Showing entry for Gamma-aminobutyric acid receptor subunit alpha-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008061
Protein NameGamma-aminobutyric acid receptor subunit alpha-1
Uniport IdP14867
GeneGABRA1
Gene Id2554
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
5. Organismal Systems 5.7 Sensory system hsa04742 Taste transduction
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
6. Human Diseases 6.5 Substance dependence hsa05033 Nicotine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071420 cellular response to histamine
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:1902476 chloride transmembrane transport
Biological Process GO:0007214 gamma-aminobutyric acid signaling pathway
Biological Process GO:1904862 inhibitory synapse assembly
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0050877 nervous system process
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0060078 regulation of postsynaptic membrane potential
Biological Process GO:0007165 signal transduction
Biological Process GO:0051932 synaptic transmission, GABAergic
molecular function GO:0005254 chloride channel activity
molecular function GO:0008144 drug binding
molecular function GO:0004890 GABA-A receptor activity
molecular function GO:0022851 GABA-gated chloride ion channel activity
molecular function GO:0005237 inhibitory extracellular ligand-gated ion channel activity
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
cellular component GO:0034707 chloride channel complex
cellular component GO:0030659 cytoplasmic vesicle membrane
cellular component GO:0032590 dendrite membrane
cellular component GO:1902711 GABA-A receptor complex
cellular component GO:0098982 GABA-ergic synapse
cellular component GO:1902710 GABA receptor complex
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099060 integral component of postsynaptic specialization membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0098794 postsynapse
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-1236394 Signaling by ERBB4
R-HSA-162582 Signal Transduction
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-977443 GABA receptor activation
R-HSA-977443 GABA receptor activation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0001969 BXGD000094 Alcoholic Intoxication Chemically-Induced Disorders; Mental Disorders
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0010093 BXGD000652 Corpus Luteum Cyst Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0011253 BXGD000706 Delusions Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014548 BXGD000928 Epilepsy, Generalized Nervous System Diseases
C0014553 BXGD000931 Absence Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019147 BXGD001289 Hepatic Coma Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0019151 BXGD001290 Hepatic Encephalopathy Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0020578 BXGD001434 Hyperventilation Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0023003 BXGD001597 Langer-Giedion Syndrome Musculoskeletal Diseases
C0026633 BXGD001910 Mouth Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029376 BXGD002132 Juvenile osteochondrosis of tibial tubercle Musculoskeletal Diseases
C0029429 BXGD002145 Osteochondrosis Musculoskeletal Diseases
C0029927 BXGD002182 Ovarian Cysts Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0030232 BXGD002197 Pallor Pathological Conditions, Signs and Symptoms
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042024 BXGD002949 Urinary Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0085762 BXGD003251 Alcohol abuse Chemically-Induced Disorders; Mental Disorders
C0149958 BXGD003395 Complex partial seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0175702 BXGD004008 Williams Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0238111 BXGD004877 Lennox-Gastaut syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0239981 BXGD005011 Hypoalbuminemia Hemic and Lymphatic Diseases
C0240991 BXGD005069 Ataxia, Sensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270736 BXGD006096 Essential Tremor Nervous System Diseases
C0270834 BXGD006114 Complex partial seizure with impairment of consciousness Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846 BXGD006116 Epileptic drop attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0270853 BXGD006119 Juvenile Myoclonic Epilepsy Nervous System Diseases
C0278161 BXGD006504 Ataxia, Motor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0312422 BXGD006888 Blackout - symptom Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0342543 BXGD007500 Central Precocious Puberty Endocrine System Diseases
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0349506 BXGD007912 Photosensitivity of skin Skin and Connective Tissue Diseases
C0376338 BXGD007990 Diagnosis, Psychiatric Mental Disorders
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0393615 BXGD008108 Familial Tremor Nervous System Diseases
C0424230 BXGD008522 Motor retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0427190 BXGD008611 Ataxia, Truncal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0432072 BXGD008718 Dysmorphic features
C0476254 BXGD008984 Dyslexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0497202 BXGD009055 Abnormal ocular motility
C0520966 BXGD009128 Abnormal coordination Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0679136 BXGD009759 Low self-esteem Behavior and Behavior Mechanisms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700178 BXGD009876 Alcoholic blackout Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0729346 BXGD009923 Osteochondritis juvenilis Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0748607 BXGD010201 Recurrent seizure Nervous System Diseases
C0750937 BXGD010259 Ataxia, Appendicular Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0750940 BXGD010260 Tremor, Rubral Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751122 BXGD010325 Infantile Severe Myoclonic Epilepsy Nervous System Diseases
C0751197 BXGD010345 Fulminant Hepatic Failure with Cerebral Edema Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0751198 BXGD010346 Hepatic Stupor Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0752323 BXGD010716 Focal Clonic Seizures Nervous System Diseases
C0877017 BXGD011329 Generalized tonic-clonic seizures with focal onset Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1096063 BXGD011600 Drug Resistant Epilepsy Nervous System Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1838604 BXGD014325 EPILEPSY, CHILDHOOD ABSENCE, 1
C1839333 BXGD014369 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2 Nervous System Diseases
C1843367 BXGD014576 Poor school performance
C1846131 BXGD014783 Photosensitive tonic-clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1846620 BXGD014832 Hemiclonic seizures Nervous System Diseases
C1847164 BXGD014854 Morning myoclonic jerks Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1849265 BXGD015028 Overgrowth
C1854686 BXGD015423 Uncontrolled eye movements
C1855568 BXGD015511 Jerky head movements
C1856408 BXGD015603 Infantile encephalopathy Nervous System Diseases
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C1862941 BXGD016145 Amyotrophic Lateral Sclerosis, Sporadic Nutritional and Metabolic Diseases; Nervous System Diseases
C1963933 BXGD016705 Punding Mental Disorders
C1970160 BXGD016810 Epilepsy, Childhood Absence, Susceptibility To, 4 Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3810400 BXGD019653 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 19 Nervous System Diseases
C3887898 BXGD019926 Infantile Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4013473 BXGD020130 EPILEPSY, IDIOPATHIC GENERALIZED, SUSCEPTIBILITY TO, 13
C4021087 BXGD020546 Abnormal social behavior Behavior and Behavior Mechanisms
C4021757 BXGD020760 EEG with polyspike wave complexes
C4021759 BXGD020762 Generalized myoclonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4022738 BXGD020974 Neurodevelopmental delay
C4023511 BXGD021206 Obtundation status Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4023685 BXGD021242 EEG with spike-wave complexes (2.5-3.5 Hz)
C4023701 BXGD021248 Impaired visuospatial constructive cognition
C4281785 BXGD022415 Childhood Absence Epilepsy Nervous System Diseases
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4477055 BXGD022912 Limb myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4505072 BXGD022953 Epileptic Syndromes Nervous System Diseases
C4551857 BXGD023424 Juvenile Myoclonic Epilepsy of Janz Nervous System Diseases
C4551993 BXGD023469 Amyotrophic Lateral Sclerosis, Familial Nutritional and Metabolic Diseases; Nervous System Diseases
C4552768 BXGD023524 Myoclonic Epilepsy, Adolescent Nervous System Diseases
C4553087 BXGD023534 Myoclonic Epilepsy, Juvenile, 1 Nervous System Diseases
C4553298 BXGD023539 Impulsive Petit Mal Epilepsy Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000203 Piperine 285.34
BXGC0000434 Ethanol 46.07
BXGC0000536 Phenol 94.11
BXGC0000964 6-Methylscutellarein 300.26
BXGC0001778 Scutellarein 286.24
BXGC0001841 Batatasin III 244.29
BXGC0002064 Amentoflavone 538.46
BXGC0002071 Apigenin 270.24
BXGC0002374 Taurine 125.15
BXGC0002867 Lappaurin 284.74
BXGC0003776 Flavones 222.24
BXGC0003885 Lormetazepam 335.19
BXGC0003886 N-Demethyldiazepam 270.71
BXGC0003963 Dechlorodiazepam 250.3
BXGC0004115 Norharman 168.19
BXGC0004596 2,6-Dibromophenol 251.9
BXGC0004662 2,6-Dimethylphenol 122.16
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0005793 Baicalein 270.24
BXGC0005867 Serotonin 176.22
BXGC0006108 1H-Imidazole-4(5)-acetic acid 126.11
BXGC0007014 Harman 182.22
BXGC0008167 Chrysin 254.24
BXGC0014991 Ethyl Beta-Carboline-3-Carboxylate 240.09
BXGC0016417 Picrotoxin 310.11
BXGC0016692 Wogonin 284.07
BXGC0018397 beta-1,4-mannan 180.06
BXGC0020867 Sandaracopimaric Acid 302.22
BXGC0021600 Ilepcimide 259.12
BXGC0021836 Honokiol 266.13
BXGC0025485 Transtorine 189.04
BXGC0028885 Secobarbital 238.13
BXGC0030085 Bicuculline 367.11
BXGC0031558 Baicalin 446.08
BXGC0033643 2,4-di-tert-butylphenol 206.17
BXGC0037354 isopimaric acid 302.22
BXGC0038577 Magnolol 266.13
BXGC0038768 2,6-Ditert-Butylphenol 206.17
BXGC0041351 pyrogallol 1,3-dimethyl ether 154.06
BXGC0042358 1,3-DIISOPROPYLBENZENE 162.14
BXGC0042946 Methylhonokiol 280.15
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein