Showing entry for HLA class II histocompatibility antigen, DO beta chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007954
Protein NameHLA class II histocompatibility antigen, DO beta chain
Uniport IdP13765
GeneHLA-DOB
Gene Id3112
DomainC1-set; MHC_II_beta
Pfam PF07654   PF00969  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04514 Cell adhesion molecules (CAMs)
5. Organismal Systems 5.1 Immune system hsa04612 Antigen processing and presentation
5. Organismal Systems 5.1 Immune system hsa04640 Hematopoietic cell lineage
5. Organismal Systems 5.1 Immune system hsa04658 Th1 and Th2 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04659 Th17 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04672 Intestinal immune network for IgA production
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04940 Type I diabetes mellitus
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05140 Leishmaniasis
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05145 Toxoplasmosis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05152 Tuberculosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05164 Influenza A
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05169 Epstein-Barr virus infection
6. Human Diseases 6.3 Immune diseases hsa05310 Asthma
6. Human Diseases 6.3 Immune diseases hsa05320 Autoimmune thyroid disease
6. Human Diseases 6.3 Immune diseases hsa05321 Inflammatory bowel disease (IBD)
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
6. Human Diseases 6.3 Immune diseases hsa05323 Rheumatoid arthritis
6. Human Diseases 6.3 Immune diseases hsa05330 Allograft rejection
6. Human Diseases 6.3 Immune diseases hsa05332 Graft-versus-host disease
6. Human Diseases 6.6 Cardiovascular diseases hsa05416 Viral myocarditis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II
molecular function GO:0023026 MHC class II protein complex binding
molecular function GO:0032395 MHC class II receptor activity
cellular component GO:0010008 endosome membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0005765 lysosomal membrane
cellular component GO:0005764 lysosome
cellular component GO:0042613 MHC class II protein complex
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-2132295 MHC class II antigen presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0036202 BXGD002581 Sarcoidosis Hemic and Lymphatic Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0039263 BXGD002805 Takayasu Arteritis Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0238694 BXGD004953 Peripheral arthritis Musculoskeletal Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C1836230 BXGD014099 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
C1836231 BXGD014100 HIV-1, RESISTANCE TO
C1836232 BXGD014101 ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO
C1836233 BXGD014102 AIDS, PROGRESSION TO
C2004493 BXGD016875 Leukemia, B-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein