Showing entry for Anaplastic thyroid carcinoma


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD004936
Disease NameAnaplastic thyroid carcinoma
Disease CUI IdC0238461
MeSH Codes C04  
Disease Class NameNeoplasms
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id HP:0000818   HP:0002664  
Human Phenotype Ontology TermAbnormality of the endocrine system; Neoplasm
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00767 BXGT003949 Acyl-CoA desaturase 6319 reviewed
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 5609 reviewed Kinase
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O14980 BXGT004119 Exportin-1 7514 reviewed Receptor
O15151 BXGT004132 Protein Mdm4 4194 reviewed Nucleic acid binding
O15169 BXGT004134 Axin-1 8312 reviewed
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O43683 BXGT004614 Mitotic checkpoint serine/threonine-protein kinase BUB1 699 reviewed Kinase
O60271 BXGT004866 C-Jun-amino-terminal kinase-interacting protein 4 9043 reviewed Enzyme modulator
O60566 BXGT004884 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 701 reviewed Kinase
O60674 BXGT004892 Tyrosine-protein kinase JAK2 3717 reviewed Kinase
O60858 BXGT004903 E3 ubiquitin-protein ligase TRIM13 10206 reviewed
O60885 BXGT004906 Bromodomain-containing protein 4 23476 reviewed Epigenetic regulator
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic 3417 reviewed
O95257 BXGT005365 Growth arrest and DNA damage-inducible protein GADD45 gamma 10912 reviewed
O95644 BXGT005389 Nuclear factor of activated T-cells, cytoplasmic 1 4772 reviewed Transcription factor
O95931 BXGT005407 Chromobox protein homolog 7 23492 reviewed Epigenetic regulator
P00338 BXGT005504 L-lactate dehydrogenase A chain 3939 reviewed Enzyme
P00352 BXGT005510 Retinal dehydrogenase 1 216 reviewed Enzyme
P00505 BXGT005560 Aspartate aminotransferase, mitochondrial 2806 reviewed
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00740 BXGT005634 Coagulation factor IX 2158 reviewed Enzyme
P00749 BXGT005641 Urokinase-type plasminogen activator 5328 reviewed Enzyme
P01100 BXGT005727 Proto-oncogene c-Fos 2353 reviewed Transcription factor
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01574 BXGT005768 Interferon beta 3456 reviewed
P01579 BXGT005770 Interferon gamma 3458 reviewed
P02452 BXGT005878 Collagen alpha-1(I) chain 1277 reviewed
P02511 BXGT005885 Alpha-crystallin B chain 1410 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P02775 BXGT005960 Platelet basic protein 5473 reviewed Signaling
P03950 BXGT006116 Angiogenin 283 reviewed
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase 5894 reviewed Kinase
P04066 BXGT006142 Tissue alpha-L-fucosidase 2517 reviewed
P04083 BXGT006147 Annexin A1 301 reviewed
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04629 BXGT006239 High affinity nerve growth factor receptor 4914 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04731 BXGT006251 Metallothionein-1A 4489 reviewed
P04792 BXGT006264 Heat shock protein beta-1 3315 reviewed
P05109 BXGT006318 Protein S100-A8 6279 reviewed Calcium-binding protein
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P05787 BXGT006385 Keratin, type II cytoskeletal 8 3856 reviewed
P06493 BXGT006445 Cyclin-dependent kinase 1 983 reviewed Kinase
P06702 BXGT006476 Protein S100-A9 6280 reviewed Calcium-binding protein
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P06744 BXGT006494 Glucose-6-phosphate isomerase 2821 reviewed Enzyme
P07202 BXGT006565 Thyroid peroxidase 7173 reviewed Enzyme
P07332 BXGT006601 Tyrosine-protein kinase Fes/Fps 2242 reviewed Kinase
P07949 BXGT006703 Proto-oncogene tyrosine-protein kinase receptor Ret 5979 reviewed Kinase
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08151 BXGT006731 Zinc finger protein GLI1 2735 reviewed
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08254 BXGT006758 Stromelysin-1 4314 reviewed Enzyme
P08473 BXGT006773 Neprilysin 4311 reviewed Enzyme
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P08670 BXGT006810 Vimentin 7431 reviewed
P08922 BXGT006843 Proto-oncogene tyrosine-protein kinase ROS 6098 reviewed Kinase
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P09237 BXGT006874 Matrilysin 4316 reviewed Enzyme
P09466 BXGT006892 Glycodelin 5047 reviewed Enzyme
P09619 BXGT006911 Platelet-derived growth factor receptor beta 5159 reviewed Kinase
P10114 BXGT007539 Ras-related protein Rap-2a 5911 reviewed Enzyme modulator
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10253 BXGT007550 Lysosomal alpha-glucosidase 2548 reviewed Enzyme
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit 5573 reviewed
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit 3815 reviewed Kinase
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP 3309 reviewed
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P11511 BXGT007717 Aromatase 1588 reviewed Enzyme
P11802 BXGT007750 Cyclin-dependent kinase 4 1019 reviewed Kinase
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src 6714 reviewed Kinase
P13489 BXGT007913 Ribonuclease inhibitor 6050 reviewed Transcription factor
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P14324 BXGT008005 Farnesyl pyrophosphate synthase 2224 reviewed Enzyme
P14618 BXGT008027 Pyruvate kinase PKM 5315 reviewed Kinase
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P14902 BXGT008065 Indoleamine 2,3-dioxygenase 1 3620 reviewed
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15531 BXGT008136 Nucleoside diphosphate kinase A 4830 reviewed Kinase
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15813 BXGT008158 Antigen-presenting glycoprotein CD1d 912 reviewed
P15941 BXGT008176 Mucin-1 4582 reviewed
P16070 BXGT008186 CD44 antigen 960 reviewed
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P16473 BXGT008234 Thyrotropin receptor 7253 reviewed G-protein coupled receptor
P17931 BXGT008356 Galectin-3 3958 reviewed Signaling
P18847 BXGT008431 Cyclic AMP-dependent transcription factor ATF-3 467 reviewed Transcription factor
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 1131 reviewed G-protein coupled receptor
P21675 BXGT008678 Transcription initiation factor TFIID subunit 1 6872 reviewed Kinase
P21953 BXGT008711 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 594 reviewed Enzyme
P22033 BXGT008721 Methylmalonyl-CoA mutase, mitochondrial 4594 reviewed Enzyme
P22455 BXGT008772 Fibroblast growth factor receptor 4 2264 reviewed Kinase
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P24941 BXGT009002 Cyclin-dependent kinase 2 1017 reviewed Kinase
P25208 BXGT009030 Nuclear transcription factor Y subunit beta 4801 reviewed
P26447 BXGT009114 Protein S100-A4 6275 reviewed Calcium-binding protein
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P27487 BXGT009187 Dipeptidyl peptidase 4 1803 reviewed Enzyme
P27708 BXGT009202 CAD protein 790 reviewed Enzyme
P28300 BXGT009243 Protein-lysine 6-oxidase 4015 reviewed
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29373 BXGT009337 Cellular retinoic acid-binding protein 2 1382 reviewed
P29401 BXGT009344 Transketolase 7086 reviewed Enzyme
P30086 BXGT009400 Phosphatidylethanolamine-binding protein 1 5037 reviewed Enzyme modulator
P30279 BXGT009415 G1/S-specific cyclin-D2 894 reviewed Enzyme modulator
P30536 BXGT009435 Translocator protein 706 reviewed
P30872 BXGT009474 Somatostatin receptor type 1 6751 reviewed G-protein coupled receptor
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P31751 BXGT009576 RAC-beta serine/threonine-protein kinase 208 reviewed Kinase
P32004 BXGT009594 Neural cell adhesion molecule L1 3897 reviewed
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P34972 BXGT009779 Cannabinoid receptor 2 1269 reviewed G-protein coupled receptor
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35346 BXGT009813 Somatostatin receptor type 5 6755 reviewed G-protein coupled receptor
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35613 BXGT009856 Basigin 682 reviewed
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41180 BXGT010230 Extracellular calcium-sensing receptor 846 reviewed G-protein coupled receptor
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P45452 BXGT010462 Collagenase 3 4322 reviewed Enzyme
P46100 BXGT010508 Transcriptional regulator ATRX 546 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P46940 BXGT010556 Ras GTPase-activating-like protein IQGAP1 8826 reviewed Enzyme modulator
P47736 BXGT010579 Rap1 GTPase-activating protein 1 5909 reviewed Enzyme modulator
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48735 BXGT010657 Isocitrate dehydrogenase [NADP], mitochondrial 3418 reviewed
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49767 BXGT010739 Vascular endothelial growth factor C 7424 reviewed Signaling
P50591 BXGT010814 Tumor necrosis factor ligand superfamily member 10 8743 reviewed Signaling
P52209 BXGT010923 6-phosphogluconate dehydrogenase, decarboxylating 5226 reviewed Enzyme
P52789 BXGT010954 Hexokinase-2 3099 reviewed Kinase
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 5347 reviewed Kinase
P53667 BXGT011008 LIM domain kinase 1 3984 reviewed Kinase
P57059 BXGT011210 Serine/threonine-protein kinase SIK1 150094 reviewed
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P62508 BXGT011431 Estrogen-related receptor gamma 2104 reviewed Nuclear receptor
P63000 BXGT011481 Ras-related C3 botulinum toxin substrate 1 5879 reviewed Enzyme modulator
P68871 BXGT011615 Hemoglobin subunit beta 3043 reviewed
P78310 BXGT011830 Coxsackievirus and adenovirus receptor 1525 reviewed
P78396 BXGT011842 Cyclin-A1 8900 reviewed Enzyme modulator
P80188 BXGT011882 Neutrophil gelatinase-associated lipocalin 3934 reviewed Enzyme
P98170 BXGT012231 E3 ubiquitin-protein ligase XIAP 331 reviewed Enzyme modulator
Q01094 BXGT012568 Transcription factor E2F1 1869 reviewed Nucleic acid binding
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 8140 reviewed Transporter
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 5604 reviewed Kinase
Q04760 BXGT012782 Lactoylglutathione lyase 2739 reviewed
Q05315 BXGT012811 Galectin-10 1178 reviewed Signaling
Q06710 BXGT012887 Paired box protein Pax-8 7849 reviewed
Q07973 BXGT012952 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial 1591 reviewed Enzyme
Q08050 BXGT012958 Forkhead box protein M1 2305 reviewed
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 3757 reviewed Ion channel
Q13085 BXGT013309 Acetyl-CoA carboxylase 1 31 reviewed
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13418 BXGT013351 Integrin-linked protein kinase 3611 reviewed Kinase
Q13478 BXGT013362 Interleukin-18 receptor 1 8809 reviewed Receptor
Q13547 BXGT013373 Histone deacetylase 1 3065 reviewed Epigenetic regulator
Q14994 BXGT013519 Nuclear receptor subfamily 1 group I member 3 9970 reviewed Nuclear receptor
Q15109 BXGT013537 Advanced glycosylation end product-specific receptor 177 reviewed Receptor
Q15116 BXGT013539 Programmed cell death protein 1 5133 reviewed
Q15717 BXGT013589 ELAV-like protein 1 1994 reviewed
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16698 BXGT013659 2,4-dienoyl-CoA reductase, mitochondrial 1666 reviewed Enzyme
Q495A1 BXGT014764 T-cell immunoreceptor with Ig and ITIM domains 201633 reviewed
Q53EZ4 BXGT015010 Centrosomal protein of 55 kDa 55165 reviewed
Q6IB77 BXGT016325 Glycine N-acyltransferase 10249 reviewed
Q86Z14 BXGT017639 Beta-klotho 152831 reviewed Enzyme
Q8TDQ0 BXGT018810 Hepatitis A virus cellular receptor 2 84868 reviewed
Q8WXD0 BXGT019009 Relaxin receptor 2 122042 reviewed G-protein coupled receptor
Q92769 BXGT019370 Histone deacetylase 2 3066 reviewed Epigenetic regulator
Q92993 BXGT019403 Histone acetyltransferase KAT5 10524 reviewed
Q96GD4 BXGT019667 Aurora kinase B 9212 reviewed Kinase
Q96J02 BXGT019679 E3 ubiquitin-protein ligase Itchy homolog 83737 reviewed Enzyme
Q96T88 BXGT019747 E3 ubiquitin-protein ligase UHRF1 29128 reviewed
Q9H3M7 BXGT020462 Thioredoxin-interacting protein 10628 reviewed
Q9HBX9 BXGT020523 Relaxin receptor 1 59350 reviewed G-protein coupled receptor
Q9HCU9 BXGT020539 Breast cancer metastasis-suppressor 1 25855 reviewed
Q9HD26 BXGT020540 Golgi-associated PDZ and coiled-coil motif-containing protein 57120 reviewed
Q9NYV4 BXGT021262 Cyclin-dependent kinase 12 51755 reviewed Kinase
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9UKV5 BXGT021751 E3 ubiquitin-protein ligase AMFR 267 reviewed
Q9UM73 BXGT021773 ALK tyrosine kinase receptor 238 reviewed Kinase
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q92911 BXGT022650 Sodium/iodide cotransporter 6528 reviewed Transporter
P16284 BXGT022972 Platelet endothelial cell adhesion molecule 5175 reviewed Cell adhesion
Q13635 BXGT024910 Protein patched homolog 1 5727 reviewed
P38646 BXGT024954 Stress-70 protein, mitochondrial 3313 reviewed
P20809 BXGT025043 Interleukin-11 3589 reviewed
P33993 BXGT025970 DNA replication licensing factor MCM7 4176 reviewed Enzyme
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
V9HWB9 BXGT026149 L-lactate dehydrogenase 3939 unreviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease