adisease

General Disease Information
BXGD Id	BXGD002153
Disease Name	Bone necrosis
Disease CUI Id	C0029445
MeSH Codes	C23 C05
Disease Class Name	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
Semantic Type	Pathologic Function
Human Phenotype Ontology Id	HP:0000924
Human Phenotype Ontology Term	Abnormality of the skeletal system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P07355	BXGT006609	Annexin A2	302	reviewed
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P10632	BXGT007592	Cytochrome P450 2C8	1558	reviewed
P10646	BXGT007598	Tissue factor pathway inhibitor	7035	reviewed	Enzyme modulator
P22004	BXGT008718	Bone morphogenetic protein 6	654	reviewed	Signaling
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P36956	BXGT009947	Sterol regulatory element-binding protein 1	6720	reviewed
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P39086	BXGT010093	Glutamate receptor ionotropic, kainate 1	2897	reviewed	Ion channel
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q5VWK5	BXGT015891	Interleukin-23 receptor	149233	reviewed	Signaling
Q92793	BXGT019374	CREB-binding protein	1387	reviewed
Q16552	BXGT023419	Interleukin-17A	3605	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}