Showing entry for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004900
Protein Name6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Uniport IdO60825
GenePFKFB2
Gene Id5208
Domain6PF2K; His_Phos_1
Pfam PF01591   PF00300  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00051 Fructose and mannose metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04152 AMPK signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006003 fructose 2,6-bisphosphate metabolic process
Biological Process GO:0006000 fructose metabolic process
Biological Process GO:0006007 glucose catabolic process
Biological Process GO:0006096 glycolytic process
Biological Process GO:0006089 lactate metabolic process
Biological Process GO:0033133 positive regulation of glucokinase activity
Biological Process GO:0045821 positive regulation of glycolytic process
Biological Process GO:0032024 positive regulation of insulin secretion
Biological Process GO:0009749 response to glucose
molecular function GO:0003873 6-phosphofructo-2-kinase activity
molecular function GO:0005524 ATP binding
molecular function GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
molecular function GO:0019901 protein kinase binding
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-70171 Glycolysis
R-HSA-70326 Glucose metabolism
R-HSA-71387 Metabolism of carbohydrates
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017654 BXGD001136 Glomerular Filtration Rate
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0025202 BXGD001832 melanoma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0428883 BXGD008639 Diastolic blood pressure
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0042541 fructose-6-phosphate 260.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein