149521 BXGD003328 Pancreatitis, Chronic Digestive System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206180 BXGD004170 Ki-1+ Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0221002 BXGD004360 Hyperparathyroidism, Primary Endocrine System Diseases
C0232493 BXGD004550 Epigastric pain Pathological Conditions, Signs and Symptoms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238339 BXGD004914 Hereditary pancreatitis Digestive System Diseases
C0262417 BXGD005238 Acute on chronic pancreatitis Digestive System Diseases
C0267963 BXGD005796 Exocrine pancreatic insufficiency Digestive System Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0376670 BXGD008007 Pancreatitis, Alcoholic Digestive System Diseases; Chemically-Induced Disorders
C0558353 BXGD009451 Tongue Carcinoma Neoplasms; Stomatognathic Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0810032 BXGD010843 Pancreatic disorders (not diabetes) Digestive System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1842402 BXGD014516 TROPICAL CALCIFIC PANCREATITIS Digestive System Diseases; Nutritional and Metabolic Diseases
C1842406 BXGD014517 Pancreatic calcification
C2931073 BXGD017952 Collagenopathy, type 2 alpha 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C2938901 BXGD018163 Tropical infectious disease
C2985280 BXGD018223 Blood Protein Measurement
C3495549 BXGD018991 Patent ductus arteriosus - persisting type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Cardiovascular Diseases
C4022560 BXGD020916 Splanchnic vein thrombosis Cardiovascular Diseases
C4022922 BXGD021039 Abnormal enzyme/coenzyme activity
C4023452 BXGD021191 Elevated C-reactive protein level
C4025731 BXGD021763 Abnormal thrombosis
C4080064 BXGD022079 Autosomal Dominant Hereditary Pancreatitis Digestive System Diseases
C4303137 BXGD022551 Infection caused by Human T-lymphotropic virus Infections; Immune System Diseases
C4551632 BXGD023377 Recurrent pancreatitis Digestive System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000528 Salicylic acid 138.12
BXGC0001789 Silibinin 482.44
BXGC0001837 Quercetin 3-rutinoside 610.52
BXGC0004760 2-Phenylethylamine 121.18
BXGC0005683 Quercetin 302.24
BXGC0005793 Baicalein 270.24
BXGC0005794 Benzylamine 107.15
BXGC0009122 Zein 174.19
BXGC0016692 Wogonin 284.07
BXGC0018170 ganhuangenin 346.07
BXGC0027353 2',6'-Dihydroxypinobanksin 304.06
BXGC0031558 Baicalin 446.08
BXGC0035278 oroxindin 460.1
BXGC0039271 Oroxylin A 284.07
BXGC0052868 skullcapflavone II 374.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein