protein

Showing entry for Guanylate cyclase soluble subunit alpha-2

　　　　　　　　　　　　

General Target Information
BXGT Id	BXGT009722
Protein Name	Guanylate cyclase soluble subunit alpha-2
Uniport Id	P33402
Gene	GUCY1A2
Gene Id	2977
Domain	Guanylate_cyc; HNOB; HNOBA
Pfam	PF00211 PF07700 PF07701
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
1. Metabolism	1.4 Nucleotide metabolism	hsa00230	Purine metabolism
1. Metabolism	1.0 Global and overview maps	hsa01100	Metabolic pathways
3. Environmental Information Processing	3.2 Signal transduction	hsa04022	cGMP-PKG signaling pathway
5. Organismal Systems	5.3 Circulatory system	hsa04270	Vascular smooth muscle contraction
4. Cellular Processes	4.3 Cellular community - eukaryotes	hsa04540	Gap junction
5. Organismal Systems	5.1 Immune system	hsa04611	Platelet activation
5. Organismal Systems	5.10 Environmental adaptation	hsa04713	Circadian entrainment
5. Organismal Systems	5.6 Nervous system	hsa04730	Long-term depression
5. Organismal Systems	5.2 Endocrine system	hsa04921	Oxytocin signaling pathway
5. Organismal Systems	5.2 Endocrine system	hsa04924	Renin secretion
5. Organismal Systems	5.4 Digestive system	hsa04970	Salivary secretion

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0035556	intracellular signal transduction
Biological Process	GO:0010750	positive regulation of nitric oxide mediated signal transduction
Biological Process	GO:0007165	signal transduction
molecular function	GO:0005525	GTP binding
molecular function	GO:0004383	guanylate cyclase activity
molecular function	GO:0020037	heme binding
molecular function	GO:0044877	protein-containing complex binding
cellular component	GO:0005737	cytoplasm

Reactome

Pathway Id	Pathway Name
R-HSA-109582	Hemostasis
R-HSA-392154	Nitric oxide stimulates guanylate cyclase
R-HSA-397014	Muscle contraction
R-HSA-418346	Platelet homeostasis
R-HSA-445355	Smooth Muscle Contraction

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0004352	BXGD000269	Autistic Disorder	Mental Disorders
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0009404	BXGD000606	Colorectal Neoplasms	Digestive System Diseases; Neoplasms
C0410702	BXGD008447	Adolescent idiopathic scoliosis	Musculoskeletal Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C1257931	BXGD011815	Mammary Neoplasms, Human	Neoplasms; Skin and Connective Tissue Diseases
C1458155	BXGD013136	Mammary Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C1837461	BXGD014234	SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C4704874	BXGD023682	Mammary Carcinoma, Human	Neoplasms; Skin and Connective Tissue Diseases

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0014031	Isosorbide Mononitrate		191.04

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}