Showing entry for cAMP-specific 3',5'-cyclic phosphodiesterase 4D


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008000
Protein NamecAMP-specific 3',5'-cyclic phosphodiesterase 4D
Uniport IdP14270
GenePde4d
Gene Id24627
DomainPDE4_UCR; PDEase_I
Pfam PF18100   PF00233  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0086024 adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate
Biological Process GO:0071875 adrenergic receptor signaling pathway
Biological Process GO:0007568 aging
Biological Process GO:0006198 cAMP catabolic process
Biological Process GO:0034622 cellular protein-containing complex assembly
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0071872 cellular response to epinephrine stimulus
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0061028 establishment of endothelial barrier
Biological Process GO:0050900 leukocyte migration
Biological Process GO:0030324 lung development
Biological Process GO:0007613 memory
Biological Process GO:0035264 multicellular organism growth
Biological Process GO:0043951 negative regulation of cAMP-mediated signaling
Biological Process GO:0045822 negative regulation of heart contraction
Biological Process GO:0033137 negative regulation of peptidyl-serine phosphorylation
Biological Process GO:1901898 negative regulation of relaxation of cardiac muscle
Biological Process GO:0030593 neutrophil chemotaxis
Biological Process GO:0022409 positive regulation of cell-cell adhesion
Biological Process GO:0032729 positive regulation of interferon-gamma production
Biological Process GO:0032743 positive regulation of interleukin-2 production
Biological Process GO:0032754 positive regulation of interleukin-5 production
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0014911 positive regulation of smooth muscle cell migration
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:0043949 regulation of cAMP-mediated signaling
Biological Process GO:0086004 regulation of cardiac muscle cell contraction
Biological Process GO:0008277 regulation of G protein-coupled receptor signaling pathway
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Biological Process GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
Biological Process GO:0010469 regulation of signaling receptor activity
Biological Process GO:0006939 smooth muscle contraction
Biological Process GO:0050852 T cell receptor signaling pathway
molecular function GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
molecular function GO:0051117 ATPase binding
molecular function GO:0031698 beta-2 adrenergic receptor binding
molecular function GO:0030552 cAMP binding
molecular function GO:0004112 cyclic-nucleotide phosphodiesterase activity
molecular function GO:0008144 drug binding
molecular function GO:0019899 enzyme binding
molecular function GO:0044325 ion channel binding
molecular function GO:0046872 metal ion binding
molecular function GO:0097110 scaffold protein binding
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0034704 calcium channel complex
cellular component GO:0005813 centrosome
cellular component GO:0005829 cytosol
cellular component GO:0005794 Golgi apparatus
cellular component GO:0016020 membrane
cellular component GO:0030016 myofibril
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:0005891 voltage-gated calcium channel complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000202 Papaverine 339.39
BXGC0000204 Theophylline 180.16
BXGC0016090 Kurarinol 456.21
BXGC0019748 Kuraidin 438.2
BXGC0026947 (2R,3R)-2-(2,4-Dihydroxy-Phenyl)-3,7-Dihydroxy-8-(5-Hydroxy-2-Isopropenyl-5-Methyl-Hexyl)-5-Methoxy-Chroman-4-One 472.21
BXGC0028625 Sophoflavescenol 368.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein