acompound

Showing entry for Methylhonokiol

General Compound Information
BXGC Id	BXGC0042946
Compound Name	Methylhonokiol
Structure
Formula	C19H20O2
InchiKey	OQFHJKZVOALSPV-UHFFFAOYSA-N
SMILES	C=CCc1ccc(c(c1)c1ccc(c(c1)CC=C)OC)O
Inchi	InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3
IUPAC	2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
Molecular Weight	280.15
Pubchem Id	155160
Chembl Id	CHEMBL89700

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1

Binding DB

50295926

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT009779	Cannabinoid receptor 2	reviewed	G-protein coupled receptor	CNR2	43.9	-	-	-
reviewed	BXGT009779	Cannabinoid receptor 2	reviewed	G-protein coupled receptor	CNR2	138	-	-	-
reviewed	BXGT008662	Cannabinoid receptor 1	reviewed	G-protein coupled receptor	CNR1	2400	-	-	-
reviewed	BXGT008662	Cannabinoid receptor 1	reviewed	G-protein coupled receptor	CNR1	790	-	-	-
reviewed	BXGT006400	Prostaglandin G/H synthase 1	reviewed		PTGS1	-	100	-	-
reviewed	BXGT011858	Prostaglandin G/H synthase 2	reviewed		PTGS2	-	60	-	-
reviewed	BXGT006941	Arachidonate 5-lipoxygenase	reviewed	Enzyme	ALOX5	-	1500	-	-
reviewed	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	-	-	-	27200
reviewed	BXGT009779	Cannabinoid receptor 2	reviewed	G-protein coupled receptor	CNR2	44	-	-	-

CHEMBL

CHEMBL89700

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P34972	BXGT009779	Cannabinoid receptor 2	reviewed	G-protein coupled receptor	CNR2	Ki	'='	44	nM
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	EC50	'='	27200	nM
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	EC50	'='	27200	nM
P05979	BXGT006400	Prostaglandin G/H synthase 1	reviewed	-	PTGS1	Inhibition	'='	90	%
P05979	BXGT006400	Prostaglandin G/H synthase 1	reviewed	-	PTGS1	IC50	'='	100	nM
P09917	BXGT006941	Arachidonate 5-lipoxygenase	reviewed	Enzyme	ALOX5	IC50	'='	1500	nM
P79208	BXGT011858	Prostaglandin G/H synthase 2	reviewed	-	PTGS2	Inhibition	'='	95	%
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	Activity	'='	822	%
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	Activity	'='	822	%
P79208	BXGT011858	Prostaglandin G/H synthase 2	reviewed	-	PTGS2	IC50	'='	60	nM
P09917	BXGT006941	Arachidonate 5-lipoxygenase	reviewed	Enzyme	ALOX5	Inhibition	'='	96	%
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	Smax	'='	1532	%
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	Smax	'='	1532	%
Q05769	BXGT012834	Prostaglandin G/H synthase 2	reviewed	-	Ptgs2	Inhibition	'='	42	%
P35354	BXGT009816	Prostaglandin G/H synthase 2	reviewed	Enzyme	PTGS2	Inhibition	'='	57	%
P34972	BXGT009779	Cannabinoid receptor 2	reviewed	G-protein coupled receptor	CNR2	Activity	-	-	-

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00397	Colorado pinyon	Pinus edulis	Nuts
BXGF00459	Wax gourd	Benincasa hispida	Gourds
BXGF00863	Pyrus bourgaeana	Pyrus bourgaeana	Human Edible Plant
BXGF01020	Baccharis truncata	Baccharis truncata	Others
BXGF01101	Ononis viscosa	Ononis viscosa	Others
BXGF01192	Cuphea hyssopifolia	Cuphea hyssopifolia	Human Edible Plant
BXGF01237	Magnolia obovata	Magnolia obovata	Medicinal Plant
BXGF01394	Holarrhena floribunda	Holarrhena floribunda	Medicinal Plant
BXGF01565	Farfugium japonicum	Farfugium japonicum	Medicinal Plant
BXGF01600	Sedum sarmentosum	Sedum sarmentosum	Medicinal Plant
BXGF01628	Salvia broussonetii	Salvia broussonetii	Others
BXGF01656	Eria rigida	Eria rigida	Others
BXGF01691	Gynoxys verrucosa	Gynoxys verrucosa	Others
BXGF01843	Triunia erythrocarpa	Triunia erythrocarpa	Others
BXGF01984	Chloranthus fortunei	Chloranthus fortunei	Others
BXGF02007	Sandoricum koetjape	Sandoricum koetjape	Medicinal Plant
BXGF02033	Suaeda maritima	Suaeda maritima	Medicinal Plant
BXGF02058	Pedicularis rex	Pedicularis rex	Others
BXGF02409	Euphorbia palustris	Euphorbia palustris	Medicinal Plant
BXGF02451	Sorbus torminalis	Sorbus torminalis	Medicinal Plant
BXGF03957	Centaurea benedicta	Centaurea benedicta	Medicinal Plant
BXGF04069	Posidonia oceanica	Posidonia oceanica	Others
BXGF04381	Chuquiraga erinacea	Chuquiraga erinacea	Others
BXGF05099	Alpinia flabellata	Alpinia flabellata	Medicinal Plant
BXGF05249	Fouquieria diguetii	Fouquieria diguetii	Others
BXGF05264	Magnolia officinalis	Magnolia officinalis	Medicinal Plant
BXGF05701	Euphorbia pithyusa	Euphorbia pithyusa	Others
BXGF05915	Fritillaria hupehensis	Fritillaria hupehensis	Medicinal Plant
BXGF06054	Angelica japonica	Angelica japonica	Medicinal Plant
BXGF06158	Lathyrus latifolius	Lathyrus latifolius	Medicinal Plant
BXGF06244	Pterocarpus erinaceus	Pterocarpus erinaceus	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}