Showing entry for Baicalein


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0005793
Compound NameBaicalein
Structure
FormulaC15H10O5
InchiKeyFXNFHKRTJBSTCS-UHFFFAOYSA-N
SMILESOC1=CC2=C(C(O)=C1O)C(=O)C=C(O2)C1=CC=CC=C1
InchiInChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
IUPAC5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
Molecular Weight270.24
Pubchem Id5281605
Chembl IdCHEMBL8260
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB 3WL
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q9CPU0 BXGT020248 Lactoylglutathione lyase reviewed Glo1 - 183 - - -
P0DTD1 BXGT023328 Replicase polyprotein 1ab reviewed rep - - - - -
Binding DB 50009001
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT009956 Testosterone 17-beta-dehydrogenase 3 reviewed HSD17B3 - 9300 - -
reviewed BXGT010038 Linoleate 9S-lipoxygenase-4 reviewed LOX1.5 - 22000 - -
reviewed BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 - 3300 - -
reviewed BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 - 11500 - -
reviewed BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B - 71000 - -
reviewed BXGT010470 1-deoxy-D-xylulose 5-phosphate reductoisomerase reviewed dxr - 2200 - -
reviewed BXGT019667 Aurora kinase B reviewed Kinase AURKB - 4060 - -
reviewed BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B - >1.00e+5 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 850 - -
reviewed BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 - >1.50e+5 - -
reviewed BXGT006736 Seed linoleate 13S-lipoxygenase-1 reviewed LOX1.1 - 22600 - -
reviewed BXGT012663 Arachidonate 15-lipoxygenase reviewed Alox15 - 15 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - >10000 - -
reviewed BXGT018400 Arachidonate 15-lipoxygenase B reviewed Alox15b - 260 - -
reviewed BXGT008009 Sucrase-isomaltase, intestinal reviewed Enzyme SI - 3.5 - -
reviewed BXGT002006 Lysine-specific demethylase 4E reviewed KDM4E - 3000 - -
reviewed BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B - >100000 - -
reviewed BXGT006445 Cyclin-dependent kinase 1 reviewed Kinase CDK1 - 6530 - -
reviewed BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 - >350000 - -
reviewed BXGT011907 4-aminobutyrate aminotransferase, mitochondrial reviewed Enzyme ABAT - 12800000 - -
reviewed BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed UGT1A1 - 4400 - -
reviewed BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed UGT1A1 - 7000 - -
reviewed BXGT009956 Testosterone 17-beta-dehydrogenase 3 reviewed HSD17B3 - 185920 - -
reviewed BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 - 9100 - -
reviewed BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 - 860 - -
reviewed BXGT012782 Lactoylglutathione lyase reviewed GLO1 - 11000 - -
reviewed BXGT010985 Death-associated protein kinase 1 reviewed Kinase DAPK1 - 120000 - -
reviewed BXGT010620 Prolyl endopeptidase reviewed Enzyme PREP - 36000 - -
reviewed BXGT009187 Dipeptidyl peptidase 4 reviewed Enzyme DPP4 - >200000 - -
reviewed BXGT008901 Sucrase-isomaltase, intestinal reviewed Si - 2.6 - -
reviewed BXGT011911 Xanthine dehydrogenase/oxidase reviewed XDH - 3300 - -
reviewed BXGT022265 Sialidase-2 reviewed Enzyme NEU2 - 130000 - -
reviewed BXGT006265 Cytochrome P450 1A1 reviewed Enzyme CYP1A1 1220 - - -
reviewed BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 260 - - -
reviewed BXGT002006 Lysine-specific demethylase 4E reviewed KDM4E 4330 - - -
reviewed BXGT016082 Prostaglandin G/H synthase 1 reviewed Ptgs1 - 50000 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - - - >100
reviewed BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 600 - - -
reviewed BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 1600 - - -
reviewed BXGT008009 Sucrase-isomaltase, intestinal reviewed Enzyme SI - 52000 - -
reviewed BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA - 500000 - -
reviewed BXGT008901 Sucrase-isomaltase, intestinal reviewed Si - 52000 - -
reviewed BXGT010602 Xanthine dehydrogenase/oxidase reviewed Enzyme XDH - 2790 - -
reviewed BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 - - - 10300
reviewed BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 - - - 22700
reviewed BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 - 28200 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 10000 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 41000 - -
reviewed BXGT009938 Receptor-type tyrosine-protein kinase FLT3 reviewed Kinase FLT3 - >10000 - -
CHEMBL CHEMBL8260
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 2685 nM
Q16678 BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 Ki '=' 260 nM
P05412 BXGT006354 Transcription factor AP-1 reviewed Transcription factor JUN FC '=' 1 -
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 3162 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 19952 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 48 %
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 5358 nM
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 780 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 4107 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 11220 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 EC50 '>' 100 mg kg-1
P27487 BXGT009187 Dipeptidyl peptidase 4 reviewed Enzyme DPP4 IC50 '>' 200000 nM
P02769 BXGT005956 Serum albumin reviewed - ALB K '=' 4 10'4L/mol
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 10000 nM
P16220 BXGT008206 Cyclic AMP-responsive element-binding protein 1 reviewed - CREB1 AC50 - - -
P02769 BXGT005956 Serum albumin reviewed - ALB KSV '=' 1 10'5L/mol
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
Q14191 BXGT013452 Werner syndrome ATP-dependent helicase reviewed Enzyme WRN Potency - 5323 nM
P47989 BXGT010602 Xanthine dehydrogenase/oxidase reviewed Enzyme XDH IC50 '=' 2790 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 0 pm/min/mg
P68871 BXGT011615 Hemoglobin subunit beta reviewed - HBB Potency '=' 31622 nM
P16581 BXGT008245 E-selectin reviewed - SELE Inhibition '=' 37 %
P16109 BXGT008194 P-selectin reviewed - SELP Inhibition '=' 52 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' -3 %
P05412 BXGT006354 Transcription factor AP-1 reviewed Transcription factor JUN AC50 - - -
P16220 BXGT008206 Cyclic AMP-responsive element-binding protein 1 reviewed - CREB1 AC50 '=' 13500 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 5011 nM
P48147 BXGT010620 Prolyl endopeptidase reviewed Enzyme PREP Inhibition '=' 64 %
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 44668 nM
P02769 BXGT005956 Serum albumin reviewed - ALB KSV '=' 2 10'5L/mol
P02769 BXGT005956 Serum albumin reviewed - ALB Kq '=' 3 10'13L/mol/s
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 15848 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 35481 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 31622 nM
O95398 BXGT005378 Rap guanine nucleotide exchange factor 3 reviewed Enzyme modulator RAPGEF3 Potency - 31622 nM
P02769 BXGT005956 Serum albumin reviewed - ALB KSV '=' 1 10'5L/mol
P02769 BXGT005956 Serum albumin reviewed - ALB KSV '=' 1 10'5L/mol
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 5011 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 15848 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Inhibition '=' 85 %
P34969 BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 IC50 '>' 350000 nM
P02769 BXGT005956 Serum albumin reviewed - ALB Kq '=' 3 10'13L/mol/s
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 28183 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Activity - - -
P48147 BXGT010620 Prolyl endopeptidase reviewed Enzyme PREP Inhibition '=' 81 %
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Ki '=' 600 nM
Q02759 BXGT012663 Arachidonate 15-lipoxygenase reviewed - Alox15 IC50 '=' 15 nM
Q16445 BXGT013629 Gamma-aminobutyric acid receptor subunit alpha-6 reviewed Ion channel GABRA6 Ki '=' 5623 nM
P31644 BXGT009557 Gamma-aminobutyric acid receptor subunit alpha-5 reviewed Ion channel GABRA5 Ki '=' 5623 nM
P47869 BXGT010590 Gamma-aminobutyric acid receptor subunit alpha-2 reviewed Ion channel GABRA2 Ki '=' 5623 nM
P78334 BXGT011834 Gamma-aminobutyric acid receptor subunit epsilon reviewed Ion channel GABRE Ki '=' 5623 nM
P18505 BXGT008409 Gamma-aminobutyric acid receptor subunit beta-1 reviewed Ion channel GABRB1 Ki '=' 5623 nM
Q8N1C3 BXGT018498 Gamma-aminobutyric acid receptor subunit gamma-1 reviewed Ion channel GABRG1 Ki '=' 5623 nM
O14764 BXGT004094 Gamma-aminobutyric acid receptor subunit delta reviewed Ion channel GABRD Ki '=' 5623 nM
O00591 BXGT003939 Gamma-aminobutyric acid receptor subunit pi reviewed Ion channel GABRP Ki '=' 5623 nM
P34903 BXGT009769 Gamma-aminobutyric acid receptor subunit alpha-3 reviewed Ion channel GABRA3 Ki '=' 5623 nM
Q9UN88 BXGT021783 Gamma-aminobutyric acid receptor subunit theta reviewed Ion channel GABRQ Ki '=' 5623 nM
Q99928 BXGT019975 Gamma-aminobutyric acid receptor subunit gamma-3 reviewed Ion channel GABRG3 Ki '=' 5623 nM
P48169 BXGT010622 Gamma-aminobutyric acid receptor subunit alpha-4 reviewed Ion channel GABRA4 Ki '=' 5623 nM
P28472 BXGT009260 Gamma-aminobutyric acid receptor subunit beta-3 reviewed Ion channel GABRB3 Ki '=' 5623 nM
P18507 BXGT008411 Gamma-aminobutyric acid receptor subunit gamma-2 reviewed Ion channel GABRG2 Ki '=' 5623 nM
P47870 BXGT010591 Gamma-aminobutyric acid receptor subunit beta-2 reviewed Ion channel GABRB2 Ki '=' 5623 nM
P14867 BXGT008061 Gamma-aminobutyric acid receptor subunit alpha-1 reviewed Ion channel GABRA1 Ki '=' 5623 nM
Q9Y468 BXGT022270 Lethal(3)malignant brain tumor-like protein 1 reviewed Epigenetic regulator L3MBTL1 Potency '=' 15848 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 631 nM
P14635 BXGT008031 G2/mitotic-specific cyclin-B1 reviewed Enzyme modulator CCNB1 IC50 '=' 6530 nM
P06493 BXGT006445 Cyclin-dependent kinase 1 reviewed Kinase CDK1 IC50 '=' 6530 nM
P37058 BXGT009956 Testosterone 17-beta-dehydrogenase 3 reviewed - HSD17B3 Inhibition - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29855 nM
P02769 BXGT005956 Serum albumin reviewed - ALB Kq '=' 4 10'13L/mol/s
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 7924 nM
O43451 BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM Activity - - -
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 7943 nM
P02769 BXGT005956 Serum albumin reviewed - ALB KSV '=' 1 10'5L/mol
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 12589 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 16788 nM
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 12589 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 12589 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 3162 nM
P16220 BXGT008206 Cyclic AMP-responsive element-binding protein 1 reviewed - CREB1 FC '=' 1 -
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 17782 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 IC50 '=' 860 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 9976 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 71 %
Q63921 BXGT016082 Prostaglandin G/H synthase 1 reviewed - Ptgs1 IC50 '=' 50000 nM
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 IC50 '=' 50000 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 EC150 '=' 18 uM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 39810 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 39810 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 260000 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR EC150 '=' 18 uM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH IC50 '=' 3300 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 35481 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 501 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '>' 10000 nM
Q9HC97 BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 EC50 '=' 22700 nM
P37058 BXGT009956 Testosterone 17-beta-dehydrogenase 3 reviewed - HSD17B3 IC50 '=' 185920 nM
P15145 BXGT008088 Aminopeptidase N reviewed - ANPEP Inhibition '=' 57 %
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 7079 nM
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 291000 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 291000 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 11220 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity - - -
P48147 BXGT010620 Prolyl endopeptidase reviewed Enzyme PREP IC50 '=' 36000 nM
P48147 BXGT010620 Prolyl endopeptidase reviewed Enzyme PREP Inhibition '=' 77 %
P35030 BXGT009784 Trypsin-3 reviewed Enzyme PRSS3 IC50 '=' 3700 nM
P07478 BXGT006630 Trypsin-2 reviewed Enzyme PRSS2 IC50 '=' 3700 nM
P07477 BXGT006629 Trypsin-1 reviewed Enzyme PRSS1 IC50 '=' 3700 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 11885 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E IC50 '=' 3000 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 12589 nM
Q9NWT6 BXGT021234 Hypoxia-inducible factor 1-alpha inhibitor reviewed - HIF1AN Inhibition - - -
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 Activity '=' 17 %
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 2238 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 28183 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 5000 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA IC50 '=' 500000 nM
P07374 BXGT006615 Urease reviewed - IC50 - - -
P54855 BXGT011088 UDP-glucuronosyltransferase 2B15 reviewed - UGT2B15 Activity '=' 5 pm/min/mg
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 1412 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 35481 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 35481 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 52000 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 3981 nM
P22460 BXGT008774 Potassium voltage-gated channel subfamily A member 5 reviewed Ion channel KCNA5 IC50 - - -
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency - 17782 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Ki '=' 1600 nM
Q9GZT9 BXGT020425 Egl nine homolog 1 reviewed - EGLN1 Activity - - -
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 12589 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 19952 nM
P14410 BXGT008009 Sucrase-isomaltase, intestinal reviewed Enzyme SI IC50 '=' 35000 nM
P35030 BXGT009784 Trypsin-3 reviewed Enzyme PRSS3 Activity - - -
P07478 BXGT006630 Trypsin-2 reviewed Enzyme PRSS2 Activity - - -
P07477 BXGT006629 Trypsin-1 reviewed Enzyme PRSS1 Activity - - -
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 1258 nM
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 2700 nM
P05453 BXGT006363 Eukaryotic peptide chain release factor GTP-binding subunit reviewed - SUP35 Inhibition - - -
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 91 %
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 1200 nM
P14151 BXGT007990 L-selectin reviewed - SELL Inhibition '=' 51 %
P14410 BXGT008009 Sucrase-isomaltase, intestinal reviewed Enzyme SI IC50 '=' 52000 nM
P05453 BXGT006363 Eukaryotic peptide chain release factor GTP-binding subunit reviewed - SUP35 Inhibition '=' 17 %
P43250 BXGT010372 G protein-coupled receptor kinase 6 reviewed Kinase GRK6 IC50 '=' 8700 nM
Q04760 BXGT012782 Lactoylglutathione lyase reviewed - GLO1 IC50 '=' 11000 nM
P48147 BXGT010620 Prolyl endopeptidase reviewed Enzyme PREP Inhibition '=' 51 %
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 1995 nM
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 10000 nM
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 Activity '=' 29 %
P02769 BXGT005956 Serum albumin reviewed - ALB Kq '=' 3 10'13L/mol/s
P02769 BXGT005956 Serum albumin reviewed - ALB Kq '=' 3 10'13L/mol/s
P04798 BXGT006265 Cytochrome P450 1A1 reviewed Enzyme CYP1A1 Ki '=' 1220 nM
Q63470 BXGT016073 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed - Dyrk1a AC50 '=' 14528 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 70794 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B IC50 '>' 100000 nM
P48147 BXGT010620 Prolyl endopeptidase reviewed Enzyme PREP Inhibition '=' 60 %
P05453 BXGT006363 Eukaryotic peptide chain release factor GTP-binding subunit reviewed - SUP35 Inhibition '=' 95 %
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 4300 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 - - -
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 25118 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 25118 nM
Q9Y3R4 BXGT022265 Sialidase-2 reviewed Enzyme NEU2 IC50 '=' 130000 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 1995 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Activity - - -
Q8K4F2 BXGT018400 Arachidonate 15-lipoxygenase B reviewed - Alox15b IC50 '=' 260 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 28183 nM
P02769 BXGT005956 Serum albumin reviewed - ALB K '=' 2 10'5L/mol
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 19952 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 56234 nM
Q9HC97 BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 Activity - - -
Q9HC97 BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 Ratio '=' 2 -
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 3981 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 6309 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency '=' 631 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 5011 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 31622 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 31622 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 7568 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 28183 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 7943 nM
P48147 BXGT010620 Prolyl endopeptidase reviewed Enzyme PREP Inhibition '=' 84 %
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Ki '=' 4330 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 14125 nM
P80404 BXGT011907 4-aminobutyrate aminotransferase, mitochondrial reviewed Enzyme ABAT IC50 '=' 12800000 nM
Q9UGI9 BXGT021682 5'-AMP-activated protein kinase subunit gamma-3 reviewed Enzyme modulator PRKAG3 Activity - - -
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 reviewed Kinase PRKAA1 Activity - - -
Q9Y478 BXGT022271 5'-AMP-activated protein kinase subunit beta-1 reviewed Kinase PRKAB1 Activity - - -
Q9UGJ0 BXGT021683 5'-AMP-activated protein kinase subunit gamma-2 reviewed Enzyme modulator PRKAG2 Activity - - -
P54619 BXGT011060 5'-AMP-activated protein kinase subunit gamma-1 reviewed Kinase PRKAG1 Activity - - -
O43741 BXGT004620 5'-AMP-activated protein kinase subunit beta-2 reviewed Enzyme modulator PRKAB2 Activity - - -
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 reviewed Kinase PRKAA2 Activity - - -
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 1636 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 12589 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 12589 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 3262 nM
P02769 BXGT005956 Serum albumin reviewed - ALB K '=' 1 10'5L/mol
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 5011 nM
Q9HC97 BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 EC50 '=' 10300 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 33498 nM
P05412 BXGT006354 Transcription factor AP-1 reviewed Transcription factor JUN FC '=' 1 -
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 17782 nM
Q9HC97 BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 Efficacy '=' 248 picometer
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 44668 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Potency '=' 3548 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 14988 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 IC50 '=' 7000 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 25118 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 7943 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 2377 nM
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency - 3981 nM
P16220 BXGT008206 Cyclic AMP-responsive element-binding protein 1 reviewed - CREB1 FC '=' 2 -
Q13332 BXGT013342 Receptor-type tyrosine-protein phosphatase S reviewed Enzyme PTPRS Inhibition '=' 80 %
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 25118 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 25118 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 41000 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 IC50 '=' 4400 nM
P53355 BXGT010985 Death-associated protein kinase 1 reviewed Kinase DAPK1 IC50 '=' 120000 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 37685 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 891 nM
P07374 BXGT006615 Urease reviewed - Inhibition - - -
Q86831 BXGT017584 Polyprotein II unreviewed - Inhibition '=' 95 %
P29990 BXGT009390 Genome polyprotein reviewed - IC50 - 35060 nM
P36888 BXGT009938 Receptor-type tyrosine-protein kinase FLT3 reviewed Kinase FLT3 IC50 '>' 10000 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 1778 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 28183 nM
Q9GZT9 BXGT020425 Egl nine homolog 1 reviewed - EGLN1 Inhibition - - -
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 15101 nM
P06804 BXGT006509 Tumor necrosis factor reviewed - Tnf Inhibition '=' 71 %
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 5623 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 2511 nM
O75604 BXGT005139 Ubiquitin carboxyl-terminal hydrolase 2 reviewed Enzyme USP2 Potency '=' 631 nM
Q57TT1 BXGT015153 Uncharacterized protein unreviewed - Tb927.8.6820 Potency - 35481 nM
Q13332 BXGT013342 Receptor-type tyrosine-protein phosphatase S reviewed Enzyme PTPRS IC50 '=' 10300 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 IC50 '=' 9100 nM
Q9HC97 BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 IC50 '=' 28200 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 794 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 90 %
P07861 BXGT006690 Neprilysin reviewed - Mme Inhibition '=' 36 %
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 2238 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 25929 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 15848 nM
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 7500 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Ratio IC50 '=' 3 -
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase reviewed Kinase AKT1 Activity - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 '=' 9200 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c IC50 '=' 85100 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 15 %
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH IC50 '=' 71500 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00149 Peach Prunus persica Fruits
BXGF00227 Welsh onion Allium fistulosum Herbs and Spices
BXGF01886 Crambe hispanica subsp. abyssinica Crambe hispanica subsp. abyssinica Human Edible Plant
BXGF02087 Utricularia vulgaris Utricularia vulgaris Medicinal Plant
BXGF02167 Scutellaria barbata Scutellaria barbata Medicinal Plant
BXGF02325 Helichrysum lindleyi Helichrysum lindleyi Others
BXGF02359 Eucommia ulmoides Eucommia ulmoides Medicinal Plant
BXGF02490 Stizophyllum riparium Stizophyllum riparium Others
BXGF03152 Sophora japonica Sophora japonica Medicinal Plant
BXGF03158 Rheum officinale Rheum officinale Medicinal Plant
BXGF03988 Rheum coreanum Rheum coreanum Others
BXGF04155 Vincetoxicum amplexicaule Vincetoxicum amplexicaule Others
BXGF04539 Rheum palmatum Rheum palmatum Medicinal Plant
BXGF04691 Oroxylum indicum Oroxylum indicum Medicinal Plant
BXGF04750 Scutellaria baicalensis Scutellaria baicalensis Medicinal Plant
BXGF05185 Parinari campestris Parinari campestris Human Edible Plant
BXGF05330 Arum ternatum thunb Arum ternatum thunb Others
BXGF05877 Rheum tanguticum Rheum tanguticum Medicinal Plant
BXGF06151 Scutellaria lateriflora Scutellaria lateriflora Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease