Showing entry for Cytochrome P450 2C8


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007592
Protein NameCytochrome P450 2C8
Uniport IdP10632
GeneCYP2C8
Gene Id1558
Domainp450
Pfam PF00067  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00591 Linoleic acid metabolism
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00830 Retinol metabolism
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00982 Drug metabolism - cytochrome P450
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
6. Human Diseases 6.1 Cancers: Overview hsa05204 Chemical carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0017144 drug metabolic process
Biological Process GO:0019373 epoxygenase P450 pathway
Biological Process GO:0008210 estrogen metabolic process
Biological Process GO:0042738 exogenous drug catabolic process
Biological Process GO:0046456 icosanoid biosynthetic process
Biological Process GO:0002933 lipid hydroxylation
Biological Process GO:0042759 long-chain fatty acid biosynthetic process
Biological Process GO:0097267 omega-hydroxylase P450 pathway
Biological Process GO:0006082 organic acid metabolic process
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0070989 oxidative demethylation
Biological Process GO:0042573 retinoic acid metabolic process
Biological Process GO:0042572 retinol metabolic process
Biological Process GO:0008202 steroid metabolic process
Biological Process GO:0006805 xenobiotic metabolic process
molecular function GO:0008392 arachidonic acid epoxygenase activity
molecular function GO:0070330 aromatase activity
molecular function GO:0034875 caffeine oxidase activity
molecular function GO:0101020 estrogen 16-alpha-hydroxylase activity
molecular function GO:0020037 heme binding
molecular function GO:0005506 iron ion binding
molecular function GO:0004497 monooxygenase activity
molecular function GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
molecular function GO:0008401 retinoic acid 4-hydroxylase activity
molecular function GO:0008395 steroid hydroxylase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-211859 Biological oxidations
R-HSA-211897 Cytochrome P450 - arranged by substrate type
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions
R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-HSA-556833 Metabolism of lipids
R-HSA-8978868 Fatty acid metabolism
R-HSA-9018677 Biosynthesis of DHA-derived SPMs
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs)
R-HSA-9018682 Biosynthesis of maresins
R-HSA-9027307 Biosynthesis of maresin-like SPMs
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003868 BXGD000233 Arthritis, Gouty Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013221 BXGD000804 Drug toxicity Chemically-Induced Disorders
C0018099 BXGD001172 Gout Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0019207 BXGD001303 Hepatoma, Morris Digestive System Diseases; Neoplasms
C0019208 BXGD001304 Hepatoma, Novikoff Digestive System Diseases; Neoplasms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023453 BXGD001652 L2 Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0023904 BXGD001721 Liver Neoplasms, Experimental Digestive System Diseases; Neoplasms
C0024530 BXGD001783 Malaria Infections
C0024535 BXGD001785 Malaria, Falciparum Infections
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0029445 BXGD002153 Bone necrosis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0030201 BXGD002194 Pain, Postoperative Pathological Conditions, Signs and Symptoms
C0030920 BXGD002263 Peptic Ulcer Digestive System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0035410 BXGD002546 Rhabdomyolysis Musculoskeletal Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038644 BXGD002776 Sudden infant death syndrome Pathological Conditions, Signs and Symptoms
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0041105 BXGD002895 Trismus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041755 BXGD002933 Adverse reaction to drug Chemically-Induced Disorders
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0086404 BXGD003278 Experimental Hepatoma Digestive System Diseases; Neoplasms
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0266807 BXGD005716 Acute gastrointestinal hemorrhage Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0270736 BXGD006096 Essential Tremor Nervous System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0441683 BXGD008809 Hormone measurement
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1832733 BXGD013873 Rhabdomyolysis, Cerivastatin-Induced Musculoskeletal Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2699541 BXGD017461 Cytokine Measurement
C4693948 BXGD023622 DRUG METABOLISM, ALTERED, CYP2C8-RELATED
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001502 Caffeine 194.19
BXGC0002024 [6]-Paradol 278.39
BXGC0002627 17alpha-ethynylestradiol 296.4
BXGC0005513 Hexadecanoic acid 256.42
BXGC0005683 Quercetin 302.24
BXGC0008676 Haem 616.49
BXGC0012243 Ukonan D 151.16
BXGC0014695 Loratadine 382.14
BXGC0015164 8-Gingerol 322.21
BXGC0016891 Nortriptyline 263.17
BXGC0021248 Shogaol 276.17
BXGC0023873 Ivermectin 874.51
BXGC0026627 Gingerol 294.18
BXGC0027421 Paclitaxel 853.33
BXGC0028204 Cinobufotalin 458.23
BXGC0030138 Colchicine 399.17
BXGC0037171 10-Gingerol 350.25
BXGC0039306 Carnosic Acid 332.2
BXGC0040042 Warfarin 308.1
BXGC0041820 Schisantherin E 538.22
BXGC0041843 [(3R,4R)-6-Methoxy-1-Oxo-3-Pentyl-3,4-Dihydroisochromen-4-Yl] Acetate 306.15
BXGC0042222 Propranolol 259.16
BXGC0042510 Fluoxetine 309.13
BXGC0042596 Isoniazid 137.06
BXGC0043126 Nicardipine 479.21
BXGC0044017 Verapamil 454.28
BXGC0052224 Ginsenoside Rh2 622.44
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein