adisease

Showing entry for Hyperinsulinism

General Disease Information
BXGD Id	BXGD001394
Disease Name	Hyperinsulinism
Disease CUI Id	C0020459
MeSH Codes	C18
Disease Class Name	Nutritional and Metabolic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0001939 HP:0000818
Human Phenotype Ontology Term	Abnormality of metabolism/homeostasis; Abnormality of the endocrine system
Disease Ontology Id	DOID:0014667 DOID:7
Disease Ontology Class Name	disease of metabolism; disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00141	BXGT003882	Serine/threonine-protein kinase Sgk1	6446	reviewed	Kinase
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00255	BXGT003903	Menin	4221	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00330	BXGT003910	Pyruvate dehydrogenase protein X component, mitochondrial	8050	reviewed	Enzyme
O00767	BXGT003949	Acyl-CoA desaturase	6319	reviewed
O14842	BXGT004106	Free fatty acid receptor 1	2864	reviewed	G-protein coupled receptor
O15120	BXGT004129	1-acyl-sn-glycerol-3-phosphate acyltransferase beta	10555	reviewed
O15294	BXGT004147	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	8473	reviewed
O15305	BXGT004152	Phosphomannomutase 2	5373	reviewed	Enzyme
O15379	BXGT004159	Histone deacetylase 3	8841	reviewed	Epigenetic regulator
O15550	BXGT004179	Lysine-specific demethylase 6A	7403	reviewed	Epigenetic regulator
O43451	BXGT004594	Maltase-glucoamylase, intestinal	8972	reviewed	Enzyme
O60240	BXGT004860	Perilipin-1	5346	reviewed
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O60701	BXGT004894	UDP-glucose 6-dehydrogenase	7358	reviewed
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O75015	BXGT005095	Low affinity immunoglobulin gamma Fc region receptor III-B	2215	reviewed	Cell adhesion
O75390	BXGT005123	Citrate synthase, mitochondrial	1431	reviewed	Enzyme
O75460	BXGT005127	Serine/threonine-protein kinase/endoribonuclease IRE1	2081	reviewed	Kinase
O75475	BXGT005130	PC4 and SFRS1-interacting protein	11168	reviewed	Signaling
O75643	BXGT005142	U5 small nuclear ribonucleoprotein 200 kDa helicase	23020	reviewed
O75844	BXGT005156	CAAX prenyl protease 1 homolog	10269	reviewed	Enzyme
O76074	BXGT005174	cGMP-specific 3',5'-cyclic phosphodiesterase	8654	reviewed
O95237	BXGT005361	Lecithin retinol acyltransferase	9227	reviewed
O95342	BXGT005373	Bile salt export pump	8647	reviewed	Transporter
O95477	BXGT005383	Phospholipid-transporting ATPase ABCA1	19	reviewed	Transporter
O95631	BXGT005387	Netrin-1	9423	reviewed	Enzyme modulator
O95749	BXGT005394	Geranylgeranyl pyrophosphate synthase	9453	reviewed
P00367	BXGT005517	Glutamate dehydrogenase 1, mitochondrial	2746	reviewed	Enzyme
P00439	BXGT005539	Phenylalanine-4-hydroxylase	5053	reviewed
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01023	BXGT005718	Alpha-2-macroglobulin	2	reviewed	Enzyme modulator
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01130	BXGT005735	Low-density lipoprotein receptor	3949	reviewed
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01275	BXGT005747	Glucagon	2641	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01308	BXGT005749	Insulin	3630	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P02461	BXGT005880	Collagen alpha-1(III) chain	1281	reviewed
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02652	BXGT005910	Apolipoprotein A-II	336	reviewed	Transporter
P02654	BXGT005911	Apolipoprotein C-I	341	reviewed
P02656	BXGT005913	Apolipoprotein C-III	345	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02753	BXGT005945	Retinol-binding protein 4	5950	reviewed	Transporter
P02765	BXGT005952	Alpha-2-HS-glycoprotein	197	reviewed	Enzyme modulator
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02786	BXGT005961	Transferrin receptor protein 1	7037	reviewed	Enzyme
P02795	BXGT005968	Metallothionein-2	4502	reviewed
P02818	BXGT005969	Osteocalcin	632	reviewed
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04083	BXGT006147	Annexin A1	301	reviewed
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04278	BXGT006182	Sex hormone-binding globulin	6462	reviewed
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04745	BXGT006255	Alpha-amylase 1	278	reviewed
P04839	BXGT006273	Cytochrome b-245 heavy chain	1536	reviewed	Ion channel
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05090	BXGT006311	Apolipoprotein D	347	reviewed
P05091	BXGT006312	Aldehyde dehydrogenase, mitochondrial	217	reviewed	Enzyme
P05093	BXGT006313	Steroid 17-alpha-hydroxylase/17,20 lyase	1586	reviewed
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05177	BXGT006336	Cytochrome P450 1A2	1544	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05413	BXGT006355	Fatty acid-binding protein, heart	2170	reviewed
P05771	BXGT006384	Protein kinase C beta type	5579	reviewed	Kinase
P06213	BXGT006425	Insulin receptor	3643	reviewed	Kinase
P06276	BXGT006430	Cholinesterase	590	reviewed
P06280	BXGT006433	Alpha-galactosidase A	2717	reviewed
P06396	BXGT006435	Gelsolin	2934	reviewed	Cellular structure
P06858	BXGT006515	Lipoprotein lipase	4023	reviewed	Enzyme
P06870	BXGT006518	Kallikrein-1	3816	reviewed	Enzyme
P07202	BXGT006565	Thyroid peroxidase	7173	reviewed	Enzyme
P07203	BXGT006566	Glutathione peroxidase 1	2876	reviewed	Enzyme
P07438	BXGT006625	Metallothionein-1B	4490	reviewed
P08047	BXGT006720	Transcription factor Sp1	6667	reviewed	Nucleic acid binding
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08100	BXGT006725	Rhodopsin	6010	reviewed	G-protein coupled receptor
P08133	BXGT006727	Annexin A6	309	reviewed
P08185	BXGT006742	Corticosteroid-binding globulin	866	reviewed	Enzyme modulator
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08670	BXGT006810	Vimentin	7431	reviewed
P08779	BXGT006824	Keratin, type I cytoskeletal 16	3868	reviewed
P08833	BXGT006827	Insulin-like growth factor-binding protein 1	3484	reviewed	Enzyme modulator
P08922	BXGT006843	Proto-oncogene tyrosine-protein kinase ROS	6098	reviewed	Kinase
P09172	BXGT006865	Dopamine beta-hydroxylase	1621	reviewed
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09493	BXGT006900	Tropomyosin alpha-1 chain	7168	reviewed	Cellular structure
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09668	BXGT006914	Pro-cathepsin H	1512	reviewed	Enzyme
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10147	BXGT007543	C-C motif chemokine 3	6348	reviewed	Signaling
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P10646	BXGT007598	Tissue factor pathway inhibitor	7035	reviewed	Enzyme modulator
P10745	BXGT007608	Retinol-binding protein 3	5949	reviewed
P10997	BXGT007643	Islet amyloid polypeptide	3375	reviewed	Signaling
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11169	BXGT007664	Solute carrier family 2, facilitated glucose transporter member 3	6515	reviewed	Transporter
P11215	BXGT007672	Integrin alpha-M	3684	reviewed
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P11597	BXGT007727	Cholesteryl ester transfer protein	1071	reviewed
P11802	BXGT007750	Cyclin-dependent kinase 4	1019	reviewed	Kinase
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12104	BXGT007773	Fatty acid-binding protein, intestinal	2169	reviewed
P12271	BXGT007786	Retinaldehyde-binding protein 1	6017	reviewed	Transporter
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13688	BXGT007943	Carcinoembryonic antigen-related cell adhesion molecule 1	634	reviewed
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P13945	BXGT007972	Beta-3 adrenergic receptor	155	reviewed	G-protein coupled receptor
P14410	BXGT008009	Sucrase-isomaltase, intestinal	6476	reviewed	Enzyme
P14672	BXGT008037	Solute carrier family 2, facilitated glucose transporter member 4	6517	reviewed	Transporter
P14735	BXGT008042	Insulin-degrading enzyme	3416	reviewed	Enzyme
P14784	BXGT008054	Interleukin-2 receptor subunit beta	3560	reviewed	Receptor
P15090	BXGT008079	Fatty acid-binding protein, adipocyte	2167	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16118	BXGT008198	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1	5207	reviewed	Kinase
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P16499	BXGT008238	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	5145	reviewed
P16671	BXGT008255	Platelet glycoprotein 4	948	reviewed	Receptor
P17252	BXGT008294	Protein kinase C alpha type	5578	reviewed	Kinase
P17861	BXGT008348	X-box-binding protein 1	7494	reviewed
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	2321	reviewed	Kinase
P18031	BXGT008369	Tyrosine-protein phosphatase non-receptor type 1	5770	reviewed
P18146	BXGT008384	Early growth response protein 1	1958	reviewed	Nucleic acid binding
P18433	BXGT008403	Receptor-type tyrosine-protein phosphatase alpha	5786	reviewed	Enzyme
P19320	BXGT008470	Vascular cell adhesion protein 1	7412	reviewed
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P19883	BXGT008528	Follistatin	10468	reviewed	Enzyme modulator
P20794	BXGT008600	Serine/threonine-protein kinase MAK	4117	reviewed	Kinase
P20839	BXGT008608	Inosine-5'-monophosphate dehydrogenase 1	3614	reviewed	Enzyme
P21554	BXGT008662	Cannabinoid receptor 1	1268	reviewed	G-protein coupled receptor
P22309	BXGT008753	UDP-glucuronosyltransferase 1-1	54658	reviewed
P22413	BXGT008764	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	5167	reviewed	Enzyme
P22748	BXGT008802	Carbonic anhydrase 4	762	reviewed
P22897	BXGT008816	Macrophage mannose receptor 1	4360	reviewed
P23443	BXGT008866	Ribosomal protein S6 kinase beta-1	6198	reviewed	Kinase
P23468	BXGT008870	Receptor-type tyrosine-protein phosphatase delta	5789	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P25098	BXGT009015	Beta-adrenergic receptor kinase 1	156	reviewed	Kinase
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P25963	BXGT009080	NF-kappa-B inhibitor alpha	4792	reviewed
P27487	BXGT009187	Dipeptidyl peptidase 4	1803	reviewed	Enzyme
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P27708	BXGT009202	CAD protein	790	reviewed	Enzyme
P28335	BXGT009255	5-hydroxytryptamine receptor 2C	3358	reviewed	G-protein coupled receptor
P28562	BXGT009270	Dual specificity protein phosphatase 1	1843	reviewed
P28845	BXGT009297	Corticosteroid 11-beta-dehydrogenase isozyme 1	3290	reviewed
P29350	BXGT009335	Tyrosine-protein phosphatase non-receptor type 6	5777	reviewed
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P29965	BXGT009388	CD40 ligand	959	reviewed	Signaling
P29973	BXGT009389	cGMP-gated cation channel alpha-1	1259	reviewed	Ion channel
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P31639	BXGT009556	Sodium/glucose cotransporter 2	6524	reviewed	Transporter
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P31751	BXGT009576	RAC-beta serine/threonine-protein kinase	208	reviewed	Kinase
P32245	BXGT009614	Melanocortin receptor 4	4160	reviewed	G-protein coupled receptor
P34949	BXGT009775	Mannose-6-phosphate isomerase	4351	reviewed	Enzyme
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P35557	BXGT009846	Glucokinase	2645	reviewed	Kinase
P35858	BXGT009876	Insulin-like growth factor-binding protein complex acid labile subunit	3483	reviewed	Receptor
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P35913	BXGT009879	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	5158	reviewed
P36956	BXGT009947	Sterol regulatory element-binding protein 1	6720	reviewed
P37088	BXGT009961	Amiloride-sensitive sodium channel subunit alpha	6337	reviewed	Ion channel
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P39900	BXGT010148	Macrophage metalloelastase	4321	reviewed	Enzyme
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41222	BXGT010237	Prostaglandin-H2 D-isomerase	5730	reviewed	Enzyme
P41235	BXGT010241	Hepatocyte nuclear factor 4-alpha	3172	reviewed	Nuclear receptor
P41252	BXGT010245	Isoleucine--tRNA ligase, cytoplasmic	3376	reviewed	Enzyme
P41595	BXGT010267	5-hydroxytryptamine receptor 2B	3357	reviewed	G-protein coupled receptor
P41968	BXGT010275	Melanocortin receptor 3	4159	reviewed	G-protein coupled receptor
P42224	BXGT010286	Signal transducer and activator of transcription 1-alpha/beta	6772	reviewed	Nucleic acid binding
P42330	BXGT010301	Aldo-keto reductase family 1 member C3	8644	reviewed	Enzyme
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P43026	BXGT010351	Growth/differentiation factor 5	8200	reviewed	Signaling
P43220	BXGT010367	Glucagon-like peptide 1 receptor	2740	reviewed	G-protein coupled receptor
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P45984	BXGT010495	Mitogen-activated protein kinase 9	5601	reviewed	Kinase
P47871	BXGT010592	Glucagon receptor	2642	reviewed	G-protein coupled receptor
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P48506	BXGT010635	Glutamate--cysteine ligase catalytic subunit	2729	reviewed	Enzyme
P48507	BXGT010636	Glutamate--cysteine ligase regulatory subunit	2730	reviewed	Enzyme
P48546	BXGT010642	Gastric inhibitory polypeptide receptor	2696	reviewed	G-protein coupled receptor
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49286	BXGT010691	Melatonin receptor type 1B	4544	reviewed	G-protein coupled receptor
P49327	BXGT010694	Fatty acid synthase	2194	reviewed	Enzyme
P49336	BXGT010697	Cyclin-dependent kinase 8	1024	reviewed	Kinase
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P50213	BXGT010779	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	3419	reviewed	Enzyme
P50416	BXGT010797	Carnitine O-palmitoyltransferase 1, liver isoform	1374	reviewed	Enzyme
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P51617	BXGT010868	Interleukin-1 receptor-associated kinase 1	3654	reviewed	Kinase
P51787	BXGT010889	Potassium voltage-gated channel subfamily KQT member 1	3784	reviewed	Ion channel
P51843	BXGT010897	Nuclear receptor subfamily 0 group B member 1	190	reviewed	Nuclear receptor
P51955	BXGT010908	Serine/threonine-protein kinase Nek2	4751	reviewed	Kinase
P52789	BXGT010954	Hexokinase-2	3099	reviewed	Kinase
P53396	BXGT010988	ATP-citrate synthase	47	reviewed	Enzyme
P54278	BXGT011038	Mismatch repair endonuclease PMS2	5395	reviewed	Nucleic acid binding
P54646	BXGT011062	5'-AMP-activated protein kinase catalytic subunit alpha-2	5563	reviewed	Kinase
P55157	BXGT011108	Microsomal triglyceride transfer protein large subunit	4547	reviewed	Transporter
P58335	BXGT011233	Anthrax toxin receptor 2	118429	reviewed	Receptor
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P60880	BXGT011335	Synaptosomal-associated protein 25	6616	reviewed	Transporter
P60953	BXGT011342	Cell division control protein 42 homolog	998	reviewed	Enzyme modulator
P78504	BXGT011844	Protein jagged-1	182	reviewed
P82279	BXGT011972	Protein crumbs homolog 1	23418	reviewed
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
Q02763	BXGT012667	Angiopoietin-1 receptor	7010	reviewed	Kinase
Q04759	BXGT012781	Protein kinase C theta type	5588	reviewed	Kinase
Q05513	BXGT012820	Protein kinase C zeta type	5590	reviewed	Kinase
Q05655	BXGT012832	Protein kinase C delta type	5580	reviewed	Kinase
Q06210	BXGT012864	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	2673	reviewed	Enzyme
Q07812	BXGT012940	Apoptosis regulator BAX	581	reviewed	Signaling
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q08345	BXGT012982	Epithelial discoidin domain-containing receptor 1	780	reviewed	Kinase
Q09328	BXGT013034	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A	4249	reviewed	Enzyme
Q09428	BXGT013036	ATP-binding cassette sub-family C member 8	6833	reviewed	Transporter
Q12778	BXGT013263	Forkhead box protein O1	2308	reviewed
Q12866	BXGT013273	Tyrosine-protein kinase Mer	10461	reviewed	Kinase
Q13085	BXGT013309	Acetyl-CoA carboxylase 1	31	reviewed
Q13131	BXGT013314	5'-AMP-activated protein kinase catalytic subunit alpha-1	5562	reviewed	Kinase
Q13285	BXGT013335	Steroidogenic factor 1	2516	reviewed	Nuclear receptor
Q13451	BXGT013356	Peptidyl-prolyl cis-trans isomerase FKBP5	2289	reviewed	Enzyme
Q13464	BXGT013357	Rho-associated protein kinase 1	6093	reviewed	Kinase
Q13627	BXGT013385	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	1859	reviewed	Kinase
Q13873	BXGT013398	Bone morphogenetic protein receptor type-2	659	reviewed	Kinase
Q13887	BXGT013401	Krueppel-like factor 5	688	reviewed	Nucleic acid binding
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14204	BXGT013456	Cytoplasmic dynein 1 heavy chain 1	1778	reviewed	Enzyme
Q14289	BXGT013459	Protein-tyrosine kinase 2-beta	2185	reviewed	Kinase
Q14457	BXGT013472	Beclin-1	8678	reviewed	Enzyme modulator
Q14469	BXGT013473	Transcription factor HES-1	3280	reviewed	Transcription factor
Q14654	BXGT013495	ATP-sensitive inward rectifier potassium channel 11	3767	reviewed	Ion channel
Q14994	BXGT013519	Nuclear receptor subfamily 1 group I member 3	9970	reviewed	Nuclear receptor
Q15078	BXGT013534	Cyclin-dependent kinase 5 activator 1	8851	reviewed	Enzyme modulator
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q15257	BXGT013554	Serine/threonine-protein phosphatase 2A activator	5524	reviewed	Enzyme modulator
Q15389	BXGT013564	Angiopoietin-1	284	reviewed	Signaling
Q15485	BXGT013574	Ficolin-2	2220	reviewed	Signaling
Q15746	BXGT013591	Myosin light chain kinase, smooth muscle	4638	reviewed	Kinase
Q15761	BXGT013596	Neuropeptide Y receptor type 5	4889	reviewed	G-protein coupled receptor
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16568	BXGT013640	Cocaine- and amphetamine-regulated transcript protein	9607	reviewed
Q16654	BXGT013650	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	5166	reviewed	Kinase
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q16836	BXGT013679	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	3033	reviewed
Q2MKA7	BXGT014140	R-spondin-1	284654	reviewed
Q59FK2	BXGT015276	Selenocysteine lyase variant	51540	unreviewed
Q687X5	BXGT016184	Metalloreductase STEAP4	79689	reviewed
Q6JQN1	BXGT016338	Acyl-CoA dehydrogenase family member 10	80724	reviewed	Enzyme
Q6P2Q9	BXGT016446	Pre-mRNA-processing-splicing factor 8	10594	reviewed	Nucleic acid binding
Q86V24	BXGT017615	Adiponectin receptor protein 2	79602	reviewed	Receptor
Q8N4E7	BXGT018511	Ferritin, mitochondrial	94033	reviewed	Storage
Q8NBP7	BXGT018541	Proprotein convertase subtilisin/kexin type 9	255738	reviewed	Enzyme
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q8TCG1	BXGT018797	Protein CIP2A	57650	reviewed
Q8WWY3	BXGT019006	U4/U6 small nuclear ribonucleoprotein Prp31	26121	reviewed	Nucleic acid binding
Q8WZA1	BXGT019024	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1	55624	reviewed
Q92793	BXGT019374	CREB-binding protein	1387	reviewed
Q92834	BXGT019381	X-linked retinitis pigmentosa GTPase regulator	6103	reviewed
Q92945	BXGT019397	Far upstream element-binding protein 2	8570	reviewed	Enzyme
Q969Q1	BXGT019610	E3 ubiquitin-protein ligase TRIM63	84676	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96FI4	BXGT019658	Endonuclease 8-like 1	79661	reviewed
Q96I15	BXGT019674	Selenocysteine lyase	51540	reviewed	Enzyme
Q96NR8	BXGT019701	Retinol dehydrogenase 12	145226	reviewed	Enzyme
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99712	BXGT019953	ATP-sensitive inward rectifier potassium channel 15	3772	reviewed	Ion channel
Q99714	BXGT019954	3-hydroxyacyl-CoA dehydrogenase type-2	3028	reviewed	Enzyme
Q9BZL6	BXGT020199	Serine/threonine-protein kinase D2	25865	reviewed	Kinase
Q9C0B1	BXGT020209	Alpha-ketoglutarate-dependent dioxygenase FTO	79068	reviewed
Q9H0F7	BXGT020435	ADP-ribosylation factor-like protein 6	84100	reviewed
Q9H0P0	BXGT020439	Cytosolic 5'-nucleotidase 3A	51251	reviewed	Enzyme
Q9H3M7	BXGT020462	Thioredoxin-interacting protein	10628	reviewed
Q9H9B1	BXGT020501	Histone-lysine N-methyltransferase EHMT1	79813	reviewed	Epigenetic regulator
Q9NPH5	BXGT021159	NADPH oxidase 4	50507	reviewed	Enzyme
Q9NRF2	BXGT021185	SH2B adapter protein 1	25970	reviewed
Q9NTG7	BXGT021211	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	23410	reviewed	Epigenetic regulator
Q9NWB1	BXGT021231	RNA binding protein fox-1 homolog 1	54715	reviewed	Nucleic acid binding
Q9NZI2	BXGT021272	Kv channel-interacting protein 1	30820	reviewed	Ion channel
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9P2K8	BXGT021302	eIF-2-alpha kinase GCN2	440275	reviewed
Q9UIQ6	BXGT021721	Leucyl-cystinyl aminopeptidase	4012	reviewed	Enzyme
Q9Y286	BXGT022225	Sialic acid-binding Ig-like lectin 7	27036	reviewed	Receptor
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
Q9Y2S2	BXGT022245	Lambda-crystallin homolog	51084	reviewed	Enzyme
Q9Y478	BXGT022271	5'-AMP-activated protein kinase subunit beta-1	5564	reviewed	Kinase
Q9Y5S8	BXGT022302	NADPH oxidase 1	27035	reviewed
Q9Y5X4	BXGT022306	Photoreceptor-specific nuclear receptor	10002	reviewed	Nuclear receptor
Q9Y5Z0	BXGT022310	Beta-secretase 2	25825	reviewed	Enzyme
Q9Y6E0	BXGT022327	Serine/threonine-protein kinase 24	8428	reviewed	Kinase
Q96QD8	BXGT022647	Sodium-coupled neutral amino acid transporter 2	54407	reviewed	Transporter
Q92482	BXGT022676	Aquaporin-3	360	reviewed	Ion channel
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
Q9UK05	BXGT023094	Growth/differentiation factor 2	2658	reviewed	Signaling
O15085	BXGT023125	Rho guanine nucleotide exchange factor 11	9826	reviewed
O14793	BXGT023280	Growth/differentiation factor 8	2660	reviewed	Signaling
P53539	BXGT023438	Protein fosB	2354	reviewed	Transcription factor
P15260	BXGT023924	Interferon gamma receptor 1	3459	reviewed	Receptor
O60232	BXGT024169	Protein ZNRD2	10534	reviewed
O43837	BXGT024635	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	3420	reviewed	Enzyme
Q96A54	BXGT024681	Adiponectin receptor protein 1	51094	reviewed	Receptor
O14520	BXGT024716	Aquaporin-7	364	reviewed	Ion channel
Q9BY76	BXGT025687	Angiopoietin-related protein 4	51129	reviewed	Signaling
Q86SQ9	BXGT025875	Dehydrodolichyl diphosphate synthase complex subunit DHDDS	79947	reviewed	Enzyme
O43172	BXGT026158	U4/U6 small nuclear ribonucleoprotein Prp4	9128	reviewed	Nucleic acid binding

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}