Showing entry for Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009672
Protein NamePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Uniport IdP32871
GenePIK3CA
Gene Id282306
DomainPI3Ka; PI3K_C2; PI3K_p85B; PI3K_rbd; PI3_PI4_kinase
Pfam PF00454   PF00792   PF02192   PF00794   PF00613  
OrganismBos taurus (Bovine)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060612 adipose tissue development
Biological Process GO:0001525 angiogenesis
Biological Process GO:0016477 cell migration
Biological Process GO:0071333 cellular response to glucose stimulus
Biological Process GO:0097009 energy homeostasis
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0044029 hypomethylation of CpG island
Biological Process GO:0001889 liver development
Biological Process GO:2000811 negative regulation of anoikis
Biological Process GO:2000270 negative regulation of fibroblast apoptotic process
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0006909 phagocytosis
Biological Process GO:0014065 phosphatidylinositol 3-kinase signaling
Biological Process GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
Biological Process GO:0048015 phosphatidylinositol-mediated signaling
Biological Process GO:0046854 phosphatidylinositol phosphorylation
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0043491 protein kinase B signaling
Biological Process GO:0043457 regulation of cellular respiration
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:2000653 regulation of genetic imprinting
Biological Process GO:0040014 regulation of multicellular organism growth
molecular function GO:0016303 1-phosphatidylinositol-3-kinase activity
molecular function GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
molecular function GO:0005524 ATP binding
molecular function GO:0043560 insulin receptor substrate binding
molecular function GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity
molecular function GO:0035004 phosphatidylinositol 3-kinase activity
molecular function GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
molecular function GO:0052742 phosphatidylinositol kinase activity
molecular function GO:0030295 protein kinase activator activity
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0030027 lamellipodium
cellular component GO:0016020 membrane
cellular component GO:0005942 phosphatidylinositol 3-kinase complex
cellular component GO:0005943 phosphatidylinositol 3-kinase complex, class IA
cellular component GO:0005944 phosphatidylinositol 3-kinase complex, class IB
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005683 Quercetin 302.24
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein