Showing entry for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008198
Protein Name6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
Uniport IdP16118
GenePFKFB1
Gene Id5207
Domain6PF2K; His_Phos_1
Pfam PF01591   PF00300  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00051 Fructose and mannose metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04152 AMPK signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04922 Glucagon signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031100 animal organ regeneration
Biological Process GO:0006003 fructose 2,6-bisphosphate metabolic process
Biological Process GO:0006000 fructose metabolic process
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0006096 glycolytic process
Biological Process GO:0045820 negative regulation of glycolytic process
Biological Process GO:0033133 positive regulation of glucokinase activity
Biological Process GO:0045821 positive regulation of glycolytic process
Biological Process GO:0051591 response to cAMP
Biological Process GO:0033762 response to glucagon
Biological Process GO:0051384 response to glucocorticoid
Biological Process GO:0032868 response to insulin
Biological Process GO:0042594 response to starvation
molecular function GO:0003873 6-phosphofructo-2-kinase activity
molecular function GO:0005524 ATP binding
molecular function GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
molecular function GO:0070095 fructose-6-phosphate binding
molecular function GO:0042802 identical protein binding
molecular function GO:0019900 kinase binding
cellular component GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-163358 PKA-mediated phosphorylation of key metabolic factors
R-HSA-163685 Integration of energy metabolism
R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors
R-HSA-70171 Glycolysis
R-HSA-70171 Glycolysis
R-HSA-70326 Glucose metabolism
R-HSA-70326 Glucose metabolism
R-HSA-71387 Metabolism of carbohydrates
R-HSA-71387 Metabolism of carbohydrates
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0035549 alpha-glycerophosphoric acid 172.01
BXGC0048845 Guanosine Triphosphate 522.99
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein