Showing entry for Nuclear transcription factor Y subunit beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009030
Protein NameNuclear transcription factor Y subunit beta
Uniport IdP25208
GeneNFYB
Gene Id4801
DomainCBFD_NFYB_HMF
Pfam PF00808  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04612 Antigen processing and presentation
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05152 Tuberculosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1990830 cellular response to leukemia inhibitory factor
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045540 regulation of cholesterol biosynthetic process
Biological Process GO:0006355 regulation of transcription, DNA-templated
molecular function GO:0003677 DNA binding
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0070491 repressing transcription factor binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
cellular component GO:0016602 CCAAT-binding factor complex
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032993 protein-DNA complex
cellular component GO:0090575 RNA polymerase II transcription regulator complex
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones
R-HSA-381042 PERK regulates gene expression
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-556833 Metabolism of lipids
R-HSA-556833 Metabolism of lipids
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8957322 Metabolism of steroids
R-HSA-8957322 Metabolism of steroids
R-HSA-9614085 FOXO-mediated transcription
R-HSA-9614657 FOXO-mediated transcription of cell death genes
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001824 BXGD000081 Agranulocytosis Hemic and Lymphatic Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0238461 BXGD004936 Anaplastic thyroid carcinoma Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0949083 BXGD011569 Hospital acquired pneumonia Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein