adisease

Showing entry for Narcolepsy

General Disease Information
BXGD Id	BXGD001984
Disease Name	Narcolepsy
Disease CUI Id	C0027404
MeSH Codes	C10 F03
Disease Class Name	Nervous System Diseases; Mental Disorders
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000707
Human Phenotype Ontology Term	Abnormality of the nervous system
Disease Ontology Id	DOID:150
Disease Ontology Class Name	disease of mental health
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00222	BXGT003899	Metabotropic glutamate receptor 8	2918	reviewed	G-protein coupled receptor
O14618	BXGT004076	Copper chaperone for superoxide dismutase	9973	reviewed	Enzyme
O14776	BXGT004097	Transcription elongation regulator 1	10915	reviewed	Transcription factor
O15409	BXGT004166	Forkhead box protein P2	93986	reviewed
O43169	BXGT004573	Cytochrome b5 type B	80777	reviewed	Enzyme
O43318	BXGT004586	Mitogen-activated protein kinase kinase kinase 7	6885	reviewed	Kinase
O43612	BXGT004605	Orexin	3060	reviewed
O43614	BXGT004606	Orexin receptor type 2	3062	reviewed	G-protein coupled receptor
O60260	BXGT004864	E3 ubiquitin-protein ligase parkin	5071	reviewed	Enzyme
O60706	BXGT004896	ATP-binding cassette sub-family C member 9	10060	reviewed	Transporter
O75044	BXGT005097	SLIT-ROBO Rho GTPase-activating protein 2	23380	reviewed	Enzyme modulator
O75628	BXGT005140	GTP-binding protein REM 1	28954	reviewed
O94760	BXGT005328	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	23576	reviewed	Enzyme
O95278	BXGT005370	Laforin	7957	reviewed
P01275	BXGT005747	Glucagon	2641	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01903	BXGT005814	HLA class II histocompatibility antigen, DR alpha chain	3122	reviewed	Immune response
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02787	BXGT005962	Serotransferrin	7018	reviewed	Enzyme
P04440	BXGT006216	HLA class II histocompatibility antigen, DP beta 1 chain	3115	reviewed	Immune response
P05155	BXGT006328	Plasma protease C1 inhibitor	710	reviewed	Enzyme modulator
P09668	BXGT006914	Pro-cathepsin H	1512	reviewed	Enzyme
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P11274	BXGT007681	Breakpoint cluster region protein	613	reviewed	Enzyme modulator
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P13765	BXGT007954	HLA class II histocompatibility antigen, DO beta chain	3112	reviewed	Immune response
P15328	BXGT008108	Folate receptor alpha	2348	reviewed
P15498	BXGT008133	Proto-oncogene vav	7409	reviewed
P18850	BXGT008433	Cyclic AMP-dependent transcription factor ATF-6 alpha	22926	reviewed
P19113	BXGT008458	Histidine decarboxylase	3067	reviewed
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P21397	BXGT008644	Amine oxidase [flavin-containing] A	4128	reviewed
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P23468	BXGT008870	Receptor-type tyrosine-protein phosphatase delta	5789	reviewed	Enzyme
P23975	BXGT008935	Sodium-dependent noradrenaline transporter	6530	reviewed	Transporter
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P28066	BXGT009227	Proteasome subunit alpha type-5	5686	reviewed
P28223	BXGT009239	5-hydroxytryptamine receptor 2A	3356	reviewed	G-protein coupled receptor
P29965	BXGT009388	CD40 ligand	959	reviewed	Signaling
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P41231	BXGT010240	P2Y purinoceptor 2	5029	reviewed	G-protein coupled receptor
P41594	BXGT010266	Metabotropic glutamate receptor 5	2915	reviewed	G-protein coupled receptor
P42658	BXGT010327	Dipeptidyl aminopeptidase-like protein 6	1804	reviewed	Enzyme
P42785	BXGT010338	Lysosomal Pro-X carboxypeptidase	5547	reviewed	Enzyme
P43220	BXGT010367	Glucagon-like peptide 1 receptor	2740	reviewed	G-protein coupled receptor
P47900	BXGT010595	P2Y purinoceptor 1	5028	reviewed	G-protein coupled receptor
P49336	BXGT010697	Cyclin-dependent kinase 8	1024	reviewed	Kinase
P49789	BXGT010742	Bis(5'-adenosyl)-triphosphatase	2272	reviewed
P51575	BXGT010861	P2X purinoceptor 1	5023	reviewed	Ion channel
P51677	BXGT010876	C-C chemokine receptor type 3	1232	reviewed	G-protein coupled receptor
P54762	BXGT011076	Ephrin type-B receptor 1	2047	reviewed	Kinase
P56373	BXGT011164	P2X purinoceptor 3	5024	reviewed	Ion channel
P58335	BXGT011233	Anthrax toxin receptor 2	118429	reviewed	Receptor
P58400	BXGT011235	Neurexin-1-beta	9378	reviewed
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q02127	BXGT012635	Dihydroorotate dehydrogenase (quinone), mitochondrial	1723	reviewed	Enzyme
Q03518	BXGT012723	Antigen peptide transporter 1	6890	reviewed	Transporter
Q05329	BXGT012814	Glutamate decarboxylase 2	2572	reviewed	Enzyme
Q05940	BXGT012846	Synaptic vesicular amine transporter	6571	reviewed	Transporter
Q07157	BXGT012920	Tight junction protein ZO-1	7082	reviewed	Cell-cell junction
Q07343	BXGT012926	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	5142	reviewed
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q12882	BXGT013276	Dihydropyrimidine dehydrogenase [NADP(+)]	1806	reviewed	Enzyme
Q13009	BXGT013305	T-lymphoma invasion and metastasis-inducing protein 1	7074	reviewed
Q13586	BXGT013380	Stromal interaction molecule 1	6786	reviewed
Q16595	BXGT013643	Frataxin, mitochondrial	2395	reviewed	Enzyme
Q30154	BXGT014296	HLA class II histocompatibility antigen, DR beta 5 chain	3127	reviewed	Immune response
Q5VZ30	BXGT015894	Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)	2572	unreviewed
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q8IV48	BXGT018339	3'-5' exoribonuclease 1	90459	reviewed	Enzyme
Q8N608	BXGT018522	Inactive dipeptidyl peptidase 10	57628	reviewed	Enzyme
Q8NBK3	BXGT018538	Formylglycine-generating enzyme	285362	reviewed
Q8TAF3	BXGT018786	WD repeat-containing protein 48	57599	reviewed
Q92736	BXGT019367	Ryanodine receptor 2	6262	reviewed	Ion channel
Q96BT7	BXGT019628	Alkylated DNA repair protein alkB homolog 8	91801	reviewed
Q96G91	BXGT019663	P2Y purinoceptor 11	5032	reviewed	G-protein coupled receptor
Q96J02	BXGT019679	E3 ubiquitin-protein ligase Itchy homolog	83737	reviewed	Enzyme
Q96RJ0	BXGT019728	Trace amine-associated receptor 1	134864	reviewed	G-protein coupled receptor
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99928	BXGT019975	Gamma-aminobutyric acid receptor subunit gamma-3	2567	reviewed	Ion channel
Q9H9B1	BXGT020501	Histone-lysine N-methyltransferase EHMT1	79813	reviewed	Epigenetic regulator
Q9HAS3	BXGT020507	Solute carrier family 28 member 3	64078	reviewed	Transporter
Q9NP56	BXGT021142	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	27115	reviewed
Q9NPH5	BXGT021159	NADPH oxidase 4	50507	reviewed	Enzyme
Q9NT68	BXGT021210	Teneurin-2	57451	reviewed
Q9NUB1	BXGT021215	Acetyl-coenzyme A synthetase 2-like, mitochondrial	84532	reviewed	Enzyme
Q9NWB1	BXGT021231	RNA binding protein fox-1 homolog 1	54715	reviewed	Nucleic acid binding
Q9UBL9	BXGT021656	P2X purinoceptor 2	22953	reviewed	Ion channel
Q9UKV0	BXGT021750	Histone deacetylase 9	9734	reviewed	Epigenetic regulator
Q9UNA4	BXGT021785	DNA polymerase iota	11201	reviewed
Q9Y259	BXGT022219	Choline/ethanolamine kinase	1120	reviewed	Kinase
Q9Y5N1	BXGT022297	Histamine H3 receptor	11255	reviewed	G-protein coupled receptor
Q9Y698	BXGT022323	Voltage-dependent calcium channel gamma-2 subunit	10369	reviewed	Ion channel
Q9Y6K8	BXGT022332	Adenylate kinase isoenzyme 5	26289	reviewed	Kinase
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q92878	BXGT023071	DNA repair protein RAD50	10111	reviewed
Q9BVI0	BXGT023340	PHD finger protein 20	51230	reviewed
O14490	BXGT023570	Disks large-associated protein 1	9229	reviewed	Receptor
O43613	BXGT025666	Orexin receptor type 1	3061	reviewed	G-protein coupled receptor
Q9HD34	BXGT025907	LYR motif-containing protein 4	57128	reviewed
P09471	BXGT026153	Guanine nucleotide-binding protein G(o) subunit alpha	2775	reviewed	Enzyme modulator
Q8N573	BXGT026157	Oxidation resistance protein 1	55074	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}