Showing entry for Resiniferatoxin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0053019
Compound NameResiniferatoxin
Structure
FormulaC37H40O9
InchiKeyDSDNAKHZNJAGHN-GGIHZKEUSA-N
SMILESCOc1cc(ccc1O)CC(=O)OCC1=C[C@H]2[C@H]3OC4(O[C@]2([C@H]2[C@@](C1)(O)C(=O)C(=C2)C)[C@@H](C[C@]3(O4)C(=C)C)C)Cc1ccccc1
InchiInChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35+,36?,37-/m1/s1
IUPAC
Molecular Weight628.27
Pubchem Id44564218
Chembl IdCHEMBL448382
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50366620
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 0.48 - - -
reviewed BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed Trpv1 0.12 - - -
reviewed BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 1.2 - - -
reviewed BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 - - - 1.9
reviewed BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed Trpv1 0.023 - - -
reviewed BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed Trpv1 4.4 - - -
reviewed BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed Trpv1 0.02 - - -
reviewed BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 - - - 0.019
reviewed BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed Trpv1 - - - 0.27
reviewed BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed Trpv1 0.0426 - - -
reviewed BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 - - - 19
reviewed BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed Trpv1 0.043 - - -
reviewed BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 - - - 0.92
reviewed BXGT018686 Transient receptor potential cation channel subfamily M member 8 reviewed Trpm8 - >100000 - -
CHEMBL CHEMBL448382
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q8R4D5 BXGT018686 Transient receptor potential cation channel subfamily M member 8 reviewed - Trpm8 Inhibition - - -
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Activity - - -
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 EC50 '=' 0 nM
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 Ki '=' 0 nM
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 Ki - - -
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 Activity - - -
Q8R4D5 BXGT018686 Transient receptor potential cation channel subfamily M member 8 reviewed - Trpm8 IC50 '>' 100000 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 FC '=' 1000 -
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 Ki '=' 4 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Ki '=' 1 nM
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 Ki '=' 0 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Ki '=' 23 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Ki '=' 14 nM
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 Ki '=' 0 nM
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 EC50 '=' 0 nM
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 Ki '=' 0 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Efficacy '=' 116 %
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Ki '=' 0 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Ki - - -
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 EC50 '=' 57 nM
Q9WUD2 BXGT021939 Transient receptor potential cation channel subfamily V member 2 reviewed - Trpv2 EC50 '=' 57 nM
Q9ERZ8 BXGT020313 Transient receptor potential cation channel subfamily V member 4 reviewed - Trpv4 EC50 '=' 57 nM
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 Relative affinity '=' 1 -
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 EC50 '=' 1 nM
Q9WUD2 BXGT021939 Transient receptor potential cation channel subfamily V member 2 reviewed - Trpv2 EC50 '=' 1 nM
Q9ERZ8 BXGT020313 Transient receptor potential cation channel subfamily V member 4 reviewed - Trpv4 EC50 '=' 1 nM
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 Relative affinity '=' 0 -
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 Relative Potency '=' 0 -
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 EC50 '=' 1 nM
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 Relative Potency '=' 1 -
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 Cation influx - - -
Q9WUD2 BXGT021939 Transient receptor potential cation channel subfamily V member 2 reviewed - Trpv2 Cation influx - - -
Q9ERZ8 BXGT020313 Transient receptor potential cation channel subfamily V member 4 reviewed - Trpv4 Cation influx - - -
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 EC50 '=' 0 nM
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 IC50 '=' 180 nM
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 Ki '=' 0 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Activity '=' 0 uM
O35433 BXGT004528 Transient receptor potential cation channel subfamily V member 1 reviewed - Trpv1 Ki '=' 0 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF06265 Euphorbia resinifera Euphorbia resinifera Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease