Showing entry for Tumor necrosis factor



                       
General Target Information
BXGT IdBXGT006509
Protein NameTumor necrosis factor
Uniport IdP06804
GeneTnf
Gene Id21926
DomainTNF
Pfam PF00229  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0000185 activation of MAPKKK activity
Biological Process GO:0009887 animal organ morphogenesis
Biological Process GO:0006915 apoptotic process
Biological Process GO:0097190 apoptotic signaling pathway
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0001775 cell activation
Biological Process GO:0045123 cellular extravasation
Biological Process GO:0071230 cellular response to amino acid stimulus
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0071316 cellular response to nicotine
Biological Process GO:0071407 cellular response to organic cyclic compound
Biological Process GO:0002439 chronic inflammatory response to antigenic stimulus
Biological Process GO:0030866 cortical actin cytoskeleton organization
Biological Process GO:0006952 defense response
Biological Process GO:0042742 defense response to bacterium
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
Biological Process GO:0048566 embryonic digestive tract development
Biological Process GO:0072577 endothelial cell apoptotic process
Biological Process GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0097191 extrinsic apoptotic signaling pathway
Biological Process GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
Biological Process GO:0032603 fractalkine production
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0006959 humoral immune response
Biological Process GO:0006954 inflammatory response
Biological Process GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
Biological Process GO:0007254 JNK cascade
Biological Process GO:0050900 leukocyte migration
Biological Process GO:0050901 leukocyte tethering or rolling
Biological Process GO:0031663 lipopolysaccharide-mediated signaling pathway
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0001774 microglial cell activation
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0097527 necroptotic signaling pathway
Biological Process GO:0010693 negative regulation of alkaline phosphatase activity
Biological Process GO:1900222 negative regulation of amyloid-beta clearance
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:2001234 negative regulation of apoptotic signaling pathway
Biological Process GO:1903347 negative regulation of bicellular tight junction assembly
Biological Process GO:0120190 negative regulation of bile acid secretion
Biological Process GO:0043537 negative regulation of blood vessel endothelial cell migration
Biological Process GO:0061048 negative regulation of branching involved in lung morphogenesis
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0031327 negative regulation of cellular biosynthetic process
Biological Process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0002719 negative regulation of cytokine production involved in immune response
Biological Process GO:0001937 negative regulation of endothelial cell proliferation
Biological Process GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Process GO:0045599 negative regulation of fat cell differentiation
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0046325 negative regulation of glucose import
Biological Process GO:0010459 negative regulation of heart rate
Biological Process GO:0032715 negative regulation of interleukin-6 production
Biological Process GO:0002037 negative regulation of L-glutamate import across plasma membrane
Biological Process GO:0050995 negative regulation of lipid catabolic process
Biological Process GO:0045930 negative regulation of mitotic cell cycle
Biological Process GO:0031642 negative regulation of myelination
Biological Process GO:0045662 negative regulation of myoblast differentiation
Biological Process GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
Biological Process GO:0045668 negative regulation of osteoblast differentiation
Biological Process GO:0090324 negative regulation of oxidative phosphorylation
Biological Process GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
Biological Process GO:0043242 negative regulation of protein-containing complex disassembly
Biological Process GO:0003085 negative regulation of systemic arterial blood pressure
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0061044 negative regulation of vascular wound healing
Biological Process GO:0045071 negative regulation of viral genome replication
Biological Process GO:0030316 osteoclast differentiation
Biological Process GO:0045760 positive regulation of action potential
Biological Process GO:1902004 positive regulation of amyloid-beta formation
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:2000334 positive regulation of blood microparticle formation
Biological Process GO:0060559 positive regulation of calcidiol 1-monooxygenase activity
Biological Process GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
Biological Process GO:0045785 positive regulation of cell adhesion
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
Biological Process GO:0045080 positive regulation of chemokine biosynthetic process
Biological Process GO:0032722 positive regulation of chemokine production
Biological Process GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus
Biological Process GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:2001272 positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
Biological Process GO:0001819 positive regulation of cytokine production
Biological Process GO:1900017 positive regulation of cytokine production involved in inflammatory response
Biological Process GO:0050715 positive regulation of cytokine secretion
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:2000573 positive regulation of DNA biosynthetic process
Biological Process GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Biological Process GO:0031622 positive regulation of fever generation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0060252 positive regulation of glial cell proliferation
Biological Process GO:0051798 positive regulation of hair follicle development
Biological Process GO:2000347 positive regulation of hepatocyte proliferation
Biological Process GO:0034116 positive regulation of heterotypic cell-cell adhesion
Biological Process GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:1903721 positive regulation of I-kappaB phosphorylation
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:0032729 positive regulation of interferon-gamma production
Biological Process GO:0032741 positive regulation of interleukin-18 production
Biological Process GO:0032731 positive regulation of interleukin-1 beta production
Biological Process GO:0150129 positive regulation of interleukin-33 production
Biological Process GO:0032755 positive regulation of interleukin-6 production
Biological Process GO:0032757 positive regulation of interleukin-8 production
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:0043507 positive regulation of JUN kinase activity
Biological Process GO:1904999 positive regulation of leukocyte adhesion to arterial endothelial cell
Biological Process GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
Biological Process GO:0043406 positive regulation of MAP kinase activity
Biological Process GO:0051044 positive regulation of membrane protein ectodomain proteolysis
Biological Process GO:0045840 positive regulation of mitotic nuclear division
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:1902565 positive regulation of neutrophil activation
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:1901224 positive regulation of NIK/NF-kappaB signaling
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0051000 positive regulation of nitric-oxide synthase activity
Biological Process GO:0051173 positive regulation of nitrogen compound metabolic process
Biological Process GO:0045672 positive regulation of osteoclast differentiation
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0050766 positive regulation of phagocytosis
Biological Process GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0071803 positive regulation of podosome assembly
Biological Process GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
Biological Process GO:0043068 positive regulation of programmed cell death
Biological Process GO:0045732 positive regulation of protein catabolic process
Biological Process GO:0031334 positive regulation of protein-containing complex assembly
Biological Process GO:0043243 positive regulation of protein-containing complex disassembly
Biological Process GO:0045860 positive regulation of protein kinase activity
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:2000010 positive regulation of protein localization to cell surface
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0051222 positive regulation of protein transport
Biological Process GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:1901671 positive regulation of superoxide dismutase activity
Biological Process GO:0050806 positive regulation of synaptic transmission
Biological Process GO:1901647 positive regulation of synoviocyte proliferation
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045994 positive regulation of translational initiation by iron
Biological Process GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
Biological Process GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
Biological Process GO:0060557 positive regulation of vitamin D biosynthetic process
Biological Process GO:0043491 protein kinase B signaling
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0032800 receptor biosynthetic process
Biological Process GO:0060693 regulation of branching involved in salivary gland morphogenesis
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:2000351 regulation of endothelial cell apoptotic process
Biological Process GO:1903140 regulation of establishment of endothelial barrier
Biological Process GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0051023 regulation of immunoglobulin secretion
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0050796 regulation of insulin secretion
Biological Process GO:0045670 regulation of osteoclast differentiation
Biological Process GO:0001932 regulation of protein phosphorylation
Biological Process GO:0050708 regulation of protein secretion
Biological Process GO:2000377 regulation of reactive oxygen species metabolic process
Biological Process GO:0050807 regulation of synapse organization
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0051384 response to glucocorticoid
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0010033 response to organic substance
Biological Process GO:0009615 response to virus
Biological Process GO:0030730 sequestering of triglyceride
Biological Process GO:0007165 signal transduction
Biological Process GO:0034138 toll-like receptor 3 signaling pathway
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway
Biological Process GO:0010573 vascular endothelial growth factor production
Biological Process GO:0042311 vasodilation
molecular function GO:0005125 cytokine activity
molecular function GO:0042802 identical protein binding
molecular function GO:0002020 protease binding
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
molecular function GO:0005164 tumor necrosis factor receptor binding
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005615 extracellular space
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0045121 membrane raft
cellular component GO:0043025 neuronal cell body
cellular component GO:0001891 phagocytic cup
cellular component GO:0005886 plasma membrane
cellular component GO:0055037 recycling endosome
cellular component GO:0030141 secretory granule
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004266 2-Propanol 60.1
BXGC0005793 Baicalein 270.24
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein