Showing entry for cGMP-dependent 3',5'-cyclic phosphodiesterase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007984
Protein NamecGMP-dependent 3',5'-cyclic phosphodiesterase
Uniport IdP14099
GenePDE2A
Gene Id281971
DomainGAF; GAF_2; PDEase_I
Pfam PF01590   PF13185   PF00233  
OrganismBos taurus (Bovine)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019933 cAMP-mediated signaling
Biological Process GO:0071321 cellular response to cGMP
Biological Process GO:0035690 cellular response to drug
Biological Process GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
Biological Process GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0046069 cGMP catabolic process
Biological Process GO:0019934 cGMP-mediated signaling
Biological Process GO:0061028 establishment of endothelial barrier
Biological Process GO:0046038 GMP catabolic process
Biological Process GO:0043951 negative regulation of cAMP-mediated signaling
Biological Process GO:0010754 negative regulation of cGMP-mediated signaling
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0043116 negative regulation of vascular permeability
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:0043117 positive regulation of vascular permeability
Biological Process GO:0010821 regulation of mitochondrion organization
Biological Process GO:0007165 signal transduction
molecular function GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
molecular function GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
molecular function GO:0030553 cGMP binding
molecular function GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
molecular function GO:0008144 drug binding
molecular function GO:0046872 metal ion binding
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005741 mitochondrial outer membrane
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0042734 presynaptic membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000204 Theophylline 180.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein