Showing entry for Theophylline


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000204
Compound NameTheophylline
Structure
FormulaC7H8N4O2
InchiKeyZFXYFBGIUFBOJW-UHFFFAOYSA-N
SMILESCN1C2=C(NC=N2)C(=O)N(C)C1=O
InchiInChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)
IUPAC1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Molecular Weight180.16
Pubchem Id2153
Chembl IdCHEMBL190
Targets of Information Source
DrugBank DB00277
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 approved antagonist
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A approved antagonist
P29275 BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B approved antagonist
Q07343 BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B reviewed - PDE4B approved inhibitor
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A approved inhibitor
P27815 BXGT009208 cAMP-specific 3',5'-cyclic phosphodiesterase 4A reviewed - PDE4A approved inhibitor
Q14432 BXGT013469 cGMP-inhibited 3',5'-cyclic phosphodiesterase A reviewed - PDE3A approved inhibitor
Q92769 BXGT019370 Histone deacetylase 2 reviewed Epigenetic regulator HDAC2 approved activator
Q99829 BXGT019968 Copine-1 reviewed - CPNE1 approved -
Q8TCT9 BXGT018801 Minor histocompatibility antigen H13 reviewed Enzyme HM13 approved -
Q15155 BXGT013548 Nodal modulator 1 reviewed - NOMO1 approved -
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 reviewed - PARP1 approved -
Q7Z5B4 BXGT017258 Protein RIC-3 reviewed - RIC3 approved -
Q9Y4R7 BXGT022284 Tubulin monoglycylase TTLL3 reviewed - TTLL3 approved -
PDB TEP
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q873X9 BXGT017640 Endochitinase B1 reviewed chiB1 - - 1500000 - -
Q8K4Z3 BXGT018403 NAD(P)H-hydrate epimerase reviewed Naxe - - - - -
O00764 BXGT003948 Pyridoxal kinase reviewed PDXK Kinase 50000 - - -
H9N289 BXGT024287 Methylxanthine N1-demethylase NdmA reviewed ndmA - - - - -
Binding DB 10847
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT017640 Endochitinase B1 reviewed chiB1 - 1500000 - -
reviewed BXGT009208 cAMP-specific 3',5'-cyclic phosphodiesterase 4A reviewed PDE4A - 386000 - -
reviewed BXGT013329 Chitotriosidase-1 reviewed CHIT1 - >500000 - -
reviewed BXGT010581 Adenosine receptor A1 reviewed ADORA1 5980 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 5600 - - -
reviewed BXGT009236 Adenosine receptor A1 reviewed ADORA1 6330 - - -
reviewed BXGT009778 Adenosine receptor A1 reviewed ADORA1 4710 - - -
reviewed BXGT010581 Adenosine receptor A1 reviewed ADORA1 7060 - - -
reviewed BXGT011253 P2Y purinoceptor 2 (Fragment) reviewed P2RY2 4550 - - -
reviewed BXGT009812 Adenosine receptor A3 reviewed ADORA3 9050 - - -
reviewed BXGT009236 Adenosine receptor A1 reviewed ADORA1 >10000 - - -
reviewed BXGT009236 Adenosine receptor A1 reviewed ADORA1 3800 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 >10000 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 9500 - - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A >10000 - - -
reviewed BXGT009236 Adenosine receptor A1 reviewed ADORA1 5300 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 350 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 8470 - - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A 2780 - - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A 1710 - - -
reviewed BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 >10000 - - -
reviewed BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 6200 - - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A 4200 - - -
reviewed BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B 7850 - - -
reviewed BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B 9200 - - -
reviewed BXGT005348 Potassium channel subfamily K member 2 reviewed Ion channel KCNK2 - - - 486000
reviewed BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 - >10000 - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A - - - 28200
reviewed BXGT010581 Adenosine receptor A1 reviewed ADORA1 9800 - - -
reviewed BXGT010529 Adenosine receptor A2a reviewed ADORA2A 16600 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 13000 - - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 25300 - - -
reviewed BXGT010581 Adenosine receptor A1 reviewed ADORA1 23000 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 14000 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 8500 - - -
reviewed BXGT007985 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A reviewed PDE1A - 500000 - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 17000 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 8700 - - -
reviewed BXGT009236 Adenosine receptor A1 reviewed ADORA1 - 2430 - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 7400 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 - >10000 - -
reviewed BXGT010529 Adenosine receptor A2a reviewed ADORA2A 14000 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 - 20000 - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 - 28000 - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 19000 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 17000 - - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 25000 - - -
reviewed BXGT010581 Adenosine receptor A1 reviewed ADORA1 13000 - - -
reviewed BXGT009236 Adenosine receptor A1 reviewed ADORA1 8500 - - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A 25000 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 - 19000 - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 8000 - - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 9400 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 26000 - - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 22000 - - -
reviewed BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 86000 - - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A 21000 - - -
reviewed BXGT009329 Adenosine receptor A2b reviewed Adora2b 15100 - - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 6700 - - -
reviewed BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B 9070 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 6920 - - -
reviewed BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform reviewed Kinase PIK3CG - 2904000 - -
reviewed BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B 7059 - - -
reviewed BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 0.6 - - -
reviewed BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 14 - - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A 0.6 - - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A 7900 - - -
reviewed BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 22300 - - -
reviewed BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 6920 - - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A 6700 - - -
reviewed BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL 82000 - - -
reviewed BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 10100 - - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A 18500 - - -
reviewed BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B 2700 - - -
reviewed BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 85100 - - -
reviewed BXGT022220 Phospholipase A-2-activating protein reviewed Enzyme modulator PLAA - >5000 - -
reviewed BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL - >5000 - -
reviewed BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI - >5000 - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 2000 - - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 9000 - - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 150 - - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 4500 - - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 20000 - - -
reviewed BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B reviewed PDE4B - 1780000 - -
reviewed BXGT013469 cGMP-inhibited 3',5'-cyclic phosphodiesterase A reviewed PDE3A - 360000 - -
reviewed BXGT012564 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B reviewed PDE1B - 320000 - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A 13800 - - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A 14000 - - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 4800 - - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a - >10000 - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 1310 - - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 16000 - - -
reviewed BXGT012562 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B reviewed PDE1B - 92000 - -
reviewed BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B reviewed PDE4B 56800 - - -
reviewed BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A 16600 - - -
reviewed BXGT010529 Adenosine receptor A2a reviewed ADORA2A 13000 - - -
reviewed BXGT009236 Adenosine receptor A1 reviewed ADORA1 20000 - - -
reviewed BXGT003916 cGMP-dependent 3',5'-cyclic phosphodiesterase reviewed PDE2A - 210000 - -
reviewed BXGT009236 Adenosine receptor A1 reviewed ADORA1 - 12700 - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 700 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 9200 - - -
reviewed BXGT009236 Adenosine receptor A1 reviewed ADORA1 6000 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 9700 - - -
reviewed BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 - - 12000 -
reviewed BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 8500 - - -
reviewed BXGT009282 Adenosine receptor A3 reviewed Adora3 100000 - - -
reviewed BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 52300 - - -
reviewed BXGT009282 Adenosine receptor A3 reviewed Adora3 85000 - - -
reviewed BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 6770 - - -
CHEMBL CHEMBL190
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 8470 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 8500 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ratio '=' 25000 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ratio '=' 25000 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki '=' 6200 nM
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P28190 BXGT009236 Adenosine receptor A1 reviewed - ADORA1 Ki '=' 3800 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki '=' 6770 nM
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki '=' 22300 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki '=' 29400 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 8000 nM
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 7943 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 19000 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki '=' 19000 nM
Q08828 BXGT013008 Adenylate cyclase type 1 reviewed - ADCY1 Kb '=' 14000 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ratio '=' 2 -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ratio '=' 2 -
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ratio '=' 2 -
P28190 BXGT009236 Adenosine receptor A1 reviewed - ADORA1 Ki '=' 6000 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 90 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 9441 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki '=' 8500 nM
P11308 BXGT007684 Transcriptional regulator ERG reviewed Transcription factor ERG Potency - 7079 nM
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 6741 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 2030 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 PCY '=' 0 -
P29275 BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B Ki '=' 2700 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 22000 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A FC '=' 0 -
P28647 BXGT009282 Adenosine receptor A3 reviewed - Adora3 Ki '=' 2000 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 2000 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 2000 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki '=' 2000 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 2 %
P47745 BXGT010581 Adenosine receptor A1 reviewed - ADORA1 EC15 '=' 62 uM
P47745 BXGT010581 Adenosine receptor A1 reviewed - ADORA1 Ki '=' 9800 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 22000 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki '=' 22000 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 6700 nM
P28190 BXGT009236 Adenosine receptor A1 reviewed - ADORA1 Ki '=' 20000 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 '=' 17104 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha reviewed Ion channel SCN3A Inhibition '=' 6 %
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha reviewed Ion channel SCN2A Inhibition '=' 6 %
P35498 BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A Inhibition '=' 6 %
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha reviewed Ion channel SCN3A Inhibition '=' 7 %
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha reviewed Ion channel SCN2A Inhibition '=' 7 %
P35498 BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A Inhibition '=' 7 %
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P54748 BXGT011071 cAMP-specific 3',5'-cyclic phosphodiesterase 4A reviewed - Pde4a Ki '=' 530000 nM
P14644 BXGT008034 cAMP-specific 3',5'-cyclic phosphodiesterase 4C reviewed - Pde4c Ki '=' 530000 nM
P14646 BXGT008035 cAMP-specific 3',5'-cyclic phosphodiesterase 4B reviewed - Pde4b Ki '=' 530000 nM
P14270 BXGT008000 cAMP-specific 3',5'-cyclic phosphodiesterase 4D reviewed - Pde4d Ki '=' 530000 nM
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 Inhibition '=' -4 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 700 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 756 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 16000 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki '=' 16000 nM
Q8BW75 BXGT017924 Amine oxidase [flavin-containing] B reviewed - Maob Activity - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A FC '=' 0 -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 14000 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 IC50 '=' 28000 nM
P47745 BXGT010581 Adenosine receptor A1 reviewed - ADORA1 Ki '=' 23000 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 IC50 '>' 10000 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a IC50 '>' 10000 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b IC50 '>' 10000 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 6700 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Affinity constant '=' 10 uM
P29275 BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B Ki '=' 9070 nM
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
P46616 BXGT010529 Adenosine receptor A2a reviewed - ADORA2A Ki '=' 13000 nM
P28647 BXGT009282 Adenosine receptor A3 reviewed - Adora3 Ki '=' 150 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 150 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 150 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki '=' 150 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Kd '=' 12000 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A FC '=' -1 -
P28647 BXGT009282 Adenosine receptor A3 reviewed - Adora3 Ki '=' 20000 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 20000 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 20000 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki '=' 20000 nM
P28647 BXGT009282 Adenosine receptor A3 reviewed - Adora3 Ki '=' 4500 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 4500 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 4500 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki '=' 4500 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Kd '=' 3162 nM
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
P14099 BXGT007984 cGMP-dependent 3',5'-cyclic phosphodiesterase reviewed - PDE2A Inhibition '=' 0 %
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Inhibition '=' 13 %
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 794 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ratio '=' 3 -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ratio '=' 3 -
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ratio '=' 3 -
E1BN64 BXGT003068 Phosphodiesterase unreviewed - PDE3B IC50 '=' 90000 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Inhibition - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Activity - - -
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 25000 nM
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 3162 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 19000 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Selectivity ratio '=' 1 -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Selectivity ratio '=' 1 -
P28190 BXGT009236 Adenosine receptor A1 reviewed - ADORA1 IC50 '=' 2430 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki '=' 0 nM
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 0 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 17000 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki '=' 17000 nM
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Inhibition - - -
P14100 BXGT007985 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A reviewed - PDE1A IC50 '=' 500000 nM
E1BN64 BXGT003068 Phosphodiesterase unreviewed - PDE3B IC50 '=' 412000 nM
P14100 BXGT007985 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A reviewed - PDE1A IC50 '=' 412000 nM
Q01061 BXGT012562 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B reviewed - PDE1B IC50 '=' 412000 nM
Q13370 BXGT013345 cGMP-inhibited 3',5'-cyclic phosphodiesterase B reviewed - PDE3B Inhibition '=' 30 %
Q14432 BXGT013469 cGMP-inhibited 3',5'-cyclic phosphodiesterase A reviewed - PDE3A Inhibition '=' 30 %
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Inhibition - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 21000 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 7900 nM
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 9200 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '>' 10000 nM
E1BN64 BXGT003068 Phosphodiesterase unreviewed - PDE3B IC50 '=' 92000 nM
P14100 BXGT007985 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A reviewed - PDE1A IC50 '=' 92000 nM
Q01061 BXGT012562 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B reviewed - PDE1B IC50 '=' 92000 nM
Q08493 BXGT012987 cAMP-specific 3',5'-cyclic phosphodiesterase 4C reviewed - PDE4C Inhibition '=' 26 %
Q07343 BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B reviewed - PDE4B Inhibition '=' 26 %
Q08499 BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D reviewed - PDE4D Inhibition '=' 26 %
P27815 BXGT009208 cAMP-specific 3',5'-cyclic phosphodiesterase 4A reviewed - PDE4A Inhibition '=' 26 %
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform reviewed Kinase PIK3CG IC50 '=' 800000 nM
P05186 BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL IC50 '>' 5000 nM
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ratio Ki '=' 0 -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ratio Ki '=' 0 -
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki ratio '=' 0 -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki ratio '=' 0 -
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki ratio '=' 0 -
P46616 BXGT010529 Adenosine receptor A2a reviewed - ADORA2A Ki '=' 14000 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Affinity constant '=' 10 uM
P29275 BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B Affinity constant '=' 10 uM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 16600 nM
P29275 BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B Ki '=' 16600 nM
P29275 BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B Ki '=' 7850 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki '=' 15100 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 13000 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki '=' 86000 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ratio Ki '=' 0 -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ratio Ki '=' 0 -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Antagonism '=' 56 %
E1BN64 BXGT003068 Phosphodiesterase unreviewed - PDE3B IC50 '=' 210000 nM
P28647 BXGT009282 Adenosine receptor A3 reviewed - Adora3 Ki '=' 85000 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Kb '=' 13700 nM
Q08493 BXGT012987 cAMP-specific 3',5'-cyclic phosphodiesterase 4C reviewed - PDE4C Inhibition '=' 27 %
Q07343 BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B reviewed - PDE4B Inhibition '=' 27 %
Q08499 BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D reviewed - PDE4D Inhibition '=' 27 %
P27815 BXGT009208 cAMP-specific 3',5'-cyclic phosphodiesterase 4A reviewed - PDE4A Inhibition '=' 27 %
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 6920 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki '=' 52300 nM
Q9Y263 BXGT022220 Phospholipase A-2-activating protein reviewed Enzyme modulator PLAA IC50 '>' 5000 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 1258 nM
Q13370 BXGT013345 cGMP-inhibited 3',5'-cyclic phosphodiesterase B reviewed - PDE3B IC50 '=' 360000 nM
Q14432 BXGT013469 cGMP-inhibited 3',5'-cyclic phosphodiesterase A reviewed - PDE3A IC50 '=' 360000 nM
O94956 BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 Inhibition '=' -25 %
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 0 %
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 26000 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 7400 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki '=' 10100 nM
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P28190 BXGT009236 Adenosine receptor A1 reviewed - ADORA1 IC50 '=' 3 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 IC50 '=' 1 nM
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P47745 BXGT010581 Adenosine receptor A1 reviewed - ADORA1 Ki '=' 13000 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 14000 nM
P29275 BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B Ki '=' 14000 nM
Q08493 BXGT012987 cAMP-specific 3',5'-cyclic phosphodiesterase 4C reviewed - PDE4C IC50 '=' 1780000 nM
Q07343 BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B reviewed - PDE4B IC50 '=' 1780000 nM
Q08499 BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D reviewed - PDE4D IC50 '=' 1780000 nM
P27815 BXGT009208 cAMP-specific 3',5'-cyclic phosphodiesterase 4A reviewed - PDE4A IC50 '=' 1780000 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 1310 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki '=' 1310 nM
Q14123 BXGT013445 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C reviewed - PDE1C IC50 '=' 356000 nM
Q01064 BXGT012564 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B reviewed - PDE1B IC50 '=' 356000 nM
P54750 BXGT011072 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A reviewed - PDE1A IC50 '=' 356000 nM
P29275 BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B Ki '=' 9000 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 25000 nM
P28647 BXGT009282 Adenosine receptor A3 reviewed - Adora3 Ki '=' 22000 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 22000 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 25300 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki '=' 25300 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 18500 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 4800 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki '=' 4800 nM
Q08493 BXGT012987 cAMP-specific 3',5'-cyclic phosphodiesterase 4C reviewed - PDE4C ED50 '=' 37 umol.kg-1
Q07343 BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B reviewed - PDE4B ED50 '=' 37 umol.kg-1
Q08499 BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D reviewed - PDE4D ED50 '=' 37 umol.kg-1
P27815 BXGT009208 cAMP-specific 3',5'-cyclic phosphodiesterase 4A reviewed - PDE4A ED50 '=' 37 umol.kg-1
Q01061 BXGT012562 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B reviewed - PDE1B Inhibition '=' 46 %
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 8700 nM
P09923 BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI IC50 '>' 5000 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 1700 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Kd '=' 1642 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Affinity constant - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Affinity constant - - -
P29275 BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B Affinity constant - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Affinity constant - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Enhancement '=' 14 %
Q14123 BXGT013445 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C reviewed - PDE1C IC50 '=' 320000 nM
Q01064 BXGT012564 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B reviewed - PDE1B IC50 '=' 320000 nM
P54750 BXGT011072 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A reviewed - PDE1A IC50 '=' 320000 nM
P29275 BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B Ki '=' 7059 nM
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 9700 nM
Q13370 BXGT013345 cGMP-inhibited 3',5'-cyclic phosphodiesterase B reviewed - PDE3B IC50 '=' 240000 nM
Q14432 BXGT013469 cGMP-inhibited 3',5'-cyclic phosphodiesterase A reviewed - PDE3A IC50 '=' 240000 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 13800 nM
P29275 BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B Ki '=' 13800 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki '=' 85100 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A EC50 '=' 28200 nM
Q08493 BXGT012987 cAMP-specific 3',5'-cyclic phosphodiesterase 4C reviewed - PDE4C Inhibition '=' 39 %
Q07343 BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B reviewed - PDE4B Inhibition '=' 39 %
Q08499 BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D reviewed - PDE4D Inhibition '=' 39 %
P27815 BXGT009208 cAMP-specific 3',5'-cyclic phosphodiesterase 4A reviewed - PDE4A Inhibition '=' 39 %
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Inhibition '=' 2100 %
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 KD hydro '=' 2 mM
P05186 BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL Ki '=' 82000 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Inhibition '<' 30 %
O00408 BXGT003916 cGMP-dependent 3',5'-cyclic phosphodiesterase reviewed - PDE2A IC50 '=' 210000 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ratio '=' 2 -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ratio '=' 2 -
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ratio '=' 2 -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki '=' 14 nM
P28647 BXGT009282 Adenosine receptor A3 reviewed - Adora3 Inhibition '=' 23 %
P28647 BXGT009282 Adenosine receptor A3 reviewed - Adora3 Ratio '>' 10 -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ratio '>' 10 -
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 25000 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki '=' 25000 nM
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki '=' 6920 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 IC50 '=' 19000 nM
P28647 BXGT009282 Adenosine receptor A3 reviewed - Adora3 Ki '=' 9000 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 9000 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 9000 nM
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ki '=' 9000 nM
Q08493 BXGT012987 cAMP-specific 3',5'-cyclic phosphodiesterase 4C reviewed - PDE4C IC50 '=' 81000 nM
Q07343 BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B reviewed - PDE4B IC50 '=' 81000 nM
Q08499 BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D reviewed - PDE4D IC50 '=' 81000 nM
P27815 BXGT009208 cAMP-specific 3',5'-cyclic phosphodiesterase 4A reviewed - PDE4A IC50 '=' 81000 nM
P28190 BXGT009236 Adenosine receptor A1 reviewed - ADORA1 Ki '=' 8500 nM
P28647 BXGT009282 Adenosine receptor A3 reviewed - Adora3 Ki '=' 100000 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 3358 nM
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 17000 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 9400 nM
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
P28647 BXGT009282 Adenosine receptor A3 reviewed - Adora3 Ratio '>' 4 -
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ratio '>' 4 -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A FC '=' 0 -
P30838 BXGT009471 Aldehyde dehydrogenase, dimeric NADP-preferring reviewed - ALDH3A1 Inhibition - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 281 nM
Q60614 BXGT015991 Adenosine receptor A2b reviewed - Adora2b Kb '=' 16000 nM
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform reviewed Kinase PIK3CD IC50 '=' 75000 nM
Q08493 BXGT012987 cAMP-specific 3',5'-cyclic phosphodiesterase 4C reviewed - PDE4C Ki '=' 56800 nM
Q07343 BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B reviewed - PDE4B Ki '=' 56800 nM
Q08499 BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D reviewed - PDE4D Ki '=' 56800 nM
P27815 BXGT009208 cAMP-specific 3',5'-cyclic phosphodiesterase 4A reviewed - PDE4A Ki '=' 56800 nM
P46616 BXGT010529 Adenosine receptor A2a reviewed - ADORA2A Ki '=' 16600 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
Q64133 BXGT016109 Amine oxidase [flavin-containing] A reviewed - Maoa Activity - - -
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ratio '=' 0 -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ratio '=' 0 -
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b Ratio '=' 0 -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition - - -
P28190 BXGT009236 Adenosine receptor A1 reviewed - ADORA1 IC50 '=' 12700 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ratio '=' 0 -
P29275 BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B Ratio '=' 0 -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ratio '=' 0 -
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a A1 selectivity '=' 1 -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 A1 selectivity '=' 1 -
P29276 BXGT009329 Adenosine receptor A2b reviewed - Adora2b A1 selectivity '=' 1 -
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 20596 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A FC '=' 0 -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 1710 nM
Q14123 BXGT013445 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C reviewed - PDE1C Inhibition '=' 13 %
P0DMS9 BXGT007507 Transmembrane domain-containing protein TMIGD3 reviewed - TMIGD3 Ki '=' 86400 nM
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 2511 nM
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki - - -
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 IC50 '=' 20000 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A FC - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
E1BN64 BXGT003068 Phosphodiesterase unreviewed - PDE3B IC50 '=' 286000 nM
P14100 BXGT007985 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A reviewed - PDE1A IC50 '=' 286000 nM
Q01061 BXGT012562 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B reviewed - PDE1B IC50 '=' 286000 nM
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 72 %
P51449 BXGT010846 Nuclear receptor ROR-gamma reviewed Nuclear receptor RORC Potency - 42163 nM
Q9Y694 BXGT022321 Solute carrier family 22 member 7 reviewed Transporter SLC22A7 Activity - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P05186 BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL IC50 '>' 100000 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 4200 nM
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 11220 nM
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki '=' 9977 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 '=' 12007 nM
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
O94788 BXGT005333 Retinal dehydrogenase 2 reviewed Enzyme ALDH1A2 Inhibition - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 56234 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 14125 nM
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 37933 nM
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '>' 135000 nM
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
A6QP37 BXGT001474 Phosphodiesterase unreviewed - PDE7B Ratio '=' 1 -
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 2 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 133000 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short reviewed - GNAS Potency - 11220 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Activity - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 '>' 10000 nM
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform reviewed Kinase PIK3CG IC50 '=' 2904000 nM
Q07343 BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B reviewed - PDE4B IC50 '>' 200000 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Inhibition - - -
A6QP37 BXGT001474 Phosphodiesterase unreviewed - PDE7B IC50 '=' 1720000 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 1258 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Kb '=' 8700 nM
E1BN64 BXGT003068 Phosphodiesterase unreviewed - PDE3B Ki '=' 77000 nM
P30837 BXGT009470 Aldehyde dehydrogenase X, mitochondrial reviewed Enzyme ALDH1B1 Inhibition - - -
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial reviewed Enzyme ALDH2 Inhibition - - -
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform reviewed Kinase PIK3CA IC50 '=' 300000 nM
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform reviewed Kinase PIK3CB IC50 '=' 800000 nM
P47895 BXGT010593 Aldehyde dehydrogenase family 1 member A3 reviewed Enzyme ALDH1A3 Inhibition - - -
P29275 BXGT009328 Adenosine receptor A2b reviewed G-protein coupled receptor ADORA2B Ki - - -
P56817 BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 Kd - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Inhibition - - -
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 IC50 '=' 133000 nM
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 reviewed Transporter ABCC3 IC50 '=' 133000 nM
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
Q13946 BXGT013406 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A reviewed - PDE7A IC50 '>' 200000 nM
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 IC50 '=' 133000 nM
P56373 BXGT011164 P2X purinoceptor 3 reviewed Ion channel P2RX3 IC50 - - -
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00038 Tea Camellia sinensis Teas
BXGF00054 Lemon Citrus limon Fruits
BXGF00055 Pummelo Citrus maxima Fruits
BXGF00059 Arabica coffee Coffea arabica Coffee and coffee products
BXGF00182 Cocoa bean Theobroma cacao Cocoa and cocoa products
BXGF03132 Ancistrocladus korupensis Ancistrocladus korupensis Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease